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Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 7/2011, Volume 108, Issue 27, pp. 11193 - 11198
MicroRNA (miRNA) species (miR) regulate mRNA translation and are implicated as mediators of disease pathology via coordinated regulation of molecular effector... 
Myeloid cells | MicroRNA | Messenger RNA | Cytokines | Synovial membrane | Rheumatoid arthritis | Collagens | Arthritis | Inflammation | Macrophages | RHEUMATOID-ARTHRITIS | PATHOGENESIS | COLLAGEN-INDUCED ARTHRITIS | AUTOIMMUNE INFLAMMATION | SYNOVIAL TISSUE | ROLES | MULTIDISCIPLINARY SCIENCES | DEFICIENT MICE | INDUCTION | EXPRESSION | T-CELLS | Arthritis, Experimental - genetics | Humans | Inositol Polyphosphate 5-Phosphatases | Synovial Membrane - immunology | Synovial Membrane - pathology | MicroRNAs - metabolism | Case-Control Studies | Arthritis, Experimental - metabolism | Arthritis, Experimental - pathology | Arthritis, Rheumatoid - metabolism | Base Sequence | Inflammation Mediators - metabolism | Phosphoric Monoester Hydrolases - genetics | Osteoarthritis - immunology | Osteoarthritis - metabolism | Arthritis, Experimental - immunology | Synovial Membrane - metabolism | Osteoarthritis - genetics | Arthritis, Rheumatoid - pathology | Mice, Knockout | Arthritis, Rheumatoid - genetics | Animals | Mice | MicroRNAs - genetics | Arthritis, Rheumatoid - immunology | Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases | Phosphoric Monoester Hydrolases - metabolism | Cytokines - biosynthesis | Physiological aspects | Genetic aspects | Health aspects | Proteins | Ribonucleic acid--RNA | Gene expression | Cells | Inositol | Translation | Autoantibodies | Therapeutic applications | Helper cells | Data processing | Homology | Src protein | Synovial fluid | Collagen | miRNA | Osteoarthritis | Tumor necrosis factor- alpha | Index Medicus | Biological Sciences
Journal Article
Arthritis Research and Therapy, ISSN 1478-6354, 03/2017, Volume 19, Issue 1, pp. 47 - 47
Background: The inhibition of pyrimidine biosynthesis by blocking the dihydroorotate dehydrogenase (DHODH) activity, the prime target of leflunomide (LEF), has... 
Pyrimidine metabolism | Collagen-Induced arthritis | Lapachol | Rheumatoid arthritis | Inflammation | DMARDs | Dihydroorotate dehydrogenase | RHEUMATOID-ARTHRITIS | LAWSONE | CYTOKINES | METASTASIS | Collagen-induced arthritis | RHEUMATOLOGY | ATOVAQUONE | PATHOGENESIS | LEFLUNOMIDE | DERIVATIVES | Index Medicus
Journal Article
Journal Article
Annals of the Rheumatic Diseases, ISSN 0003-4967, 04/2012, Volume 71, Issue 4, pp. 575 - 581
Objectives Osteoarthritis is associated with cell death and extracellular matrix degradation in articular cartilage. Autophagy is an essential cellular... 
MAMMALIAN TARGET | LIFE-SPAN | AGING-RELATED LOSS | MUTANT HUNTINGTIN | IN-VIVO | DISEASE | MOUSE | MICE | RHEUMATOLOGY | MTOR | CARTILAGE | Arthritis, Experimental - drug therapy | TOR Serine-Threonine Kinases - metabolism | Immunosuppressive Agents - therapeutic use | Male | Osteoarthritis - drug therapy | Autophagy - drug effects | Arthritis, Experimental - metabolism | Arthritis, Experimental - pathology | Anti-Inflammatory Agents - therapeutic use | Osteoarthritis - pathology | Immunosuppressive Agents - pharmacology | Chondrocytes - metabolism | ADAMTS5 Protein | Drug Evaluation, Preclinical - methods | Sirolimus - therapeutic use | Anti-Inflammatory Agents - pharmacology | Mice, Inbred C57BL | Osteoarthritis - metabolism | Treatment Outcome | Sirolimus - pharmacology | Cartilage, Articular - pathology | ADAM Proteins - metabolism | Animals | Signal Transduction - drug effects | Mice | Autophagy (Cytology) | Care and treatment | Rapamycin | Dosage and administration | Models | Research | Osteoarthritis | Protein kinases | Knee | Antigens | Enzymes | Aging | Homeostasis | Calcification | Arthritis | Inflammation | Kinases | Gene expression | Autophagy | Apoptosis | Immunohistochemistry | TOR protein | Synovitis | Phosphorylation | Cartilage (articular) | Joint diseases | Synovium | Signal transduction | Cell death | ribosomal protein S6 | Interleukin 1 | Immunofluorescence | Ligaments | Phagocytosis | Cartilage diseases | Index Medicus | mTOR | autophagy | osteoarthritis | cartilage | rapamycin
Journal Article
Science, ISSN 0036-8075, 2/2008, Volume 319, Issue 5863, pp. 624 - 627
Cathepsin K was originally identified as an osteoclast-specific lysosomal protease, the inhibitor of which has been considered might have therapeutic... 
T lymphocytes | Messenger RNA | Cytokines | Dendritic cells | DNA | Toll like receptors | Bones | Osteoclasts | Reports | Inflammation | Arthritis | ACTIVATION | BONE LOSS | DENDRITIC CELLS | AUTOIMMUNITY | MULTIDISCIPLINARY SCIENCES | PYCNODYSOSTOSIS | ADJUVANTS | ANTIGEN PRESENTATION | LYSOSOMAL CYSTEINE PROTEASES | T-CELLS | INNATE IMMUNITY | Arthritis, Experimental - drug therapy | Encephalomyelitis, Autoimmune, Experimental - metabolism | T-Lymphocytes - enzymology | Dendritic Cells - immunology | Dinucleoside Phosphates - immunology | Encephalomyelitis, Autoimmune, Experimental - immunology | Male | Osteoporosis - drug therapy | Endosomes - metabolism | Antigens, CD - metabolism | Arthritis, Experimental - metabolism | Freund's Adjuvant - immunology | Protease Inhibitors - pharmacology | T-Lymphocytes - drug effects | Dendritic Cells - drug effects | Autoimmune Diseases - metabolism | Autoimmune Diseases - drug therapy | Cathepsins - antagonists & inhibitors | Bone Resorption | Cathepsin K | Cytokines - metabolism | DNA - immunology | Signal Transduction | Autoimmune Diseases - immunology | Rats | Arthritis, Experimental - immunology | DNA - metabolism | Dinucleoside Phosphates - metabolism | Animals | Cathepsins - metabolism | Lymphocyte Activation - drug effects | T-Lymphocytes - immunology | Mice | Toll-Like Receptor 9 - metabolism | Cathepsins - deficiency | Autoimmunity | Care and treatment | Control | Physiological aspects | Cathepsins | Influence | Models | Properties | Biochemistry | Pharmacology | Cellular biology | Autoimmune diseases | Rodents | Index Medicus
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 7/2015, Volume 112, Issue 27, pp. E3564 - E3573
Journal Article
Nature Communications, ISSN 2041-1723, 03/2015, Volume 6, Issue 1, pp. 6651 - 6651
Journal Article
Journal of Immunology, ISSN 0022-1767, 01/2014, Volume 192, Issue 1, pp. 59 - 72
Pathogenic Th cells and myeloid cells are involved in the pathogenesis of multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE), an... 
RHEUMATOID-ARTHRITIS | DENDRITIC CELLS | EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS | PATHOGENIC T(H)17 CELLS | CENTRAL-NERVOUS-SYSTEM | CLASS-II TRANSACTIVATOR | IMMUNOLOGY | INFLAMMATORY RESPONSE | MACROPHAGE POLARIZATION | T-CELLS | GENOME-WIDE ASSOCIATION | Encephalomyelitis, Autoimmune, Experimental - metabolism | Dendritic Cells - immunology | Humans | STAT Transcription Factors - metabolism | Encephalomyelitis, Autoimmune, Experimental - immunology | Janus Kinases - metabolism | Th1 Cells - immunology | CD4-Positive T-Lymphocytes - immunology | Th1 Cells - metabolism | Th17 Cells - metabolism | Myeloid Cells - immunology | Dendritic Cells - drug effects | Female | Myeloid Cells - drug effects | Th17 Cells - cytology | Dendritic Cells - metabolism | Macrophages - immunology | Pyrazoles - pharmacology | Pyrimidines - administration & dosage | Encephalomyelitis, Autoimmune, Experimental - drug therapy | CD4-Positive T-Lymphocytes - metabolism | Mice, Transgenic | Pyrimidines - pharmacology | Janus Kinases - antagonists & inhibitors | Macrophages - metabolism | Pyrazoles - administration & dosage | Animals | Signal Transduction - drug effects | Cell Differentiation - drug effects | Myeloid Cells - metabolism | Th17 Cells - immunology | Macrophages - drug effects | Mice | Th1 Cells - cytology | CD4-Positive T-Lymphocytes - drug effects | Index Medicus | Abridged Index Medicus
Journal Article
Arthritis & Rheumatology, ISSN 2326-5191, 11/2014, Volume 66, Issue 11, pp. 2989 - 3000
Objective. Colony-stimulating factor 1 receptor (CSF-1R) essentially modulates monocyte proliferation, migration, and activation, which are considered... 
RHEUMATOID-ARTHRITIS | COLLAGEN-INDUCED ARTHRITIS | HUMAN SYNOVIAL FIBROBLASTS | TUMOR-NECROSIS-FACTOR | M-CSF | TRANSGENIC EXPRESSION | DENDRITIC CELLS | C-FMS | AUTOIMMUNE ARTHRITIS | INFLAMMATORY ARTHRITIS | RHEUMATOLOGY | Bone and Bones - pathology | Receptor, Macrophage Colony-Stimulating Factor - antagonists & inhibitors | Arthritis, Experimental - drug therapy | Cartilage - pathology | Humans | Middle Aged | Dendritic Cells - pathology | Synovial Membrane - pathology | Antibodies, Monoclonal - therapeutic use | Male | Monocytes - metabolism | Cartilage - drug effects | Synovial Membrane - drug effects | Case-Control Studies | Receptor, Macrophage Colony-Stimulating Factor - metabolism | Arthritis, Experimental - metabolism | Bone and Bones - drug effects | Arthritis, Experimental - pathology | Arthritis, Rheumatoid - metabolism | Bone and Bones - metabolism | Monocytes - pathology | Female | Mice, Inbred DBA | Osteoarthritis - pathology | Antibodies, Monoclonal - immunology | Dendritic Cells - metabolism | Disease Models, Animal | Osteoclasts - pathology | Macrophages - pathology | Antibodies, Monoclonal - pharmacology | Osteoarthritis - metabolism | Cartilage - metabolism | Osteoclasts - metabolism | Synovial Membrane - metabolism | Arthritis, Rheumatoid - pathology | Macrophages - metabolism | Animals | Mice | Receptor, Macrophage Colony-Stimulating Factor - drug effects | Rheumatism | Rodents | Arthritis | Index Medicus | Abridged Index Medicus
Journal Article