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Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 8/2010, Volume 107, Issue 33, pp. 14875 - 14880
The neuronal circuits involved in the regulation of feeding behavior and energy expenditure are soft-wired, reflecting the relative activity of the... 
Obesity | Gliosis | Neurons | Neuroglia | Arcuate nucleus | Body weight | Rats | Melanocortins | Mice | Synapses | Brain | Inflammation | Vulnerability | High-fat diet | Synaptic plasticity | DEFENSE | MECHANISM | FOOD-INTAKE | GHRELIN | MULTIDISCIPLINARY SCIENCES | NPY/AGRP NEURONS | RATS | vulnerability | brain | ARCUATE NUCLEUS | BODY-WEIGHT | inflammation | high-fat diet | synaptic plasticity | LEPTIN RESISTANCE | FEEDING CIRCUITS | Immunohistochemistry | Synaptic Transmission - physiology | Melanocortins - metabolism | Male | Neuropeptide Y - metabolism | Neurons - ultrastructure | Synapses - metabolism | Female | Obesity - etiology | Neurons - metabolism | Arcuate Nucleus of Hypothalamus - pathology | Gliosis - etiology | Dietary Fats - adverse effects | Arcuate Nucleus of Hypothalamus - metabolism | Gliosis - metabolism | Mice, Inbred C57BL | Mice, Transgenic | Arcuate Nucleus of Hypothalamus - physiopathology | Hypothalamus - pathology | Microscopy, Electron | Hypothalamus - physiopathology | Rats, Sprague-Dawley | Obesity - metabolism | Pro-Opiomelanocortin - metabolism | Animals | Hypothalamus - metabolism | Diet | Neuroplasticity | Physiological aspects | Hypothalamus | Research | Properties | Neuropeptide Y | Brain architecture | Feeding behavior | Circuits | Blood vessels | Energy expenditure | Melanocortin | Data processing | Proopiomelanocortin | Neuronal-glial interactions | High fat diet | Diets | Blood-brain barrier | Dendrites | Cell body | Biological Sciences
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 06/2017, Volume 127, Issue 7, pp. 2868 - 2880
Obesity increases sympathetic nerve activity (SNA) via activation of proopiomelanocortin neurons in the arcuate nucleus (ArcN), and this action requires... 
MEDICINE, RESEARCH & EXPERIMENTAL | LIPID-METABOLISM | DORSOMEDIAL HYPOTHALAMIC NUCLEUS | PARAVENTRICULAR NUCLEUS | MESSENGER-RNA | BROWN ADIPOSE-TISSUE | CATECHOLAMINERGIC NEURONS | CARDIOVASCULAR-RESPONSE | MEDIATED INHIBITION | LEPTIN-RECEPTOR | EXPRESSING NEURONS | Blood Pressure | Receptors, Neuropeptide Y - metabolism | Neuropeptide Y - genetics | Sympathetic Nervous System - physiopathology | Obesity - genetics | Sympathetic Nervous System - metabolism | Paraventricular Hypothalamic Nucleus - physiopathology | Neuropeptide Y - metabolism | Sympathetic Nervous System - pathology | Arcuate Nucleus of Hypothalamus - pathology | Heart Rate | Arcuate Nucleus of Hypothalamus - metabolism | Gene Expression Regulation | Mice, Transgenic | Obesity - physiopathology | Arcuate Nucleus of Hypothalamus - physiopathology | Obesity - metabolism | Obesity - pathology | Animals | Agouti-Related Protein - biosynthesis | Receptors, Neuropeptide Y - genetics | Agouti-Related Protein - genetics | Paraventricular Hypothalamic Nucleus - metabolism | Mice | Chronic Disease | Paraventricular Hypothalamic Nucleus - pathology | Neuropeptide Y | Psychological aspects | Nervous system, Sympathetic | Obesity | Physiological aspects | Genetic aspects | Health aspects | Hypertension | Dopamine | Peptides | Neurons | Arcuate nucleus | Nervous system | Neuropeptides | Proopiomelanocortin | Paraventricular nucleus | Gene expression | Metabolism | Hypothalamus (dorsomedial) | Heart rate | Rodents | Blood pressure | Food
Journal Article
American Journal of Physiology - Regulatory Integrative and Comparative Physiology, ISSN 0363-6119, 12/2016, Volume 311, Issue 6, pp. R1032 - R1044
Journal Article
Journal Article
Journal Article
Psychoneuroendocrinology, ISSN 0306-4530, 2012, Volume 38, Issue 1, pp. 122 - 134
Summary Epidemiological evidence demonstrates the neuroendocrine link between stress, depression and diabetes. This study observed glucose intolerance of rats... 
Endocrinology & Metabolism | Psychiatry | Icariin | Chronic unpredictable mild stress | Fluoxetine | Insulin signaling | Hypothalamic corticotropin releasing factor system | DEPRESSION | UROCORTIN-II | PSYCHIATRY | CHRONIC MILD STRESS | ARCUATE NUCLEUS | NEUROSCIENCES | NEUROPEPTIDE-Y | DIABETES-MELLITUS | ENDOCRINOLOGY & METABOLISM | CENTRAL-NERVOUS-SYSTEM | HPA AXIS | PITUITARY-ADRENAL AXIS | GLUCOSE-PRODUCTION | Insulin - physiology | Rats, Wistar | Male | Urocortins - genetics | Phosphatidylinositol 3-Kinases - metabolism | Insulin Receptor Substrate Proteins - metabolism | Flavonoids - therapeutic use | Paraventricular Hypothalamic Nucleus - physiopathology | Corticotropin-Releasing Hormone - biosynthesis | Protein Processing, Post-Translational - drug effects | Arcuate Nucleus of Hypothalamus - drug effects | Corticotropin-Releasing Hormone - antagonists & inhibitors | Antidepressive Agents - pharmacology | Corticotropin-Releasing Hormone - genetics | Flavonoids - pharmacology | Urocortins - biosynthesis | Fluoxetine - therapeutic use | Hypothalamus - drug effects | Phosphorylation - drug effects | Drug Evaluation, Preclinical | Thiazolidinediones - pharmacology | Glucose Intolerance - physiopathology | Fluoxetine - pharmacology | Arcuate Nucleus of Hypothalamus - metabolism | Insulin Resistance | Rats | Suppressor of Cytokine Signaling Proteins - genetics | Anhedonia | Arcuate Nucleus of Hypothalamus - physiopathology | Enzyme Activation - drug effects | Hypothalamus - physiopathology | Hypoglycemic Agents - pharmacology | Antidepressive Agents - therapeutic use | Corticotropin-Releasing Hormone - physiology | Gene Expression Regulation - drug effects | Up-Regulation - drug effects | Suppressor of Cytokine Signaling 3 Protein | Paraventricular Hypothalamic Nucleus - drug effects | Animals | Signal Transduction - drug effects | Glucose Intolerance - psychology | Paraventricular Hypothalamic Nucleus - metabolism | Signal Transduction - physiology | Chronic Disease | Suppressor of Cytokine Signaling Proteins - biosynthesis | Stress, Psychological - physiopathology | Corticotropin releasing hormone | Brain | Peptides | Depression, Mental | ACTH | Diabetes | Glucose | Glucose tolerance tests | Insulin | Dextrose
Journal Article
PLoS ONE, ISSN 1932-6203, 12/2013, Volume 8, Issue 12, p. e81563
GPR40 has been reported to be activated by long-chain fatty acids, such as docosahexaenoic acid (DHA). However, reports studying functional role of GPR40 in... 
NEUROPATHIC PAIN | NERVOUS-SYSTEM | CELLS | DOCOSAHEXAENOIC ACID | MULTIDISCIPLINARY SCIENCES | INSULIN-SECRETION | RECEPTOR GPR40 | EXPRESSION | ASTROCYTES | BETA-ENDORPHIN | BRAIN | Propionates - pharmacology | Chronic Pain - chemically induced | Pain Management | Injections, Intraventricular | Male | Receptors, G-Protein-Coupled - agonists | Neuroglia - drug effects | Glial Fibrillary Acidic Protein | beta-Endorphin - metabolism | Piperidines - pharmacology | Time Factors | Arcuate Nucleus of Hypothalamus - drug effects | Flavonoids - pharmacology | Nuclear Proteins - genetics | Pro-Opiomelanocortin - genetics | Methylamines - pharmacology | Disease Models, Animal | Astrocytes - drug effects | Gene Expression | Chronic Pain - drug therapy | Hyperalgesia - metabolism | Signal Transduction | Arcuate Nucleus of Hypothalamus - metabolism | Nuclear Proteins - metabolism | Arcuate Nucleus of Hypothalamus - physiopathology | Pyrimidines - pharmacology | Nerve Tissue Proteins - genetics | Freund's Adjuvant | Hyperalgesia - physiopathology | Nerve Tissue Proteins - metabolism | Pro-Opiomelanocortin - metabolism | Chronic Pain - metabolism | Docosahexaenoic Acids - pharmacology | Animals | Hyperalgesia - drug therapy | Receptors, G-Protein-Coupled - antagonists & inhibitors | Benzoates - pharmacology | Neuroglia - metabolism | Mice | Receptors, G-Protein-Coupled - genetics | Chronic Pain - physiopathology | beta-Endorphin - genetics | Astrocytes - metabolism | Brain | Unsaturated fatty acids | Care and treatment | Pain | Analysis | Control systems | Beta-endorphin | Intermedin | Intermediate filament proteins | Chronic pain | Omega-3 fatty acids | Neurosciences | Arcuate nucleus | Chains | Proopiomelanocortin | Hypothalamus | Kinases | Docosahexaenoic acid | Neuronal-glial interactions | Cyclin-dependent kinase | Rodents | Cell cycle | Trends | Inhibition | Pretreatment | c-Fos protein | Pharmaceutical sciences | Pain perception | Narcotics | Glial fibrillary acidic protein | Inflammation | Injection | Fatty acids | Studies | Signaling | Hypotheses | Flavopiridol | Freund's adjuvant | Pharmacy | Endorphins | Laboratory animals
Journal Article
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, ISSN 0363-6119, 11/2011, Volume 301, Issue 5, pp. R1569 - R1583
Journal Article
PLoS ONE, ISSN 1932-6203, 11/2014, Volume 9, Issue 11, p. e112109
We have generated a novel monoclonal antibody targeting human FGFR1c (R1c mAb) that caused profound body weight and body fat loss in diet-induced obese mice... 
LEPTIN | INDUCED SUPPRESSION | ENERGY HOMEOSTASIS | SIGNALING PATHWAY | FOOD-INTAKE | INSULIN-RESISTANCE | MULTIDISCIPLINARY SCIENCES | MICE | RAT-BRAIN | FGF FAMILY | SUBFORNICAL ORGAN | Receptor, Melanocortin, Type 4 - deficiency | Serum Response Factor - genetics | Chemokine CCL7 - metabolism | Obesity - drug therapy | Humans | Receptor, Fibroblast Growth Factor, Type 1 - metabolism | Chemokine CCL7 - agonists | Receptors, Somatostatin - genetics | Glucose Intolerance - drug therapy | Hypothalamus - drug effects | Ribosomal Protein S6 Kinases, 70-kDa - metabolism | Signal Transduction | Antibodies, Monoclonal - pharmacology | Arcuate Nucleus of Hypothalamus - metabolism | Ribosomal Protein S6 Kinases, 70-kDa - genetics | Obesity - physiopathology | Receptor, Melanocortin, Type 4 - genetics | Receptor, Fibroblast Growth Factor, Type 1 - antagonists & inhibitors | Receptors, Somatostatin - deficiency | Mice, Knockout | Hypothalamus - metabolism | Energy Metabolism | Chemokine CCL2 - agonists | Mice, Obese | Mitogen-Activated Protein Kinases - genetics | Mice | Glucose Intolerance - metabolism | Serum Response Factor - agonists | Circumventricular Organs - metabolism | Receptor, Fibroblast Growth Factor, Type 1 - genetics | Obesity - genetics | Arcuate Nucleus of Hypothalamus - drug effects | Chemokine CCL7 - genetics | Female | Chemokine CCL2 - metabolism | Glucose Intolerance - physiopathology | Glucose Intolerance - genetics | Serum Response Factor - metabolism | Gene Expression Regulation | Chemokine CCL2 - genetics | Arcuate Nucleus of Hypothalamus - physiopathology | Leptin - genetics | Hypothalamus - physiopathology | Obesity - metabolism | Eating - drug effects | Animals | Circumventricular Organs - physiopathology | Circumventricular Organs - drug effects | Leptin - deficiency | Mitogen-Activated Protein Kinases - metabolism | Neuropeptide Y | Obesity | RNA | Leptin | Monoclonal antibodies | Fibroblast growth factors | Glucose | Dextrose | Brain | Body fat | Body weight | Neurobiology | Body weight loss | Proteins | Fibroblasts | Sensors | p70 S6 kinase | Growth factors | c-Fos protein | Cytokines | Gene expression | Intolerance | Food intake | Melanin-concentrating hormone | Monocyte chemoattractant protein | Ligands | Monocyte chemoattractant protein 1 | Metabolic disorders | Fibroblast growth factor | Neurosciences | Animal models | Biomedical research | Laboratories | Arcuate nucleus | Hypothalamus | Kinases | Engineering | Rodents | Food | Data analysis | Nutrition | Orexins | Research & development--R&D | Weight loss | Organs | Extracellular signal-regulated kinase | Melanocortin | Energy expenditure | Chromatography | Glucose tolerance | Weight control | Brain research | Diabetes | Chemokines | Melanin | Research & development | R&D
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 10/2015, Volume 10, Issue 10, p. e0139462
Some animals and humans fed a high-energy diet (HED) are diet-resistant (DR), remaining as lean as individuals who were naive to HED. Other individuals become... 
SPRAGUE-DAWLEY RATS | EFFERENT PROJECTIONS | LEPTIN | FOOD-INTAKE | NPY | MULTIDISCIPLINARY SCIENCES | FEEDING-BEHAVIOR | NEURONS | RECEPTOR | DORSOMEDIAL HYPOTHALAMUS | NEUROPEPTIDE-Y | Dietary Fats - metabolism | Ventromedial Hypothalamic Nucleus - physiopathology | Melanocortins - metabolism | gamma-Aminobutyric Acid - metabolism | Arcuate Nucleus of Hypothalamus - metabolism | Leptin - metabolism | Rats | Obesity - physiopathology | Receptor, Melanocortin, Type 4 - metabolism | Ventromedial Hypothalamic Nucleus - metabolism | Arcuate Nucleus of Hypothalamus - physiopathology | Caloric Restriction - methods | Rats, Sprague-Dawley | alpha-MSH - metabolism | Paraventricular Hypothalamic Nucleus - physiopathology | Peptides, Cyclic - metabolism | Neuropeptide Y - metabolism | Animals | Paraventricular Hypothalamic Nucleus - metabolism | Body Weight - physiology | alpha-MSH - analogs & derivatives | Diet - methods | Obesity | Energy metabolism | Bioenergetics | Low-calorie diet | Physiological aspects | Development and progression | Genetic aspects | Research | Neurosciences | Body weight | Mental health | Homeostasis | Neuropeptides | Paraventricular nucleus | Hypothalamus | Experiments | Nuclei | γ-Aminobutyric acid | Hypothalamus (ventromedial) | Energy | Restoration | Rodents | Population | Physiology | Neuropeptide Y | Carbohydrates | Medical research | Phenotypes | Nutrient deficiency | Neurons | Melanocortin | Pharmacology | Hypothalamus (dorsomedial) | Low energy | Sensitivity | Weight control | Diet | Flux density | Gastrointestinal surgery
Journal Article