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Food and Chemical Toxicology, ISSN 0278-6915, 12/2011, Volume 49, Issue 12, pp. 3407 - 3417
► The biomarkers were evaluated in clams exposed to Cd and BaP. ► The combined toxicity of Cd and BaP is much higher than single contaminant. ► The mixture of... 
BaP | Bioaccumulation | Ruditapes philippinarum | Enzymes activities mRNA expression | DNA INTEGRITY | OXIDATIVE STRESS | RAINBOW-TROUT | INDUCED METALLOTHIONEIN | ENZYME-ACTIVITY | POLYCYCLIC AROMATIC-HYDROCARBONS | FOOD SCIENCE & TECHNOLOGY | MUSSELS MYTILUS-GALLOPROVINCIALIS | MEDITERRANEAN MUSSEL | mRNA expression | FRESH-WATER MUSSEL | DIGESTIVE GLAND | TOXICOLOGY | Enzymes activities | Metallothionein - metabolism | Shellfish | Glutathione - metabolism | Cadmium - pharmacokinetics | RNA, Messenger - metabolism | Gills - drug effects | Glutathione - drug effects | Glutathione - analysis | Glutathione S-Transferase pi - drug effects | Cadmium - analysis | Bivalvia - chemistry | Superoxide Dismutase - metabolism | Glutathione S-Transferase pi - genetics | Biomarkers - metabolism | Benzo(a)pyrene - toxicity | Glutathione S-Transferase pi - metabolism | Superoxide Dismutase - analysis | Cadmium - toxicity | RNA, Messenger - genetics | Biomarkers - analysis | Glutathione Transferase - metabolism | Gills - metabolism | Metallothionein - analysis | Aryl Hydrocarbon Hydroxylases - drug effects | Water Pollutants, Chemical - analysis | Superoxide Dismutase - drug effects | Aryl Hydrocarbon Hydroxylases - analysis | Aryl Hydrocarbon Hydroxylases - metabolism | Benzo(a)pyrene - pharmacokinetics | Benzo(a)pyrene - analysis | Glutathione Transferase - analysis | Animals | Water Pollutants, Chemical - toxicity | Glutathione Transferase - drug effects | Metallothionein - drug effects | Cadmium | Enzymes | Messenger RNA | Biological markers | Food contamination | Contaminants | Sod | Biochemistry | Pollutants | Copper | Zinc | Glutathione
Journal Article
Biological Psychiatry, ISSN 0006-3223, 2007, Volume 62, Issue 6, pp. 635 - 641
Background CYP2B6 is the primary enzyme involved in bupropion (Zyban; GlaxoSmithKline, Research Triangle Park, North Carolina) metabolism. Genetic... 
Psychiatry | genetic | CYP2A6 | nicotine | Bupropion | CYP2B6 | smoking | pharmacogenetic | NICOTINE C-OXIDATION | PLACEBO | GENETIC POLYMORPHISMS | VARIANTS | PSYCHIATRY | HUMAN LIVER-MICROSOMES | NEUROSCIENCES | ALLELE FREQUENCIES | SMOKERS | EFAVIRENZ | SUSTAINED-RELEASE BUPROPION | CYTOCHROME P4502B6 | Behavior, Addictive - drug therapy | Bupropion - metabolism | Haplotypes | Behavior Therapy | Cytochrome P-450 CYP2A6 | Oxidoreductases, N-Demethylating - genetics | Follow-Up Studies | Humans | Aryl Hydrocarbon Hydroxylases - genetics | Male | Mixed Function Oxygenases - metabolism | Placebos | Tobacco Use Disorder - psychology | Adult | Female | Tobacco Use Disorder - genetics | Smoking - psychology | Oxidoreductases, N-Demethylating - metabolism | Bupropion - therapeutic use | Bupropion - pharmacokinetics | Pharmacogenetics | Smoking - drug therapy | Genotype | Smoking - genetics | Tobacco Use Disorder - drug therapy | Treatment Outcome | Aryl Hydrocarbon Hydroxylases - drug effects | Smoking Cessation - methods | Aryl Hydrocarbon Hydroxylases - metabolism | Oxidoreductases, N-Demethylating - drug effects | Polymorphism, Genetic - genetics | Behavior, Addictive - psychology | Mixed Function Oxygenases - genetics | Cytochrome P-450 CYP2B6 | Mixed Function Oxygenases - drug effects | Physiological aspects | Smoking cessation programs | Genetic aspects | Cytochrome P-450
Journal Article
Toxicology and Applied Pharmacology, ISSN 0041-008X, 2009, Volume 234, Issue 1, pp. 1 - 13
The present study focuses on the molecular mechanism and interspecies differences in susceptibility of avian aryl hydrocarbon receptor (AHR)-cytochrome (CYP1A)... 
TCDD | Xenobiotic response element | Avian species | CYP1A5 | Enhancer | Aryl hydrocarbon receptor isoform | TRANSCRIPTIONAL ACTIVATION | Aryl hydrocarbon receptor iso orm | ZEBRAFISH DANIO-RERIO | AH RECEPTOR | REGULATORY ELEMENTS | P-450C GENE | CONGENER-SPECIFIC METABOLISM | LAKE BIWA | MESSENGER-RNA | PHARMACOLOGY & PHARMACY | TOXICOLOGY | EMBRYO HEPATOCYTES | HALOGENATED AROMATIC-HYDROCARBONS | Transcription, Genetic - drug effects | Species Specificity | Chickens - metabolism | Dose-Response Relationship, Drug | Protein Isoforms - metabolism | Mutagenicity Tests | Cloning, Molecular | Environmental Pollutants - administration & dosage | Receptors, Aryl Hydrocarbon - metabolism | Chickens - genetics | Electrophoretic Mobility Shift Assay | Environmental Pollutants - toxicity | Binding Sites | Receptors, Aryl Hydrocarbon - drug effects | Aryl Hydrocarbon Hydroxylases - drug effects | Base Sequence - drug effects | Sequence Analysis, DNA | Enhancer Elements, Genetic - drug effects | Polychlorinated Dibenzodioxins - administration & dosage | Aryl Hydrocarbon Hydroxylases - metabolism | Response Elements - drug effects | Protein Isoforms - drug effects | Animals | Signal Transduction - drug effects | Polychlorinated Dibenzodioxins - toxicity | Birds - metabolism | Birds - genetics | Hydrocarbons | Herbicides | Analysis | Dioxin | Cytochrome P-450 | Index Medicus | DIOXIN | MUTAGENESIS | GELS | HYDROCARBONS | CLONING | PROMOTERS | IN VITRO | GENES | CHICKENS | RECEPTORS | 60 APPLIED LIFE SCIENCES
Journal Article
Toxicology and Applied Pharmacology, ISSN 0041-008X, 2005, Volume 205, Issue 3, pp. 247 - 258
In mammals, CYP3A isozymes collectively comprise the largest portion of the liver and small intestinal CYP protein. They are involved in the metabolism of an... 
Zebrafish larva | Xenobiotics | CYP3A | TRANSCRIPTIONAL ACTIVATION | RAINBOW-TROUT | xenobiotics | RABBIT HEPATOCYTES | PRIMARY CULTURES | PREGNANE-X-RECEPTOR | CYTOCHROME-P450 3A | MESSENGER-RNAS | TISSUE DISTRIBUTION | PHARMACOLOGY & PHARMACY | TOXICOLOGY | zebrafish larva | MEDAKA ORYZIAS-LATIPES | HUMAN-LIVER | Intestines - drug effects | Sequence Analysis, Protein - methods | Oxidoreductases, N-Demethylating - genetics | Receptors, Aryl Hydrocarbon - antagonists & inhibitors | Aryl Hydrocarbon Hydroxylases - genetics | Gene Expression Regulation, Developmental - genetics | Intestines - embryology | Zebrafish - embryology | Xenobiotics - chemistry | Xenobiotics - pharmacology | Dexamethasone - pharmacology | Larva - drug effects | Polychlorinated Dibenzodioxins - pharmacology | Reverse Transcriptase Polymerase Chain Reaction - methods | Larva - genetics | Oxidoreductases, N-Demethylating - metabolism | In Situ Hybridization - methods | Polychlorinated Dibenzodioxins - antagonists & inhibitors | Oligonucleotides, Antisense - pharmacology | Zebrafish Proteins - metabolism | Larva - metabolism | Zebrafish Proteins - antagonists & inhibitors | Gene Expression Regulation, Developmental - drug effects | Receptors, Aryl Hydrocarbon - drug effects | Aryl Hydrocarbon Hydroxylases - drug effects | Zebrafish - genetics | Aryl Hydrocarbon Hydroxylases - metabolism | Oxidoreductases, N-Demethylating - drug effects | Animals | Signal Transduction - drug effects | Zebrafish - metabolism | Signal Transduction - physiology | Rifampin - pharmacology | Zebrafish Proteins - genetics | Zebrafish Proteins - drug effects | RNA, Messenger | Herbicides | Messenger RNA | Dexamethasone | Isoenzymes | Dioxin | Cytochrome P-450 | Genetic aspects | Rifampin | Steroid hormones | DIOXIN | ANTIBIOTICS | DEXAMETHASONE | SUBSTRATES | TRANSCRIPTION | INTESTINES | 60 APPLIED LIFE SCIENCES | OLIGONUCLEOTIDES | XENOBIOTICS | POLYMERASE CHAIN REACTION | METABOLISM | GENES | LARVAE | LIVER | EMBRYOS | MAMMALS
Journal Article
Clinical Pharmacology & Therapeutics, ISSN 0009-9236, 07/2005, Volume 78, Issue 1, pp. 25 - 33
Journal Article
Toxicology and Applied Pharmacology, ISSN 0041-008X, 05/2012, Volume 261, Issue 1, pp. 88 - 96
The persistent environmental contaminant, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is an ovarian toxicant. These studies were designed to characterize the... 
TCDD | Aryl hydrocarbon receptor | Ovary | Steroidogenesis | Proliferation | Antral follicle | GONADOTROPIN-SECRETION | DIBENZO-P-DIOXINS | MESSENGER-RNA | PROGESTERONE SECRETION | AGONIST 2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN | LACTATIONAL EXPOSURE | REPRODUCTIVE SENESCENCE | PHARMACOLOGY & PHARMACY | ENDOCRINE DISRUPTION | TOXICOLOGY | LUTEINIZED GRANULOSA-CELLS | SERUM DIOXIN CONCENTRATIONS | Ovarian Follicle - growth & development | Receptors, Aryl Hydrocarbon - drug effects | Aryl Hydrocarbon Hydroxylases - drug effects | Aryl Hydrocarbon Hydroxylases - metabolism | Dose-Response Relationship, Drug | Dioxins - toxicity | Ovarian Follicle - drug effects | Animals | Time Factors | Cytochrome P-450 CYP1B1 | Pregnenolone - pharmacology | Receptors, Aryl Hydrocarbon - metabolism | Dioxins - administration & dosage | Female | Mice | Gonadal Steroid Hormones - secretion | In Vitro Techniques | Herbicides | Somatotropin | Growth | Dioxin | Cytochrome P-450 | Hormones, Sex | Hormones | Progesterone | Steroid hormones | Index Medicus | Cell culture | Transcription | Secretion | Sex | Tissue culture | Data processing | Follicles | Pregnenolone | Sex hormones | Testosterone | Toxicants | Contaminants | Androstenedione | Aryl hydrocarbon receptors | Growth hormone | DIOXIN | HYDROXYPREGNENONE | HYDROCARBONS | PROGESTERONE | TESTOSTERONE | STH | SEX | ANIMAL TISSUES | 60 APPLIED LIFE SCIENCES | ANDROSTENEDIONE | TISSUE CULTURES | AMINO ACIDS | IN VITRO | ESTRADIOL | OVARIES | MICE | SECRETION | RECEPTORS | steroidogenesis | ovary | antral follicle | proliferation | aryl hydrocarbon receptor
Journal Article
Journal Article
Clinical Pharmacology & Therapeutics, ISSN 0009-9236, 12/2008, Volume 84, Issue 6, pp. 722 - 728
Journal Article
Molecular Psychiatry, ISSN 1359-4184, 04/2006, Volume 11, Issue 4, pp. 400 - 409
We investigated the effect of slow metabolism of nicotine, predicted by CYP2A6 genotypes resulting in <= 50% activity, on baseline smoking behaviours and... 
Drug metabolism | Clinical trial | CYP2A6 | Pharmacogenetics | Nicotine replacement therapy | Smoking | clinical trial | CYTOCHROME-P450 2A6 | nicotine replacement therapy | PSYCHIATRY | METABOLITE RATIO | BIOCHEMISTRY & MOLECULAR BIOLOGY | COTININE LEVELS |