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Annals of the Rheumatic Diseases, ISSN 0003-4967, 04/2012, Volume 71, Issue 4, pp. 575 - 581
...), a key inhibitor of autophagy, has disease-modifying activity in experimental osteoarthritis... 
Life Sciences & Biomedicine | Rheumatology | Science & Technology | Arthritis, Experimental - drug therapy | TOR Serine-Threonine Kinases - metabolism | Immunosuppressive Agents - therapeutic use | Male | Osteoarthritis - drug therapy | Autophagy - drug effects | Arthritis, Experimental - metabolism | Arthritis, Experimental - pathology | Anti-Inflammatory Agents - therapeutic use | Osteoarthritis - pathology | Immunosuppressive Agents - pharmacology | Chondrocytes - metabolism | ADAMTS5 Protein | Drug Evaluation, Preclinical - methods | Sirolimus - therapeutic use | Anti-Inflammatory Agents - pharmacology | Mice, Inbred C57BL | Osteoarthritis - metabolism | Treatment Outcome | Sirolimus - pharmacology | Cartilage, Articular - pathology | ADAM Proteins - metabolism | Animals | Signal Transduction - drug effects | Mice | Autophagy (Cytology) | Care and treatment | Rapamycin | Dosage and administration | Models | Research | Osteoarthritis | Protein kinases | Knee | Antigens | Enzymes | Aging | Homeostasis | Calcification | Arthritis | Inflammation | Kinases | Gene expression | Autophagy | Apoptosis | Immunohistochemistry | TOR protein | Synovitis | Phosphorylation | Cartilage (articular) | Joint diseases | Synovium | Signal transduction | Cell death | ribosomal protein S6 | Interleukin 1 | Immunofluorescence | Ligaments | Phagocytosis | Cartilage diseases | Index Medicus | mTOR | autophagy | osteoarthritis | cartilage | rapamycin
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 02/2015, Volume 112, Issue 8, pp. 2509 - 2514
Journal Article
Biochimica et biophysica acta. Molecular basis of disease, ISSN 0925-4439, 09/2016, Volume 1862, Issue 9, pp. 1459 - 1471
.... This has revealed the potential of AC as a therapy for many of these diseases... 
Ceramide | Enzymes | Lysosomal storage diseases | Sphingolipids | Cell signaling | Biochemistry & Molecular Biology | Biophysics | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Neoplasms - metabolism | Arthritis - metabolism | Farber Lipogranulomatosis - genetics | Humans | Epilepsies, Myoclonic - metabolism | Farber Lipogranulomatosis - drug therapy | Metabolic Syndrome - metabolism | Metabolic Syndrome - drug therapy | Retinal Degeneration - metabolism | Farber Lipogranulomatosis - metabolism | Disease Models, Animal | Sphingolipidoses - drug therapy | Enzyme Replacement Therapy | Muscular Atrophy, Spinal - metabolism | Acid Ceramidase - genetics | Ceramides - metabolism | Bacterial Infections - drug therapy | Cystic Fibrosis - metabolism | Retinal Degeneration - drug therapy | Diabetes Mellitus - drug therapy | Diabetes Mellitus - metabolism | Epilepsies, Myoclonic - complications | Sphingolipidoses - genetics | Mice, Knockout | Neoplasms - drug therapy | Animals | Arthritis - drug therapy | Muscular Atrophy, Spinal - drug therapy | Epilepsies, Myoclonic - drug therapy | Mice | Acid Ceramidase - therapeutic use | Muscular Atrophy, Spinal - complications | Sphingolipidoses - metabolism | Cystic Fibrosis - drug therapy | Bacterial Infections - metabolism | Care and treatment | Physiological aspects | Ceramides | Respiratory tract diseases | Plant lipids | Biopharmaceutics | Medical research | Membrane lipids | Medical colleges | Lung diseases | Epilepsy | Sphingosine | Medicine, Experimental
Journal Article
Journal Article
Bone (New York, N.Y.), ISSN 8756-3282, 02/2016, Volume 83, pp. 210 - 219
Journal Article
PloS one, ISSN 1932-6203, 09/2017, Volume 12, Issue 9, pp. e0183484 - e0183484
Carbidopa is a drug that blocks conversion of levodopa to dopamine outside of central nervous system (CNS... 
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | T-Lymphocyte Subsets - immunology | Arthritis, Experimental - drug therapy | Antiparkinson Agents - pharmacology | Encephalomyelitis, Autoimmune, Experimental - metabolism | Encephalomyelitis, Autoimmune, Experimental - immunology | Arthritis, Experimental - metabolism | Arthritis, Experimental - pathology | Carbidopa - pharmacology | Lymphocyte Activation - immunology | T-Lymphocytes - metabolism | Dopamine Agents - pharmacology | T-Lymphocyte Subsets - drug effects | T-Lymphocytes - drug effects | Inflammation Mediators - metabolism | Autoimmune Diseases - metabolism | Macrophages - immunology | Disease Models, Animal | Cytokines - metabolism | Encephalomyelitis, Autoimmune, Experimental - drug therapy | Autoimmune Diseases - immunology | Arthritis, Experimental - immunology | Macrophages - metabolism | Animals | Lymphocyte Activation - drug effects | T-Lymphocyte Subsets - metabolism | Lymphocyte Count | Macrophages - drug effects | T-Lymphocytes - immunology | Mice | Autoimmunity - drug effects | Complications and side effects | Parkinson's disease | Carbidopa | Physiological aspects | Genetic aspects | Dosage and administration | Research | T cells | Drug therapy | Brain | Neurosciences | Animal models | Oligodendrocyte-myelin glycoprotein | Central nervous system | Parkinsons disease | Nervous system | Lymphocytes T | Arthritis | Biochemistry | Kinases | Cell activation | Immunology | Lymphocytes | Levodopa | Trends | Movement disorders | Immune system | Legs | Encephalitis | Antigens | Immunological memory | Memory cells | Dopamine | Serotonin | Cytokines | Neurodegenerative diseases | Dendritic cells | Myelin | Organs | Inflammation | Glycoproteins | Gene expression | Disease control | Conversion | Experimental allergic encephalomyelitis | Medicine | Side effects | Collagen | Infiltration | Autoimmune diseases | Molecular biology | In vitro methods and tests | Index Medicus | Activation
Journal Article