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1. Full Text Aryl Hydrocarbon Receptor Antagonists Promote the Expansion of Human Hematopoietic Stem Cells
by Anthony E. Boitano and Jian Wang and Russell Romeo and Laure C. Bouchez and Albert E. Parker and Sue E. Sutton and John R. Walker and Colin A. Flaveny and Gary H. Perdew and Michael S. Denison and Peter G. Schultz and Michael P. Cooke
Science (American Association for the Advancement of Science), ISSN 0036-8075, 9/2010, Volume 329, Issue 5997, pp. 1345 - 1348
Hep G2 cells | Cytokines | REPORTS | Stem cells | Multipotent stem cells | Bone marrow | Cultured cells | Transplantation | Aryl hydrocarbon receptors | Hematopoietic stem cells | Blood | Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Biological and medical sciences | Medical sciences | Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy | Bone marrow, stem cells transplantation. Graft versus host reaction | Transfusions. Complications. Transfusion reactions. Cell and gene therapy | Antigens, CD34 - analysis | Cell Proliferation | Receptors, Aryl Hydrocarbon - antagonists & inhibitors | Species Specificity | Cell Count | Humans | Aryl Hydrocarbon Hydroxylases - genetics | Antigens, CD - analysis | Multipotent Stem Cells - drug effects | Hematopoiesis | Polychlorinated Dibenzodioxins - pharmacology | Hematopoietic Stem Cells - physiology | Receptors, Aryl Hydrocarbon - metabolism | Multipotent Stem Cells - physiology | Hematopoietic Stem Cells - drug effects | Signal Transduction | Purines - metabolism | Purines - pharmacology | Cells, Cultured | Hematopoietic Stem Cell Transplantation | Hematopoietic Stem Cells - metabolism | Mice, SCID | AC133 Antigen | Aryl Hydrocarbon Hydroxylases - metabolism | Cell Lineage | Animals | Multipotent Stem Cells - cytology | Small Molecule Libraries | Hematopoietic Stem Cells - cytology | Cytochrome P-450 CYP1B1 | Mice, Inbred NOD | Mice | Glycoproteins - analysis | Cytokines - pharmacology | Peptides - analysis | Physiological aspects | Arylation | Human | Receptors | Aromatic compounds | Modulation | Hydrocarbons | Derivatives | Culture | Index Medicus
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2. Full Text Influence of omeprazol on the antiplatelet action of clopidogrel associated to aspirin
by GILARD, M and ARNAUD, B and LE GAL, G and ABGRALL, J. F and BOSCHAT, J
Journal of thrombosis and haemostasis, ISSN 1538-7933, 11/2006, Volume 4, Issue 11, pp. 2508 - 2509
Peripheral Vascular Disease | Life Sciences & Biomedicine | Hematology | Cardiovascular System & Cardiology | Science & Technology | Ticlopidine - pharmacology | Humans | Aryl Hydrocarbon Hydroxylases - genetics | Ticlopidine - antagonists & inhibitors | Male | Mixed Function Oxygenases - metabolism | Omeprazole - antagonists & inhibitors | Phosphoproteins - metabolism | Coronary Disease - metabolism | Protein Processing, Post-Translational - drug effects | Coronary Disease - complications | Platelet Aggregation Inhibitors - pharmacology | Female | Omeprazole - pharmacology | Microfilament Proteins - metabolism | Aspirin - pharmacology | Phosphorylation - drug effects | Aspirin - antagonists & inhibitors | Aryl Hydrocarbon Hydroxylases - antagonists & inhibitors | Platelet Function Tests - methods | Enzyme Inhibitors - pharmacology | Angioplasty - methods | Mixed Function Oxygenases - antagonists & inhibitors | Cell Adhesion Molecules - metabolism | Ticlopidine - analogs & derivatives | Aryl Hydrocarbon Hydroxylases - metabolism | Platelet Activation - genetics | Thrombosis - metabolism | Angioplasty - adverse effects | Coronary Disease - genetics | Drug Antagonism | Cytochrome P-450 CYP2C19 | Thrombosis - etiology | Thrombosis - genetics | Aged | Platelet Activation - drug effects | Polymorphism, Single Nucleotide | Coronary Disease - surgery | Mixed Function Oxygenases - genetics | Index Medicus | Phosphorylation | Enzyme Inhibitors | Angioplasty | Cell Adhesion Molecules | Mixed Function Oxygenases | Life Sciences | Coronary Disease | Phosphoproteins | Platelet Function Tests | Aspirin | Thrombosis | Ticlopidine | Omeprazole | Human health and pathology | Microfilament Proteins | Platelet Activation | Platelet Aggregation Inhibitors | Protein Processing, Post-Translational | Aryl Hydrocarbon Hydroxylases
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3. Full Text Comparative Pharmacokinetics of Vitamin K Antagonists: Warfarin, Phenprocoumon and Acenocoumarol
by Ufer, Mike
2005, Volume 44, Issue 12, 20
Warfarin | Phenprocoumon | Vitamin K antagonists | Acenocoumarol | Pharmacotherapy | Internal Medicine | Medicine & Public Health | Pharmacology/Toxicology | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Biological and medical sciences | Medical sciences | Blood. Blood coagulation. Reticuloendothelial system | Pharmacology. Drug treatments | Cytochrome P-450 CYP2C9 | Hydroxylation | Acenocoumarol - pharmacokinetics | Humans | Thrombin - antagonists & inhibitors | Aryl Hydrocarbon Hydroxylases - genetics | Azetidines - pharmacokinetics | Mixed Function Oxygenases - antagonists & inhibitors | Vitamin K Epoxide Reductases | Aryl Hydrocarbon Hydroxylases - metabolism | Polymorphism, Genetic | Warfarin - pharmacokinetics | Vitamin K - antagonists & inhibitors | Animals | Anticoagulants - pharmacokinetics | Benzylamines - pharmacokinetics | Phenprocoumon - pharmacokinetics | Index Medicus
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4. Full Text Identification of the human cytochrome P450 enzymes involved in the two oxidative steps in the bioactivation of clopidogrel to its pharmacologically active metabolite
by Kazui, Miho and Nishiya, Yumi and Ishizuka, Tomoko and Hagihara, Katsunobu and Farid, Nagy A and Okazaki, Osamu and Ikeda, Toshihiko and Kurihara, Atsushi
Drug metabolism and disposition, ISSN 0090-9556, 01/2010, Volume 38, Issue 1, pp. 92 - 99
Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Biological and medical sciences | Pharmacology. Drug treatments | Medical sciences | Microsomes - metabolism | Humans | Aryl Hydrocarbon Hydroxylases - genetics | Cytochrome P-450 Enzyme System - metabolism | Sulfaphenazole - pharmacology | Microsomes - drug effects | Cytochrome P-450 CYP3A - genetics | Cytochrome P-450 CYP1A2 - genetics | Antibodies - immunology | Omeprazole - pharmacology | Microsomes, Liver - enzymology | Platelet Aggregation Inhibitors - pharmacokinetics | Ticlopidine - pharmacokinetics | Oxidoreductases, N-Demethylating - metabolism | Aryl Hydrocarbon Hydroxylases - immunology | Oxidation-Reduction | Enzyme Inhibitors - pharmacology | Ticlopidine - analogs & derivatives | Oxidoreductases, N-Demethylating - immunology | Cytochrome P-450 CYP3A - metabolism | Cell Line, Tumor | Cytochrome P-450 Enzyme System - genetics | Theophylline - pharmacology | Kinetics | Cytochrome P-450 CYP2C9 | Theophylline - analogs & derivatives | Oxidoreductases, N-Demethylating - genetics | Glutathione - metabolism | Ketoconazole - pharmacology | Biotransformation - physiology | Cytochrome P-450 CYP1A2 Inhibitors | Microsomes, Liver - drug effects | Ticlopidine - metabolism | NADP - metabolism | Platelet Aggregation Inhibitors - metabolism | Cytochrome P-450 CYP3A - immunology | Cell Line | Aryl Hydrocarbon Hydroxylases - antagonists & inhibitors | Cytochrome P-450 CYP1A2 - immunology | Biocatalysis | Mephenytoin - analogs & derivatives | Cytochrome P-450 CYP1A2 - metabolism | Aryl Hydrocarbon Hydroxylases - metabolism | Mephenytoin - pharmacology | Antibodies - pharmacology | Cytochrome P-450 CYP3A Inhibitors | Cytochrome P-450 CYP2C19 | Clopidogrel | Cytochrome P-450 CYP2B6 | Index Medicus
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5. Full Text Structure of mammalian cytochrome P450 2B4 complexed with 4-(4-chlorophenyl)imidazole at 1.9-Å resolution: Insight into the range of P450 conformations and the coordination of redox partner binding
by Scott, Emily E and White, Mark A and He, You Ai and Johnson, Eric F and Stout, C. David and Halpert, James R
The Journal of biological chemistry, ISSN 0021-9258, 06/2004, Volume 279, Issue 26, pp. 27294 - 27301
Aryl Hydrocarbon Hydroxylases - genetics | Imidazoles - chemistry | Molecular Sequence Data | Crystallography, X-Ray | Cytochrome P450 Family 2 | Heme - chemistry | Enzyme Inhibitors - chemistry | Aryl Hydrocarbon Hydroxylases - chemistry | Binding Sites | Imidazoles - metabolism | Recombinant Proteins - metabolism | Amino Acid Sequence | Rabbits | Aryl Hydrocarbon Hydroxylases - antagonists & inhibitors | Recombinant Proteins - antagonists & inhibitors | Enzyme Inhibitors - metabolism | Protein Structure, Secondary | Enzyme Inhibitors - pharmacology | Models, Molecular | Recombinant Proteins - chemistry | Imidazoles - pharmacology | Recombinant Proteins - genetics | Aryl Hydrocarbon Hydroxylases - metabolism | Animals | Amino Acid Substitution | Index Medicus
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6. Full Text Histamine2 -Receptor Antagonists Are an Alternative to Proton Pump Inhibitor in Patients Receiving Clopidogrel
by Wu, Chun–Ying and Chan, Francis Ka–Leung and Wu, Ming–Shiang and Kuo, Ken N and Wang, Chang–Bi and Tsao, Chen–Rong and Lin, Jaw–Town
Gastroenterology (New York, N.Y. 1943), ISSN 0016-5085, 2010, Volume 139, Issue 4, pp. 1165 - 1171.e4
Gastroenterology and Hepatology | Clopidogrel | Proton Pump Inhibitor | Acute Coronary Syndrome | Proton Pump Inhibitors - adverse effects | Ticlopidine - therapeutic use | Humans | Aryl Hydrocarbon Hydroxylases - genetics | Proportional Hazards Models | Acute Coronary Syndrome - mortality | Histamine H2 Antagonists - adverse effects | Male | Proton Pump Inhibitors - therapeutic use | Histamine H2 Antagonists - therapeutic use | Ticlopidine - analogs & derivatives | Acute Coronary Syndrome - drug therapy | Histamine H2 Antagonists - administration & dosage | Proton Pump Inhibitors - administration & dosage | Cytochrome P-450 CYP2C19 | Ticlopidine - adverse effects | Aryl Hydrocarbon Hydroxylases - physiology | Ticlopidine - administration & dosage | Female | Aged | Retrospective Studies | Drug Therapy, Combination | Platelet Aggregation Inhibitors - therapeutic use | Cohort Studies | Index Medicus | Abridged Index Medicus
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7. Full Text Cytochrome P450 2C9-CYP2C9
by Van Booven, Derek and Marsh, Sharon and McLeod, Howard and Carrillo, Michelle Whirl and Sangkuhl, Katrin and Klein, Teri E and Altman, Russ B
Pharmacogenetics and genomics, ISSN 1744-6872, 04/2010, Volume 20, Issue 4, pp. 277 - 281
CYP2C9 | Warfarin | CYP2C93 | CYP2C92 | Phenytoin | PharmGKB | Pharmacology & Pharmacy | Genetics & Heredity | Life Sciences & Biomedicine | Biotechnology & Applied Microbiology | Science & Technology | Biological and medical sciences | Medical sciences | General pharmacology | Pharmacology. Drug treatments | Pharmacokinetics. Pharmacogenetics. Drug-receptor interactions | Cytochrome P-450 CYP2C9 | Drug-Related Side Effects and Adverse Reactions - enzymology | Aryl Hydrocarbon Hydroxylases - antagonists & inhibitors | Pharmacogenetics | Gene Frequency | Humans | Aryl Hydrocarbon Hydroxylases - genetics | Enzyme Induction | Substrate Specificity | Aryl Hydrocarbon Hydroxylases - metabolism | Genetic Variation | Phenotype | Drug-Related Side Effects and Adverse Reactions - genetics | Alleles | Molecular Structure | Aryl Hydrocarbon Hydroxylases - chemistry | Index Medicus | phenytoin | warfarin
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8. Full Text Resveratrol Inhibits Dioxin-Induced Expression of Human CYP1A1 and CYP1B1 by Inhibiting Recruitment of the Aryl Hydrocarbon Receptor Complex and RNA Polymerase II to the Regulatory Regions of the Corresponding Genes
by Beedanagari, Sudheer R and Bebenek, Ilona and Bui, Peter and Hankinson, Oliver
Toxicological sciences, ISSN 1096-6080, 7/2009, Volume 110, Issue 1, pp. 61 - 67
CYP1A1 | CYP1B1 | ChIP assay | Dioxin | Resveratrol | Life Sciences & Biomedicine | Toxicology | Science & Technology | Chromatin - metabolism | Cytochrome P-450 CYP1A1 - genetics | Aryl Hydrocarbon Hydroxylases - biosynthesis | Immunoprecipitation | Receptors, Aryl Hydrocarbon - antagonists & inhibitors | Humans | Aryl Hydrocarbon Hydroxylases - genetics | Aryl Hydrocarbon Receptor Nuclear Translocator - biosynthesis | Antimutagenic Agents - pharmacology | Stilbenes - pharmacology | Dioxins - toxicity | Cytochrome P-450 CYP1A2 - genetics | Enzyme Induction - drug effects | Dioxins - antagonists & inhibitors | RNA Polymerase II - antagonists & inhibitors | Cells, Cultured | Receptors, Aryl Hydrocarbon - genetics | DNA Primers | Gene Expression Regulation - drug effects | Cytochrome P-450 CYP1A2 - biosynthesis | Cell Line, Tumor | Cytochrome P-450 CYP1B1 | RNA Polymerase II - genetics | Aryl Hydrocarbon Receptor Nuclear Translocator - genetics | Cytochrome P-450 CYP1A1 - biosynthesis | Chromatin - genetics | Index Medicus | and ChIP assay | dioxin | Carcinogenicity | resveratrol
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9. Full Text Use of Phenoxyaniline Analogues To Generate Biochemical Insights into the Interactio n of Polybrominated Diphenyl Ether with CYP2B Enzymes
by Chen, Chao and Liu, Jingbao and Halpert, James R and Wilderman, P. Ross
Biochemistry (Easton), ISSN 0006-2960, 02/2018, Volume 57, Issue 5, pp. 817 - 826
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Cytochrome P-450 CYP2B1 - genetics | Aniline Compounds | Humans | Aryl Hydrocarbon Hydroxylases - genetics | NADPH Oxidases - metabolism | Substrate Specificity | Cytochrome P-450 Enzyme Inhibitors - metabolism | Structure-Activity Relationship | Environmental Pollutants - metabolism | Cytochromes b5 - metabolism | Cytochrome P-450 CYP2B6 - metabolism | Cytochrome P-450 CYP2B6 Inhibitors - metabolism | Cytochrome P-450 CYP2B6 - drug effects | Hydrocarbons, Halogenated - metabolism | Cytochrome P-450 CYP2B1 - chemistry | Cytochrome P450 Family 2 - genetics | Inhibitory Concentration 50 | Cytochrome P-450 CYP2B1 - metabolism | Molecular Structure | Aryl Hydrocarbon Hydroxylases - chemistry | Benzene Derivatives - pharmacology | Cytochrome P450 Family 2 - antagonists & inhibitors | Recombinant Proteins - metabolism | Rabbits | Aryl Hydrocarbon Hydroxylases - antagonists & inhibitors | Mutagenesis, Site-Directed | Oxidation-Reduction | Cytochrome P-450 CYP2B6 - genetics | Halogenated Diphenyl Ethers - pharmacology | Rats | Cytochrome P450 Family 2 - chemistry | Cytochrome P-450 CYP2B1 - antagonists & inhibitors | Aryl Hydrocarbon Hydroxylases - metabolism | Cytochrome P-450 CYP2B6 Inhibitors - pharmacology | Halogenated Diphenyl Ethers - metabolism | Cytochrome P-450 Enzyme Inhibitors - pharmacology | Animals | Cytochrome P450 Family 2 - metabolism | Alkylation - drug effects | Cytochrome P-450 CYP2B6 - chemistry | Amino Acid Substitution | Research | Chemical properties | Aniline | Cytochrome P-450 | Index Medicus
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10. Full Text Dexfenfluramine and the oestrogen-metabolizing enzyme CYP1B1 in the development of pulmonary arterial hypertension
by Dempsie, Yvonne and Macritchie, Neil A and White, Kevin and Morecroft, Ian and Wright, Audrey F and Nilsen, Margaret and Loughlin, Lynn and Mair, Kirsty M and MacLean, Margaret R
Cardiovascular research, ISSN 0008-6363, 07/2013, Volume 99, Issue 1, pp. 24 - 34
Tryptophan hydroxylase | CYP1B1 | Oestrogen | Dexfenfluramine | Pulmonary arterial hypertension | Cardiac & Cardiovascular Systems | Life Sciences & Biomedicine | Cardiovascular System & Cardiology | Science & Technology | Cell Proliferation | Aryl Hydrocarbon Hydroxylases - genetics | Myocytes, Smooth Muscle - pathology | Hypertension, Pulmonary - physiopathology | Male | Hypertension, Pulmonary - chemically induced | Muscle, Smooth, Vascular - physiopathology | Hypertension, Pulmonary - prevention & control | Norfenfluramine - toxicity | Dose-Response Relationship, Drug | Arterial Pressure | Female | Myocytes, Smooth Muscle - drug effects | Estradiol - pharmacology | Hypertension, Pulmonary - enzymology | Tryptophan Hydroxylase - metabolism | Disease Models, Animal | Muscle, Smooth, Vascular - drug effects | Aryl Hydrocarbon Hydroxylases - antagonists & inhibitors | Ovariectomy | Myocytes, Smooth Muscle - enzymology | Mice, Inbred C57BL | Cells, Cultured | Enzyme Inhibitors - pharmacology | Familial Primary Pulmonary Hypertension | Hypertension, Pulmonary - genetics | Pulmonary Artery - physiopathology | Pulmonary Artery - enzymology | Aryl Hydrocarbon Hydroxylases - metabolism | Mice, Knockout | Muscle, Smooth, Vascular - pathology | Animals | Aryl Hydrocarbon Hydroxylases - deficiency | Serotonin - metabolism | Sex Factors | Cytochrome P-450 CYP1B1 | Mice | Ventricular Pressure | Hypertension, Pulmonary - pathology | Muscle, Smooth, Vascular - enzymology | Ventricular Function, Right | Index Medicus | Original
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