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Clinical Cancer Research, ISSN 1078-0432, 06/2004, Volume 10, Issue 11, pp. 3839 - 3852
Purpose: The purpose of this study was to examine interactions between the proteasome inhibitor bortezomib (Velcade) and the histone deacetylase (HDAC)... 
RESISTANT | ACTIVATED PROTEIN-KINASE | HYDROXAMIC ACID SAHA | MECHANISM | ONCOLOGY | HUMAN LEUKEMIA-CELLS | MITOCHONDRIAL DYSFUNCTION | FACTOR-KAPPA-B | HEMATOLOGIC MALIGNANCIES | CANCER | ARSENIC TRIOXIDE | Free Radical Scavengers - pharmacology | Reactive Oxygen Species | Oxidative Stress | Humans | Membrane Glycoproteins - biosynthesis | Oxygen - metabolism | Dose-Response Relationship, Drug | Protease Inhibitors - pharmacology | Proto-Oncogene Proteins c-bcl-2 - metabolism | Multiple Myeloma - drug therapy | Intracellular Membranes - pathology | Antineoplastic Agents - pharmacology | X-Linked Inhibitor of Apoptosis Protein | Hydroxamic Acids - pharmacology | Syndecans | Tumor Suppressor Proteins - metabolism | Bortezomib | Cell Survival | Cyclin-Dependent Kinase Inhibitor p21 | Neoplasm Proteins - biosynthesis | Cell Cycle Proteins - metabolism | Enzyme Inhibitors - pharmacology | Proteoglycans - biosynthesis | Cyclin D1 - biosynthesis | Mitochondria - metabolism | Multiple Myeloma - metabolism | Proto-Oncogene Proteins c-bcl-2 - biosynthesis | Blotting, Western | Sodium Oxybate - pharmacology | Cyclin-Dependent Kinase Inhibitor p27 | Multiple Myeloma - pathology | Proteins - metabolism | Cell Cycle | Membrane Potentials | Myeloid Cell Leukemia Sequence 1 Protein | Acetylcysteine - pharmacology | Cell Line, Tumor | Cytosol - metabolism | Syndecan-1 | Histone Deacetylase Inhibitors | Pyrazines - pharmacology | Apoptosis | Boronic Acids - pharmacology
Journal Article
Cancer Cell, ISSN 1535-6108, 01/2013, Volume 23, Issue 1, pp. 23 - 34
Journal Article
Cancer Biology & Therapy, ISSN 1538-4047, 11/2011, Volume 12, Issue 10, pp. 924 - 938
Here, we show that tamoxifen resistance is induced by cancer-associated fibroblasts (CAFs). Coculture of estrogen receptor positive (ER+) MCF7 cells with... 
Warburg Effect | TIGAR | metformin | reactive oxygen species (ROS) | cancer associated fibroblasts | microenvironment | glucose uptake | drug resistance | tumor stroma | mitochondrial oxidative phosphorylation | aerobic glycolysis | tamoxifen | oxidative stress | Binding | Proteins | Landes | Calcium | Bioscience | Biology | Cell | Cycle | Cancer | Organogenesis | Oxidative stress | Reactive oxygen species (ROS) | Tumor stroma | Cancer associated fibroblasts | Microenvironment | Drug resistance | Tamoxifen | Glucose uptake | Aerobic glycolysis | Metformin | Mitochondrial oxidative phosphorylation | Warburg effect | CYCLIN D1 | TAMOXIFEN RESISTANCE | C-MYC | ENDOCRINE THERAPY | ESTROGEN-RECEPTOR | FIBROBLASTS | NEOADJUVANT CHEMOTHERAPY | CAVEOLIN-1 EXPRESSION | ONCOLOGY | NITRIC-OXIDE | Estradiol - analogs & derivatives | Apoptosis - drug effects | Coculture Techniques | Humans | Ketone Bodies - metabolism | Drug Resistance, Neoplasm | Intracellular Signaling Peptides and Proteins - metabolism | Breast Neoplasms - metabolism | Fulvestrant | Estrogen Receptor Modulators - therapeutic use | Female | Estradiol - pharmacology | Fibroblasts - metabolism | Tumor Microenvironment - drug effects | Arsenic Trioxide | Estradiol - therapeutic use | Arsenicals - pharmacology | Lactic Acid - metabolism | Metformin - pharmacology | Mitochondria - metabolism | Mitochondria - drug effects | Breast Neoplasms - drug therapy | Poly(ADP-ribose) Polymerase Inhibitors | Estrogen Receptor Modulators - pharmacology | Hypoglycemic Agents - pharmacology | Oxides - pharmacology | Apoptosis Regulatory Proteins | Fibroblasts - drug effects | Tamoxifen - therapeutic use | Tamoxifen - pharmacology | Cell Line, Tumor | Doxorubicin - pharmacology | Index Medicus | Research Paper
Journal Article
Cancer Letters, ISSN 0304-3835, 2016, Volume 381, Issue 2, pp. 287 - 295
Highlights • ATO reduces cell viability and clonogenic survival and triggers apoptosis in RMS cells • ATO upregulates Noxa, which is required for ATO-induced... 
Hematology, Oncology and Palliative Medicine | Arsenic trioxide | Hedgehog | Cell death | Rhabdomyosarcoma | Apoptosis | Noxa | NEUROBLASTOMA-CELLS | CHILDRENS ONCOLOGY GROUP | PRECLINICAL TESTING PROGRAM | EWING SARCOMA | ONCOLOGY | PATHWAY | RESISTANCE | ERIBULIN MESYLATE | TUMOR-GROWTH | ACUTE PROMYELOCYTIC LEUKEMIA | Up-Regulation | Vincristine - pharmacology | Caspase Inhibitors - pharmacology | Zinc Finger Protein GLI1 - metabolism | Apoptosis - drug effects | Tubulin Modulators - pharmacology | Furans - pharmacology | Humans | Rhabdomyosarcoma - metabolism | Gene Expression Regulation, Neoplastic | Hedgehog Proteins - metabolism | Rhabdomyosarcoma - pathology | Antineoplastic Combined Chemotherapy Protocols - pharmacology | Dose-Response Relationship, Drug | Proto-Oncogene Proteins c-bcl-2 - metabolism | Transfection | RNA Interference | Time Factors | Rhabdomyosarcoma - drug therapy | Ketones - pharmacology | Cell Survival - drug effects | Zinc Finger Protein GLI1 - genetics | Arsenicals - pharmacology | Mitochondria - metabolism | Mitochondria - drug effects | Mitochondria - pathology | Drug Synergism | Oxides - pharmacology | Signal Transduction - drug effects | Cell Line, Tumor | Rhabdomyosarcoma - genetics | Vinblastine - pharmacology | Proto-Oncogene Proteins c-bcl-2 - genetics | Arsenic | Drugs | Proteins | Pediatrics | Transcription factors | Leukemia | Medical prognosis | Colonies & territories | Cancer therapies | Deoxyribonucleic acid--DNA | Cancer
Journal Article
Chemico-Biological Interactions, ISSN 0009-2797, 2009, Volume 182, Issue 1, pp. 37 - 44
The proved radio- and chemo-sensitizing capacity of genistein supports the potential use of this isoflavone in antitumour therapies. In this regard, we... 
Arsenic trioxide | Genistein | Tyrosine kinase inhibitors | Apoptosis | Mitogen-activated protein kinases | U937 leukaemia cells | CANCER-CELLS | ESTROGEN-RECEPTORS | OXIDATIVE STRESS | BIOCHEMISTRY & MOLECULAR BIOLOGY | OXYGEN SPECIES GENERATION | TYROSINE KINASES | SIGNAL-TRANSDUCTION | HUMAN PROMONOCYTIC CELLS | GENE-EXPRESSION | PHARMACOLOGY & PHARMACY | HYDROGEN-PEROXIDE | TOXICOLOGY | GLUTATHIONE DEPLETION | Reactive Oxygen Species - metabolism | Apoptosis - drug effects | Humans | Immunoblotting | Hydroquinones - pharmacology | U937 Cells | Antineoplastic Agents - pharmacology | Catechin - pharmacology | Estradiol - pharmacology | Adamantane - analogs & derivatives | Adamantane - pharmacology | Arsenicals - pharmacology | RNA, Small Interfering - pharmacology | Etoposide - pharmacology | Antioxidants - pharmacology | Drug Synergism | Oxides - pharmacology | Mitogen-Activated Protein Kinases - antagonists & inhibitors | Genistein - pharmacology | HL-60 Cells | Catechin - analogs & derivatives | Protein Kinase Inhibitors - pharmacology | Enzyme Activation | Cell Cycle - drug effects | Microscopy, Fluorescence | Mitogen-Activated Protein Kinases - metabolism | Tyrosine | Cysteine | Catechin | Arsenic | Leukemia | Estrogen | Etoposide | Antioxidants | Analysis | Angiogenesis inhibitors | Protein kinases | Isoflavones | Index Medicus
Journal Article