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The Journal of Immunology, ISSN 0022-1767, 11/2009, Volume 183, Issue 10, pp. 6469 - 6477
Alternatively activated macrophages (AAM) play a crucial role in type 2 immunity. Mice deficient in ST2, a receptor for the latest member of the IL-1 family,... 
IL-1-LIKE CYTOKINE IL-33 | IMMUNE-RESPONSE | ST2 RECEPTOR | EFFECTOR FUNCTION | MAST-CELLS | IN-VIVO | INDUCED ARTHRITIS | ALVEOLAR MACROPHAGES | INTERLEUKIN-1 RECEPTOR | IMMUNOLOGY | T-CELLS | Interleukin-1 Receptor-Like 1 Protein | Asthma - metabolism | Epithelial Cells - metabolism | Ovalbumin - immunology | Humans | Middle Aged | Chemokine CCL24 - metabolism | Interleukin-13 - immunology | Male | Interleukins - metabolism | Receptors, Interleukin - metabolism | Signal Transduction - immunology | Inflammation - metabolism | Interleukins - immunology | Asthma - immunology | Chemokine CCL17 - immunology | Adult | Female | Interleukin-4 - genetics | Macrophages, Alveolar - immunology | Recombinant Proteins - metabolism | Cell Polarity - immunology | Lung - pathology | Receptors, Interleukin - immunology | Interleukin-33 | Macrophage Activation - immunology | Receptors, Interleukin-1 - immunology | Interleukin-4 - metabolism | Receptors, Interleukin-4 - metabolism | Inflammation - immunology | Receptors, Interleukin-4 - immunology | Interleukin-13 - metabolism | Chemokine CCL24 - immunology | Receptors, Interleukin - genetics | Mice, Knockout | Receptors, Interleukin-1 - metabolism | Interleukin-4 - immunology | Animals | Eosinophilia - immunology | Recombinant Proteins - immunology | Epithelial Cells - immunology | Receptors, Interleukin-4 - genetics | Mice | Mice, Inbred BALB C | Macrophages, Alveolar - metabolism | Chemokine CCL17 - metabolism | Lung - immunology | Index Medicus | Abridged Index Medicus
Journal Article
NATURE, ISSN 0028-0836, 07/2011, Volume 475, Issue 7354, pp. 110 - U133
High-dose intravenous immunoglobulin is a widely used therapeutic preparation of highly purified immunoglobulin G (IgG) antibodies. It is administered at high... 
IMMUNITY IN-VIVO | ALLERGIC INFLAMMATION | RESPONSES | ANTIINFLAMMATORY ACTIVITY | DC-SIGN | DENDRITIC CELL | MULTIDISCIPLINARY SCIENCES | BONE-MARROW | TYPE-2 IMMUNITY | AUTOIMMUNE-DISEASE | Cell Adhesion Molecules - genetics | Dendritic Cells - immunology | Humans | Lectins, C-Type - immunology | Th2 Cells - immunology | Cell Adhesion Molecules - immunology | Lectins, C-Type - genetics | Th2 Cells - drug effects | Interleukins - metabolism | Receptors, IgG - metabolism | Immunoglobulins, Intravenous - metabolism | Lectins, C-Type - metabolism | Immunoglobulin G - immunology | Inflammation - drug therapy | Interleukins - immunology | Basophils - immunology | Arthritis - immunology | Immunoglobulin G - pharmacology | Interleukins - pharmacology | Bone Marrow | Autoimmune Diseases - drug therapy | Macrophages - immunology | Basophils - drug effects | Arthritis - pathology | Interleukin-33 | Immunoglobulin G - chemistry | Interleukin-4 - metabolism | Autoimmune Diseases - immunology | Crystallization | Receptors, Cell Surface - metabolism | Inflammation - immunology | Macrophages - cytology | Receptors, IgG - immunology | Cell Adhesion Molecules - metabolism | Immunoglobulins, Intravenous - pharmacology | Receptors, Cell Surface - immunology | Interleukin-4 - immunology | Animals | Arthritis - drug therapy | Ligands | Dendritic Cells - cytology | Immunoglobulins, Intravenous - chemistry | Mice | Basophils - metabolism | Immunoglobulins, Intravenous - immunology | Immunoglobulin G - metabolism | Receptors, Cell Surface - genetics | Index Medicus
Journal Article
Arthritis & Rheumatology, ISSN 2326-5191, 11/2016, Volume 68, Issue 11, pp. 2717 - 2727
Journal Article
Arthritis & Rheumatology, ISSN 2326-5191, 11/2016, Volume 68, Issue 11, pp. 2646 - 2661
Journal Article
Blood, ISSN 0006-4971, 01/2010, Volume 115, Issue 2, pp. 335 - 343
Journal Article
Arthritis Research and Therapy, ISSN 1478-6354, 06/2014, Volume 16, Issue 3, pp. R122 - R122
Introduction: Neutrophil extracellular traps (NETs) have recently been implicated in a number of autoimmune conditions, including rheumatoid arthritis (RA). We... 
AUTOANTIBODIES | NETOSIS | CITRULLINATION | THROMBOSIS | DEATH | MECHANISMS | INDUCTION | RHEUMATOLOGY | HISTONES | CELL-FREE DNA | INNATE IMMUNITY | Immunohistochemistry | Leukocyte Elastase - metabolism | Hydrolases - genetics | Reactive Oxygen Species - metabolism | Arthritis, Rheumatoid - blood | Extracellular Traps - metabolism | Extracellular Traps - genetics | Humans | Middle Aged | Citrulline - metabolism | Neutrophils - ultrastructure | Male | Signal Transduction - immunology | Extracellular Traps - immunology | Reactive Oxygen Species - immunology | Female | Arthritis, Rheumatoid - diagnosis | Neutrophils - metabolism | Hydrolases - metabolism | Microscopy, Electron, Scanning | Peroxidase - immunology | DNA - immunology | Histones - immunology | Cells, Cultured | Neutrophils - immunology | Nucleosomes - metabolism | Peptides, Cyclic - immunology | DNA - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Synovial Fluid - immunology | Autoantibodies - immunology | Hydrolases - immunology | Histones - metabolism | Arthritis, Rheumatoid - immunology | Leukocyte Elastase - immunology | Nucleosomes - immunology | Microscopy, Fluorescence | Protein-Arginine Deiminases | Peroxidase - metabolism | Photographic industry | Product enhancement | Immunoglobulin G | Enzyme-linked immunosorbent assay | Index Medicus
Journal Article
Blood, ISSN 0006-4971, 03/2005, Volume 105, Issue 6, pp. 2473 - 2479
The tyrosine kinase inhibitor imatinib (imatinib, ST1571, Glivec, and Gleevec) is increasingly used in patients undergoing allogeneic transplantation for... 
CHRONIC MYELOGENOUS LEUKEMIA | RHEUMATOID-ARTHRITIS | LYMPHOCYTE RESPONSES | DENDRITIC CELLS | VIRUS INFECTION | TYROSINE KINASE | HEALTHY-INDIVIDUALS | STEM-CELL | HEMATOLOGY | ANTIGEN RECEPTOR | CHRONIC MYELOID-LEUKEMIA | Immunodominant Epitopes - immunology | CD8-Positive T-Lymphocytes - cytology | Humans | Graft vs Host Disease - immunology | Stem Cell Transplantation | Lymphocyte Activation - immunology | Protein Kinase Inhibitors - immunology | Adaptor Proteins, Signal Transducing - immunology | Receptors, Antigen, T-Cell - immunology | Phosphorylation - drug effects | Protein Processing, Post-Translational - immunology | Jurkat Cells | Lectins, C-Type | Leukemia - therapy | Piperazines - therapeutic use | Pyrimidines - pharmacology | Piperazines - pharmacology | Lymphocyte Specific Protein Tyrosine Kinase p56(lck) - antagonists & inhibitors | Signal Transduction - drug effects | Up-Regulation - immunology | Leukemia - immunology | ZAP-70 Protein-Tyrosine Kinase - immunology | Graft vs Leukemia Effect - immunology | CD8-Positive T-Lymphocytes - immunology | Antigens, CD - immunology | Pyrimidines - immunology | Lymphocyte Specific Protein Tyrosine Kinase p56(lck) - immunology | Transplantation, Homologous | Dose-Response Relationship, Drug | Signal Transduction - immunology | Interleukin-2 - immunology | Protein Processing, Post-Translational - drug effects | Antigens, Differentiation, T-Lymphocyte - immunology | Herpesvirus 4, Human - immunology | Membrane Proteins - immunology | Clinical Trials as Topic | Imatinib Mesylate | Receptors, Interleukin-2 - immunology | Sequence Homology, Nucleic Acid | Up-Regulation - drug effects | Cytomegalovirus - immunology | Lymphocyte Activation - drug effects | Protein Kinase Inhibitors - therapeutic use | Pyrimidines - therapeutic use | Piperazines - immunology | Cell Proliferation - drug effects | Protein Kinase Inhibitors - pharmacology | Benzamides | Genome, Human - immunology | Protein Structure, Tertiary - drug effects | Index Medicus | Abridged Index Medicus
Journal Article
Nature Immunology, ISSN 1529-2908, 06/2017, Volume 18, Issue 7, pp. 800 - 812
An imbalance in the lineages of immunosuppressive regulatory T cells (T cells) and the inflammatory T 17 subset of helper T cells leads to the development of... 
Forkhead Transcription Factors - immunology | Humans | Encephalomyelitis, Autoimmune, Experimental - immunology | Sjogren's Syndrome - immunology | Immunoblotting | Intracellular Signaling Peptides and Proteins - immunology | Case-Control Studies | T-Lymphocytes, Regulatory - immunology | DNA-Binding Proteins - metabolism | Flow Cytometry | Chromatin Immunoprecipitation | Forkhead Transcription Factors - metabolism | Histone Acetyltransferases - metabolism | Nuclear Receptor Subfamily 1, Group F, Member 3 - metabolism | HEK293 Cells | Adaptor Proteins, Signal Transducing - immunology | Acetylation | Colitis - immunology | Lysine Acetyltransferase 5 | Transcription Factors - immunology | Real-Time Polymerase Chain Reaction | STAT3 Transcription Factor - metabolism | Cytokines - immunology | Nuclear Receptor Subfamily 1, Group F, Member 3 - immunology | DNA-Binding Proteins - immunology | Smad Proteins - immunology | Mice, Transgenic | Mice, Knockout | Transcription Factors - metabolism | Cell Differentiation - immunology | Microscopy, Confocal | Animals | Adaptor Proteins, Signal Transducing - genetics | Th17 Cells - immunology | Trans-Activators - metabolism | Mice | HeLa Cells | Proteasome Endopeptidase Complex - metabolism | STAT3 Transcription Factor - immunology | Arthritis, Rheumatoid - immunology | Smad Proteins - metabolism | Microscopy, Fluorescence
Journal Article
Immunity, ISSN 1074-7613, 07/2013, Volume 39, Issue 1, pp. 111 - 122
Immune cells sense microbial products through Toll-like receptors (TLR), which trigger host defense responses including type 1 interferons (IFNs) secretion. A... 
TUMOR-NECROSIS-FACTOR | ACTIVATION | I INTERFERONS | CHORIOMENINGITIS VIRUS | PROTEIN-TYROSINE PHOSPHATASES | HOST-DEFENSE | MURINE LUPUS | INFLAMMATORY ARTHRITIS | IMMUNOLOGY | NF-KAPPA-B | T-CELLS | Lymphocytic choriomeningitis virus - immunology | Colitis - genetics | Humans | Autoimmunity - genetics | Immunoblotting | Arthritis - genetics | Interferon Type I - immunology | Lymphocytic Choriomeningitis - immunology | Host-Pathogen Interactions - immunology | Protein Tyrosine Phosphatase, Non-Receptor Type 22 - immunology | Autoimmunity - immunology | Myeloid Cells - immunology | TNF Receptor-Associated Factor 3 - genetics | Colitis - chemically induced | HEK293 Cells | Arthritis - immunology | Interferon Type I - metabolism | Lymphocytic choriomeningitis virus - physiology | Toll-Like Receptors - metabolism | Colitis - immunology | Lymphocytic Choriomeningitis - genetics | Cell Line | Lymphocytic Choriomeningitis - virology | Mice, Inbred C57BL | Protein Tyrosine Phosphatase, Non-Receptor Type 22 - genetics | Protein Tyrosine Phosphatase, Non-Receptor Type 22 - metabolism | Toll-Like Receptors - immunology | Cells, Cultured | Immunity - immunology | Mice, Transgenic | TNF Receptor-Associated Factor 3 - metabolism | Ubiquitination - immunology | Reverse Transcriptase Polymerase Chain Reaction | Mice, Knockout | Animals | Dextran Sulfate - immunology | TNF Receptor-Associated Factor 3 - immunology | Toll-Like Receptors - genetics | Interferon Type I - genetics | Myeloid Cells - metabolism | Mice | Immunity - genetics | Ubiquitin | Autoimmunity | Interferon | Biological response modifiers | Index Medicus
Journal Article
Arthritis & Rheumatology, ISSN 2326-5191, 12/2016, Volume 68, Issue 12, pp. 2878 - 2888
Journal Article
Arthritis Research and Therapy, ISSN 1478-6354, 09/2013, Volume 15, Issue 5, pp. R136 - R136
Introduction: The aim of this study was to characterize interleukin 17 (IL-17) and interleukin 22 (IL-22) producing cells in peripheral blood (PB), skin,... 
RHEUMATOID-ARTHRITIS | MATRIX METALLOPROTEINASES | SYNOVIAL-FLUID | INTERLEUKIN 22 | AUTOIMMUNE ARTHRITIS | PERIPHERAL-BLOOD | PROINFLAMMATORY CYTOKINES | RHEUMATOLOGY | POTENTIAL ROLE | T-CELLS | SKIN INFLAMMATION | Immunohistochemistry | Receptors, CCR6 - immunology | Leukocytes, Mononuclear - metabolism | Receptors, CCR4 - immunology | Skin - metabolism | Humans | Interleukins - cerebrospinal fluid | Middle Aged | Interleukin-17 - immunology | Synovial Membrane - immunology | Synovial Membrane - pathology | Male | CD4-Positive T-Lymphocytes - pathology | CD4-Positive T-Lymphocytes - immunology | Receptors, Interleukin - metabolism | Receptors, CCR4 - metabolism | Arthritis, Psoriatic - pathology | Flow Cytometry | Psoriasis - pathology | Th17 Cells - metabolism | T-Lymphocytes, Helper-Inducer - immunology | Interleukins - immunology | Leukocytes, Mononuclear - immunology | Psoriasis - metabolism | Receptors, CCR6 - metabolism | Adult | Female | T-Lymphocytes, Helper-Inducer - pathology | Arthritis, Psoriatic - metabolism | Skin - pathology | Skin - immunology | Th17 Cells - pathology | Interleukin-17 - blood | Psoriasis - immunology | T-Lymphocytes, Helper-Inducer - metabolism | Interleukins - blood | Receptors, Interleukin - immunology | CD4-Positive T-Lymphocytes - metabolism | Interleukin-17 - cerebrospinal fluid | Synovial Membrane - metabolism | Leukocytes, Mononuclear - pathology | Arthritis, Psoriatic - immunology | Lymphocyte Count | Th17 Cells - immunology | Aged | Interleukins | T cells | Osteoarthritis | Enzyme-linked immunosorbent assay | Psoriatic arthritis | Index Medicus
Journal Article
Journal of Leukocyte Biology, ISSN 0741-5400, 09/2009, Volume 86, Issue 3, pp. 655 - 662
A prototypic mechanism for enhancement of inflammation by an endogenous molecule is described. The nuclear protein HMGB1 has previously been demonstrated to... 
innate cell‐mediated immunity | cell activation | Innate cell-mediated immunity | Cell activation | CELLS | ACTIVATION | RECEPTOR | IMMUNOLOGY | innate cell-mediated immunity | HUMAN MONOCYTES | CELL BIOLOGY | GROUP CHROMOSOMAL-PROTEINS | AMPHOTERIN | DNA | HIGH-MOBILITY-GROUP-BOX-1 | MOBILITY GROUP BOX-1 | HEMATOLOGY | BINDING | Coculture Techniques | Cytokines - analysis | Humans | Synovial Membrane - immunology | HMGB1 Protein - immunology | HMGB1 Protein - isolation & purification | Lipopolysaccharides - immunology | HMGB1 Protein - genetics | Recombinant Proteins - isolation & purification | Toll-Like Receptor 9 - immunology | Signal Transduction - immunology | HMGB1 Protein - pharmacology | Leukocytes, Mononuclear - immunology | Fibroblasts - metabolism | Inflammation Mediators - immunology | Cell Survival - drug effects | Biotinylation | Leukocytes, Mononuclear - drug effects | Oligodeoxyribonucleotides - immunology | Cells, Cultured | Interleukin-1beta - immunology | Rats | Inflammation - immunology | Toll-Like Receptor 4 - immunology | Recombinant Proteins - pharmacology | Synovial Membrane - metabolism | Arthritis, Rheumatoid - pathology | Animals | Recombinant Proteins - immunology | Signal Transduction - drug effects | Lipopolysaccharides - pharmacology | Interleukin-6 - biosynthesis | Toll-Like Receptor 2 - immunology | Fibroblasts - immunology | Ligands | Toll-Like Receptor 1 - immunology | Index Medicus
Journal Article