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Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 2013, Volume 110, Issue 27, pp. 11115 - 11120
...) interact with the aryl hydrocarbon receptor (Ahr) to induce osteoclastic bone resorption through the activation of cytochrome P450 1a/1b (Cyp1) enzymes... 
Bone resorption | Enzymes | Cell lines | Stem cells | Bones | Osteoclasts | Cultured cells | Bone marrow cells | Cigarette smoking | Aryl hydrocarbon receptors | Osteoblast | Skeletal remodeling | Toxicology | Bone formation | toxicology | TARGET | RESORPTION | MULTIDISCIPLINARY SCIENCES | osteoblast | AHR | skeletal remodeling | CANCER | IN-VITRO | INHIBITION | METABOLISM | bone formation | CIGARETTE-SMOKE | HEALTH | OSTEOCLAST DIFFERENTIATION | Smoking - adverse effects | Cytochrome P-450 CYP1A1 - genetics | Receptors, Aryl Hydrocarbon - deficiency | Aryl Hydrocarbon Hydroxylases - biosynthesis | Humans | Aryl Hydrocarbon Hydroxylases - genetics | Male | Carcinogens - toxicity | Cytochrome P-450 CYP1A2 - genetics | Cytochrome P-450 CYP1A2 - deficiency | Bone Resorption - metabolism | Female | Cytochrome P-450 CYP1A1 - deficiency | Disease Models, Animal | Bone Resorption - etiology | Benzo(a)pyrene - toxicity | Smoke - adverse effects | Mice, Inbred C57BL | Receptors, Aryl Hydrocarbon - genetics | Smoking - genetics | Receptors, Aryl Hydrocarbon - physiology | Tobacco - toxicity | Mice, Knockout | Enzyme Induction - genetics | Animals | Aryl Hydrocarbon Hydroxylases - deficiency | Cytochrome P-450 CYP1A2 - biosynthesis | Bone Resorption - pathology | Cytochrome P-450 CYP1B1 | Polychlorinated Dibenzodioxins - toxicity | Mice | Cytochrome P-450 CYP1A1 - biosynthesis | Osteoporosis | Carcinogens | Cocarcinogens | Hydrocarbons | Physiological aspects | Health aspects | Smoking | Index Medicus | Biological Sciences
Journal Article
PloS one, ISSN 1932-6203, 2011, Volume 6, Issue 3, p. e17979
... , * Introduction Accumulation of various genetic alterations has been considered as a prerequisite for cancer development. These genetic alterations often results... 
GENE | GASTRIC-CANCER | PATHWAY | MULTIDISCIPLINARY SCIENCES | ONCOGENIC ACTIVITY | EGFR | FAMILY | Promoter Regions, Genetic | Aryl Hydrocarbon Hydroxylases - antagonists & inhibitors | Humans | Aryl Hydrocarbon Hydroxylases - genetics | Molecular Sequence Data | MAP Kinase Kinase 1 - metabolism | MAP Kinase Kinase 2 - metabolism | DNA Methylation | Base Sequence | DNA | Steroid Hydroxylases - antagonists & inhibitors | Cell Line, Tumor | Proto-Oncogene Protein c-ets-1 - physiology | Polymorphism, Single Nucleotide | Steroid Hydroxylases - genetics | Chromatin | Phosphatases | RNA | Luciferase | Cancer cells | Development and progression | Cancer | Biotechnology | Transcription factors | Ets-1 protein | Immunoprecipitation | Target recognition | Phosphoprotein phosphatase | Leukemia | Stimulation | Biology | Kinases | Phosphatase | Proteins | Angiogenesis | Signal transduction | Evolutionary conservation | Rodents | DNA methylation | Inhibition | Deoxyribonucleic acid--DNA | CpG islands | Antigens | Sequences | Medical technology | Epidermal growth factor receptors | Cloning | Extracellular signal-regulated kinase | Gene expression | Signaling | Hospitals | Inhibitors | Mutagenesis | Adenoviruses | Regulatory mechanisms (biology) | Protein phosphatase | Mutation | Binding sites | Data processing | siRNA | Promoters | Basic Medicine | Steroid Hydroxylases: antagonists & inhibitors | MAP Kinase Kinase 1: metabolism | Medical and Health Sciences | Medicin och hälsovetenskap | Aryl Hydrocarbon Hydroxylases: antagonists & inhibitors | Aryl Hydrocarbon Hydroxylases: genetics | Steroid Hydroxylases: genetics | Medicinsk genetik | Medical Genetics | Medicinska och farmaceutiska grundvetenskaper | Proto-Oncogene Protein c-ets-1: physiology | MAP Kinase Kinase 2: metabolism | Deoxyribonucleic acid
Journal Article
by Thorgeirsson, Thorgeir E and Gudbjartsson, Daniel F and Surakka, Ida and Vink, Jacqueline M and Amin, Najaf and Geller, Frank and Sulem, Patrick and Rafnar, Thorunn and Esko, Tõnu and Walter, Stefan and Gieger, Christian and Rawal, Rajesh and Mangino, Massimo and Prokopenko, Inga and Mägi, Reedik and Keskitalo, Kaisu and Gudjonsdottir, Iris H and Gretarsdottir, Solveig and Stefansson, Hreinn and Thompson, John R and Aulchenko, Yurii S and Nelis, Mari and Aben, Katja K and den Heijer, Martin and Dirksen, Asger and Ashraf, Haseem and Soranzo, Nicole and Valdes, Ana M and Steves, Claire and Uitterlinden, André G and Hofman, Albert and Tönjes, Anke and Kovacs, Peter and Hottenga, Jouke Jan and Willemsen, Gonneke and Vogelzangs, Nicole and Döring, Angela and Dahmen, Norbert and Nitz, Barbara and Pergadia, Michele L and Saez, Berta and De Diego, Veronica and Lezcano, Victoria and Garcia-Prats, Maria D and Ripatti, Samuli and Perola, Markus and Kettunen, Johannes and Hartikainen, Anna-Liisa and Pouta, Anneli and Laitinen, Jaana and Isohanni, Matti and Huei-Yi, Shen and Allen, Maxine and Krestyaninova, Maria and Hall, Alistair S and Jones, Gregory T and van Rij, Andre M and Mueller, Thomas and Dieplinger, Benjamin and Haltmayer, Meinhard and Jonsson, Steinn and Matthiasson, Stefan E and Oskarsson, Hogni and Tyrfingsson, Thorarinn and Kiemeney, Lambertus A and Mayordomo, Jose I and Lindholt, Jes S and Pedersen, Jesper Holst and Franklin, Wilbur A and Wolf, Holly and Montgomery, Grant W and Heath, Andrew C and Martin, Nicholas G and Madden, Pamela A F and Giegling, Ina and Rujescu, Dan and Järvelin, Marjo-Riitta and Salomaa, Veikko and Stumvoll, Michael and Spector, Tim D and Wichmann, H-Erich and Metspalu, Andres and Samani, Nilesh J and Penninx, Brenda W and Oostra, Ben A and Boomsma, Dorret I and Tiemeier, Henning and van Duijn, Cornelia M and Kaprio, Jaakko and Gulcher, Jeffrey R and McCarthy, Mark I and Peltonen, Leena and Thorsteinsdottir, Unnur and Stefansson, Kari and The ENGAGE Consortium and ENGAGE Consortium
Nature genetics, ISSN 1546-1718, 2010, Volume 42, Issue 5, pp. 448 - 453
Journal Article
Toxicology and applied pharmacology, ISSN 0041-008X, 07/2013, Volume 270, Issue 2, pp. 174 - 184
CYP3A proteins are the most abundant CYPs in the liver and intestines, and they play a pivotal role in drug metabolism. In mammals, CYP3A genes are induced by... 
Zebrafish | AHR2 | Intestine | Liver | Dioxin | CYP3A65 | CYTOCHROME-P450 | NUCLEAR RECEPTORS | INDUCTION | IDENTIFICATION | PREGNANE-X-RECEPTOR | GENE | ARYL-HYDROCARBON RECEPTOR | SIGNALING PATHWAY | PHARMACOLOGY & PHARMACY | TOXICOLOGY | LIGAND | EXPRESSION | Gene Expression Regulation, Enzymologic - drug effects | Aryl Hydrocarbon Hydroxylases - biosynthesis | Oxidoreductases, N-Demethylating - genetics | Liver - enzymology | Aryl Hydrocarbon Hydroxylases - genetics | Green Fluorescent Proteins - genetics | RNA, Messenger - biosynthesis | Liver - drug effects | Polychlorinated Dibenzodioxins - pharmacology | Receptors, Aryl Hydrocarbon - metabolism | Oxidoreductases, N-Demethylating - metabolism | Green Fluorescent Proteins - metabolism | Zebrafish Proteins - biosynthesis | Animals, Genetically Modified | Zebrafish Proteins - metabolism | Liver - metabolism | RNA, Messenger - genetics | Receptors, Aryl Hydrocarbon - genetics | In Situ Hybridization, Fluorescence | Zebrafish - genetics | Aryl Hydrocarbon Hydroxylases - metabolism | Animals | Green Fluorescent Proteins - biosynthesis | Zebrafish - metabolism | Liver - physiology | Oxidoreductases, N-Demethylating - biosynthesis | Zebrafish Proteins - genetics | Proteins | Herbicides | Cytochrome P-450 | Physiological aspects | Tryptophan | Genetic engineering | Genetic transcription | Xenobiotics | Index Medicus | DIOXIN | KYNURENINE | TRYPTOPHAN | ANTIBIOTICS | DEXAMETHASONE | METABOLISM | DNA | GENES | LIVER | TRANSCRIPTION | INTESTINES | 60 APPLIED LIFE SCIENCES
Journal Article
Toxicology and applied pharmacology, ISSN 0041-008X, 09/2014, Volume 279, Issue 3, pp. 380 - 390
Polychlorinated biphenyls (PCBs) are persistent organic pollutants associated with non-alcoholic fatty liver disease (NAFLD) in epidemiologic studies. The... 
PCBs | NAFLD | AhR | PXR | CAR | Aroclor 1260 | PREGNANE-X-RECEPTOR | CROSS-TALK | CONSTITUTIVE ANDROSTANE RECEPTOR | INSULIN-RESISTANCE | GENE-EXPRESSION | PHARMACOLOGY & PHARMACY | MICE | TOXICOLOGY | ENERGY-METABOLISM | HEPATIC STEATOSIS | POLYCHLORINATED-BIPHENYLS | DRUG-METABOLISM | Inflammation - chemically induced | Receptors, Aryl Hydrocarbon - biosynthesis | Inflammation - pathology | Aryl Hydrocarbon Hydroxylases - biosynthesis | Liver - pathology | Toll-Like Receptor 4 - biosynthesis | Gene Expression - drug effects | Fatty Liver - pathology | Aryl Hydrocarbon Hydroxylases - genetics | Fatty Liver - chemically induced | Aroclors - toxicity | Cytochrome P450 Family 2 | Cytochrome P-450 CYP3A - genetics | Non-alcoholic Fatty Liver Disease | Environmental Pollutants - toxicity | Real-Time Polymerase Chain Reaction | Steroid Hydroxylases - genetics | Cytochrome P-450 CYP3A - biosynthesis | Glucose Tolerance Test | Obesity - chemically induced | Membrane Proteins - genetics | Mice, Inbred C57BL | Adipose Tissue - pathology | Receptors, Aryl Hydrocarbon - genetics | Toll-Like Receptor 4 - genetics | Adipokines - metabolism | Cholesterol - metabolism | Obesity - pathology | Triglycerides - metabolism | Membrane Proteins - biosynthesis | Animals | Diet | Mice | Blood Glucose - metabolism | Steroid Hydroxylases - biosynthesis | POLYCHLORINATED BIPHENYLS | 60 APPLIED LIFE SCIENCES | DIET | LYMPHOKINES | GLUCOSE | INFLAMMATION | GENES | LIVER | CORN OIL | FATS | METABOLIC DISEASES | RADIOPROTECTIVE SUBSTANCES | RECEPTORS | SCANNING ELECTRON MICROSCOPY | AMINOTRANSFERASES | BLOOD | HEMATOXYLIN
Journal Article
The New England journal of medicine, ISSN 1533-4406, 2009, Volume 360, Issue 4, pp. 363 - 375
...T h e n e w e ngl a nd j o u r na l o f m e dic i n e n engl j med 360;4 nejm.org january 22, 2009 363 original article Genetic Determinants of Response... 
ST-ELEVATION | MEDICINE, GENERAL & INTERNAL | PERCUTANEOUS CORONARY INTERVENTION | DUODENAL ENTEROCYTES | OF-FUNCTION POLYMORPHISM | SEQUENCE VARIATIONS | MDR1 GENE | DRUG RESPONSE | ASPIRIN | ELEVATION MYOCARDIAL-INFARCTION | P-GLYCOPROTEIN | Myocardial Infarction - genetics | Myocardial Infarction - epidemiology | Follow-Up Studies | Ticlopidine - pharmacology | Ticlopidine - therapeutic use | Humans | Middle Aged | Aryl Hydrocarbon Hydroxylases - genetics | Male | Angioplasty, Balloon, Coronary | Myocardial Infarction - therapy | Cytochrome P-450 CYP3A - genetics | Receptors, Purinergic P2 - genetics | Receptors, Purinergic P2Y12 | Ticlopidine - adverse effects | Platelet Aggregation Inhibitors - pharmacology | Female | Integrin beta3 - genetics | Registries | Stroke - epidemiology | Platelet Aggregation - drug effects | Platelet Aggregation Inhibitors - therapeutic use | Platelet Aggregation Inhibitors - adverse effects | Mortality | Genotype | Combined Modality Therapy | Ticlopidine - analogs & derivatives | Aryl Hydrocarbon Hydroxylases - metabolism | Polymorphism, Genetic | ATP-Binding Cassette, Sub-Family B, Member 1 - genetics | Cytochrome P-450 CYP2C19 | ATP Binding Cassette Transporter, Sub-Family B | Aged | Mutation | Complications and side effects | Usage | Analysis | Clopidogrel | Cardiovascular diseases | Genetic polymorphisms | Risk factors | Heart attacks | Biomedical research | Angina pectoris | Acute coronary syndromes | Kinases | Index Medicus | Abridged Index Medicus
Journal Article
Molecular Psychiatry, ISSN 1359-4184, 05/2004, Volume 9, Issue 5, pp. 442 - 473
Genetic factors contribute to the phenotype of drug response. We systematically analyzed all available pharmacogenetic data from Medline databases (1970-2003... 
Antidepressant | Antipsychotic | Pharmacogenetics | Cytochrome P450 | Dose recommendation | Pharmacogenomics | NEUROLEPTIC-MALIGNANT-SYNDROME | PSYCHIATRY | BIOCHEMISTRY & MOLECULAR BIOLOGY | antidepressant | DOPAMINE D3 RECEPTOR | cytochrome P450 | SEROTONIN TRANSPORTER GENE | NEUROSCIENCES | CYTOCHROME-P450 2D6 CYP2D6 | AMITRIPTYLINE N-DEMETHYLATION | CATECHOL-O-METHYLTRANSFERASE | INDUCED MOVEMENT-DISORDERS | pharmacogenomics | dose recommendation | MANGANESE SUPEROXIDE-DISMUTASE | antipsychotic | STATE PLASMA-CONCENTRATIONS | ULTRARAPID METABOLIZER PHENOTYPE | pharmacogenetics | Cytochrome P-450 CYP2C9 | Mixed Function Oxygenases - deficiency | Humans | Aryl Hydrocarbon Hydroxylases - genetics | Mixed Function Oxygenases - metabolism | Cytochromes - genetics | Receptors, Neurotransmitter - genetics | Cytochrome P-450 CYP2D6 - deficiency | Dose-Response Relationship, Drug | Genetic Variation | Cytochromes - metabolism | Dopamine - metabolism | Cytochrome P-450 CYP2D6 - genetics | Genotype | Antipsychotic Agents - pharmacokinetics | Aryl Hydrocarbon Hydroxylases - metabolism | Antipsychotic Agents - administration & dosage | Carrier Proteins - genetics | Drug Resistance - genetics | Phenotype | Norepinephrine - metabolism | Aryl Hydrocarbon Hydroxylases - deficiency | Cytochrome P-450 CYP2C19 | Epistasis, Genetic | Serotonin - metabolism | Alleles | Cytochrome P-450 CYP2D6 - metabolism | Antidepressive Agents - administration & dosage | Inactivation, Metabolic - genetics | Antidepressive Agents - pharmacokinetics | Mixed Function Oxygenases - genetics
Journal Article