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humans (589) 589
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arachidonate 15-lipoxygenase - genetics (460) 460
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Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 05/2013, Volume 288, Issue 22, pp. 15830 - 15842
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 05/2015, Volume 125, Issue 5, pp. 1944 - 1954
DCs are able to undergo rapid maturation, which subsequently allows them to initiate and orchestrate T cell-driven immune responses. DC maturation must be... 
MEDICINE, RESEARCH & EXPERIMENTAL | DENDRITIC CELLS | MULTIPLE-SCLEROSIS | NRF2 | INFLAMMATION | BONE-MARROW | TISSUE-DAMAGE | OXIDIZED PHOSPHOLIPIDS | E-DEFICIENT MICE | EXPRESSION | AUTOIMMUNE ENCEPHALOMYELITIS | Lymphoid Tissue - enzymology | Dendritic Cells - immunology | Humans | Encephalomyelitis, Autoimmune, Experimental - immunology | Lymphoid Tissue - immunology | Arachidonate 15-Lipoxygenase - deficiency | Female | Cell Differentiation | Phospholipids - metabolism | Fatty Acids - metabolism | Arachidonate 12-Lipoxygenase - deficiency | Arachidonate 12-Lipoxygenase - genetics | Adaptive Immunity | Encephalomyelitis, Autoimmune, Experimental - pathology | Oxidation-Reduction | Mice, Inbred C57BL | Arachidonate 12-Lipoxygenase - physiology | Mice, Knockout | Lymphoid Tissue - pathology | Animals | Arachidonate 15-Lipoxygenase - genetics | Encephalomyelitis, Autoimmune, Experimental - enzymology | NF-E2-Related Factor 2 - metabolism | Th17 Cells - immunology | Arachidonate 15-Lipoxygenase - physiology | Dendritic Cells - cytology | Mice | Oxidases | Physiological aspects | Lipid peroxidation | Research | Dendritic cells | Proteins | Enzymes | Transcription factors | Cytokines | Lymphocytes | Rodents | Lipids | Oxidation | Paralysis | Experiments | Deoxyribonucleic acid--DNA | Whooping cough | Autoimmunity | Immunology
Journal Article
Diabetes, ISSN 0012-1797, 11/2017, Volume 66, Issue 11, pp. 2875 - 2887
Journal Article
by Xu, J and Zhang, Y and Xiao, Y and Ma, S and Liu, Q and Dang, S and Jin, M and Shi, Y and Wan, B and Zhang, Y
Cell Death and Disease, ISSN 2041-4889, 04/2013, Volume 4, Issue 4, pp. e569 - e569
12/15-Lipoxygenase (12/15-LO) is an enzyme that converts polyunsaturated fatty acids into bioactive lipid derivatives. In this study, we showed that inhibition... 
Baicalein | EAE | PPARβ/δ | 12/15-LO | Microglia | PPAR beta/delta | ACTIVATION | EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS | baicalein | ARACHIDONIC-ACID | KAPPA-B | GLIAL-CELLS | CELL BIOLOGY | GAMMA AGONISTS | APPEARING WHITE-MATTER | CENTRAL-NERVOUS-SYSTEM | microglia | EXPRESSION | T-CELLS | Arachidonate 12-Lipoxygenase - metabolism | NF-kappa B - metabolism | PPAR-beta - agonists | Microglia - pathology | Female | Encephalomyelitis, Autoimmune, Experimental - genetics | 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid - pharmacology | PPAR delta - genetics | Arachidonate 12-Lipoxygenase - genetics | 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid - metabolism | Cell Line | NF-kappa B - antagonists & inhibitors | Encephalomyelitis, Autoimmune, Experimental - pathology | Microglia - drug effects | PPAR-beta - metabolism | T-Lymphocytes | Encephalomyelitis, Autoimmune, Experimental - drug therapy | Flavanones - pharmacology | Enzyme Inhibitors - pharmacology | Microglia - enzymology | Arachidonate 15-Lipoxygenase - metabolism | PPAR-beta - genetics | Gene Expression Regulation - drug effects | Animals | Arachidonate 15-Lipoxygenase - genetics | Encephalomyelitis, Autoimmune, Experimental - enzymology | Mitogen-Activated Protein Kinases - antagonists & inhibitors | NF-kappa B - genetics | Signal Transduction - drug effects | PPAR delta - agonists | Mitogen-Activated Protein Kinases - genetics | Mice | PPAR delta - metabolism | Cell Movement | Mitogen-Activated Protein Kinases - metabolism | Original | PPARβ | 15-LO
Journal Article
Journal Article
Journal of Lipid Research, ISSN 0022-2275, 03/2015, Volume 56, Issue 3, pp. 562 - 577
Journal Article
The Journal of Immunology, ISSN 0022-1767, 12/2003, Volume 171, Issue 12, pp. 6856 - 6865
Journal Article
Stroke, ISSN 0039-2499, 09/2008, Volume 39, Issue 9, pp. 2538 - 2543
Background and Purpose-The concept of the neurovascular unit suggests that effects on brain vasculature must be considered if neuroprotection is to be achieved... 
Baicalein | Edema | Endothelial cell | Blood-brain barrier | Lipoxygenase | blood-brain barrier | edema | RAT | endothelial cell | baicalein | 15-LIPOXYGENASE | MODEL | BLOOD-BRAIN-BARRIER | CLINICAL NEUROLOGY | STROKE | lipoxygenase | INHIBITION | DISRUPTION | ENDOTHELIAL-CELLS | PERIPHERAL VASCULAR DISEASE | CEREBRAL-ISCHEMIA | ORGANELLE DEGRADATION | Arachidonate 12-Lipoxygenase - metabolism | Humans | Oxidative Stress - physiology | Ischemic Attack, Transient - enzymology | Brain Edema - enzymology | Brain Edema - prevention & control | Brain Ischemia - enzymology | Cytoprotection - drug effects | Membrane Proteins - metabolism | Brain Infarction - drug therapy | Arachidonate 12-Lipoxygenase - genetics | Ischemic Attack, Transient - physiopathology | Tight Junctions - drug effects | Brain Infarction - enzymology | Tight Junctions - metabolism | Ischemic Attack, Transient - drug therapy | Flavanones - therapeutic use | Mice, Inbred C57BL | Cells, Cultured | Enzyme Inhibitors - pharmacology | Hydrogen Peroxide - pharmacology | Arachidonate 15-Lipoxygenase - drug effects | Claudin-5 | Brain Ischemia - physiopathology | Brain Infarction - physiopathology | Arachidonate 15-Lipoxygenase - metabolism | Blood-Brain Barrier - drug effects | Enzyme Inhibitors - therapeutic use | Blood-Brain Barrier - metabolism | Mice, Knockout | Animals | Arachidonate 15-Lipoxygenase - genetics | Brain Edema - physiopathology | Brain Ischemia - drug therapy | Arachidonate 12-Lipoxygenase - drug effects | Mice | Oxidative Stress - drug effects | Endothelial Cells - enzymology | Endothelial Cells - drug effects | Immunoglobulin G - metabolism | blood–brain barrier
Journal Article
Circulation, ISSN 0009-7322, 10/2004, Volume 110, Issue 14, pp. 2024 - 2031
Background-Mice lacking leukocyte type 12/15-lipoxygenase (12/15-LO) show reduced atherosclerosis in several models. 12/15-LO is expressed in a variety of... 
Lipids | Atherosclerosis | Cell adhesion molecules | Endothelium | atherosclerosis | endothelium | HUMAN ATHEROGENESIS | CELLS | cell adhesion molecules | lipids | CARDIAC & CARDIOVASCULAR SYSTEMS | MAMMALIAN LIPOXYGENASES | MOUSE | LOW-DENSITY-LIPOPROTEIN | 15-LIPOXYGENASE | HYPERCHOLESTEROLEMIA | PERIPHERAL VASCULAR DISEASE | RABBIT | HEMATOLOGY | UP-REGULATION | EXPRESSION | Endothelium, Vascular - cytology | Dinoprost - blood | Apolipoproteins E - deficiency | Cells, Cultured - cytology | Foam Cells - cytology | Macrophages, Peritoneal - cytology | RNA, Messenger - biosynthesis | Interleukin-4 - pharmacology | Arachidonate 15-Lipoxygenase - deficiency | Bone Marrow Transplantation | Hyperlipoproteinemia Type II - enzymology | Dinoprost - analogs & derivatives | Myocytes, Smooth Muscle - drug effects | Macrophages, Peritoneal - drug effects | Myocytes, Smooth Muscle - cytology | Arachidonate 12-Lipoxygenase - deficiency | Arachidonate 12-Lipoxygenase - genetics | Autocrine Communication | Cells, Cultured - drug effects | Hyperlipoproteinemia Type II - blood | Myocytes, Smooth Muscle - enzymology | Macrophages, Peritoneal - enzymology | Lipoproteins, LDL - pharmacology | Arachidonate 12-Lipoxygenase - physiology | Radiation Chimera | Cell Adhesion - drug effects | Muscle, Smooth, Vascular - cytology | Arteriosclerosis - enzymology | Cells, Cultured - enzymology | Mice, Knockout | Animals | Arachidonate 15-Lipoxygenase - genetics | Cell Differentiation - drug effects | Apolipoproteins E - genetics | Triglycerides - blood | Arachidonate 15-Lipoxygenase - physiology | Mice | Endothelial Cells - enzymology | Endothelial Cells - drug effects | Hyperlipoproteinemia Type II - genetics
Journal Article