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gene silencing (28) 28
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base sequence (27) 27
drosophila (27) 27
protein binding (27) 27
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hela cells (25) 25
apoptosis (24) 24
immunoprecipitation (24) 24
rna, messenger - genetics (24) 24
analysis (23) 23
binding sites (23) 23
dicer (23) 23
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biogenesis (21) 21
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ribonuclease iii - metabolism (21) 21
signal transduction (21) 21
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genetics (20) 20
medicine (20) 20
science (20) 20
transcription (20) 20
double-stranded-rna (19) 19
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argonaute2 (18) 18
messenger-rna (18) 18
molecular biology (18) 18
ribonuclease iii - genetics (18) 18
rnai (18) 18
virology (18) 18
down-regulation (17) 17
hek293 cells (17) 17
life sciences (17) 17
microbiology (17) 17
pathway (17) 17
physiological aspects (17) 17
posttranscriptional regulation (17) 17
recognition (17) 17
translation (17) 17
crystal-structure (16) 16
dna methylation (16) 16
gene regulation (16) 16
mutation (16) 16
nucleic acids (16) 16
3' untranslated regions (15) 15
ago2 (15) 15
biochemistry (15) 15
cleavage (15) 15
genetics & heredity (15) 15
genomes (15) 15
infections (15) 15
interference (15) 15
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Cell death and differentiation, ISSN 1476-5403, 2016, Volume 24, Issue 2, pp. 212 - 224
Increasing evidence has indicated that long noncoding RNAs (lncRNAs) are of great importance in different cell contexts. However, only a very small number of... 
PLAYER | EVOLUTION | LONG NONCODING RNAS | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSCRIPTION | ALPHA | PLURIPOTENCY | MECHANISMS | EXPRESSION | ACUTE PROMYELOCYTIC LEUKEMIA | CANCER BIOLOGY | CELL BIOLOGY | Oncogene Proteins, Fusion - metabolism | Leukemia, Promyelocytic, Acute - pathology | MicroRNAs - antagonists & inhibitors | Humans | Child, Preschool | Infant | Male | MicroRNAs - metabolism | Autophagy-Related Protein-1 Homolog - metabolism | Intracellular Signaling Peptides and Proteins - metabolism | Autophagy - drug effects | Proteolysis - drug effects | Leukemia, Promyelocytic, Acute - metabolism | HEK293 Cells | Female | E2F1 Transcription Factor - antagonists & inhibitors | Membrane Proteins - metabolism | Child | Intracellular Signaling Peptides and Proteins - genetics | Infant, Newborn | Tretinoin - pharmacology | Argonaute Proteins - metabolism | Argonaute Proteins - genetics | Membrane Proteins - genetics | Intracellular Signaling Peptides and Proteins - antagonists & inhibitors | E2F1 Transcription Factor - metabolism | Down-Regulation - drug effects | Mice, SCID | Animals | Membrane Proteins - antagonists & inhibitors | Cell Differentiation - drug effects | Oncogene Proteins, Fusion - genetics | Adolescent | Cell Line, Tumor | Oncogene Proteins, Fusion - antagonists & inhibitors | Mice | MicroRNAs - genetics | Leukemia, Promyelocytic, Acute - genetics | E2F1 Transcription Factor - genetics | Autophagy-Related Protein-1 Homolog - genetics | Autophagy-Related Protein-1 Homolog - antagonists & inhibitors | Original Paper
Journal Article
Biochemistry, ISSN 0006-2960, 12/2013, Volume 52, Issue 51, pp. 9329 - 9338
Unlocked nucleic acid (UNA) is an acyclic analogue of RNA that can be introduced into RNA or DNA oligonucleotides. The increased flexibility conferred by the... 
SINGLE-NUCLEOTIDE | MECHANISM | MODIFIED OLIGONUCLEOTIDES | ANALOGS | STABILITY | BIOCHEMISTRY & MOLECULAR BIOLOGY | MACHADO-JOSEPH-DISEASE | MUTANT HUNTINGTIN | GENES | EXPANDED CAG REPEATS | SIRNA | Trinucleotide Repeats | Oligonucleotides - chemistry | Immunoprecipitation | Ataxin-3 | Humans | Base Pair Mismatch | Recombinant Proteins - biosynthesis | RNA, Messenger - metabolism | Repressor Proteins - antagonists & inhibitors | RNA, Small Interfering - chemistry | Nerve Tissue Proteins - chemistry | Base Sequence | RNA, Messenger - antagonists & inhibitors | Drug Design | Nuclear Proteins - genetics | Mutant Proteins - antagonists & inhibitors | Repressor Proteins - metabolism | Recombinant Proteins - metabolism | Cell Line | Nerve Tissue Proteins - antagonists & inhibitors | Argonaute Proteins - metabolism | Repressor Proteins - chemistry | Gene Silencing | Recombinant Proteins - chemistry | Repressor Proteins - genetics | Mutant Proteins - metabolism | Nuclear Proteins - metabolism | Nuclear Proteins - chemistry | Nerve Tissue Proteins - genetics | Mutant Proteins - biosynthesis | Hydrolysis | Nerve Tissue Proteins - metabolism | Huntingtin Protein | Oligonucleotides - metabolism | Base Pairing | Mutant Proteins - chemistry | Nuclear Proteins - antagonists & inhibitors | Alleles | RNA, Messenger - chemistry | Kinetics | RNA, Small Interfering - metabolism | Gene expression | Research | Nucleic acids
Journal Article
The Journal of biological chemistry, ISSN 1083-351X, 2017, Volume 292, Issue 28, pp. 11804 - 11814
...), a ribonucleoprotein complex that contains miRNA-engaged Argonaute (Ago) and the scaffold protein GW182... 
post-translational modification (PTM) | RISC | CELLS | microRNA (miRNA) | EDD | HYPERPLASTIC-DISCS | UBIQUITIN LIGASE | DNA-DAMAGE RESPONSE | BIOCHEMISTRY & MOLECULAR BIOLOGY | BINDING-PROTEIN | DEUBIQUITINASE DUBA | PROTEIN-KINASES | FAMILY | E3 LIGASE | Toll-like receptor (TLR) | TRAF3 | Argonaute | UBR5 | p90RSK | phosphorylation | RNA-Binding Proteins - genetics | Phosphorylation | Autoantigens - metabolism | Humans | Cercopithecus aethiops | Ubiquitin-Protein Ligases - antagonists & inhibitors | MicroRNAs - metabolism | Green Fluorescent Proteins - genetics | RNA, Messenger - metabolism | Autoantigens - genetics | Recombinant Fusion Proteins - metabolism | Ribosomal Protein S6 Kinases, 90-kDa - metabolism | RNA Interference | TNF Receptor-Associated Factor 3 - genetics | RNA, Messenger - antagonists & inhibitors | HEK293 Cells | Toll-Like Receptors - metabolism | 3' Untranslated Regions | RNA-Binding Proteins - antagonists & inhibitors | Green Fluorescent Proteins - metabolism | TNF Receptor-Associated Factor 3 - antagonists & inhibitors | Signal Transduction | Ubiquitin-Protein Ligases - metabolism | TNF Receptor-Associated Factor 3 - metabolism | Animals | Ribosomal Protein S6 Kinases, 90-kDa - genetics | Protein Processing, Post-Translational | HeLa Cells | Mutation | Ubiquitin-Protein Ligases - genetics | COS Cells | RNA-Binding Proteins - metabolism | Amino Acid Substitution
Journal Article
Journal Article
Biochemical journal, ISSN 1470-8728, 2008, Volume 413, Issue 3, pp. 429 - 436
Ago (Argonaute) proteins are essential effectors of RNA-mediated gene silencing. To explore potential regulatory mechanisms for Ago proteins, we examined the phosphorylation of human Ago2... 
Argonaute (Ago) | Phosphorylation | RNA interference (RNAi) | Processing body | Mitogen-activated protein kinase (MAPK) | RISC | SMALL RNAS | CRYSTAL-STRUCTURE | HUMAN-CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | mitogen-activated protein kinase (MAPK) | MICRORNA-DEPENDENT LOCALIZATION | TRANSLATION | PROTEIN-SYNTHESIS | SLICER | REPRESSION | processing body | MIRNAS | phosphorylation | Arsenites - pharmacology | Immunoprecipitation | Eukaryotic Initiation Factor-2 - chemistry | Humans | Molecular Sequence Data | JNK Mitogen-Activated Protein Kinases - metabolism | Intracellular Signaling Peptides and Proteins - metabolism | Mitogen-Activated Protein Kinase Kinases - metabolism | Mass Spectrometry | Eukaryotic Initiation Factor-2 - metabolism | Flavonoids - pharmacology | p38 Mitogen-Activated Protein Kinases - metabolism | Glutathione Transferase | Phosphorylation - drug effects | Protein-Serine-Threonine Kinases - metabolism | Recombinant Proteins - metabolism | Amino Acid Sequence | Cell Line | JNK Mitogen-Activated Protein Kinases - antagonists & inhibitors | Mitogen-Activated Protein Kinase Kinases - antagonists & inhibitors | Recombinant Proteins - chemistry | Serine - genetics | Imidazoles - pharmacology | Serine - chemistry | Sodium Compounds - pharmacology | Serine - metabolism | Anthracenes - pharmacology | Blotting, Western | Sequence Homology, Amino Acid | Microscopy, Confocal | Eukaryotic Initiation Factor-2 - genetics | p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors | Argonaute Proteins | Pyridines - pharmacology | Mutation
Journal Article
PLoS ONE, ISSN 1932-6203, 06/2016, Volume 11, Issue 6, p. e0157520
RNA interference (RNAi) is being developed as a potential tool for insect pest management. Increased understanding of the RNAi pathway in target insect pests... 
DOUBLE-STRANDED-RNA | MULTIDISCIPLINARY SCIENCES | ARGONAUTE | INSECTS | DICER-2 | DISTINCT ROLES | GENOME | Coleoptera - genetics | Pest Control, Biological | RNA, Small Interfering - genetics | Vacuolar Proton-Translocating ATPases - genetics | Coleoptera - metabolism | Transcriptome | Argonaute Proteins - antagonists & inhibitors | Coleoptera - growth & development | Vacuolar Proton-Translocating ATPases - metabolism | Gene Knockdown Techniques | RNA Interference | Larva - growth & development | Plants, Genetically Modified | Larva - genetics | RNA, Double-Stranded - metabolism | Insect Proteins - metabolism | Zea mays - genetics | Argonaute Proteins - metabolism | Argonaute Proteins - genetics | Ribonuclease III - genetics | Ribonuclease III - metabolism | Plant Immunity - genetics | Larva - metabolism | Insect Proteins - genetics | Zea mays - parasitology | Ribonuclease III - antagonists & inhibitors | Insect Proteins - antagonists & inhibitors | Vacuolar Proton-Translocating ATPases - antagonists & inhibitors | Animals | Zea mays - immunology | RNA, Double-Stranded - genetics | RNA, Small Interfering - metabolism | RNA-mediated interference | Genes | Mortality | Double-stranded RNA | Interference | Pest control | Corn | siRNA | RNA-induced silencing complex | Pests | Argonaute 2 protein | Gene expression | Ribonucleic acid--RNA | Transgenic plants | Proteins | Beetles | Developmental stages | Insects | Plant tissues | Efficiency | Adults | Catalysis | Endonuclease | Laccase | RNA | Ribonucleic acid
Journal Article
Genes & development, ISSN 0890-9369, 2006, Volume 20, Issue 21, pp. 2985 - 2995
.... Arthropods lack the protein-based adaptive immune response found in vertebrates. Here we show that the central catalytic component of the RNA-induced silencing complex ( RISC... 
Antiviral defense | Cricket paralysis virus | dsRNA-binding domain | RNAi suppressor | Drosophila C virus | VIRAL SUPPRESSOR | DEFENSE | DOUBLE-STRANDED-RNA | BINDING MOTIF | PROTEIN | Cricket Paralysis virus | RECOGNITION | DEVELOPMENTAL BIOLOGY | DISTINCT ROLES | CELL BIOLOGY | INTERFERING RNA | ANIMAL VIRUS | GENETICS & HEREDITY | INFECTION | antiviral defense | RNA-Induced Silencing Complex - physiology | Drosophila melanogaster - immunology | RNA-Induced Silencing Complex - genetics | Gene Silencing | Viral Proteins - genetics | Viral Proteins - metabolism | RNA Helicases - antagonists & inhibitors | Drosophila Proteins - physiology | Animals | RNA Interference | Ribonuclease III | Argonaute Proteins | Drosophila melanogaster - enzymology | Insect Viruses - immunology | RNA, Double-Stranded - metabolism | RNA, Viral - metabolism | Drosophila Proteins - genetics | Drosophila Proteins - antagonists & inhibitors | Drosophila melanogaster - virology | Insect Viruses - genetics | Suppression, Genetic | Genetic research | Drosophila | Genetic aspects | Drosophila Proteins | Innate immunity | Viral Proteins | Virology | Insect Viruses | Life Sciences | Microbiology and Parasitology | RNA Helicases | Immunology | RNA, Viral | RNA, Double-Stranded | Drosophila melanogaster | RNA-Induced Silencing Complex | Research Paper
Journal Article
Scientific Reports, ISSN 2045-2322, 02/2016, Volume 6, Issue 1, p. 20520
Journal Article
Nature (London), ISSN 1476-4687, 2010, Volume 466, Issue 7306, pp. 637 - 641
...) pathway to regulate protein synthesis. Drosophila e2f1 and dp messenger RNAs are translationally repressed by let-7 and miR-184*, respectively... 
GENE | LET-7 MICRORNA | 4E-BP | MULTIDISCIPLINARY SCIENCES | GROWTH | DISTINCT ROLES | MUTATIONS | IDENTIFICATION | DROSOPHILA | CELL-DEATH | Up-Regulation | Protein Biosynthesis | MicroRNAs - antagonists & inhibitors | Humans | Male | MicroRNAs - metabolism | Neurons - cytology | Drosophila Proteins - metabolism | RNA, Messenger - metabolism | Drosophila Proteins - biosynthesis | Trans-Activators - genetics | Eukaryotic Initiation Factor-2 - metabolism | Female | Neurons - metabolism | Parkinson Disease - metabolism | Trans-Activators - biosynthesis | Dopamine - metabolism | Protein-Serine-Threonine Kinases - metabolism | Eukaryotic Initiation Factors - metabolism | Cell Line | RNA-Induced Silencing Complex - antagonists & inhibitors | Down-Regulation | RNA, Messenger - genetics | Protein-Serine-Threonine Kinases - genetics | E2F1 Transcription Factor - metabolism | Eukaryotic Initiation Factors - biosynthesis | Parkinson Disease - genetics | Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 | Animals | RNA-Induced Silencing Complex - metabolism | Argonaute Proteins | Protein Binding | Trans-Activators - metabolism | E2F1 Transcription Factor - biosynthesis | MicroRNAs - genetics | Drosophila Proteins - genetics | RNA-Induced Silencing Complex - chemistry | E2F1 Transcription Factor - genetics | Drosophila melanogaster | Parkinson Disease - etiology | Models | Genetic aspects | Genetic translation | Phosphotransferases | Proteins | Statistical analysis | Insects | Neurons | Cell cycle | Cell division | Mutation | Kinases | Binding sites | Apoptosis | Index Medicus
Journal Article
ChemBioChem, ISSN 1439-4227, 06/2016, Volume 17, Issue 11, pp. 985 - 989
Journal Article
Journal Article