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Journal Article
Science (American Association for the Advancement of Science), ISSN 1095-9203, 2004, Volume 303, Issue 5658, pp. 672 - 676
... (a heterochromatin-associated chromodomain protein), and Tas3 (a novel protein). In addition, the complex contains small RNAs that require the Dicer ribonuclease for their production... 
Gene silencing | Heterochromatin | Chromatin | RNA | Gels | DNA | Small interfering RNA | Reporter genes | Genetic loci | Reports | Methylation | H3 LYSINE-9 METHYLATION | FISSION YEAST | DOMAIN | EPIGENETIC CONTROL | GENE | HISTONE H3 | MULTIDISCIPLINARY SCIENCES | TRANSCRIPTION | TETRAHYMENA | INTERFERENCE | Endoribonucleases - chemistry | Schizosaccharomyces pombe Proteins - chemistry | Endoribonucleases - genetics | Endoribonucleases - isolation & purification | Molecular Sequence Data | Centromere - metabolism | RNA-Binding Proteins | Cell Cycle Proteins - chemistry | Schizosaccharomyces - genetics | Heterochromatin - metabolism | RNA Interference | Chromosomes, Fungal - metabolism | Mass Spectrometry | Schizosaccharomyces pombe Proteins - metabolism | Cell Cycle Proteins - genetics | Genes, Reporter | Amino Acid Sequence | Cell Cycle Proteins - isolation & purification | Ribonuclease III - metabolism | Schizosaccharomyces pombe Proteins - genetics | Endoribonucleases - metabolism | Cell Cycle Proteins - metabolism | Precipitin Tests | RNA, Fungal - metabolism | Schizosaccharomyces pombe Proteins - isolation & purification | Schizosaccharomyces - metabolism | Argonaute Proteins | Protein Binding | Models, Genetic | Mutation | RNA, Small Interfering - metabolism | Proteins | Yeast | Ribonucleic acid--RNA | Genes | Chromosomes, Fungal | Schizosaccharomyces pombe Proteins | Life Sciences | Centromere | Ribonuclease III | RNA, Fungal | Genetics | RNA, Small Interfering | Cell Cycle Proteins | Schizosaccharomyces
Journal Article
Journal Article
Cell (Cambridge), ISSN 0092-8674, 2006, Volume 126, Issue 1, pp. 93 - 106
...; the small nuclear RNA (snRNA) binding protein SmD3; and two markers of Cajal bodies, trimethylguanosine-capped snRNAs and the U2 snRNA binding protein U2B... 
RNA-POLYMERASE-II | H3 LYSINE-9 METHYLATION | DIRECTED DNA METHYLATION | TERMINAL DOMAIN | CHROMATIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | HETEROCHROMATIN FORMATION | SIRNA | FLUORESCENT PROTEIN | HISTONE METHYLATION | LIVING PLANT-CELLS | CELL BIOLOGY | RNA, Small Interfering - genetics | Autoantigens - metabolism | snRNP Core Proteins | Methyltransferases - metabolism | Methyltransferases - genetics | Ribonucleoproteins, Small Nuclear - genetics | Drosophila Proteins - metabolism | Autoantigens - genetics | Protein Subunits - metabolism | Arabidopsis Proteins - metabolism | DNA Methylation | RNA, Small Nuclear - genetics | Cell Nucleolus - metabolism | Coiled Bodies - metabolism | Protein Subunits - genetics | Coiled Bodies - genetics | Arabidopsis Proteins - genetics | Cell Nucleolus - genetics | Gene Expression Regulation, Plant - genetics | DNA-Directed RNA Polymerases - genetics | Protein Structure, Tertiary - genetics | Binding Sites - genetics | Arabidopsis - metabolism | Arabidopsis - genetics | Argonaute Proteins | Drosophila Proteins - genetics | RNA, Small Nuclear - metabolism | DNA-Directed RNA Polymerases - metabolism | Gene Silencing - physiology | Macromolecular Substances - metabolism | Ribonucleoproteins, Small Nuclear - metabolism | RNA, Small Interfering - metabolism | Arabidopsis thaliana | Gene silencing | Analysis | Ribonucleoproteins | Genetic aspects | Research | Methylation | RNA | Developmental biology | DNA | DNA polymerases | Protein binding | Protein Structure, Tertiary | Plants genetics | Protein Subunits | Cell Nucleolus | Drosophila Proteins | Arabidopsis | Gene Silencing | Ribonucleoproteins, Small Nuclear | Autoantigens | Macromolecular Substances | Coiled Bodies | Life Sciences | Arabidopsis Proteins | DNA-Directed RNA Polymerases | Methyltransferases | Gene Expression Regulation, Plant | Genetics | RNA, Small Interfering | RNA, Small Nuclear | Binding Sites
Journal Article
Biochemistry, ISSN 0006-2960, 12/2013, Volume 52, Issue 51, pp. 9329 - 9338
Unlocked nucleic acid (UNA) is an acyclic analogue of RNA that can be introduced into RNA or DNA oligonucleotides. The increased flexibility conferred by the... 
SINGLE-NUCLEOTIDE | MECHANISM | MODIFIED OLIGONUCLEOTIDES | ANALOGS | STABILITY | BIOCHEMISTRY & MOLECULAR BIOLOGY | MACHADO-JOSEPH-DISEASE | MUTANT HUNTINGTIN | GENES | EXPANDED CAG REPEATS | SIRNA | Trinucleotide Repeats | Oligonucleotides - chemistry | Immunoprecipitation | Ataxin-3 | Humans | Base Pair Mismatch | Recombinant Proteins - biosynthesis | RNA, Messenger - metabolism | Repressor Proteins - antagonists & inhibitors | RNA, Small Interfering - chemistry | Nerve Tissue Proteins - chemistry | Base Sequence | RNA, Messenger - antagonists & inhibitors | Drug Design | Nuclear Proteins - genetics | Mutant Proteins - antagonists & inhibitors | Repressor Proteins - metabolism | Recombinant Proteins - metabolism | Cell Line | Nerve Tissue Proteins - antagonists & inhibitors | Argonaute Proteins - metabolism | Repressor Proteins - chemistry | Gene Silencing | Recombinant Proteins - chemistry | Repressor Proteins - genetics | Mutant Proteins - metabolism | Nuclear Proteins - metabolism | Nuclear Proteins - chemistry | Nerve Tissue Proteins - genetics | Mutant Proteins - biosynthesis | Hydrolysis | Nerve Tissue Proteins - metabolism | Huntingtin Protein | Oligonucleotides - metabolism | Base Pairing | Mutant Proteins - chemistry | Nuclear Proteins - antagonists & inhibitors | Alleles | RNA, Messenger - chemistry | Kinetics | RNA, Small Interfering - metabolism | Gene expression | Research | Nucleic acids
Journal Article
PLoS ONE, ISSN 1932-6203, 07/2014, Volume 9, Issue 7, p. e102957
.... Mutation of Lys402 enhances the stability of Ago2 protein and impairment of cellular sumoylation by siRNA-or shRNA-mediated extinction of Ubc9 or in Ubc9 knockout mouse tissues results in increased... 
SMALL RNAS | SUMO | PML DEGRADATION | BIOGENESIS | PATHWAY | PHOSPHORYLATION | MULTIDISCIPLINARY SCIENCES | POSTTRANSLATIONAL MODIFICATIONS | PROTEINS | CANCER | E3 UBIQUITIN LIGASE | RNA, Small Interfering - genetics | Molecular Chaperones - metabolism | Humans | Protein Processing, Post-Translational - genetics | Nuclear Pore Complex Proteins - genetics | Small Ubiquitin-Related Modifier Proteins - genetics | Phosphorylation - genetics | SUMO-1 Protein - genetics | Lysine - metabolism | Argonaute Proteins - metabolism | Sumoylation - genetics | Argonaute Proteins - genetics | Nuclear Pore Complex Proteins - metabolism | Small Ubiquitin-Related Modifier Proteins - metabolism | Molecular Chaperones - genetics | Ubiquitin-Protein Ligases - metabolism | Ubiquitin-Conjugating Enzymes - genetics | Lysine - genetics | Animals | Ubiquitin-Conjugating Enzymes - metabolism | Cell Line, Tumor | Mice | SUMO-1 Protein - metabolism | HeLa Cells | Ubiquitin-Protein Ligases - genetics | Gene Silencing - physiology | Post-translational modification | RNA | Lysine | Ligases | Post-transcription | Phosphorylation | Arsenic | Laboratories | Genes | Biosynthesis | Tissues | DNA repair | Proteins | SUMO protein | Post-translation | Ran-binding protein | Localization | Ubiquitin-protein ligase | Deoxyribonucleic acid--DNA | Enzymes | Translation | Stability | Extinction | RNA-mediated interference | Hot spots | siRNA | Argonaute 2 protein | Gene expression | Ribonucleic acid--RNA | Gene silencing | Cancer | Life Sciences | Molecular biology | Biochemistry, Molecular Biology | Deoxyribonucleic acid | Ribonucleic acid | DNA
Journal Article
Science (American Association for the Advancement of Science), ISSN 1095-9203, 2009, Volume 325, Issue 5941, pp. 750 - 753
.... We reconstituted long double-stranded RNA-- and duplex siRNA--initiated RISC activities with the use of recombinant Drosophila Dicer-2, R2D2, and Ago2 proteins... 
Proteins | Phenotypes | Messenger RNA | Double stranded RNA | Passengers | Drosophila | Small interfering RNA | Reports | Biochemistry | Ovaries | Embryos | DROSOPHILA TRANSLIN | MUTANT | PROTEIN | CLEAVES | MULTIDISCIPLINARY SCIENCES | COMPLEXES | R2D2 | MECHANISMS | SIRNA | ARGONAUTE2 | STRAND | RNA Helicases - metabolism | RNA-Binding Proteins - genetics | RNA-Induced Silencing Complex - genetics | Molecular Sequence Data | Drosophila Proteins - metabolism | Drosophila melanogaster - genetics | RNA, Small Interfering - chemistry | RNA Interference | Carrier Proteins - chemistry | RNA Helicases - genetics | RNA, Double-Stranded - metabolism | RNA, Double-Stranded - chemistry | Recombinant Proteins - metabolism | Amino Acid Sequence | Catalytic Domain | Ribonuclease III - genetics | Ribonuclease III - metabolism | Models, Molecular | Drosophila Proteins - chemistry | Drosophila Proteins - isolation & purification | Carrier Proteins - genetics | Animals | Carrier Proteins - metabolism | Drosophila melanogaster - chemistry | Carrier Proteins - isolation & purification | RNA-Induced Silencing Complex - metabolism | Argonaute Proteins | Drosophila melanogaster - enzymology | Protein Conformation | Drosophila Proteins - genetics | Mutation | RNA-Binding Proteins - metabolism | RNA, Small Interfering - metabolism | Nucleases | Promoters (Genetics) | Research | Properties | Ribonucleic acid--RNA | Molecular biology | C3PO | RISC | RNAi | endoribonuclease | Dcr-2 | Ago2
Journal Article
Journal Article