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Nature, ISSN 0028-0836, 10/2012, Volume 490, Issue 7421, pp. 547 - 551
Mitochondrial respiratory function is frequently impaired in human cancers(1-4). However, the mechanisms by which mitochondrial dysfunction contributes to... 
OXIDATIVE STRESS | INVASION | TISSUE OVERGROWTH | PATHWAY | REGENERATION | MULTIDISCIPLINARY SCIENCES | GROWTH | MIDGUT | STEM-CELL PROLIFERATION | COOPERATION | CANCER | Neoplasms - metabolism | Up-Regulation | Compound Eye, Arthropod - ultrastructure | Reactive Oxygen Species - metabolism | Oxidative Stress | JNK Mitogen-Activated Protein Kinases - metabolism | Intracellular Signaling Peptides and Proteins - metabolism | Wnt1 Protein - metabolism | Drosophila Proteins - metabolism | Drosophila melanogaster - genetics | Oncogene Protein p21(ras) - metabolism | Drosophila melanogaster - metabolism | Compound Eye, Arthropod - growth & development | Protein-Serine-Threonine Kinases - metabolism | Disease Models, Animal | Compound Eye, Arthropod - pathology | Signal Transduction | Drosophila melanogaster - cytology | Mitochondria - metabolism | Imaginal Discs - pathology | Mitochondria - pathology | Clone Cells - metabolism | Disease Progression | Transcription Factors - metabolism | Animals | Clone Cells - pathology | Cell Transformation, Neoplastic | Drosophila melanogaster - enzymology | Imaginal Discs - metabolism | Neoplasms - pathology | Oncogene Protein p21(ras) - genetics | Cell interaction | Drosophila | Development and progression | Genetic aspects | Mitochondrial DNA | Observations | Properties | Tumors | Oxidative stress | Insects | Rodents | Cloning | Cell cycle | Respiratory system | Cancer | Apoptosis | Defects | Index Medicus
Journal Article
Science, ISSN 0036-8075, 4/2011, Volume 332, Issue 6027, pp. 354 - 358
Cytonemes are types of filopodia in the Drosophila wing imaginal disc that are proposed to serve as conduits in which morphogen signaling proteins move between... 
Shock heating | Larvae | Receptors | Heat | Image resolution | Signaling proteins | Drosophila | Imaging | REPORTS | Instars | Cell separation | EYE | INHIBITION | PATTERN | SPITZ | DISC | TRIGGERS | MULTIDISCIPLINARY SCIENCES | EGF RECEPTOR | Wings, Animal - cytology | Pseudopodia - ultrastructure | Protein-Tyrosine Kinases - metabolism | Wings, Animal - ultrastructure | Hedgehog Proteins - metabolism | Trachea - metabolism | Drosophila Proteins - metabolism | Recombinant Fusion Proteins - metabolism | Fibroblast Growth Factors - metabolism | Wings, Animal - growth & development | Membrane Proteins - metabolism | Compound Eye, Arthropod - growth & development | Protein-Serine-Threonine Kinases - metabolism | Compound Eye, Arthropod - metabolism | Trachea - growth & development | Signal Transduction | Trachea - cytology | Protein-Serine-Threonine Kinases - genetics | Receptors, Cell Surface - metabolism | Compound Eye, Arthropod - cytology | Drosophila - cytology | Epidermal Growth Factor - metabolism | Drosophila - ultrastructure | Heat-Shock Response | Animals | Larva | Pseudopodia - metabolism | Receptors, Fibroblast Growth Factor - metabolism | Ligands | Drosophila - growth & development | Drosophila - metabolism | Drosophila Proteins - genetics | Receptors, Cell Surface - genetics | Genetic aspects | Proteins | Signal transduction | Insects | Cellular biology | Developmental biology | Index Medicus | Discs | Pathways | Fibroblasts | Disks | Growth factors
Journal Article
PLoS ONE, ISSN 1932-6203, 02/2013, Volume 8, Issue 2, pp. e52088 - e52088
The Toll-like receptor (TLR)-mediated NF-kappa B pathway is tightly controlled because overactivation may result in severe damage to the host, such as in the... 
BLACK TIGER SHRIMP | CAENORHABDITIS-ELEGANS | SHRIMP PENAEUS-MONODON | MULTIDISCIPLINARY SCIENCES | ANTIMICROBIAL PEPTIDE GENES | INFECTION | TOLL SIGNALING PATHWAY | RECEPTORS | DROSOPHILA | INNATE IMMUNITY | SARM | Gills - microbiology | Molecular Sequence Data | Cytoplasm - metabolism | NF-kappa B - metabolism | Intestines - metabolism | Armadillo Domain Proteins - genetics | Phylogeny | Antimicrobial Cationic Peptides - metabolism | Promoter Regions, Genetic - genetics | Hepatopancreas - virology | Hemocytes - virology | White spot syndrome virus 1 - genetics | Base Sequence | Intestines - virology | Vibrio alginolyticus - genetics | Hepatopancreas - metabolism | Penaeidae - metabolism | Cytoplasm - genetics | Hemocytes - microbiology | Toll-Like Receptors - metabolism | Antimicrobial Cationic Peptides - genetics | Drosophila - genetics | Amino Acid Sequence | Cell Line | Penaeidae - virology | Penaeidae - genetics | Tissue Distribution - genetics | Penaeidae - microbiology | Gills - metabolism | Arthropod Proteins - genetics | Hemocytes - metabolism | Vibrio alginolyticus - metabolism | Gills - virology | White spot syndrome virus 1 - metabolism | Animals | Hepatopancreas - microbiology | Intestines - microbiology | NF-kappa B - genetics | Toll-Like Receptors - genetics | Armadillo Domain Proteins - metabolism | Arthropod Proteins - metabolism | Drosophila - metabolism | Infection | RNA | Health aspects | Analysis | Drosophila | Water-borne diseases | Shellfish | Viruses | White spot syndrome | Infections | Kinases | Inflammatory diseases | Proteins | Intestine | Hepatopancreas | Toll-like receptors | Bacteria | NF-κB protein | Immune response | Bacterial infections | RNA-mediated interference | Double-stranded RNA | Gene expression | Immune systems | Gene silencing | Ribonucleic acids | Cytoplasm | Cancer | Vibrio | Index Medicus
Journal Article
Developmental and Comparative Immunology, ISSN 0145-305X, 01/2018, Volume 78, pp. 132 - 140
Journal Article
Nature Communications, ISSN 2041-1723, 02/2017, Volume 8, Issue 1, pp. 14401 - 14401
The insect immune deficiency (IMD) pathway resembles the tumour necrosis factor receptor network in mammals and senses diaminopimelic-type peptidoglycans... 
ACTIVATION | PEPTIDOGLYCAN | MULTIDISCIPLINARY SCIENCES | TICK VECTOR | IMD PATHWAY | COLONIZATION | LYME-DISEASE | PGRP-LC | IXODES-SCAPULARIS | DROSOPHILA | INNATE IMMUNITY | Borrelia burgdorferi - immunology | Humans | Immunologic Deficiency Syndromes - veterinary | Lipids - immunology | Recombinant Proteins | Arthropods - metabolism | Drosophila Proteins - metabolism | Drosophila melanogaster - metabolism | Anaplasma marginale - pathogenicity | HEK293 Cells | Ixodes - metabolism | Immunologic Deficiency Syndromes - immunology | Carrier Proteins | Disease Models, Animal | Signal Transduction | Phosphatidylglycerols - immunology | Gene Silencing | Ubiquitin-Protein Ligases - metabolism | Lipids - adverse effects | Arthropods - immunology | Ubiquitin-Conjugating Enzymes - genetics | Fas-Associated Death Domain Protein | Transcription Factors - genetics | Transcription Factors - metabolism | Anaplasma phagocytophilum - immunology | Lyme Disease - immunology | Animals | Borrelia burgdorferi - pathogenicity | Escherichia coli - genetics | Ubiquitin-Conjugating Enzymes - metabolism | Adaptor Proteins, Signal Transducing - genetics | X-Linked Inhibitor of Apoptosis Protein - metabolism | Anaplasma marginale - immunology | Anaplasma phagocytophilum - pathogenicity | Drosophila Proteins - genetics | Adaptor Proteins, Signal Transducing - metabolism | Ixodes - immunology | RNA, Small Interfering - metabolism | Index Medicus
Journal Article
Science, ISSN 0036-8075, 2/2009, Volume 323, Issue 5918, pp. 1218 - 1222
We constructed a large-scale functional network model in Drosophila melanogaster built around two key transcription factors involved in the process of... 
Phenotypes | Kidneys | Renal cell carcinoma | Genes | Drosophila | Reports | Gene expression regulation | Embryos | Papillae | Tumors | Cancer | SYSTEM | CARBONIC-ANHYDRASE-IX | DIFFERENTIAL-DIAGNOSIS | UBIQUITIN LIGASE | MULTIDISCIPLINARY SCIENCES | GENE-EXPRESSION | MARKERS | PROTEINS | MELANOGASTER | MAP | RENAL-CELL CARCINOMA | Compound Eye, Arthropod - embryology | Drosophila melanogaster - embryology | Kidney Neoplasms - genetics | Phosphorylation | Homeodomain Proteins - metabolism | Humans | Phosphoprotein Phosphatases - metabolism | Embryo, Nonmammalian - metabolism | Carcinoma, Renal Cell - genetics | Molecular Sequence Data | Gene Expression Profiling | Janus Kinases - metabolism | Kidney Neoplasms - metabolism | Drosophila Proteins - metabolism | Gene Regulatory Networks | Drosophila melanogaster - genetics | Fushi Tarazu Transcription Factors - metabolism | Drosophila melanogaster - metabolism | Kidney - metabolism | Transcription, Genetic | Nervous System - embryology | Nuclear Proteins - genetics | Repressor Proteins - metabolism | Compound Eye, Arthropod - metabolism | Amino Acid Sequence | Cell Line | Fushi Tarazu Transcription Factors - genetics | Signal Transduction | Repressor Proteins - genetics | Nuclear Proteins - metabolism | Transcription Factors - genetics | Homeodomain Proteins - genetics | Transcription Factors - metabolism | Carcinoma, Renal Cell - metabolism | Animals | Drosophila Proteins - genetics | Apoptosis | Physiological aspects | Genetic aspects | DNA binding proteins | Segmentation (Morphology) | Phosphotransferases | Identification and classification | Genetics | Models | Kidney diseases | Insects | Index Medicus
Journal Article
Comparative Biochemistry and Physiology, Part C, ISSN 1532-0456, 11/2014, Volume 166, pp. 65 - 74
Heat shock proteins (hsps) are induced by a wide range of environmental stressors including heavy metals in aquatic organisms. However, the effect of heavy... 
Copepod | Oxidative stress | Tigriopus japonicus | Antioxidant enzyme activities | Heat shock protein | Heavy metal | ENVIRONMENTAL-POLLUTANTS | MOLECULAR CHAPERONES | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRACE-METALS | COPPER | ZOOLOGY | CADMIUM | ENDOCRINOLOGY & METABOLISM | GENE-EXPRESSION | CRASSOSTREA-VIRGINICA | CHIRONOMUS-RIPARIUS | TOXICOLOGY | GLUTATHIONE DEPLETION | MARINE | Reactive Oxygen Species - metabolism | Copepoda - drug effects | Glutathione - metabolism | Water Pollutants, Chemical - administration & dosage | HSP20 Heat-Shock Proteins - genetics | Male | Toxicity Tests, Acute | Oxidoreductases - chemistry | HSP20 Heat-Shock Proteins - metabolism | Reactive Oxygen Species - agonists | Dose-Response Relationship, Drug | Glutathione - agonists | Glutathione - genetics | Female | HSP20 Heat-Shock Proteins - agonists | HSP70 Heat-Shock Proteins - agonists | Metals, Heavy - administration & dosage | Copepoda - metabolism | Republic of Korea | Biomarkers - metabolism | Copepoda - growth & development | Oxidoreductases - metabolism | Oxidoreductases - genetics | Gene Expression Regulation, Developmental - drug effects | HSP70 Heat-Shock Proteins - genetics | Arthropod Proteins - agonists | Arthropod Proteins - genetics | HSP70 Heat-Shock Proteins - metabolism | Environmental Exposure - adverse effects | Animals | Water Pollutants, Chemical - toxicity | Metals, Heavy - toxicity | Arthropod Proteins - metabolism | Oxidative Stress - drug effects | Biomarkers - chemistry | Aquaculture | Antioxidants | Heat shock proteins | Enzymes | Heavy metals | Coastal ecosystems | Index Medicus
Journal Article
Bioconjugate Chemistry, ISSN 1043-1802, 04/2018, Volume 29, Issue 4, pp. 898 - 904
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 02/2017, Volume 114, Issue 9, pp. 2241 - 2246
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 03/2012, Volume 287, Issue 13, pp. 10060 - 10069
The prophenoloxidase (proPO) system is activated upon recognition of pathogens by pattern recognition proteins (PRPs), including a lipopolysaccharide-and... 
BLACK TIGER SHRIMP | MANDUCA-SEXTA | FENNEROPENAEUS-CHINENSIS | GRAM-NEGATIVE BACTERIA | LIPOTEICHOIC ACID | BIOCHEMISTRY & MOLECULAR BIOLOGY | PENAEUS-MONODON | LITOPENAEUS-VANNAMEI | TOBACCO HORNWORM | MOLECULAR-CLONING | INNATE IMMUNITY | Antimicrobial Cationic Peptides - immunology | Catechol Oxidase - immunology | Glucans - immunology | Vibrio - immunology | Enzyme Precursors - genetics | Lipopolysaccharides - metabolism | Antimicrobial Cationic Peptides - metabolism | Lipopolysaccharides - immunology | Vibrio Infections - metabolism | Enzyme Activation - immunology | Vibrio - metabolism | Lectins - metabolism | Vibrio Infections - genetics | Penaeidae - metabolism | Catechol Oxidase - genetics | Glucans - metabolism | Antimicrobial Cationic Peptides - genetics | Lectins - immunology | Vibrio - genetics | Enzyme Precursors - immunology | Penaeidae - microbiology | Glucans - pharmacology | Arthropod Proteins - genetics | Arthropod Proteins - immunology | Enzyme Activation - drug effects | Enzyme Precursors - metabolism | Animals | Catechol Oxidase - metabolism | Lipopolysaccharides - pharmacology | Arthropod Proteins - metabolism | Protein Binding | Lectins - genetics | Enzyme Activation - genetics | Penaeidae - immunology | Index Medicus | Pattern Recognition Protein | Phenoloxidase | Carbohydrate-binding Protein | RNA Interference (RNAi) | Pathogen-associated Molecular Pattern (PAMP) | β-Glucan | Enzymology | Shrimp | Lipopolysaccharide (LPS) | Pattern Recognition Receptor
Journal Article
Nature, ISSN 0028-0836, 12/2010, Volume 468, Issue 7324, pp. 691 - 695
The odour of acids has a distinct quality that is perceived as sharp, pungent and often irritating. How acidity is sensed and translated into an appropriate... 
TRANSMISSION | FLY BRAIN | MULTIDISCIPLINARY SCIENCES | NEURONS | MINOS | CHEMOSENSORY RECEPTORS | AVOIDANCE-BEHAVIOR | CARBON-DIOXIDE | MELANOGASTER | TARGETED EXPRESSION | REVEALS | Sensilla - cytology | Receptors, Odorant - metabolism | Temperature | Drosophila melanogaster - physiology | Arthropod Antennae - innervation | Carbonic Acid - pharmacology | Drosophila Proteins - metabolism | Acids - analysis | Odorants - analysis | Olfactory Pathways - physiology | Sensory Receptor Cells - metabolism | Drosophila melanogaster - anatomy & histology | Olfactory Pathways - drug effects | Acids - pharmacology | Arthropod Antennae - drug effects | Arthropod Antennae - cytology | Carbon Dioxide - metabolism | Carbonic Acid - metabolism | Arthropod Antennae - anatomy & histology | Drosophila melanogaster - cytology | Acetic Acid - pharmacology | Receptors, Ionotropic Glutamate - metabolism | Drosophila melanogaster - drug effects | Animals | Maze Learning | Sensory Receptor Cells - drug effects | Calcium Signaling - drug effects | Olfactory Pathways - cytology | Acetic Acid - analysis | Physiological aspects | Sensory receptors | Genetic aspects | Research | Drosophila | Rhinencephalon | Acidity | Pheromones | Insects | Cellular biology | Molecular biology | Neurons | Index Medicus | Drosophila Proteins | Receptors, Odorant | Olfactory Pathways | Carbonic Acid | Carbon Dioxide | Sensory Receptor Cells | Life Sciences | Acetic Acid | Arthropod Antennae | Odors | Acids | Food and Nutrition | Receptors, Ionotropic Glutamate | Drosophila melanogaster | Sensilla | Calcium Signaling
Journal Article