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agouti-related protein (87) 87
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Science, ISSN 0036-8075, 4/2004, Volume 304, Issue 5667, pp. 108 - 110
In adult mammals, the adipocyte-derived hormone leptin acts on the brain to reduce food intake by regulating the activity of neurons in the arcuate nucleus of... 
Neurites | Neuroscience | Neurons | Food intake | Innervation | Reports | Mice | Adults | Hypothalamus | Hormones | Critical periods | ENERGY-BALANCE | BODY-WEIGHT | NERVOUS-SYSTEM | OBESITY | THYROID-HORMONE | MULTIDISCIPLINARY SCIENCES | BRAIN-DEVELOPMENT | Paraventricular Hypothalamic Nucleus - physiology | Hypothalamus - growth & development | Neurites - physiology | Culture Techniques | Dorsomedial Hypothalamic Nucleus - physiology | Hypothalamic Area, Lateral - cytology | Arcuate Nucleus of Hypothalamus - cytology | Axons - physiology | Proteins - analysis | Arcuate Nucleus of Hypothalamus - growth & development | Carbocyanines | Leptin - physiology | Paraventricular Hypothalamic Nucleus - cytology | Nerve Fibers - physiology | Hypothalamic Area, Lateral - physiology | Neurons - physiology | Leptin - pharmacology | Animals, Newborn | Eating | Signal Transduction | Dorsomedial Hypothalamic Nucleus - cytology | Hypothalamus - physiology | Hypothalamic Area, Lateral - growth & development | Intercellular Signaling Peptides and Proteins | Mice, Inbred C57BL | Feeding Behavior | Leptin - genetics | Recombinant Proteins - pharmacology | Arcuate Nucleus of Hypothalamus - physiology | Animals | Hypothalamus - cytology | Mice, Obese | Dorsomedial Hypothalamic Nucleus - growth & development | Leptin - deficiency | Paraventricular Hypothalamic Nucleus - growth & development | Agouti-Related Protein | alpha-MSH - analysis | Physiological aspects | Chemical properties | Eating (Physiology) | Leptin | Neurology | Nutrition | Rodents
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 03/2004, Volume 24, Issue 11, pp. 2797 - 2805
The arcuate nucleus of the hypothalamus (ARH) is a critical component of forebrain pathways that regulate a variety of neuroendocrine functions, including an... 
POMC | Obesity | Neuroendocrine | Leptin | NPY | Arcuate | Development | Axon | cFos | Projection | Hypothalamus | Feeding | arcuate | development | SUPRAOPTIC NUCLEI | neuroendocrine | MEDIOBASAL HYPOTHALAMUS | ZUCKER FA/FA RAT | FOOD-INTAKE | CONTAINING NEURONS | leptin | NEUROSCIENCES | NEUROPEPTIDE-Y | PARAVENTRICULAR NUCLEUS | ENERGY HOMEOSTASIS | feeding | GENE-EXPRESSION | POSTNATAL-DEVELOPMENT | axon | projection | hypothalamus | obesity | Hypothalamus - growth & development | Proto-Oncogene Proteins c-fos - biosynthesis | Hypothalamic Area, Lateral - cytology | Arcuate Nucleus of Hypothalamus - cytology | Male | Neurons - cytology | Arcuate Nucleus of Hypothalamus - growth & development | Paraventricular Hypothalamic Nucleus - cytology | Arcuate Nucleus of Hypothalamus - drug effects | Female | Leptin - pharmacology | Neurons - metabolism | Hypothalamus - drug effects | Neurons - drug effects | Animals, Newborn | Dorsomedial Hypothalamic Nucleus - drug effects | Dorsomedial Hypothalamic Nucleus - cytology | Hypothalamic Area, Lateral - growth & development | Mice, Inbred C57BL | Neural Pathways - growth & development | Feeding Behavior - physiology | Gene Expression Regulation - drug effects | Paraventricular Hypothalamic Nucleus - drug effects | Animals | Hypothalamus - cytology | Neural Pathways - cytology | Pro-Opiomelanocortin - biosynthesis | Hypothalamic Area, Lateral - drug effects | Dorsomedial Hypothalamic Nucleus - growth & development | Mice | Appetite Regulation - physiology | Paraventricular Hypothalamic Nucleus - growth & development | Fluorescent Dyes | Aging - metabolism | Plasticity | Repair
Journal Article
Nature, ISSN 0028-0836, 2014, Volume 507, Issue 7491, pp. 238 - 242
Hunger is a hard-wired motivational state essential for survival. Agouti-related peptide (AgRP)-expressing neurons in the arcuate nucleus (ARC) at the base of... 
POMC NEURONS | LEPTIN | ENERGY-EXPENDITURE | PROTEIN | FOOD-INTAKE | NPY | MULTIDISCIPLINARY SCIENCES | FEEDING-BEHAVIOR | RECEPTORS | CELL-TYPES | HYPOTHALAMUS | Dependovirus - genetics | Paraventricular Hypothalamic Nucleus - physiology | Neural Pathways - drug effects | Neuronal Plasticity - drug effects | Arcuate Nucleus of Hypothalamus - cytology | Male | Neural Pathways - physiology | Cell Tracking | Eating - physiology | Satiety Response - physiology | Hunger - drug effects | Paraventricular Hypothalamic Nucleus - cytology | Clozapine - pharmacology | Thyrotropin-Releasing Hormone - metabolism | Neuronal Plasticity - physiology | Female | Food Deprivation | Integrases - metabolism | Agouti-Related Protein - deficiency | Appetite - physiology | Neurons - metabolism | Neurons - drug effects | Neurons, Afferent - drug effects | Peptide Fragments - metabolism | Arcuate Nucleus of Hypothalamus - metabolism | Appetite - drug effects | Clozapine - analogs & derivatives | Agouti-Related Protein - metabolism | Eating - drug effects | Rabies virus - genetics | Animals | Pituitary Adenylate Cyclase-Activating Polypeptide - metabolism | Brain Mapping | Mice | Neurons, Afferent - metabolism | Peptide Fragments - deficiency | Hunger - physiology | Physiological aspects | Electrophysiology | Neuropeptides | Physiological research | Hunger | Research | Studies | Brain | Neurons | Experiments | Light | Food
Journal Article
PLoS ONE, ISSN 1932-6203, 10/2012, Volume 7, Issue 10, p. e46923
Current evidence suggests that ghrelin, a stomach derived peptide, exerts its orexigenic action through specific modulation of Sirtuin1 (SIRT1)/p53 and... 
MAMMALIAN TARGET | HORMONE | BSX | MULTIDISCIPLINARY SCIENCES | GROWTH | INCREASES | RESISTANCE | AMPK | APPETITE | AGOUTI-RELATED PEPTIDE | NEUROPEPTIDE-Y | Ghrelin - administration & dosage | TOR Serine-Threonine Kinases - metabolism | Arcuate Nucleus of Hypothalamus - cytology | Male | Neuropeptide Y - metabolism | Appetite Stimulants - administration & dosage | Time Factors | Arcuate Nucleus of Hypothalamus - drug effects | Hypothalamus - drug effects | Appetite Stimulants - pharmacology | Hypothalamus - physiology | Arcuate Nucleus of Hypothalamus - metabolism | Rats | Ghrelin - pharmacology | Arcuate Nucleus of Hypothalamus - physiology | Agouti-Related Protein - metabolism | Rats, Sprague-Dawley | Feeding Behavior - physiology | Feeding Behavior - drug effects | Transcription Factors - metabolism | Eating - drug effects | Animals | Hypothalamus - metabolism | Hypothalamus - cytology | Signal Transduction - drug effects | Neuropeptide Y | Brain | RNA | DNA binding proteins | Tumor proteins | Protein kinases | Protein binding | TOR protein | Transcription factors | Peptides | p53 Protein | Arcuate nucleus | Neuropeptides | Thyroid gland | Hypothalamus | Kinases | AMP-activated protein kinase | Experiments | Proteins | Signal transduction | Pathways | Energy | FOXO1 protein | Metabolites | Ghrelin | Rodents | Modulation | Forkhead protein | Physiology | Chronic illnesses | Stomach | AMP | Rapamycin | Metabolism | Gene expression | Fatty acids | SIRT1 protein | Medicine | Signaling | Agouti-related protein | Metabolic pathways | Diabetes | Endocrinology
Journal Article
Science, ISSN 0036-8075, 5/2006, Volume 312, Issue 5775, pp. 927 - 930
Journal Article
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 11/2017, Volume 114, Issue 47, pp. E10216 - E10223
The pulsatile release of luteinizing hormone (LH) is critical for mammalian fertility. However, despite several decades of investigation, the identity of the... 
Kisspeptin | GnRH | Fertility | Arcuate nucleus | Pulse | kisspeptin | GONADOTROPIN-RELEASING-HORMONE | RHESUS-MONKEY | MULTIDISCIPLINARY SCIENCES | fertility | ARCUATE KISSPEPTIN NEURONS | MOUSE | arcuate nucleus | NUCLEUS | pulse | MEDIAN-EMINENCE | PITUITARY | SECRETION | RECEPTORS | NEUROKININ B | Luteinizing hormone | Physiological aspects | Genetic aspects | Research | Neurons | Biological Sciences | PNAS Plus
Journal Article
Cell Metabolism, ISSN 1550-4131, 02/2013, Volume 17, Issue 2, pp. 236 - 248
Neuropepetide Y (NPY) is best known for its powerful stimulation of food intake and its effects on reducing energy expenditure. However, the pathways involved... 
ENERGY-BALANCE | BODY-WEIGHT | MESSENGER-RNA | ADAPTIVE THERMOGENESIS | FOOD-INTAKE | ENDOCRINOLOGY & METABOLISM | BROWN ADIPOSE-TISSUE | NORMAL RATS | NEUROPEPTIDE-Y INFUSION | DIET-INDUCED OBESITY | VENTROMEDIAL HYPOTHALAMUS | CELL BIOLOGY | Thermogenesis - genetics | Tyrosine 3-Monooxygenase - metabolism | Temperature | Receptors, Neuropeptide Y - metabolism | Arcuate Nucleus of Hypothalamus - cytology | Male | Neurons - cytology | Neuropeptide Y - genetics | Paraventricular Hypothalamic Nucleus - enzymology | RNA, Messenger - metabolism | Sympathetic Nervous System - metabolism | Neuropeptide Y - metabolism | Paraventricular Hypothalamic Nucleus - cytology | Mitochondrial Proteins - metabolism | Diet, High-Fat | Models, Animal | Energy Metabolism - genetics | Pro-Opiomelanocortin - genetics | Arcuate Nucleus of Hypothalamus - metabolism | Mice, Inbred C57BL | RNA, Messenger - genetics | Gene Expression Regulation | Feeding Behavior | Signal Transduction - genetics | Agouti-Related Protein - metabolism | Pro-Opiomelanocortin - metabolism | Tyrosine 3-Monooxygenase - genetics | Animals | Ion Channels - metabolism | Oxygen Consumption - genetics | Neurons - enzymology | Glutamate Decarboxylase - metabolism | Adipose Tissue, Brown - metabolism | Mice | Uncoupling Protein 1 | Neuropeptide Y | Tyrosine | Neurosciences | Neurons | Eating disorders | Phenols | Universities and colleges | Hydroxylases
Journal Article