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Molecular Cell, ISSN 1097-2765, 2009, Volume 35, Issue 6, pp. 868 - 880
Journal Article
Science, ISSN 0036-8075, 1/2004, Volume 303, Issue 5658, pp. 672 - 676
RNA interference (RNAi) is a widespread silencing mechanism that acts at both the posttranscriptional and transcriptional levels. Here, we describe the... 
Gene silencing | Heterochromatin | Chromatin | RNA | Gels | DNA | Small interfering RNA | Reporter genes | Genetic loci | Reports | Methylation | H3 LYSINE-9 METHYLATION | FISSION YEAST | DOMAIN | EPIGENETIC CONTROL | GENE | HISTONE H3 | MULTIDISCIPLINARY SCIENCES | TRANSCRIPTION | TETRAHYMENA | INTERFERENCE | Endoribonucleases - chemistry | Schizosaccharomyces pombe Proteins - chemistry | Endoribonucleases - genetics | Endoribonucleases - isolation & purification | Molecular Sequence Data | Centromere - metabolism | RNA-Binding Proteins | Cell Cycle Proteins - chemistry | Schizosaccharomyces - genetics | Heterochromatin - metabolism | RNA Interference | Chromosomes, Fungal - metabolism | Mass Spectrometry | Schizosaccharomyces pombe Proteins - metabolism | Cell Cycle Proteins - genetics | Genes, Reporter | Amino Acid Sequence | Cell Cycle Proteins - isolation & purification | Ribonuclease III - metabolism | Schizosaccharomyces pombe Proteins - genetics | Endoribonucleases - metabolism | Cell Cycle Proteins - metabolism | Precipitin Tests | RNA, Fungal - metabolism | Schizosaccharomyces pombe Proteins - isolation & purification | Schizosaccharomyces - metabolism | Argonaute Proteins | Protein Binding | Models, Genetic | Mutation | RNA, Small Interfering - metabolism | Proteins | Yeast | Ribonucleic acid--RNA | Genes | Ago1 protein | RITS complex | Chp1 protein | Dicer protein | Tas3 protein | epigenetics | ribonuclease | Index Medicus | Chromosomes, Fungal | Schizosaccharomyces pombe Proteins | Life Sciences | Centromere | Ribonuclease III | RNA, Fungal | Genetics | RNA, Small Interfering | Cell Cycle Proteins | Schizosaccharomyces
Journal Article
Nature Structural and Molecular Biology, ISSN 1545-9993, 10/2012, Volume 19, Issue 10, pp. 998 - 1005
Journal Article
Nature Cell Biology, ISSN 1465-7392, 07/2017, Volume 19, Issue 7, pp. 820 - 832
Understanding the roles of splicing factors and splicing events during tumorigenesis would open new avenues for targeted therapies. Here we identify an... 
NONCODING RNA | PAXILLIN | COLORECTAL-CANCER | GENE-EXPRESSION | SELF-RENEWAL | PROLIFERATION | LIVER DEVELOPMENT | PROGRESSION | TUMOR-INITIATING CELLS | CANCER STEM-CELLS | CELL BIOLOGY | Paxillin - metabolism | RNA-Binding Proteins - genetics | Up-Regulation | Paxillin - genetics | Cell Proliferation | Alternative Splicing | Exons | Humans | Gene Expression Regulation, Neoplastic | Male | MicroRNAs - metabolism | SOXB1 Transcription Factors - metabolism | Octamer Transcription Factor-3 - genetics | Transfection | RNA Interference | SOXB1 Transcription Factors - genetics | Time Factors | Carcinoma, Hepatocellular - genetics | 3' Untranslated Regions | Binding Sites | Nanog Homeobox Protein - genetics | Argonaute Proteins - metabolism | Argonaute Proteins - genetics | Liver Neoplasms - genetics | Mice, Inbred C57BL | Gene Expression Profiling - methods | RNA, Long Noncoding - genetics | Tumor Burden | Hep G2 Cells | Animals | Carrier Proteins - metabolism | Mice, Nude | Octamer Transcription Factor-3 - metabolism | Liver Neoplasms - metabolism | Protein Binding | High-Throughput Nucleotide Sequencing | Mice | MicroRNAs - genetics | RNA, Long Noncoding - metabolism | Nanog Homeobox Protein - metabolism | RNA-Binding Proteins - metabolism | Carcinoma, Hepatocellular - metabolism | Alternative splicing | Translation | Transcription | Splicing | MiRNA | Hepatocellular carcinoma | Gene expression | Argonaute 2 protein | Gene sequencing | Degradation | Liver cancer | 3' Untranslated regions | Ribonucleic acids | Translation elongation | Tumorigenesis | Splicing factors | Elongation | Index Medicus
Journal Article
Nature, ISSN 0028-0836, 07/2010, Volume 466, Issue 7306, pp. 637 - 641
Gain-of-function mutations in leucine-rich repeat kinase 2 (LRRK2) cause familial as well as sporadic Parkinson's disease characterized by age-dependent... 
PATHWAYS | KINASE-ACTIVITY | GENE | LET-7 MICRORNA | 4E-BP | MULTIDISCIPLINARY SCIENCES | DISTINCT ROLES | MUTATIONS | DROSOPHILA | PARKINSONS-DISEASE | CELL-DEATH | Up-Regulation | Protein Biosynthesis | MicroRNAs - antagonists & inhibitors | Humans | Male | MicroRNAs - metabolism | Neurons - cytology | Drosophila Proteins - metabolism | RNA, Messenger - metabolism | Drosophila Proteins - biosynthesis | Trans-Activators - genetics | Eukaryotic Initiation Factor-2 - metabolism | Female | Neurons - metabolism | Parkinson Disease - metabolism | Trans-Activators - biosynthesis | Dopamine - metabolism | Protein-Serine-Threonine Kinases - metabolism | Eukaryotic Initiation Factors - metabolism | Cell Line | RNA-Induced Silencing Complex - antagonists & inhibitors | Down-Regulation | RNA, Messenger - genetics | Protein-Serine-Threonine Kinases - genetics | E2F1 Transcription Factor - metabolism | Eukaryotic Initiation Factors - biosynthesis | Parkinson Disease - genetics | Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 | Animals | RNA-Induced Silencing Complex - metabolism | Argonaute Proteins | Protein Binding | Trans-Activators - metabolism | E2F1 Transcription Factor - biosynthesis | MicroRNAs - genetics | Drosophila Proteins - genetics | RNA-Induced Silencing Complex - chemistry | E2F1 Transcription Factor - genetics | Drosophila melanogaster | Parkinson Disease - etiology | Models | Genetic aspects | Genetic translation | Phosphotransferases | Proteins | Statistical analysis | Insects | Neurons | Cell cycle | Cell division | Mutation | Kinases | Binding sites | Apoptosis | Index Medicus
Journal Article
RNA, ISSN 1355-8382, 10/2013, Volume 19, Issue 10, pp. 1405 - 1418
PIWI proteins and their associated PIWI-interacting RNAs (piRNAs) protect genome integrity by silencing transposons in animal germlines. The molecular... 
BmPAPI | TUDOR | Mitochondria | PiRNA | PIWI | Arginine methylation | NUAGE FORMATION | mitochondria | BIOCHEMISTRY & MOLECULAR BIOLOGY | SUBCELLULAR-LOCALIZATION | 3' TERMINI | SPLICEOSOMAL SM PROTEINS | DROSOPHILA | PIWI-INTERACTING RNAS | TUDOR-DOMAIN | ROYAL FAMILY | arginine methylation | STRUCTURAL BASIS | piRNA | Surface Plasmon Resonance | RNA, Small Interfering - genetics | Immunoprecipitation | RNA-Induced Silencing Complex - genetics | DNA Primers - genetics | Mitochondrial Proteins - genetics | DNA Primers - chemistry | Drosophila Proteins - metabolism | Ovary - cytology | Drosophila melanogaster - genetics | Arginine - analogs & derivatives | Drosophila melanogaster - metabolism | RNA, Small Interfering - chemistry | Bombyx - metabolism | Mitochondria - genetics | Membrane Transport Proteins - genetics | Mitochondrial Proteins - metabolism | DNA Primers - metabolism | Female | Membrane Transport Proteins - metabolism | Real-Time Polymerase Chain Reaction | Ovary - metabolism | Protein Structure, Tertiary | Recombinant Proteins - metabolism | Argonaute Proteins - metabolism | Argonaute Proteins - genetics | RNA, Messenger - genetics | Mitochondria - metabolism | Recombinant Proteins - genetics | Bombyx - genetics | Germ Cells | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Carrier Proteins - genetics | Blotting, Northern | Animals | Carrier Proteins - metabolism | Fluorescent Antibody Technique | RNA-Induced Silencing Complex - metabolism | Drosophila Proteins - genetics | Arginine - metabolism | RNA, Small Interfering - metabolism | Index Medicus | Genomes
Journal Article
Cell, ISSN 0092-8674, 2005, Volume 123, Issue 4, pp. 607 - 620
In the and mammalian RNA interference pathways, siRNAs direct the protein Argonaute2 (Ago2) to cleave corresponding mRNA targets, silencing their expression.... 
PATHWAYS | RISC | PROTEIN | MESSENGER-RNA | DROSOPHILA-MELANOGASTER | BIOCHEMISTRY & MOLECULAR BIOLOGY | INDUCED SILENCING COMPLEX | MICRORNA TARGETS | INTERFERENCE | DISTINCT ROLES | ARGONAUTE2 | CELL BIOLOGY | Oligonucleotides - genetics | RNA Helicases - metabolism | RNA, Small Interfering - genetics | RNA-Binding Proteins - genetics | Drosophila melanogaster - embryology | Microtubule-Associated Proteins - genetics | Microtubule-Associated Proteins - metabolism | Humans | RNA-Induced Silencing Complex - genetics | Embryo, Nonmammalian - metabolism | MicroRNAs - metabolism | Drosophila Proteins - metabolism | Drosophila melanogaster - genetics | Drosophila melanogaster - metabolism | RNA, Small Interfering - chemistry | RNA Interference | Thionucleotides - chemistry | Base Sequence | Female | RNA Helicases - genetics | RNA, Double-Stranded - metabolism | Catalysis | Nucleic Acid Conformation | RNA, Double-Stranded - chemistry | Ovary - metabolism | Cell Line | Nerve Tissue Proteins | Manganese - chemistry | Mutation - genetics | Magnesium - chemistry | Oligonucleotides - metabolism | Animals | Cell-Free System | Ribonuclease III | RNA, Double-Stranded - genetics | RNA-Induced Silencing Complex - metabolism | Argonaute Proteins | MicroRNAs - genetics | Models, Genetic | Drosophila Proteins - genetics | HeLa Cells | Kinetics | RNA-Binding Proteins - metabolism | RNA, Small Interfering - metabolism | Enzymes | Messenger RNA | Index Medicus
Journal Article
12.