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1. Full Text Specific Aquaporins Facilitate the Diffusion of Hydrogen Peroxide across Membranes
by Gerd P. Bienert and Anders L. B. Møller and Kim A. Kristiansen and Alexander Schulz and Ian M. Møller and Jan K. Schjoerring and Thomas P. Jahn
Journal of Biological Chemistry, ISSN 0021-9258, 01/2007, Volume 282, Issue 2, pp. 1183 - 1192
The metabolism of aerobic organisms continuously produces reactive oxygen species. Although potentially toxic, these compounds also function in signaling. One... 
YEAST | WATER CHANNELS AQUAPORINS | OXIDATIVE STRESS | TRANSPORT | REACTIVE OXYGEN | FUNCTIONAL EXPRESSION | BIOCHEMISTRY & MOLECULAR BIOLOGY | MITOCHONDRIA | H2O2 | SACCHAROMYCES-CEREVISIAE | CELL | Saccharomyces cerevisiae - genetics | Humans | Hydrogen Peroxide - pharmacokinetics | Aquaporin 5 - genetics | Aquaporin 1 - metabolism | Aquaporins - genetics | Arabidopsis Proteins - metabolism | Saccharomyces cerevisiae - metabolism | Osmosis - physiology | Aquaporin 4 - genetics | Cell Membrane - metabolism | Diffusion | Transformation, Genetic | Silver - pharmacology | Arabidopsis Proteins - genetics | Gene Expression | Arabidopsis | Water - metabolism | Rats | Aquaporins - metabolism | Aquaporin 3 - genetics | Spheroplasts - metabolism | Aquaporin 1 - genetics | Aquaporin 2 - metabolism | Catalase - metabolism | Aquaporin 3 - metabolism | Microscopy, Confocal | Animals | Aquaporin 5 - metabolism | Aquaporin 4 - metabolism | Aquaporin 2 - genetics | Index Medicus
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2. Full Text Differential expression of aquaporin‐3 and aquaporin‐5 in pancreatic ductal adenocarcinoma
by Direito, Inês and Paulino, Jorge and Vigia, Emanuel and Brito, Maria Alexandra and Soveral, Graça
Journal of Surgical Oncology, ISSN 0022-4790, 06/2017, Volume 115, Issue 8, pp. 980 - 996
Background and ObjectivesAquaporin-5 (AQP5) and -3 (AQP3) are protein channels that showed to be up-regulated in a variety of tumors. Our goal was to... 
aquaporins | expression pattern | pancreatic cancer | biomarker | pancreas | duodenum | CANCER-CELLS | SURGERY | METASTASIS | PROLIFERATION | DRUG-RESISTANCE | AQP5 | BREAST-CANCER | COLON-CANCER | GROWTH-FACTOR RECEPTOR | LUNG-CANCER | ONCOLOGY | SQUAMOUS-CELL CARCINOMA | Pancreatic Neoplasms - metabolism | Cadherins - metabolism | Humans | Middle Aged | Ki-67 Antigen - metabolism | Male | Neoplasm Proteins - metabolism | Case-Control Studies | Pancreatic Ducts - metabolism | Aquaporin 3 - metabolism | Receptor, Epidermal Growth Factor - metabolism | Adenocarcinoma - metabolism | Aquaporin 5 - metabolism | Keratins - metabolism | Adult | Female | Aged | Cell growth | Aquaporins | Cancer surgery | Index Medicus
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3. Full Text Role of Human Aquaporin 5 In Colorectal Carcinogenesis
by Kang, Sung Koo and Chae, Young Kwang and Woo, Janghee and Kim, Myoung Sook and Park, Jong Chul and Lee, Juna and Soria, Jean Charles and Jang, Se Jin and Sidransky, David and Moon, Chulso
American Journal of Pathology, The, ISSN 0002-9440, 2008, Volume 173, Issue 2, pp. 518 - 525
While overexpression of several aquaporins (AQPs) has been reported in different types of human cancer, the role of AQPs in carcinogenesis has not been clearly... 
Pathology | OVEREXPRESSION | GENE | ANGIOGENESIS | PHOSPHORYLATION | PROTEIN-KINASE | WATER CHANNELS | AQP5 | PATHOLOGY | CANCER | EXPRESSION | CAMP | Cyclin D1 - metabolism | Phosphorylation | Cell Proliferation | Signal Transduction | Humans | Cells, Cultured | Aquaporin 5 - genetics | Extracellular Signal-Regulated MAP Kinases - metabolism | Cyclin-Dependent Kinase 4 - metabolism | Cell Transformation, Neoplastic - metabolism | Colonic Neoplasms - metabolism | Animals | Aquaporin 5 - metabolism | Colonic Neoplasms - pathology | Liver Neoplasms - metabolism | Mutation | Liver Neoplasms - secondary | Index Medicus | Abridged Index Medicus | Regular
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4. Full Text Regulation of the hyperosmotic induction of aquaporin 5 and VEGF in retinal pigment epithelial cells: Involvement of NFAT5
by Hollborn, Margrit and Vogler, Stefanie and Reichenbach, Andreas and Wiedemann, Peter and Bringmann, Andreas and Kohen, Leon
Molecular Vision, ISSN 1090-0535, 2015, Volume 21, pp. 360 - 377
Purpose: High intake of dietary salt increases extracellular osmolarity, which results in hypertension, a risk factor of neovascular age-related macular... 
DIABETIC-RETINOPATHY | FACTOR 1-ALPHA HIF-1-ALPHA | HYPERTONIC INDUCTION | BIOCHEMISTRY & MOLECULAR BIOLOGY | DOWN-REGULATION | OPHTHALMOLOGY | NF-KAPPA-B | EXPRESSION | BLOOD-PRESSURE | MULLER CELLS | ENDOTHELIAL GROWTH-FACTOR | WATER | RNA, Small Interfering - genetics | Retinal Pigment Epithelium - metabolism | Epithelial Cells - metabolism | Sodium Chloride - pharmacology | Epithelial Cells - drug effects | Humans | Sucrose - pharmacology | NF-kappa B - metabolism | Vascular Endothelial Growth Factor A - metabolism | Aquaporin 5 - genetics | Vascular Endothelial Growth Factor A - genetics | Aquaporins - genetics | Vascular Endothelial Growth Factor A - secretion | Osmolar Concentration | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Mitogen-Activated Protein Kinase 1 - genetics | Transcription, Genetic | p38 Mitogen-Activated Protein Kinases - metabolism | Aquaporin 5 - agonists | Phosphorylation - drug effects | Epithelial Cells - cytology | Retinal Pigment Epithelium - drug effects | Mitogen-Activated Protein Kinase 3 - genetics | Signal Transduction | Hypoxia-Inducible Factor 1, alpha Subunit - genetics | Gene Expression Regulation | p38 Mitogen-Activated Protein Kinases - genetics | Aquaporins - metabolism | Transcription Factors - antagonists & inhibitors | Transcription Factors - genetics | Triamcinolone Acetonide - pharmacology | Transcription Factors - metabolism | Aquaporin 5 - metabolism | Mitogen-Activated Protein Kinase 3 - metabolism | NF-kappa B - genetics | Primary Cell Culture | Transcription Factors - agonists | Retinal Pigment Epithelium - cytology | Mitogen-Activated Protein Kinase 1 - metabolism | RNA, Small Interfering - metabolism | Index Medicus
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5. Full Text Water Permeation Drives Tumor Cell Migration in Confined Microenvironments
by Stroka, Kimberly M and Jiang, Hongyuan and Chen, Shih-Hsun and Tong, Ziqiu and Wirtz, Denis and Sun, Sean X and Konstantopoulos, Konstantinos
Cell, ISSN 0092-8674, 04/2014, Volume 157, Issue 3, pp. 611 - 623
Cell migration is a critical process for diverse (patho)physiological phenomena. Intriguingly, cell migration through physically confined spaces can persist... 
ACTIN-POLYMERIZATION | LOCALIZATION | INVASION | TRANSPORTERS | BIOCHEMISTRY & MOLECULAR BIOLOGY | NA+/H+ ANTIPORTER | VOLUME | INTRACELLULAR PH | MOTILITY DRIVEN | ION CHANNELS | CANCER | CELL BIOLOGY | Water | Animals | Aquaporin 5 - metabolism | Models, Biological | Humans | Actins - metabolism | Cell Line, Tumor | Cell Size | Cell Membrane - metabolism | Mice | Cell Movement | Sodium-Hydrogen Exchangers - metabolism | Aquaporins | Myosin | Polymerization | Muscle proteins | Microfluidics | Biomedical engineering | Tumors | Index Medicus
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6. Full Text Expression of aquaporin 5 increases proliferation and metastasis potential of lung cancer
by Zhang, Ziqiang and Chen, Zhihong and Song, Yuanlin and Zhang, Pinghai and Hu, Jie and Bai, Chunxue
The Journal of Pathology, ISSN 0022-3417, 06/2010, Volume 221, Issue 2, pp. 210 - 220
Water channel aquaporin 5 (AQP5) is highly expressed at the apical membrane of alveolar type I epithelial cells and confers high osmotic water permeability.... 
p38 mitogen‐activated protein kinase (p38 MAPK) | extracellular signal‐regulated protein kinase (ERK) | proliferating cell nuclear antigen (PCNA) | epidermal growth factor receptor (EGFR) | aquaporin 5 | MUC5AC | Extracellular signal-regulated protein kinase (ERK) | Aquaporin 5 | Proliferating cell nuclear antigen (PCNA) | p38 mitogen-activated protein kinase (p38 MAPK) | Epidermal growth factor receptor (EGFR) | ACTIVATED PROTEIN-KINASE | COLORECTAL CARCINOGENESIS | MUCIN | WATER CHANNELS | PATHOLOGY | TUMORS | BRAIN EDEMA | ONCOLOGY | SIGNALING PATHWAY | EPIDERMAL-GROWTH-FACTOR | SQUAMOUS-CELL CARCINOMA | GENE DISRUPTION | extracellular signal-regulated protein kinase (ERK) | Receptor, Epidermal Growth Factor - genetics | Up-Regulation | Cell Proliferation | Humans | Lung Neoplasms - metabolism | p38 Mitogen-Activated Protein Kinases - genetics | Lung Neoplasms - pathology | Male | Signal Transduction - genetics | Aquaporin 5 - genetics | Permeability | Neoplasm Proteins - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Receptor, Epidermal Growth Factor - metabolism | Animals | Aquaporin 5 - metabolism | Proliferating Cell Nuclear Antigen - genetics | Lung Neoplasms - etiology | Mitogen-Activated Protein Kinase 3 - metabolism | Mice | p38 Mitogen-Activated Protein Kinases - metabolism | Proliferating Cell Nuclear Antigen - metabolism | Cell Movement | Index Medicus
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7. Full Text Immunolocalization of Aquaporin 1, 5, and 9 in the Female Pig Reproductive System
by Skowronski, Mariusz T and Kwon, Tae-Hwan and Nielsen, Soren
Journal of Histochemistry and Cytochemistry, ISSN 0022-1554, 01/2009, Volume 57, Issue 1, pp. 61 - 67
Thirteen mammalian aquaporin (AQP) isoforms have been identified, and they have a unique tissue-specific pattern of expression. AQPs have been documented in... 
Immunolocalization | Female reproductive system | Aquaporins | Pig | LOCALIZATION | immunolocalization | RAT | UTERUS | AQP9 | aquaporins | WATER CHANNELS | pig | CELL BIOLOGY | female reproductive system | OOCYTES | KIDNEY | EXPRESSION | Fallopian Tubes - cytology | Immunohistochemistry | Epithelial Cells - metabolism | Swine - metabolism | Ovary - blood supply | Uterus - metabolism | Aquaporins - metabolism | Immunoblotting | Ovary - cytology | Aquaporin 1 - metabolism | Fallopian Tubes - metabolism | Animals | Aquaporin 5 - metabolism | Endothelium, Vascular - metabolism | Uterus - cytology | Fallopian Tubes - blood supply | Female | Uterus - blood supply | Capillaries - metabolism | Myocytes, Smooth Muscle - metabolism | Ovary - metabolism | Index Medicus
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8. Full Text Autoantibodies against Muscarinic Type 3 Receptor in Sjögren's Syndrome Inhibit Aquaporin 5 Trafficking
by Lee, Byung Ha and Gauna, Adrienne E and Perez, Geidys and Park, Yun-Jong and Pauley, Kaleb M and Kawai, Toshihisa and Cha, Seunghee
PLoS ONE, ISSN 1932-6203, 01/2013, Volume 8, Issue 1, pp. e53113 - e53113
Sjogren's syndrome (SjS) is a chronic autoimmune disease that mainly targets the salivary and lacrimal glands. It has been controversial whether... 
ABNORMAL DISTRIBUTION | SUBMANDIBULAR-GLANDS | NOD MICE | APICAL PLASMA-MEMBRANE | 2ND EXTRACELLULAR LOOP | MULTIDISCIPLINARY SCIENCES | MOUSE MODEL | WATER CHANNEL | HSG CELLS | SALIVARY ACINAR-CELLS | ACETYLCHOLINE-RECEPTOR | Cell Line | Autoantibodies - metabolism | Sjogren's Syndrome - pathology | Lacrimal Apparatus - cytology | Calcium - metabolism | Humans | Middle Aged | Aquaporin 5 - genetics | Sjogren's Syndrome - metabolism | Lacrimal Apparatus - metabolism | Receptor, Muscarinic M3 - genetics | Receptor, Muscarinic M3 - antagonists & inhibitors | Salivary Glands - cytology | Protein Transport | Carbachol - pharmacology | Receptor, Muscarinic M3 - immunology | Aquaporin 5 - metabolism | Adult | Female | Aged | Salivary Glands - metabolism | Cell Membrane - drug effects | Plasma | Aquaporin 5 | Neurosciences | Sjogren's syndrome | Immunoprecipitation | Acetylcholine receptors (muscarinic) | Glands | Cognitive ability | Science | Bladder | Stimulation | Arthritis | Blockage | Proteins | Immunology | Isotypes | Urinary bladder | Moisture content | Rodents | Water transport | Rheumatism | Physiology | Protein transport | Irritation | Immunoglobulins | Autoantibodies | Secretion | Aquaporins | Salivary gland | Shrinkage | Dentistry | Studies | Carbachol | Membrane trafficking | Cell size | Index Medicus
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9. Full Text Differential expression of inwardly rectifying K+ channels and aquaporins 4 and 5 in autoimmune uveitis indicates misbalance in Müller glial cell‐dependent ion and water homeostasis
by Eberhardt, Christina and Amann, Barbara and Feuchtinger, Annette and Hauck, Stefanie M and Deeg, Cornelia A
Glia, ISSN 0894-1491, 05/2011, Volume 59, Issue 5, pp. 697 - 707
Reactive gliosis is a well‐established response to virtually every retinal disease. Autoimmune uveitis, a sight threatening disease, is characterized by... 
glial swelling | Kir channels | aquaporin 5 | spontaneous autoimmune disease | quantitative image analysis | Glial swelling | Spontaneous autoimmune disease | Aquaporin 5 | Quantitative image analysis | LACRIMAL GLANDS | KIR4.1 | MEMBRANE | RAT RETINA | MODEL | NEUROSCIENCES | EQUINE RECURRENT UVEITIS | RECTIFIER POTASSIUM CHANNEL | CENTRAL-NERVOUS-SYSTEM | DETAILED QUANTIFICATION | MOUSE LUNG | Immunohistochemistry | Autoimmune Diseases - physiopathology | Retina - metabolism | Water-Electrolyte Balance - physiology | Blotting, Western | Animals | Aquaporin 5 - metabolism | Retina - cytology | Aquaporin 4 - metabolism | Statistics, Nonparametric | Horses | Neuroglia - metabolism | Neurons - metabolism | Autoimmune Diseases - metabolism | Potassium Channels, Inwardly Rectifying - metabolism | Uveitis - physiopathology | Uveitis - metabolism | Aquaporin 4 | Index Medicus
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10. Full Text Store-operated Ca2+ entry regulates Ca2+-activated chloride channels and eccrine sweat gland function
by Concepcion, Axel R and Vaeth, Martin and Wagner, Larry E and Eckstein, Miriam and Hecht, Lee and Jun, Yang and Crottes, David and Seidl, Maximilian and Shin, Hyosup P and Weidinger, Carl and Cameron, Scott and Turvey, Stuart E and Issekutz, Thomas and Meyts, Isabelle and Lacruz, Rodrigo S and Cuk, Mario and Yule, David I and Feske, Stefan
Journal of Clinical Investigation, ISSN 0021-9738, 11/2016, Volume 126, Issue 11, pp. 4303 - 4318
Eccrine sweat glands are essential for sweating and thermoregulation in humans. Loss-of-function mutations in the Ca2+ release activated Ca2+ (CRAC) channel... 
MEDICINE, RESEARCH & EXPERIMENTAL | COMBINED IMMUNODEFICIENCY | HYPOHIDROTIC ECTODERMAL DYSPLASIA | CALCIUM-ENTRY | IMMUNE-DEFICIENCY | CL-CHANNEL | WATER CHANNEL | ACINAR-CELLS | SALIVARY-GLAND | CRAC CHANNELS | CELL-LINE | ORAI1 Protein - metabolism | Anoctamin-1 | ORAI1 Protein - genetics | Sweat - secretion | Calcium Signaling - physiology | Humans | Male | Aquaporin 5 - genetics | Chloride Channels - genetics | Neoplasm Proteins - metabolism | Stromal Interaction Molecule 1 - genetics | Stromal Interaction Molecule 2 - metabolism | Mice, Knockout | Chloride Channels - metabolism | Stromal Interaction Molecule 1 - metabolism | Animals | Aquaporin 5 - metabolism | Sweat Glands - metabolism | Female | Mice | Neoplasm Proteins - genetics | Stromal Interaction Molecule 2 - genetics | Index Medicus | Abridged Index Medicus
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11. Full Text Relationship of aquaporin 1, 3, and 5 expression in lung cancer cells to cellular differentiation, invasive growth, and metastasis potential
by Machida, Yuichiro, MD and Ueda, Yoshimichi, MD, PhD and Shimasaki, Miyako, PhD and Sato, Katsuaki, MD, PhD and Sagawa, Motoyasu, MD, PhD and Katsuda, Shogo, MD, PhD and Sakuma, Tsutomu, MD, PhD
Human Pathology, ISSN 0046-8177, 2011, Volume 42, Issue 5, pp. 669 - 678
Summary An oncogenic capacity of aquaporins, transmembrane channels for water, was recently proposed. This study seeks to elucidate the involvement of... 
Pathology | Cellular differentiation | Lung cancer | Invasion and metastasis | Aquaporin 1, 3, and 5 | MIGRATION | BRONCHIOLOALVEOLAR CARCINOMA | OVEREXPRESSION | WATER CHANNELS | PATHOLOGY | SUBTYPE SUGGESTS | Adenocarcinoma - pathology | Prognosis | Adenocarcinoma, Bronchiolo-Alveolar - pathology | Carcinoma, Squamous Cell - metabolism | Carcinoma, Squamous Cell - pathology | Humans | Lung Neoplasms - metabolism | Middle Aged | Lung Neoplasms - pathology | Male | Aquaporin 5 - genetics | RNA, Messenger - metabolism | Aquaporin 1 - metabolism | Adenocarcinoma - metabolism | Aged, 80 and over | Adult | Female | Cell Differentiation | Lung - metabolism | Neoplasm Invasiveness | Aquaporin 3 - genetics | Adenocarcinoma - secondary | Blotting, Western | Adenocarcinoma, Bronchiolo-Alveolar - secondary | Aquaporin 1 - genetics | Aquaporin 3 - metabolism | Aquaporin 5 - metabolism | Adenocarcinoma, Bronchiolo-Alveolar - metabolism | Carcinoma, Squamous Cell - secondary | Aged | Immunohistochemistry | Analysis | Aquaporins | Cancer cells | Development and progression | Metastasis | Proteins | Studies | Angiogenesis | Signal transduction | Cell cycle | Permeability | Kinases | Tumors | Index Medicus
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12. Full Text Aquaporin 5 increases keratinocyte-derived chemokine expression and NF-κB activity through ERK activation
by Sakamoto, Yuima and Hisatsune, Akinori and Katsuki, Hiroshi and Horie, Ichiro and Isohama, Yoichiro
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 06/2014, Volume 448, Issue 4, pp. 355 - 360
Aquaporin-5 (AQP5) is a water-selective channel protein that is expressed in submucosal glands and alveolar epithelial cells in the lungs. Recent studies have... 
TNF-α | Aquaporin 5 | Keratinocyte chemoattractant | MIGRATION | PERMEABILITY | TNF-alpha | ALVEOLAR EPITHELIAL-CELLS | MEMBRANE | BIOCHEMISTRY & MOLECULAR BIOLOGY | WATER CHANNELS | PROLIFERATION | BIOPHYSICS | MOLECULAR-CLONING | MICE | DECREASED EXPRESSION | MOUSE LUNG | Tumor Necrosis Factor-alpha - metabolism | Cell Line | NIH 3T3 Cells | RNA, Small Interfering - genetics | Gene Expression | RNA, Messenger - genetics | NF-kappa B - metabolism | Alveolar Epithelial Cells - metabolism | Chemokine CXCL1 - genetics | Aquaporin 5 - genetics | RNA, Messenger - metabolism | Chemokines - genetics | Gene Knockdown Techniques | MAP Kinase Signaling System | Inflammation - metabolism | Animals | Aquaporin 5 - metabolism | Keratinocytes - metabolism | Chemokines - metabolism | Mice | Chemokine CXCL1 - metabolism | Aquaporin 5 - antagonists & inhibitors | Index Medicus
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