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Journal of Clinical Investigation, ISSN 0021-9738, 08/2018, Volume 128, Issue 9, pp. 3941 - 3956
The t-SNARE protein SNAP23 conventionally functions as a component of the cellular machinery required for intracellular transport vesicle fusion with target... 
MEMBRANE-FUSION | 3T3-L1 ADIPOCYTES | MEDICINE, RESEARCH & EXPERIMENTAL | RECYCLING ENDOSOMES | GLUT4 TRANSLOCATION | INSULIN-RESISTANCE | TRANS-GOLGI NETWORK | CONGENITAL GENERALIZED LIPODYSTROPHY | AUTOPHAGOSOME BIOGENESIS | LIPID DROPLETS | PTRF MUTATIONS | Vesicular Transport Proteins - metabolism | Autophagy-Related Protein 7 - metabolism | Qb-SNARE Proteins - metabolism | Qb-SNARE Proteins - genetics | Adipocytes - cytology | Male | Autophagy - physiology | Membrane Proteins - deficiency | Qb-SNARE Proteins - deficiency | Qc-SNARE Proteins - metabolism | Proteolysis | Membrane Proteins - metabolism | bcl-2-Associated X Protein - deficiency | Autophagy-Related Proteins - genetics | bcl-2-Associated X Protein - genetics | Autophagy-Related Proteins - deficiency | Membrane Proteins - genetics | Vesicular Transport Proteins - genetics | bcl-2-Associated X Protein - metabolism | Lipodystrophy - metabolism | 3T3-L1 Cells | Autophagy-Related Protein 7 - genetics | Qc-SNARE Proteins - deficiency | Mice, Knockout | Animals | Vesicular Transport Proteins - deficiency | Adipocytes - metabolism | Lipodystrophy - pathology | Qc-SNARE Proteins - genetics | Mice | Apoptosis - physiology | Autophagy-Related Proteins - metabolism | Autophagy-Related Protein 7 - deficiency | Physiological aspects | Autophagy (Cytology) | Apoptotic proteins | Fat cells | Health aspects | Membrane proteins | Membranes | Adipose tissue | Bax protein | Liver | Lysosomes | SNAP receptors | Biosynthesis | Adipocytes | Vesicle fusion | Glucose | Autophagy | Proteins | Hyperglycemia | Cell activation | Fatty liver | Rodents | Diabetes mellitus (non-insulin dependent) | Phenotypes | Diabetes mellitus | Inflammation | Insulin | Steatosis | Cell death | Insulin resistance | Lipodystrophy | Mutation | Vacuoles | Apoptosis
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 01/2011, Volume 286, Issue 1, pp. 491 - 501
Bcl-2 family proteins regulate a critical step in apoptosis referred to as mitochondrial outer membrane permeabilization (MOMP). Members of a subgroup of the... 
MITOCHONDRIAL-MEMBRANE PERMEABILIZATION | ANTAGONIST ABT-737 | MCL-1 | BIOCHEMISTRY & MOLECULAR BIOLOGY | MIMETIC ABT-737 | APOPTOTIC PROTEIN BAK | SENSITIVITY | OLIGOMERIZATION | BCL-2 FAMILY-MEMBERS | BH3-ONLY PROTEINS | CELL-DEATH | bcl-2-Associated X Protein - chemistry | Humans | Protein Multimerization | Cell Membrane Permeability | Molecular Sequence Data | Proto-Oncogene Proteins - chemistry | bcl-2 Homologous Antagonist-Killer Protein - metabolism | Proto-Oncogene Proteins c-bcl-2 - metabolism | Bcl-2-Like Protein 11 | BH3 Interacting Domain Death Agonist Protein - chemistry | HEK293 Cells | Protein Structure, Quaternary | Cell Membrane - metabolism | Membrane Proteins - metabolism | BH3 Interacting Domain Death Agonist Protein - metabolism | Protein Structure, Tertiary | Proto-Oncogene Proteins - metabolism | Amino Acid Sequence | Peptide Fragments - metabolism | Cytochromes c - secretion | Apoptosis Regulatory Proteins - chemistry | bcl-2-Associated X Protein - metabolism | Apoptosis Regulatory Proteins - metabolism | Animals | Membrane Proteins - chemistry | Liposomes - metabolism | Mice | Adaptor Proteins, Signal Transducing - metabolism | bcl-X Protein - metabolism | bcl-2 Homologous Antagonist-Killer Protein - chemistry | Apoptosis | Cytochrome c | BH3 Peptides | Mitochondria | Cell Death | Liposomes | Cell Biology | Bcl-2 Family Proteins
Journal Article
Cell death & disease, ISSN 2041-4889, 06/2016, Volume 7, Issue 6, pp. e2266 - e2266
How BH3-only proteins activate Bax/Bak, the two gateway proteins of the mitochondria-dependent apoptotic pathway, remains incompletely understood. Although all... 
PROSURVIVAL BCL-2 PROTEINS | APOPTOTIC PORE | X-L | MCL-1 | MITOCHONDRIA | BAX | BH3 DOMAINS | BCL-X(L) | CELL-DEATH | REVEALS | CELL BIOLOGY | BH3 Interacting Domain Death Agonist Protein - deficiency | RNA, Small Interfering - antagonists & inhibitors | RNA, Small Interfering - genetics | Humans | Myeloid Cell Leukemia Sequence 1 Protein - metabolism | bcl-2 Homologous Antagonist-Killer Protein - genetics | bcl-X Protein - genetics | BH3 Interacting Domain Death Agonist Protein - genetics | Green Fluorescent Proteins - genetics | bcl-2 Homologous Antagonist-Killer Protein - metabolism | Recombinant Fusion Proteins - metabolism | Tumor Suppressor Protein p53 - genetics | Biphenyl Compounds - pharmacology | Nitrophenols - pharmacology | Apoptosis Regulatory Proteins - deficiency | bcl-X Protein - antagonists & inhibitors | Apoptosis Regulatory Proteins - genetics | Genes, Reporter | bcl-2-Associated X Protein - genetics | Green Fluorescent Proteins - metabolism | Myeloid Cell Leukemia Sequence 1 Protein - antagonists & inhibitors | Signal Transduction | HCT116 Cells | Gene Expression Regulation | bcl-2-Associated X Protein - metabolism | Proto-Oncogene Proteins - genetics | Bcl-2-Like Protein 11 - genetics | Mitochondria - metabolism | Proto-Oncogene Proteins - deficiency | Gene Knockout Techniques | Sulfonamides - pharmacology | Tumor Suppressor Protein p53 - deficiency | Piperazines - pharmacology | Myeloid Cell Leukemia Sequence 1 Protein - genetics | Recombinant Fusion Proteins - genetics | Bcl-2-Like Protein 11 - deficiency | bcl-X Protein - metabolism | Apoptosis | RNA, Small Interfering - metabolism | Original
Journal Article
Molecular Cell, ISSN 1097-2765, 10/2009, Volume 36, Issue 1, pp. 15 - 27
The multifunctional, stress-inducible molecular chaperone HSP70 has important roles in aiding protein folding and maintaining protein homeostasis. HSP70... 
PROTEINS | CHEMBIO | CELLCYCLE | CANCER-CELLS | HSP70 | CHAPERONE-MEDIATED AUTOPHAGY | NEGATIVE REGULATION | LYSOSOMAL MEMBRANE | BIOCHEMISTRY & MOLECULAR BIOLOGY | HEAT-SHOCK RESPONSE | APAF-1 APOPTOSOME | P53 PROTEINS | P62 | CELL-DEATH | CELL BIOLOGY | HSP70 Heat-Shock Proteins - antagonists & inhibitors | Microtubule-Associated Proteins - metabolism | Sequestosome-1 Protein | Humans | NF-kappa B - metabolism | Cathepsin L - metabolism | Autophagy - drug effects | DNA-Binding Proteins - metabolism | Caspases - metabolism | Lysosomes - metabolism | Protein Binding - drug effects | Lymphoma - pathology | Protein Interaction Domains and Motifs | Cell Death - drug effects | Lysosomes - drug effects | Cell Survival - drug effects | HSP40 Heat-Shock Proteins - metabolism | Tumor Suppressor Protein p53 - metabolism | Ubiquitin-Protein Ligases - metabolism | HSP70 Heat-Shock Proteins - genetics | Mice, Transgenic | Mice, Inbred Strains | Sulfonamides - pharmacology | Apoptotic Protease-Activating Factor 1 - metabolism | HSP70 Heat-Shock Proteins - metabolism | Transcription Factors - metabolism | Animals | Sulfonamides - therapeutic use | Lymphoma - prevention & control | Sulfonamides - metabolism | Cell Line, Tumor | Mice | Adaptor Proteins, Signal Transducing - metabolism | Protein Multimerization - drug effects | Protein Binding - physiology | Proteins | Heat shock proteins | Analysis | Tumors
Journal Article
The FEBS Journal, ISSN 1742-464X, 07/2016, Volume 283, Issue 14, pp. 2690 - 2700
B‐cell lymphoma 2 (BCL‐2) family proteins mediate mitochondrial apoptosis by regulating mitochondrial outer membrane permeabilization (MOMP), which leads to... 
pro‐apoptotic; sensitizer | direct activator | BH3‐only | derepressor | mitochondrial apoptosis | effector | mitochondrial outer membrane permeabilization | anti‐apoptotic | B‐cell lymphoma 2 | Derepressor | Anti-apoptotic | Mitochondrial outer membrane permeabilization | Pro-apoptotic; sensitizer | Mitochondrial apoptosis | Direct activator | Effector | B-cell lymphoma 2 | BH3-only | anti-apoptotic | pro-apoptotic; sensitizer | DNA-BINDING DOMAIN | MITOCHONDRIAL OUTER-MEMBRANE | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | PROMOTE APOPTOSIS | DIRECT ACTIVATION | sensitizer | CELL-DEATH | BAX ACTIVATION | CHANGES CONFORMATION | pro-apoptotic | PROLYL ISOMERASE PIN1 | PEPTIDE COMPLEX | Signal Transduction | Tumor Suppressor Protein p53 - antagonists & inhibitors | Humans | Protein Multimerization | Tumor Suppressor Protein p53 - metabolism | bcl-2-Associated X Protein - metabolism | Models, Molecular | Permeability | Mitochondrial Membranes - metabolism | bcl-X Protein - chemistry | Proto-Oncogene Proteins c-bcl-2 - metabolism | Animals | Models, Biological | Protein Conformation | Proto-Oncogene Proteins c-bcl-2 - chemistry | Protein Interaction Domains and Motifs | Tumor Suppressor Protein p53 - chemistry | Apoptosis - physiology | bcl-X Protein - metabolism | Tumor proteins | Protein-protein interactions | Protein binding | Apoptosis | Proteins | Lymphomas
Journal Article
PLoS ONE, ISSN 1932-6203, 2011, Volume 6, Issue 3, p. e18330
TRAIL is a promising therapeutic agent for human malignancies. TRAIL often requires mitochondrial dysfunction, referred to as the Type II death receptor... 
CYTOCHROME-C | PATHWAY | MCL-1 | MITOCHONDRIA | BIOLOGY | RESISTANCE | BAX | TRAIL-INDUCED APOPTOSIS | CHOLANGIOCARCINOMA CELLS | EXPRESSION | CARCINOMA | Apoptosis - drug effects | Inhibitor of Apoptosis Proteins - genetics | Humans | Zinc Finger Protein Gli2 | bcl-2 Homologous Antagonist-Killer Protein - genetics | Hedgehog Proteins - metabolism | Immunoblotting | BH3 Interacting Domain Death Agonist Protein - genetics | bcl-2 Homologous Antagonist-Killer Protein - metabolism | Promoter Regions, Genetic - genetics | TNF-Related Apoptosis-Inducing Ligand - pharmacology | Bcl-2-Like Protein 11 | Chromatin Immunoprecipitation | Hedgehog Proteins - genetics | RNA Interference | Kruppel-Like Transcription Factors - metabolism | Veratrum Alkaloids - pharmacology | Apoptosis Regulatory Proteins - genetics | Electrophoretic Mobility Shift Assay | Inhibitor of Apoptosis Proteins - metabolism | Membrane Proteins - metabolism | Nuclear Proteins - genetics | BH3 Interacting Domain Death Agonist Protein - metabolism | bcl-2-Associated X Protein - genetics | Proto-Oncogene Proteins - metabolism | Cell Line | Membrane Proteins - genetics | bcl-2-Associated X Protein - metabolism | Nuclear Proteins - metabolism | Proto-Oncogene Proteins - genetics | Signal Transduction - genetics | Transcription Factors - genetics | Reverse Transcriptase Polymerase Chain Reaction | X-Linked Inhibitor of Apoptosis Protein - genetics | Apoptosis Regulatory Proteins - metabolism | Transcription Factors - metabolism | Signal Transduction - drug effects | X-Linked Inhibitor of Apoptosis Protein - metabolism | Cell Line, Tumor | Zinc Finger Protein GLI1 | Kruppel-Like Transcription Factors - genetics | Biochemistry | Cell death | Health aspects | Analysis | Cancer cells | Cancer | Bax protein | Toxicity | Cytotoxicity | XIAP protein | Metastasis | Neoplasms | Proteins | Signal transduction | Hepatitis | Mitochondria | Hepatology | Gastroenterology | Tumor necrosis factor-TNF | Inhibition | Cholangiocarcinoma | Immunoglobulins | Mortality | Pharmacology | siRNA | Chemical compounds | Signaling | Glioma | Hedgehog protein | Pancreatic cancer | Ligands | BIM protein | Apoptosis | Tumors
Journal Article
Blood, ISSN 0006-4971, 03/2009, Volume 113, Issue 12, pp. 2805 - 2815
During hematopoiesis, myeloid cell leukemia-1 (MCL-1) mediates the survival of bone marrow progenitors and lymphocytes. However, its requirement during myeloid... 
SURVIVAL | COLONY-STIMULATING FACTOR | CONGENITAL NEUTROPENIA | HEMATOPOIETIC STEM-CELLS | ESCHERICHIA-COLI | APOPTOTIC RESPONSES | MICE | HEMATOLOGY | BCL-2 FAMILY-MEMBERS | BH3-ONLY PROTEINS | T-LYMPHOCYTES | Granulocytes - cytology | Proto-Oncogene Proteins c-bcl-2 - physiology | Escherichia coli | bcl-2 Homologous Antagonist-Killer Protein - deficiency | bcl-2 Homologous Antagonist-Killer Protein - genetics | bcl-2-Associated X Protein - physiology | Recombinant Proteins | Macrophages, Peritoneal - cytology | Filgrastim | Membrane Proteins - deficiency | Bcl-2-Like Protein 11 | Apoptosis Regulatory Proteins - deficiency | Membrane Proteins - physiology | Tumor Suppressor Proteins - deficiency | Gene Deletion | Tumor Suppressor Proteins - genetics | Apoptosis Regulatory Proteins - genetics | bcl-2-Associated X Protein - deficiency | Myelopoiesis - drug effects | bcl-2-Associated X Protein - genetics | Macrophage Activation - physiology | Myelopoiesis - physiology | bcl-2 Homologous Antagonist-Killer Protein - physiology | Specific Pathogen-Free Organisms | Bone Marrow Cells - cytology | Membrane Proteins - genetics | Macrophages, Peritoneal - physiology | Mice, Inbred C57BL | Proto-Oncogene Proteins - genetics | Proto-Oncogene Proteins - deficiency | Organ Specificity | Mice, Knockout | Granulocyte Colony-Stimulating Factor - pharmacology | Tumor Suppressor Proteins - physiology | Animals | Myeloid Cell Leukemia Sequence 1 Protein | Proto-Oncogene Proteins - physiology | Apoptosis Regulatory Proteins - physiology | Mice | Apoptosis - physiology | Phagocytosis | Phagocytes, Granulocytes, and Myelopoiesis
Journal Article
Cell Cycle, ISSN 1538-4101, 11/2011, Volume 10, Issue 22, pp. 3938 - 3947
The cisplatin-induced ATM-dependent phosphorylated (p)-ΔNp63α plays an important role in transcriptional regulation of specific genes encoding mRNAs and... 
Binding | Proteins | Landes | Calcium | Bioscience | Biology | Cell | Cycle | Cancer | Organogenesis | Squamous cell carcinoma | MicroRNA | Cell death | Cisplatin resistance | Tumor protein p63 | Autophagy | Apoptosis | CARCINOMA-CELLS | tumor protein p63 | autophagy | cell death | INTRINSIC-APOPTOTIC PATHWAY | cisplatin resistance | DNA-DAMAGE | apoptosis | LUNG-CANCER CELLS | MDM4 MDMX | CELL BIOLOGY | CYCLE CONTROL | TUBULAR EPITHELIAL-CELLS | microRNA | P53 FAMILY | TRANSCRIPTIONAL REGULATION | HUMAN HEAD | squamous cell carcinoma | Phosphorylation | MicroRNAs - antagonists & inhibitors | Proto-Oncogene Proteins c-bcl-2 - physiology | Carcinoma, Squamous Cell - genetics | Carcinoma, Squamous Cell - pathology | Humans | Apoptosis - genetics | Antineoplastic Agents - therapeutic use | RNA, Messenger - metabolism | Tumor Suppressor Protein p53 - genetics | Tumor Suppressor Protein p53 - physiology | Proto-Oncogene Proteins c-bcl-2 - metabolism | Tumor Suppressor Proteins - genetics | Apoptosis Regulatory Proteins - genetics | Antineoplastic Agents - pharmacology | Autophagy - genetics | Gene Expression Regulation, Neoplastic - drug effects | Nuclear Proteins - genetics | Genes, Reporter | Proto-Oncogene Proteins - metabolism | Transcription Factors - physiology | Tumor Suppressor Proteins - metabolism | Luciferases - analysis | Tumor Suppressor Protein p53 - metabolism | Nuclear Proteins - metabolism | Proto-Oncogene Proteins - genetics | Mitochondria - metabolism | Cisplatin - pharmacology | Transcription Factors - genetics | Apoptosis Regulatory Proteins - metabolism | Transcription Factors - metabolism | Tumor Suppressor Proteins - physiology | Drug Resistance, Neoplasm - genetics | Carcinoma, Squamous Cell - drug therapy | Cisplatin - therapeutic use | Proto-Oncogene Proteins - physiology | Cell Line, Tumor | Apoptosis Regulatory Proteins - physiology | Nuclear Proteins - physiology | MicroRNAs - physiology | Proto-Oncogene Proteins c-bcl-2 - genetics | Report
Journal Article
Science, ISSN 0036-8075, 1/2003, Volume 299, Issue 5604, pp. 223 - 226
A small molecule, α-(trichloromethyl)-4-pyridineethanol (PETCM), was identified by high-throughput screening as an activator of caspase-3 in extracts of a... 
Molecules | Gels | Cell death | HeLa cells | Small interfering RNA | Cytochromes | Biochemistry | Cell extracts | Research Article | Apoptosis | Tumors | CYTOCHROME-C | APOPTOSIS | ACTIVATION | GENE | MULTIDISCIPLINARY SCIENCES | HL-60 CELLS | DIFFERENTIATION | ACIDIC NUCLEAR-PROTEIN | EXPRESSION | CELL-DEATH | FAMILY | Deoxyadenine Nucleotides - metabolism | Caspase 9 | Protein Precursors - isolation & purification | Nuclear Proteins - isolation & purification | Protein Precursors - chemistry | Pyridines - chemistry | Humans | Molecular Sequence Data | Nuclear Proteins - pharmacology | Neuropeptides | Thymosin - analogs & derivatives | Thymosin - chemistry | Proteins - isolation & purification | Caspases - metabolism | RNA Interference | Tumor Suppressor Proteins - chemistry | Caspase 3 | Thymosin - metabolism | Recombinant Proteins - metabolism | Thymosin - isolation & purification | Amino Acid Sequence | Apoptotic Protease-Activating Factor 1 | Deoxyadenine Nucleotides - pharmacology | Tumor Suppressor Proteins - metabolism | Signal Transduction | Thymosin - pharmacology | Intracellular Signaling Peptides and Proteins | Nuclear Proteins - metabolism | Mitochondria - metabolism | Recombinant Proteins - pharmacology | Nuclear Proteins - chemistry | Cytochrome c Group - metabolism | Protein Precursors - metabolism | Protein Precursors - pharmacology | Proteins - metabolism | Tumor Suppressor Proteins - isolation & purification | Cell Extracts | Proteins - pharmacology | Pyridines - pharmacology | Enzyme Activation | HeLa Cells | Proteins - chemistry | Molecular biology | Cells | Cancer
Journal Article
Biochemical Journal, ISSN 0264-6021, 07/2004, Volume 381, Issue 1, pp. 213 - 219
Proteins of the NACHT [NAIP (neuronal apoptosis inhibitory protein), CIITA (MHC class II transcription activator), HET-E (incompatibility locus protein from... 
CLAN | Caspase 1 | Nod2 | Nod1 | Nuclear factor κB (NF-κB) | Interleukin-1β | nuclear factor kappa B (NF-kappa B) | APOPTOSIS | ACTIVATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | caspase 1 | BACTERIAL PEPTIDOGLYCAN | SELF-ASSOCIATION | PROCASPASE-9 | interleukin-1 beta | CARD PROTEIN | SYNDROME | OLIGOMERIZATION | NF-KAPPA-B | Neuronal Apoptosis-Inhibitory Protein | Peptidoglycan - metabolism | Protein Kinases - metabolism | Kidney - embryology | Humans | DNA, Complementary - genetics | Molecular Sequence Data | Monocytes - metabolism | NF-kappa B - metabolism | Nerve Tissue Proteins - chemistry | Peptides - metabolism | Protein Isoforms - metabolism | Cloning, Molecular | Receptor-Interacting Protein Serine-Threonine Kinase 2 | Calcium-Binding Proteins - metabolism | Protein Structure, Tertiary | Cell Line | NF-kappa B - antagonists & inhibitors | Carrier Proteins - antagonists & inhibitors | Intracellular Signaling Peptides and Proteins | Nod2 Signaling Adaptor Protein | Immunity, Innate | Macromolecular Substances | Nerve Tissue Proteins - metabolism | Adaptor Proteins, Signal Transducing | Apoptosis Regulatory Proteins | Carrier Proteins - metabolism | CARD Signaling Adaptor Proteins | Nod1 Signaling Adaptor Protein | Interleukin-1 - secretion | Nucleoside-Phosphate Kinase - metabolism | NB-ARC domain, nucleotide-binding domain shared by Apaf-1, certain R gene products and CED-4 | NACHT, NAIP (neuronal apoptosis inhibitory protein), CIITA (MHC class II transcription activator), HET-E (incompatibility locus protein from Podospora anserina) and TP1 (telomerase-associated protein) | TLR, Toll-like receptor | CARDIAK, CARD-containing interleukin-1β-converting-enzyme-associated kinase | Apaf-1, apoptotic protease-activating factor 1 | RICK, RIP-like interacting CLARP kinase | CLAN, CARD, LRR and NACHT domain-containing protein | interleukin-1β | ECL®, enhanced chemiluminescence | NAC, nucleotide-binding domain and CARD-containing protein | CARD, caspase-recruitment domain | NALP, NACHT, LRR and PYRIN protein 1 | PAN, PAAD- and NACHT-containing protein | NF-κB, nuclear factor κB | ORF, open reading frame | RIP2, receptor-interacting protein | LRR, leucine-rich repeat | IKK, inhibitory κB kinase | PAAD, pyrin, AIM (absent-in-melanoma), ASC (apoptosis-associated speck-like protein containing a CARD) and death-domain-like | PGN, peptidoglycan | LPS, lipopolysaccharide | RACE, rapid amplification of cDNA ends | nuclear factor κB (NF-κB) | PAMP, pathogen-associated molecular pattern | HEK-293T, human embryonic kidney
Journal Article
PLoS ONE, ISSN 1932-6203, 01/2016, Volume 11, Issue 1, p. e0145780
This study has been undertaken to explore the therapeutic effects of deguelin and specific siRNAs in HeLa cells. The data provided clearly show the silencing... 
APOPTOSIS | CANCER CELLS | INHIBITOR | GASTRIC-CANCER | MULTIDISCIPLINARY SCIENCES | GROWTH | Ribosomal Protein S6 Kinases - metabolism | Apoptosis - drug effects | Humans | Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors | Myeloid Cell Leukemia Sequence 1 Protein - metabolism | Rotenone - analogs & derivatives | bcl-X Protein - chemistry | Proto-Oncogene Proteins c-bcl-2 - metabolism | RNA Interference | Mitogen-Activated Protein Kinase 1 - genetics | Rotenone - pharmacology | Myeloid Cell Leukemia Sequence 1 Protein - chemistry | bcl-Associated Death Protein - metabolism | Proto-Oncogene Proteins c-bcl-2 - chemistry | Phosphorylation - drug effects | Binding Sites | Protein Structure, Tertiary | Mitogen-Activated Protein Kinase 3 - genetics | bcl-Associated Death Protein - chemistry | Cytochromes c - metabolism | Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors | Rotenone - chemistry | Mitochondrial Membranes - metabolism | Mitogen-Activated Protein Kinase 3 - metabolism | Protein Binding | Molecular Docking Simulation | HeLa Cells | bcl-X Protein - metabolism | Mitogen-Activated Protein Kinase 1 - metabolism | Phosphorylation | Apoptotic proteins | RNA | HeLa cells | Genetic aspects | Research | Health aspects | Rotenone | Cytochrome | Biotechnology | Bax protein | Bcl-2 protein | Serine | Multiple myeloma | Oncology | Hydrophobicity | Kinases | Autophagy | Stomach cancer | Proteins | Angiogenesis | Mitochondria | Bcl-x protein | Cell cycle | Life sciences | Inhibition | Dimerization | Medical research | Extracellular signal-regulated kinase | Pharmacology | Grooves | siRNA | Chemical compounds | Mcl-1 protein | Cytochrome c | Medicine | Molecular biology | Apoptosis
Journal Article
Chemical Biology & Drug Design, ISSN 1747-0277, 03/2014, Volume 83, Issue 3, pp. 317 - 323
Overexpression of Bcl‐2 has been recognized in various malignancies. Recently, HA14‐1, a Bcl‐2 antagonist, has been identified for its anti‐apoptotic effect.... 
anti‐apoptotic proteins | apoptosis‐regulating proteins | pro‐apoptotic proteins | cervical cancer | anti-apoptotic proteins | apoptosis-regulating proteins | pro-apoptotic proteins | CANCER-CELLS | MOLECULE BCL-2 INHIBITOR | CHEMISTRY, MEDICINAL | ANTAGONIST | BIOCHEMISTRY & MOLECULAR BIOLOGY | SENSITIZE | DEATH | BH3 DOMAIN | BAX | ORGANIC-COMPOUND | EXPRESSION | bcl-2-Associated X Protein - chemistry | Nitriles - pharmacology | Apoptosis - drug effects | Humans | bcl-2 Homologous Antagonist-Killer Protein - genetics | bcl-X Protein - genetics | Nitriles - chemical synthesis | bcl-2 Homologous Antagonist-Killer Protein - metabolism | Benzopyrans - chemistry | bcl-X Protein - chemistry | Proto-Oncogene Proteins c-bcl-2 - metabolism | Benzopyrans - chemical synthesis | Proto-Oncogene Proteins c-bcl-2 - chemistry | Benzopyrans - pharmacology | Binding Sites | bcl-2-Associated X Protein - genetics | Protein Structure, Tertiary | Proto-Oncogene Proteins - metabolism | Cell Survival - drug effects | Tumor Suppressor Protein p53 - metabolism | bcl-2-Associated X Protein - metabolism | Apoptosis Regulatory Proteins - metabolism | Gene Expression Regulation - drug effects | Nitriles - chemistry | Molecular Docking Simulation | HeLa Cells | bcl-X Protein - metabolism | bcl-2 Homologous Antagonist-Killer Protein - chemistry | Tumor proteins | Analysis | Cervical cancer | Protein binding | Apoptosis | Index Medicus
Journal Article