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arc/arg3.1 (22) 22
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plasticity (13) 13
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cytoskeletal proteins - metabolism (11) 11
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expression (7) 7
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Neuron, ISSN 0896-6273, 06/2018, Volume 98, Issue 6, pp. 1124 - 1132.e7
Neuronal activity regulates the transcription and translation of the immediate-early gene Arc/Arg3.1, a key mediator of synaptic plasticity.... 
reversal learning | Arc/Arg3.1 | AMPA receptor trafficking | mGluR-LTD | synaptic plasticity | Barnes maze | Arc/Arg3.1 turnover | cognitive flexibility | ubiquitin | GAG PROTEIN | RNA | LONG-TERM DEPRESSION | GENE-EXPRESSION | MGLUR-LTD | ARC/ARG3.1 | DEGRADATION | RECEPTOR | TRANSLATION | SYNAPTIC PLASTICITY | NEUROSCIENCES | Long-Term Synaptic Depression - genetics | Long-Term Synaptic Depression - physiology | Reversal Learning - physiology | Cytoskeletal Proteins - genetics | Receptors, Metabotropic Glutamate - metabolism | RNA, Messenger - metabolism | Nerve Tissue Proteins - genetics | Gene Knock-In Techniques | Protein Transport | Spatial Learning - physiology | Nerve Tissue Proteins - metabolism | Neuronal Plasticity - genetics | Ubiquitination | Animals | Time Factors | Proteolysis | Cognition - physiology | Cytoskeletal Proteins - metabolism | Mice | Mutation | Receptors, AMPA - metabolism | Ubiquitin | Medical colleges | Genetic transcription | Neurophysiology | Transcription | Neurons | Memory | Spatial discrimination learning | Spatial discrimination | Cognitive ability | Gene expression | Variance analysis | ARC protein | Learning | Proteins | Plasticity (synaptic) | Protein synthesis | Reversal learning | Protein expression | Software | Glutamic acid receptors (metabotropic) | Spatial memory | Arg3.1 | Arc | Arg3.1 turnover
Journal Article
Nature Neuroscience, ISSN 1097-6256, 02/2017, Volume 20, Issue 3, pp. 476 - 483
Journal Article
PLoS ONE, ISSN 1932-6203, 07/2012, Volume 7, Issue 7, p. e41688
Expression of activity-regulated cytoskeleton associated protein (Arc) is crucial for diverse types of experience-dependent synaptic plasticity and long-term... 
MESSENGER-RNA TRANSLATION | AMPA RECEPTORS | CYTOSKELETON-ASSOCIATED PROTEIN | NEUROTROPHIC FACTOR | MULTIDISCIPLINARY SCIENCES | GYRUS IN-VIVO | RECEPTOR ACTIVATION | ARC/ARG3.1 | EXPRESSION | BRAIN | FEEDBACK LOOP | Sequence Deletion | Cytoskeletal Proteins - genetics | Humans | Transcriptome | 3' Untranslated Regions - genetics | Male | MicroRNAs - metabolism | Neurons - cytology | Neuronal Plasticity - genetics | Synapses - metabolism | Base Sequence | HEK293 Cells | Cytoskeletal Proteins - metabolism | Brain-Derived Neurotrophic Factor - metabolism | Neurons - metabolism | Dendrites - metabolism | Rats | Up-Regulation - genetics | Long-Term Potentiation - genetics | Hippocampus - cytology | Nerve Tissue Proteins - genetics | Rats, Sprague-Dawley | Protein Transport | Nerve Tissue Proteins - metabolism | Point Mutation | Animals | Oligonucleotides, Antisense - genetics | Intracellular Space - metabolism | MicroRNAs - genetics | Hippocampus - physiology | Infection | Luciferase | MicroRNA | Brain | Syngeneic grafts | Brain cancer | Genes | Neuroblastoma | Gene deletion | Experiments | Proteins | Nucleoli | Lysates | Transfection | Clonal deletion | Rodents | Plasticity | Long term memory | miRNA | Localization | Growth factors | Deoxyribonucleic acid--DNA | Translation | Neurons | Long-term potentiation | Cloning | Gene expression | Ribonucleic acid--RNA | snoRNA | ARC protein | Dentate gyrus | Brain research | Plasticity (synaptic) | Brain-derived neurotrophic factor | 3' Untranslated regions | Anxieties | MicroRNAs | Morphology | Point mutation | Cytoskeleton | Protein expression | Alzheimers disease | Peptide nucleic acids | Hippocampus | Binding sites | Kidney transplantation | Tumors | RNA | Deoxyribonucleic acid | Ribonucleic acid | Cultures | DNA
Journal Article
Neuropsychopharmacology, ISSN 0893-133X, 05/2017, Volume 42, Issue 6, pp. 1220 - 1230
Deficits in cognitive flexibility are prominent in stress-related psychiatric disorders, including depression. Ketamine has rapid antidepressant efficacy, but... 
DEPRESSION | ACTIVATION | PSYCHIATRY | ARC/ARG3.1 | D-ASPARTATE ANTAGONIST | SYNAPTIC PLASTICITY | NEUROSCIENCES | MESSENGER-RNA | MOOD DISORDERS | PATHWAY | IMPAIRMENTS | PHARMACOLOGY & PHARMACY | ANTIDEPRESSANT ACTIONS | Original
Journal Article
Nature Neuroscience, ISSN 1097-6256, 07/2013, Volume 16, Issue 7, pp. 874 - 883
The activity-regulated cytoskeletal protein Arc (also known as Arg3.1) is required for long-term memory formation and synaptic plasticity. Arc expression is... 
CONSOLIDATION | EARLY GENE ARC/ARG3.1 | CYTOSKELETON-ASSOCIATED PROTEIN | MESSENGER-RNA | ACTIN POLYMERIZATION | LONG-TERM POTENTIATION | DENTATE GYRUS | TRANSLATION | SYNAPTIC PLASTICITY | EXPRESSION | NEUROSCIENCES | Disks Large Homolog 4 Protein | Cytoskeletal Proteins - genetics | Embryo, Mammalian | Nuclear Localization Signals - genetics | Rats, Long-Evans | Neuronal Plasticity - drug effects | Male | Protein Transport - drug effects | Excitatory Postsynaptic Potentials - drug effects | Cell Nucleus - metabolism | Neuronal Plasticity - physiology | Neurons - ultrastructure | beta-Galactosidase - metabolism | Cytoskeletal Proteins - metabolism | Membrane Proteins - metabolism | Homeostasis - drug effects | Tetrodotoxin - pharmacology | Neurons - drug effects | Excitatory Postsynaptic Potentials - genetics | Receptors, AMPA - metabolism | GABA-A Receptor Antagonists - pharmacology | Brain - cytology | Gene Expression Regulation - genetics | Mice, Inbred C57BL | Proto-Oncogene Proteins c-fos - metabolism | Nuclear Localization Signals - metabolism | Rats | Mice, Transgenic | Bicuculline - pharmacology | Mutation - genetics | Nerve Tissue Proteins - genetics | Protein Transport - genetics | Nerve Tissue Proteins - metabolism | Animals | Homeostasis - physiology | Guanylate Kinases - metabolism | Mice | beta-Galactosidase - genetics | Cell Nucleus - drug effects | Homeostasis - genetics | Cellular control mechanisms | Tumor suppressor genes | Neural transmission | Genetic aspects | Research | Properties | Gene expression
Journal Article