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Journal of Neuroscience, ISSN 0270-6474, 01/2009, Volume 29, Issue 2, pp. 393 - 401
Glucocorticoids exert an opposing rapid regulation of glutamate and GABA synaptic inputs to hypothalamic magnocellular neurons via the activation of... 
GABA | Magnocellular neuron | Endocannabinoid | Glucocorticoid | Nitric oxide | SUPRAOPTIC NUCLEUS | endocannabinoid | glucocorticoid | nitric oxide | ACTIVATION | magnocellular neuron | NITRIC-OXIDE SYNTHASE | NEUROSCIENCES | MEMBRANE ESTROGEN-RECEPTORS | ENDOCANNABINOID RELEASE | PARAVENTRICULAR NUCLEUS | G(alpha) | ADRENALECTOMIZED RATS | NEURONS | VASOPRESSIN | OXYTOCIN | G(beta)gamma | Cannabinoid Receptor Modulators - metabolism | Synaptic Transmission - physiology | gamma-Aminobutyric Acid - metabolism | GTP-Binding Proteins - antagonists & inhibitors | Male | Penicillamine - analogs & derivatives | Patch-Clamp Techniques - methods | Quinoxalines - pharmacology | Dexamethasone - pharmacology | Piperidines - pharmacology | Dronabinol - analogs & derivatives | Neurons - physiology | Nitric Oxide Donors - pharmacology | Dronabinol - pharmacology | Neurons - drug effects | Electric Stimulation - methods | Pyrans - pharmacology | Guanosine Diphosphate - pharmacology | Pyrazoles - pharmacology | Cyclic AMP-Dependent Protein Kinases - metabolism | Synapses - drug effects | Synapses - physiology | Penicillamine - pharmacology | Valine - analogs & derivatives | Enzyme Inhibitors - pharmacology | Rats | Excitatory Amino Acid Antagonists - pharmacology | Thionucleotides - pharmacology | Rats, Sprague-Dawley | Animals | Guanosine Diphosphate - analogs & derivatives | Hypothalamus - cytology | Signal Transduction - drug effects | Arginine - pharmacology | Cannabinoid Receptor Modulators - antagonists & inhibitors | Glucocorticoids - pharmacology | Glutamic Acid - metabolism | Valine - pharmacology | In Vitro Techniques | Nitric Oxide - metabolism | GTP-Binding Proteins - metabolism | Gβγ
Journal Article
Clinical and Experimental Pharmacology and Physiology, ISSN 0305-1870, 01/2008, Volume 35, Issue 1, pp. 29 - 34
SUMMARY • The aim of the present study was to determine whether inhibition of dipeptidyl peptidase IV (DPP IV) elevates arterial blood pressure and whether any... 
3-N-[(2S,3S)-2-amino-3-methylpentanoyl]-1,3-thiazolidine | N2-(diphenylacetyl)-N-[(4-hydroxyphenyl)methyl]-d-arginine amide | P32/98 | Wistar-Kyoto rat | neuropeptide Y | dipeptidyl peptidase IV | spontaneously hypertensive rat | Y1 receptor | BIBP 3226 | peptide YY | 3‐N‐[(2S,3S)‐2‐amino‐3‐methylpentanoyl]‐1,3‐thiazolidine | Wistar‐Kyoto rat | N2‐(diphenylacetyl)‐N‐[(4‐hydroxyphenyl)methyl]‐d‐arginine amide | BIBP 3226 | Neuropeptide Y | Spontaneously hypertensive rat | N2-(diphenylacetyl)-N-[(4-hydroxyphenyl)methyl]-D- arginine amide | Peptide YY | Dipeptidyl peptidase IV | PHYSIOLOGY | SPONTANEOUSLY HYPERTENSIVE-RATS | NHE3 | NEUROPEPTIDE-Y | N2-(diphenylacetyl)-N-[(4-hydroxyphenyl)methyl]-D-arginine amide | PHARMACOLOGY & PHARMACY | RECEPTORS | NORADRENALINE | Y-1 receptor | GLUCOSE-TOLERANCE | VASOCONSTRICTION | Antihypertensive Agents - pharmacology | Dipeptidyl Peptidase 4 - metabolism | Captopril - pharmacology | Hydralazine - pharmacology | Dipeptidyl-Peptidase IV Inhibitors - therapeutic use | Rats, Inbred WKY | Receptors, Neuropeptide Y - metabolism | Hypertension - drug therapy | Ganglionic Blockers - pharmacology | Dipeptidyl-Peptidase IV Inhibitors - pharmacology | Arginine - analogs & derivatives | Dose-Response Relationship, Drug | Drug Interactions | Receptors, Neuropeptide Y - drug effects | Pentanoic Acids - pharmacology | Angiotensin-Converting Enzyme Inhibitors - pharmacology | Blood Pressure - drug effects | Hypertension - enzymology | Hypertension - genetics | Thiazolidines - pharmacology | Disease Models, Animal | Chlorisondamine - pharmacology | Rats, Inbred SHR | Vasodilator Agents - pharmacology | Rats | Antihypertensive Agents - therapeutic use | Hypertension - physiopathology | Animals | Arginine - pharmacology | Receptors, Neuropeptide Y, drug effects | Antihypertensive Agents, therapeutic use | Hypertension, enzymology | Arginine, pharmacology | Hypertension, drug therapy | Arginine, analogs and derivatives | Hypertension, genetics | Pentanoic Acids, pharmacology | Captopril, pharmacology | Vasodilator Agents, pharmacology | Ganglionic Blockers, pharmacology | Hypertension, physiopathology | Blood Pressure, drug effects | Dipeptidyl-Peptidase IV Inhibitors, therapeutic use | Angiotensin-Converting Enzyme Inhibitors, pharmacology | Antihypertensive Agents, pharmacology | Chlorisondamine, pharmacology | Receptors, Neuropeptide Y, metabolism | Hydralazine, pharmacology | Dipeptidyl-Peptidase IV Inhibitors, pharmacology | Thiazolidines, pharmacology | Antigens, CD26, metabolism | Antigens, CD26, antagonists and inhibitors | Hypertension | Blood pressure | Captopril | Analysis
Journal Article
Journal Article
Clinical and Experimental Pharmacology and Physiology, ISSN 0305-1870, 03/2007, Volume 34, Issue 3, pp. 223 - 229
SUMMARY • The important role of the cannabinoid system in the modulation of anxiety like behaviours in clinical and experimental studies has been proposed.... 
interaction | anxiety | cannabinoids | nitric oxide | plus-maze test | rat | plus‐maze test | Cannabinoids | Anxiety | Plus-maze test | Rat | Interaction | Nitric oxide | PHYSIOLOGY | ANTAGONIST | ACETYLCHOLINE-RELEASE | SR 141716A | PHARMACOLOGICAL BLOCKADE | CORTICOTROPIN-RELEASING-FACTOR | AGONIST CP-55,940 | GABA RELEASE | IN-VIVO | PHARMACOLOGY & PHARMACY | MICE | MODULATION | NG-Nitroarginine Methyl Ester - pharmacology | Analgesics - pharmacology | Microinjections | Rats, Wistar | Cannabinoids - administration & dosage | Anxiety - psychology | Enzyme Inhibitors - pharmacology | Receptors, Cannabinoid - physiology | Anxiety - physiopathology | Morpholines - pharmacology | Rats | Male | Nitric Oxide - physiology | Benzoxazines | Cannabinoids - pharmacology | Naphthalenes - pharmacology | Stereotaxic Techniques | Animals | Piperidines - pharmacology | Arginine - pharmacology | Nitric Oxide Synthase Type I - antagonists & inhibitors | Hippocampus - physiology | Pyrazoles - pharmacology | Receptors, Cannabinoid, physiology | NG-Nitroarginine Methyl Ester, pharmacology | Anxiety, physiopathology | Arginine, pharmacology | Cannabinoids, pharmacology | Cannabinoids, administration and dosage | Nitric Oxide Synthase Type I, antagonists and inhibitors | Enzyme Inhibitors, pharmacology | Anxiety, psychology | Naphthalenes, pharmacology | Hippocampus, physiology | Piperidines, pharmacology | Pyrazoles, pharmacology | Analgesics, pharmacology | Morpholines, pharmacology | Nitric Oxide, physiology | Physiological aspects
Journal Article
Free Radical Biology and Medicine, ISSN 0891-5849, 01/2000, Volume 28, Issue 1, pp. 55 - 63
Reactive oxygen species have been shown to be involved in the mutagenicity, clastogenicity, and apoptosis of mammalian cells treated with arsenic or cadmium.... 
Excision repair | Reactive oxygen species | Peroxynitrite | Hydrogen peroxide | Free radicals | Nitric oxide | nitric oxide | free radicals | OXIDATIVE STRESS | peroxynitrite | NITRIC-OXIDE SYNTHASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | hydrogen peroxide | SODIUM ARSENITE | STRAND BREAKS | excision repair | CHINESE-HAMSTER CELLS | reactive oxygen species | HEAT-SHOCK RESPONSE | L-ARGININE | ENDOCRINOLOGY & METABOLISM | HYDROGEN-PEROXIDE | WELL WATER | MALIGNANT NEOPLASMS | Cadmium Chloride - toxicity | Catalase - pharmacology | Free Radical Scavengers - pharmacology | Amitrole - pharmacology | Mutagens - toxicity | Citrulline - analogs & derivatives | Reactive Oxygen Species - metabolism | Nitric Oxide Synthase - antagonists & inhibitors | Endothelium, Vascular - drug effects | Molsidomine - analogs & derivatives | Thiourea - pharmacology | Endothelium, Vascular - chemistry | Phenanthrolines - pharmacology | Chromans - pharmacology | Arsenites - toxicity | Cattle | Superoxides - metabolism | Nitric Oxide Donors - pharmacology | Superoxide Dismutase - pharmacology | N-Glycosyl Hydrolases - pharmacology | Cells, Cultured | Enzyme Inhibitors - pharmacology | Sodium Selenite - pharmacology | Antioxidants - pharmacology | Onium Compounds - pharmacology | Hydrogen Peroxide - metabolism | Nitroarginine - pharmacology | Nitrates - metabolism | Bacterial Proteins - pharmacology | DNA-Formamidopyrimidine Glycosylase | Animals | Citrulline - pharmacology | Ditiocarb - pharmacology | Escherichia coli Proteins | Sodium Compounds - toxicity | Uric Acid - pharmacology | Molsidomine - pharmacology | Thiomalates - pharmacology | Aorta - cytology | DNA Damage | Nitric Oxide - metabolism | Thiourea - analogs & derivatives | formamidopyrimidine-DNA glycosylase | formamidopyrimidine | 3-morpholinosydnonimine | 8-oxoguanine
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 04/2001, Volume 276, Issue 17, pp. 13750 - 13755
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 6/2007, Volume 104, Issue 24, pp. 9982 - 9987
Arginine contains the guanidinium group and thus has structural similarity to ligands of imidazoline and α-2 adrenoceptors (α-2 AR). Therefore, we investigated... 
Cell culture techniques | Signal transduction | Receptors | Imidazolines | Fluorescence | Agonists | Ligands | Toxins | Endothelial cells | Whooping cough | Calcium | Agmatine | Rauwolscine | rauwolscine | calcium | DEPENDENT VASODILATION | VASCULAR RELAXATION | MULTIDISCIPLINARY SCIENCES | agmatine | RELAXING FACTOR | PORCINE CORONARY-ARTERIES | RELEASE | SYNTHASE | SMOOTH-MUSCLE | CHOLESTEROL-FED RABBITS | S-NITROSOTHIOLS | Endothelium, Vascular - cytology | Aniline Compounds | Humans | Receptors, Adrenergic, alpha-2 - metabolism | Culture Media, Serum-Free | Adrenergic alpha-Antagonists - pharmacology | Calcium - analysis | Agmatine - pharmacology | Virulence Factors, Bordetella - pharmacology | Type C Phospholipases - antagonists & inhibitors | Yohimbine - pharmacology | Dose-Response Relationship, Drug | Idazoxan - pharmacology | Arginine - antagonists & inhibitors | Estrenes - pharmacology | Pyrrolidinones - pharmacology | Agmatine - chemistry | Dexmedetomidine - pharmacology | Molecular Structure | Cell Culture Techniques | Nitric Oxide Synthase Type III - metabolism | Umbilical Veins - cytology | Nitrates - analysis | NG-Nitroarginine Methyl Ester - pharmacology | Nitric Oxide - biosynthesis | Nifedipine - pharmacology | Idazoxan - chemistry | Endothelial Cells - metabolism | Nitric Oxide - antagonists & inhibitors | Cells, Cultured | Imidazolines - pharmacology | Calcium Channel Blockers - pharmacology | Enzyme Activation - drug effects | Arginine - chemistry | Xanthenes | Endothelial Cells - cytology | Arginine - pharmacology | Lipopolysaccharides - pharmacology | Second Messenger Systems - physiology | Nitrites - analysis | Endothelial Cells - enzymology | Fluorescent Dyes | Biological Sciences
Journal Article
Clinical and Experimental Pharmacology and Physiology, ISSN 0305-1870, 05/2007, Volume 34, Issue 5, pp. 387 - 392
SUMMARY • Astragaloside IV is a component from the widely used traditional Chinese herb Astragalus membranaceus and its effect on rat aortic ring contraction... 
endothelium | nitric oxide | aortic rings | vessel contraction and relaxation | astragaloside IV | Astragaloside IV | Nitric oxide | Vessel contraction and relaxation | Aortic rings | Endothelium | SMOOTH-MUSCLE | PHYSIOLOGY | CONTRACTION | TONE | L-ARGININE | PHARMACOLOGY & PHARMACY | CHANNELS | Triterpenes - pharmacology | Muscle, Smooth, Vascular - metabolism | Calcium - metabolism | Nitric Oxide Synthase - antagonists & inhibitors | Male | Saponins - chemistry | Endothelium, Vascular - physiology | Dose-Response Relationship, Drug | Quinoxalines - pharmacology | Intracellular Fluid - drug effects | Triterpenes - chemistry | Phenylephrine - pharmacology | Oxadiazoles - pharmacology | Aorta, Thoracic - physiology | Potassium Chloride - pharmacology | Molecular Structure | Aorta, Thoracic - drug effects | Cyclic GMP - biosynthesis | Intracellular Fluid - metabolism | Muscle, Smooth, Vascular - drug effects | NG-Nitroarginine Methyl Ester - pharmacology | Vasoconstrictor Agents - pharmacology | Vasodilator Agents - pharmacology | Acetylcholine - pharmacology | Rats | Vasodilator Agents - isolation & purification | Muscle, Smooth, Vascular - cytology | Rats, Sprague-Dawley | Indomethacin - pharmacology | Nitroarginine - pharmacology | Aorta, Thoracic - cytology | Calcium Chloride - pharmacology | Animals | Saponins - isolation & purification | Triterpenes - isolation & purification | Vasodilator Agents - chemistry | Nitric Oxide Synthase - metabolism | Vasodilation - drug effects | In Vitro Techniques | Saponins - pharmacology | NG-Nitroarginine Methyl Ester, pharmacology | Triterpenes, pharmacology | Calcium, metabolism | Nitric Oxide Synthase, antagonists and inhibitors | Muscle, Smooth, Vascular, metabolism | Vasodilator Agents, chemistry | Quinoxalines, pharmacology | Aorta, Thoracic, drug effects | Triterpenes, chemistry | Vasodilator Agents, pharmacology | Saponins, chemistry | Intracellular Fluid, drug effects | Nitric Oxide Synthase, metabolism | Aorta, Thoracic, cytology | Potassium Chloride, pharmacology | Aorta, Thoracic, physiology | Calcium Chloride, pharmacology | Vasoconstrictor Agents, pharmacology | Muscle, Smooth, Vascular, drug effects | Nitroarginine, pharmacology | Saponins, pharmacology | Vasodilation, drug effects | Triterpenes, isolation and purification | Cyclic GMP, biosynthesis | Vasodilator Agents, isolation and purification | Acetylcholine, pharmacology | Oxadiazoles, pharmacology | Muscle, Smooth, Vascular, cytology | Phenylephrine, pharmacology | Saponins, isolation and purification | Endothelium, Vascular, physiology | Indomethacin, pharmacology | Intracellular Fluid, metabolism
Journal Article
Free Radical Biology and Medicine, ISSN 0891-5849, 2004, Volume 36, Issue 8, pp. 994 - 1010
As rat spermatozoa undergo epididymal maturation, they acquire the ability to exhibit a spontaneous burst of luminol-peroxidase-dependent chemiluminescence... 
Epididymis | Peroxynitrite | Free radicals | Sperm | Nitric oxide | Luminol | Peroxidase | NADPH OXIDASE | nitric oxide | free radicals | LUMINOL CHEMILUMINESCENCE | peroxynitrite | LIPID-PEROXIDATION | peroxidase | NITRIC-OXIDE SYNTHASE | MOUSE SPERMATOZOA | BIOCHEMISTRY & MOLECULAR BIOLOGY | HUMAN SPERM FUNCTION | PROTEIN-TYROSINE PHOSPHORYLATION | epididytnis | sperm | SUPEROXIDE ANION | ENDOCRINOLOGY & METABOLISM | HYDROGEN-PEROXIDE | CELLULAR MECHANISMS | luminol | Catalase - pharmacology | Epididymis - metabolism | Temperature | Reactive Oxygen Species | Uncoupling Agents - pharmacology | Rats, Wistar | Calcium - metabolism | Capsaicin - pharmacology | Nitric Oxide Synthase - antagonists & inhibitors | Male | Spermatozoa - metabolism | Culture Media - metabolism | Acrosome Reaction | Time Factors | Indicators and Reagents - pharmacology | Rotenone - pharmacology | Bicarbonates - chemistry | NADH, NADPH Oxidoreductases - metabolism | Diterpenes - pharmacology | NG-Nitroarginine Methyl Ester - pharmacology | Deferoxamine - pharmacology | Superoxide Dismutase - pharmacology | Oxidation-Reduction | Enzyme Inhibitors - pharmacology | Rats | Onium Compounds - pharmacology | Arginine - chemistry | Luminol - pharmacology | Microscopy, Confocal | Animals | Iron Chelating Agents - pharmacology | Models, Biological | Acridines - pharmacology | Glucose - chemistry | 4-Chloromercuribenzenesulfonate - pharmacology | Fructose - chemistry | Microscopy, Fluorescence | Peroxidase - metabolism
Journal Article
Journal Article
Peptides, ISSN 0196-9781, 2010, Volume 31, Issue 4, pp. 736 - 756
In recent years, studies have advocated neuropeptide systems as modulators for the behavioral states found in mood disorders such as depression and anxiety... 
Neuropeptide Y | Animal models | Oxytocin | Galanin | Substance P | Depression | Corticotropin-releasing factor | Stress | Vasopressin | Urocortin | Receptor antagonists | Teneurin | Anxiety | Cholecystokinin | Tyr-MIF-1 | MELANOCYTE-STIMULATING-HORMONE | SOCIAL-INTERACTION TEST | CHOLECYSTOKININ-B RECEPTOR | ELEVATED PLUS-MAZE | NK1 RECEPTOR ANTAGONIST | FEAR-POTENTIATED STARTLE | PHARMACOLOGY & PHARMACY | BIOCHEMISTRY & MOLECULAR BIOLOGY | FORCED SWIMMING TEST | ANTIDEPRESSANT-LIKE ACTIVITY | CORTICOTROPIN-RELEASING-FACTOR | PLACEBO-CONTROLLED TRIAL | Oxytocin - pharmacology | Humans | Anxiety - drug therapy | MSH Release-Inhibiting Hormone - therapeutic use | Depression - drug therapy | Social Behavior | Neuropeptides - pharmacology | Cholecystokinin - therapeutic use | Corticotropin-Releasing Hormone - therapeutic use | Behavior, Animal - drug effects | Urocortins - pharmacology | Disease Models, Animal | Arginine Vasopressin - therapeutic use | Urocortins - therapeutic use | Galanin - therapeutic use | Neuropeptide Y - therapeutic use | Cholecystokinin - pharmacology | Neuropeptide Y - pharmacology | Arginine Vasopressin - pharmacology | Corticotropin-Releasing Hormone - pharmacology | Neuropeptides - therapeutic use | Galanin - pharmacology | Neuropsychological Tests | Animals | MSH Release-Inhibiting Hormone - analogs & derivatives | MSH Release-Inhibiting Hormone - pharmacology | Oxytocin - therapeutic use | Analysis | ACTH | Serotonin uptake inhibitors | Neuropeptides | Hormones | Control | Peptides | Rodents | Disorders | Moods | Modulators
Journal Article