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Journal of Neuroscience Research, ISSN 0360-4012, 02/2018, Volume 96, Issue 2, pp. 253 - 264
Oxidative stress and neural degeneration have been shown to be involved in the pathogenesis of Parkinson's disease (PD). The P2Y6 purinergic receptor (P2Y6R)... 
Parkinson's disease | P2Y6R | MPP | oxidative stress | SH‐SY5Y | SH-SY5Y | LIPID-PEROXIDATION | SIGNALING MOLECULE | SUBSTANTIA-NIGRA | NEUROSCIENCES | PROTECTS | INHIBITION | PATHWAY | P2Y RECEPTOR | SUPEROXIDE-DISMUTASE | PARKINSONS-DISEASE | Malondialdehyde - metabolism | RNA, Small Interfering - genetics | Reactive Oxygen Species - metabolism | 1-Methyl-4-phenylpyridinium - pharmacology | Humans | Herbicides - pharmacology | Thiourea - pharmacology | Transfection | Apyrase - pharmacology | Receptors, Purinergic P2 - genetics | Receptors, Purinergic P2 - metabolism | Superoxide Dismutase-1 - metabolism | Cell Line, Tumor | Purinergic P2 Receptor Antagonists - pharmacology | Purinergic P2 Receptor Agonists - pharmacology | Cell Death - drug effects | Gene Expression Regulation, Neoplastic - drug effects | Oxidative Stress - drug effects | Uridine Diphosphate - pharmacology | Isothiocyanates - pharmacology | Neuroblastoma - pathology | Thiourea - analogs & derivatives | Nitric Oxide Synthase Type II - metabolism | RNA, Small Interfering - metabolism | Oxidative stress | Neurons | Cell death | Nitric oxide | Biochemistry | Superoxide | Mitogens | Reactive oxygen species | Pathogenesis | Superoxide dismutase | Kinases | Neurodegeneration | Down-regulation | Degeneration | Inhibition | Movement disorders | Neurodegenerative diseases | Extracellular signal-regulated kinase | Pharmacology | Inflammation | siRNA | Malondialdehyde | Nitric-oxide synthase | Microglia | Signaling | Protein kinase | Apyrase | Viability | Apoptosis
Journal Article
Plant Physiology, ISSN 0032-0889, 8/2011, Volume 156, Issue 4, pp. 1740 - 1753
This study investigates the role of extracellular nucleotides and apyrase enzymes in regulating stomatal aperture. Prior data indicate that the expression of... 
Peels | Leaves | Roux | Luminescence | Protoplasts | Guard cells | Stomata | CELL BIOLOGY AND SIGNAL TRANSDUCTION | Plants | Nucleotides | Plant cells | NADPH OXIDASE | PROTEIN | SURFACE-AREA | THALIANA | CA2+ CHANNELS | GUARD-CELL PROTOPLASTS | POLLEN GERMINATION | CLOSURE | ATP RELEASE | NITRIC-OXIDE GENERATION | PLANT SCIENCES | Arabidopsis - physiology | RNA Interference - drug effects | Arabidopsis - enzymology | Nitric Oxide - pharmacology | Adenosine Triphosphate - secretion | Extracellular Space - drug effects | Promoter Regions, Genetic - genetics | Adenosine Triphosphate - pharmacology | Arabidopsis Proteins - metabolism | Extracellular Space - metabolism | Light | Nucleotides - pharmacology | Plant Stomata - drug effects | Pyridoxal Phosphate - analogs & derivatives | Plant Stomata - enzymology | Triazines - metabolism | Arabidopsis Proteins - genetics | Gene Expression Regulation, Plant - radiation effects | Arabidopsis - drug effects | Pyridoxal Phosphate - pharmacology | Apyrase - antagonists & inhibitors | Apyrase - metabolism | Enzyme Inhibitors - pharmacology | Extracellular Space - radiation effects | Hydrogen Peroxide - pharmacology | RNA Interference - radiation effects | Thionucleotides - pharmacology | Adenosine Triphosphate - analogs & derivatives | Adenosine Diphosphate - pharmacology | Arabidopsis - genetics | Abscisic Acid - pharmacology | Gene Expression Regulation, Plant - drug effects | Plant Stomata - radiation effects | Models, Biological | Apyrase - genetics | Adenosine Diphosphate - analogs & derivatives | Plant Stomata - physiology | Arabidopsis Proteins - antagonists & inhibitors | Arabidopsis thaliana | Physiological aspects | Research | Plant physiology
Journal Article
Nature, ISSN 0028-0836, 04/1997, Volume 386, Issue 6625, pp. 616 - 619
Journal Article
mBio, ISSN 2161-2129, 02/2016, Volume 7, Issue 1, p. e00058
Eukaryal taxa differ with respect to the structure and mechanism of the RNA triphosphatase (RTPase) component of the mRNA capping apparatus. Protozoa, fungi,... 
YEAST | ACTIVE-SITE | CAPPING ENZYME LEF4 | CRYSTAL-STRUCTURE | MICROBIOLOGY | NUCLEOSIDE TRIPHOSPHATASE | DRUG TARGET | MUTATIONAL ANALYSIS | APPARATUS | STRUCTURAL DETERMINANTS | INDUCIBLE EXPRESSION SYSTEM | Gallic Acid - pharmacology | Antioxidants - chemistry | Protozoan Proteins - antagonists & inhibitors | Caffeic Acids - pharmacology | Trypanocidal Agents - chemistry | Protozoan Proteins - genetics | Trypanosoma brucei brucei - enzymology | Depsides - pharmacology | RNA Interference | Acid Anhydride Hydrolases - genetics | Enzyme Inhibitors - chemistry | Glucosides - chemistry | Inhibitory Concentration 50 | Quinic Acid - pharmacology | Cinnamates - chemistry | Gallic Acid - analogs & derivatives | Binding Sites | Gallic Acid - chemistry | Trypanosoma brucei brucei - growth & development | Quercetin - analogs & derivatives | Quinic Acid - analogs & derivatives | Catalytic Domain | Glucosides - pharmacology | Quercetin - chemistry | Apyrase - metabolism | Enzyme Inhibitors - pharmacology | Quinic Acid - chemistry | Depsides - chemistry | Caffeic Acids - chemistry | Antioxidants - pharmacology | Cinnamates - pharmacology | Drug Discovery | Trypanosoma brucei brucei - drug effects | Small Molecule Libraries - chemistry | Quercetin - pharmacology | Trypanocidal Agents - pharmacology | Acid Anhydride Hydrolases - antagonists & inhibitors
Journal Article
Journal of Applied Physiology, ISSN 8750-7587, 05/2010, Volume 108, Issue 5, pp. 1293 - 1303
Capsaicin-sensitive lung vagal afferents (CSLVAs) are important in detecting pulmonary reactive oxygen species (ROS). We investigated the mechanisms underlying... 
Reactive oxygen species | Lung vagal C fibers | INHALED WOOD SMOKE | SPORT SCIENCES | AIR-EMBOLISM | PHYSIOLOGY | COUGH SENSORS | MECHANISMS | lung vagal C fibers | RELATIVE CONTRIBUTIONS | SENSORY TRANSDUCTION | reactive oxygen species | PULMONARY C-FIBERS | HYDROGEN-PEROXIDE | ANESTHETIZED RATS | MEMBRANE-RECEPTORS | Smoking - adverse effects | Lung - innervation | Reactive Oxygen Species - metabolism | Calcium Channels - metabolism | Capsaicin - pharmacology | Reflex - drug effects | Vagus Nerve - drug effects | Male | Smoke | Sensory System Agents - pharmacology | Respiratory Mechanics - drug effects | Heart Rate - drug effects | Adenosine Deaminase - pharmacology | Time Factors | Apyrase - pharmacology | Adenosine Triphosphate - metabolism | Inhalation Exposure | Blood Pressure - drug effects | Pyridoxal Phosphate - analogs & derivatives | Ankyrins - agonists | Neurons, Afferent - drug effects | Pyridoxal Phosphate - pharmacology | Vagus Nerve - metabolism | TRPC Cation Channels | Rats | Purinergic P2 Receptor Agonists | Antioxidants - pharmacology | Rats, Sprague-Dawley | Respiration, Artificial | Indomethacin - pharmacology | Cyclooxygenase Inhibitors - pharmacology | Receptors, Purinergic P2X | Animals | Signal Transduction - drug effects | Receptors, Purinergic P2 - metabolism | TRPA1 Cation Channel | Acetylcysteine - pharmacology | Ankyrins - metabolism | Neurons, Afferent - metabolism
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 01/2003, Volume 278, Issue 1, pp. 131 - 138
Journal Article
Journal Article
Journal of Periodontal Research, ISSN 0022-3484, 04/2013, Volume 48, Issue 2, pp. 169 - 176
Background and Objective Mechanical stress is an important factor in maintaining homeostasis of the periodontium. Interleukin‐1beta (IL‐1β) and adenosine... 
human periodontal ligament cells | interleukin‐1beta | mechanical stress | P2X7 receptor | adenosine triphosphate | Human periodontal ligament cells | Interleukin-1beta | Mechanical stress | Adenosine triphosphate | HUMAN TENDON CELLS | PROINFLAMMATORY CYTOKINES | ORTHODONTIC TOOTH MOVEMENT | interleukin-1beta | FAMILY | MATRIX METALLOPROTEINASES | IL-1-BETA RELEASE | P2X RECEPTOR | DENTISTRY, ORAL SURGERY & MEDICINE | GENE-EXPRESSION | NITRIC-OXIDE | ATP RELEASE | Interleukin-1beta - drug effects | RNA, Small Interfering - genetics | Up-Regulation | Calcium Signaling - physiology | Coloring Agents | Humans | 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine - analogs & derivatives | Stress, Mechanical | Purinergic P2X Receptor Antagonists - pharmacology | Luminescent Measurements | Receptors, Purinergic P2X7 - genetics | Adenosine Triphosphate - pharmacology | Tetrazolium Salts | Periodontal Ligament - cytology | Benzenesulfonates - pharmacology | Adenosine Triphosphate - antagonists & inhibitors | Time Factors | Apyrase - pharmacology | Suramin - analogs & derivatives | Thiazoles | Cell Culture Techniques | Adenosine Triphosphate - physiology | Cell Survival - physiology | Suramin - pharmacology | Interleukin-1beta - analysis | Interleukin-1beta - physiology | Cells, Cultured | Calcium Channel Blockers - pharmacology | Receptors, Purinergic P2X7 - physiology | Adenosine Diphosphate - pharmacology | 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine - pharmacology | Homeostasis - physiology | Signal Transduction - physiology | Adenosine Diphosphate - analogs & derivatives | Dactinomycin - pharmacology | RNA | Interleukins | Analysis | Muscle proteins | Enzyme-linked immunosorbent assay | Cells
Journal Article
PLoS ONE, ISSN 1932-6203, 10/2011, Volume 6, Issue 10, p. e26125
Thrombosis is common in ovarian cancer. However, the interaction of platelets with ovarian cancer cells has not been critically examined. To address this, we... 
OVEREXPRESSION | ACTIVATION | DIMERIC BETA-GLYCOPROTEIN-I | GLYCOPROTEIN IB-ALPHA | MULTIDISCIPLINARY SCIENCES | TUMOR-CELLS | B7-H1 | GROWTH-FACTOR | RECEPTORS | EXPERIMENTAL LUNG METASTASIS | KALLIKREIN GENES | Oligonucleotide Array Sequence Analysis | Humans | Ovarian Neoplasms - pathology | Epithelial-Mesenchymal Transition - drug effects | Peptide Fragments - pharmacology | Gene Expression Profiling | Epithelial-Mesenchymal Transition - genetics | Receptors, Thrombin - antagonists & inhibitors | Neovascularization, Pathologic - pathology | Adenosine Triphosphate - pharmacology | Ovarian Neoplasms - genetics | Apyrase - pharmacology | Receptors, Purinergic P2Y1 - metabolism | Female | Adenosine Monophosphate - pharmacology | Gene Expression Regulation, Neoplastic - drug effects | Ovarian Neoplasms - blood supply | Receptors, Purinergic P2Y12 - metabolism | Cell Survival - drug effects | Reproducibility of Results | Adenosine Diphosphate - pharmacology | Platelet Adhesiveness - drug effects | Drug Synergism | Signal Transduction - drug effects | Adenosine Monophosphate - analogs & derivatives | Arachidonic Acid - pharmacology | Receptors, Thrombin - metabolism | Adenosine Diphosphate - analogs & derivatives | Cell Degranulation - drug effects | Collagen | Genes | Cancer cells | Metastasis | Gene expression | Thrombosis | Blood clot | Ovarian cancer | Cytochrome | Ovarian carcinoma | Proteinase-activated receptor 1 | Antagonists | ADP | Autophagy | Metastases | Angiogenesis | Cell activation | Histopathology | Blood platelets | Cell cycle | Thromboembolism | Epinephrine | Cell survival | Gynecology | Breast cancer | Tumor cell lines | Survival | Obstetrics | Adhesion | Signaling | Medical prognosis | Cell lines | Degranulation | Biomarkers | Fatalities | Apyrase | Platelets | P-selectin | Phagocytosis | Cancer | Apoptosis
Journal Article
Journal of the American Heart Association, ISSN 2047-9980, 08/2017, Volume 6, Issue 8, p. n/a
Background GPVI (Glycoprotein VI) is the essential platelet collagen receptor in atherothrombosis. Dimeric GPVI‐Fc (Revacept) binds to GPVI binding sites on... 
platelet | glycoprotein | thrombosis | Thrombosis | Platelet | Glycoprotein | CARDIAC & CARDIOVASCULAR SYSTEMS | COLLAGEN RECEPTOR | PLATELET-AGGREGATION | ATHEROSCLEROSIS | ARTERIAL THROMBUS FORMATION | ADHESION | INHIBITION | GPVI-FC | ANTIPLATELET DRUGS | EXPRESSION | BLOOD | Thrombosis - chemically induced | Carotid Artery Injuries - blood | Recombinant Fusion Proteins - pharmacology | Humans | Carotid Artery Injuries - drug therapy | Male | Immunoglobulin Fc Fragments - toxicity | Glycoproteins - pharmacology | Platelet Aggregation Inhibitors - toxicity | Dose-Response Relationship, Drug | Fibrinolytic Agents - pharmacokinetics | Apyrase - pharmacology | Carotid Artery Diseases - pathology | Chlorides | Glycoproteins - toxicity | Platelet Aggregation Inhibitors - pharmacology | Female | Glycoproteins - pharmacokinetics | Platelet Aggregation - drug effects | Platelet Aggregation Inhibitors - pharmacokinetics | Thrombosis - blood | Thrombosis - prevention & control | Carotid Artery Injuries - chemically induced | Carotid Artery Injuries - pathology | Disease Models, Animal | Platelet Membrane Glycoproteins - pharmacokinetics | Mice, Inbred C57BL | Plaque, Atherosclerotic | Apyrase - pharmacokinetics | Ferric Compounds | Fibrinolytic Agents - pharmacology | Thrombosis - pathology | Animals | Carotid Artery Diseases - blood | Immunoglobulin Fc Fragments - pharmacology | Platelet Membrane Glycoproteins - pharmacology | Platelet Membrane Glycoproteins - toxicity | Antigens, CD - pharmacology | Fibrinolytic Agents - toxicity | Hemorrhage - chemically induced | Antigens, CD - toxicity | Apyrase - toxicity
Journal Article
Immunobiology, ISSN 0171-2985, 2015, Volume 221, Issue 1, pp. 84 - 93
Abstract Regulatory T cells that express CD39 (CD39+ Treg) exhibit specific immunomodulatory properties. Ectonucleotidase CD39 hydrolyses ATP and ADP. ATP is a... 
Allergy and Immunology | Advanced Basic Science | ART1 | NAD | CD39 | Immune regulation | P2X7 receptor | ATP | RHEUMATOID-ARTHRITIS | NAD GLYCOHYDROLASE ACTIVITIES | SURFACE-PROTEINS | IMMUNOLOGY | HUMAN MONOCYTES | NICOTINAMIDE ADENINE-DINUCLEOTIDE | ECTO-ADP-RIBOSYLTRANSFERASES | MULTIPLE-SCLEROSIS | P2X RECEPTOR | PURINERGIC RECEPTOR | ATP RELEASE | T-Lymphocyte Subsets - immunology | Antigens, CD - immunology | Receptors, Adenosine A2 - immunology | Cell Proliferation | T-Lymphocyte Subsets - cytology | Humans | Male | L-Selectin - genetics | Antigens, CD - genetics | Receptors, Purinergic P2X7 - genetics | Adenosine Triphosphate - pharmacology | L-Selectin - immunology | Adenosine A2 Receptor Agonists - pharmacology | Receptors, Adenosine A2 - genetics | T-Lymphocyte Subsets - drug effects | Adult | Female | Cell Death - drug effects | Receptors, Purinergic P2X7 - immunology | ADP Ribose Transferases - immunology | Triazines - pharmacology | GPI-Linked Proteins - immunology | Phenethylamines - pharmacology | Signal Transduction | Gene Expression Regulation | NAD - pharmacology | Apyrase - immunology | Immunophenotyping | Adenosine - pharmacology | Triazoles - pharmacology | ADP Ribose Transferases - genetics | Adenosine A2 Receptor Antagonists - pharmacology | Adenosine - analogs & derivatives | Apyrase - genetics | Adolescent | Primary Cell Culture | GPI-Linked Proteins - genetics | Enzymes | Evaluation | T cells | Analysis
Journal Article
Journal of General Physiology, ISSN 0022-1295, 06/2007, Volume 129, Issue 6, pp. 485 - 491
Journal Article