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Molecular Neurobiology, ISSN 0893-7648, 11/2016, Volume 53, Issue 9, pp. 6426 - 6443
Artemether, a lipid-soluble derivative of artemisinin has been reported to possess anti-inflammatory properties. In this study, we have investigated the... 
Neurology | NF-κB | Neurosciences | Biomedicine | BV2 microglia | HT22 hippocampal neurons | Nrf2 | Neurobiology | Artemether | Neuroinflammation | Cell Biology | ALZHEIMERS-DISEASE | INFLAMMATORY REACTIONS | NEUROSCIENCES | BV-2 CELLS | PROTECTS | STAT3 ACTIVATION | NF-kappa B | CULTURED ASTROCYTES | HEME OXYGENASE-1 | NF-KAPPA-B | ARTEMISININ | Neuroprotective Agents - therapeutic use | Inflammation - pathology | Microglia - metabolism | Heme Oxygenase-1 - metabolism | Transcriptional Activation - genetics | Antioxidants - metabolism | Transcriptional Activation - drug effects | NF-kappa B - metabolism | Lipopolysaccharides | Artemisinins - pharmacology | Cell Nucleus - metabolism | Neuroprotective Agents - pharmacology | Inflammation - drug therapy | Amyloid beta-Peptides - metabolism | Microglia - pathology | NF-E2-Related Factor 2 - genetics | p38 Mitogen-Activated Protein Kinases - metabolism | Artemisinins - chemistry | Cell Line | Cell Survival - drug effects | Microglia - drug effects | Prostaglandin-E Synthases - metabolism | Neurotoxins - toxicity | Antimalarials - therapeutic use | Antimalarials - pharmacology | Dinoprostone - metabolism | Amyloid Precursor Protein Secretases - metabolism | Animals | Artemisinins - therapeutic use | MAP Kinase Signaling System - drug effects | Aspartic Acid Endopeptidases - metabolism | NF-E2-Related Factor 2 - metabolism | Antimalarials - chemistry | Cyclooxygenase 2 - metabolism | Interleukin-6 - biosynthesis | NAD(P)H Dehydrogenase (Quinone) - metabolism | Mice | Cell Nucleus - drug effects | Nitric Oxide - metabolism | Tumor Necrosis Factor-alpha - biosynthesis | Nitric Oxide Synthase Type II - metabolism | Nervous system diseases | Neurons | Nitric oxide | Heme | Amyloid beta-protein | Synthetic prostaglandins E | Mitogens | Protein kinases | Proteins | Enzymes | Inflammation | Kinases | Index Medicus
Journal Article
The New Phytologist, ISSN 0028-646X, 1/2011, Volume 189, Issue 1, pp. 176 - 189
Biosynthesis of the sesquiterpene lactone and potent antimalarial drug artemisinin occurs in glandular trichomes of Artemisia annua plants and is subjected to... 
Leaves | Enzymes | Artemisinins | Plant growth regulators | Genes | Trichomes | Biosynthesis | Plants | Plant glands | Aldehydes | artemisinin | cDNA‐AFLP transcript profiling | cytokinin | gibberellin | sesquiterpenoid | glandular trichome | jasmonate | fatty acyl‐CoA reductase | CDNA-AFLP transcript profiling | Glandular trichome | Jasmonate | Artemisinin | Gibberellin | Fatty acyl-CoA reductase | Cytokinin | Sesquiterpenoid | AMORPHA-4,11-DIENE SYNTHASE | IN-VIVO TRANSFORMATIONS | FATTY ACYL-COENZYME | fatty acyl-CoA reductase | PLANT SCIENCES | GENE | KEY ENZYME | cDNA-AFLP transcript profiling | MOLECULAR-CLONING | CELL-DIFFERENTIATION | JASMONIC ACID | EXPRESSION | Aldehyde Oxidoreductases - physiology | Antimalarials - metabolism | Sesquiterpenes - metabolism | Artemisia annua - growth & development | Gene Expression - drug effects | Plant Proteins - physiology | Artemisia annua - metabolism | Gene Expression Profiling | Cyclopentanes - pharmacology | Cytokinins - pharmacology | Aldehyde Oxidoreductases - metabolism | Oxylipins - metabolism | Gibberellins - metabolism | Antimalarials - chemistry | Oxylipins - pharmacology | Gibberellins - pharmacology | Artemisinins - metabolism | Cyclopentanes - metabolism | Cytokinins - metabolism | Plant Proteins - metabolism | Plant Growth Regulators - metabolism | Plant Growth Regulators - pharmacology | Amplified Fragment Length Polymorphism Analysis | Artemisinins - chemistry | Thiols | Metabolites | Analysis | Surgery | Genomics | Plant genetics | Physiological aspects | Chemical properties | Hormones | Universities and colleges | Gene expression
Journal Article
PLoS One, ISSN 1932-6203, 2010, Volume 5, Issue 12, pp. e14222 - e14222
Background Production of pharmaceuticals in plants provides an alternative for chemical synthesis, fermentation or natural sources. Nicotiana benthamiana is... 
ACID | ANNUA | YIELD | BIOSYNTHESIS | BIOLOGY | PLANTS | REDUCTASE | MOLECULAR-CLONING | EXPRESSION SYSTEM | ANTIMALARIAL-DRUG ARTEMISININ | TOBACCO | Oligonucleotides - chemistry | Antimalarials - metabolism | Chemistry, Pharmaceutical - methods | Gas Chromatography-Mass Spectrometry | Models, Chemical | Plant Extracts - pharmacology | Tobacco - metabolism | Open Reading Frames | Cytochrome P-450 Enzyme System - metabolism | Mitochondria - metabolism | Oxygen - metabolism | Antimalarials - pharmacology | Artemisinins - pharmacology | Plant Extracts - metabolism | Agrobacterium tumefaciens - metabolism | Plant Leaves - metabolism | Tobacco - genetics | Drug Design | Artemisinins - metabolism | Plant Proteins - metabolism | Oxidases | Malaria | Transferases | Genetic aspects | Fermentation | Chemical synthesis | Health aspects | Drugs | Biotechnology | Metabolomics | Dehydrogenases | Laboratories | Genes | Artemisinin | Alcohol | Biosynthesis | Drug resistance | Proteins | Engineering | Leaves | Parasitic diseases | Precursors | Physiology | Oxidation | Trends | Vector-borne diseases | Plants (botany) | Metabolism | Chromatography | Tobacco | Acids | Headspace | Growth hormones | Scientific imaging | Infiltration | Mass spectrometry | Pharmaceuticals | Reductase | acid | reductase | expression system | plants | biosynthesis | annua | yield | tobacco | molecular-cloning | antimalarial-drug artemisinin
Journal Article
Journal Article
New Phytologist, ISSN 0028-646X, 6/2013, Volume 198, Issue 4, pp. 1191 - 1202
Six transcription factors of APETALA2/ethylene-response factor (AP2/ERF) family were cloned and analyzed in . Real-time quantitative polymerase chain reaction... 
Full papers | Disease resistance | Leaves | Transcription factors | Artemisinins | Genetic vectors | Genes | Biosynthesis | Trichomes | Plants | Biochemical pathways | artemisinin | disease resistance to B. cinerea | trichome specific | artemisinin biosynthetic pathway | dihydroartemisinic acid | secondary metabolism | Dihydroartemisinic acid | Artemisinin biosynthetic pathway | Secondary metabolism | Trichome specific | Artemisinin | Disease resistance to B. cinerea | ANTIMALARIAL-DRUG | cinerea | AMORPHA-4,11-DIENE SYNTHASE | IN-VIVO TRANSFORMATIONS | TERPENE METABOLISM | PLANT SCIENCES | GENE | KEY ENZYME | MOLECULAR-CLONING | EXPRESSION | disease resistance to B | JASMONATE | Plant Diseases - immunology | Glucuronidase - metabolism | Molecular Sequence Data | Artemisia annua - metabolism | Plant Diseases - microbiology | Disease Resistance - immunology | Gene Expression Profiling | Artemisia annua - immunology | Artemisia annua - genetics | Botrytis - physiology | Organ Specificity - genetics | Biosynthetic Pathways - genetics | Cell Nucleus - metabolism | RNA Interference | Gene Expression Regulation, Plant | Plant Diseases - genetics | Plant Proteins - metabolism | Real-Time Polymerase Chain Reaction | Artemisinins - chemistry | Transcription Factors - genetics | Subcellular Fractions - metabolism | Protein Transport | Transcription Factors - metabolism | Plant Proteins - genetics | Plant Leaves - genetics | Artemisia annua - microbiology | Artemisinins - metabolism | Arabidopsis thaliana | Chemical properties | RNA | Analysis
Journal Article