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Science, ISSN 0036-8075, 9/2010, Volume 329, Issue 5997, pp. 1345 - 1348
Although practiced clinically for more than 40 years, the use of hematopoietic stem cell (HSC) transplants remains limited by the ability to expand these cells... 
Hep G2 cells | Cytokines | REPORTS | Stem cells | Multipotent stem cells | Bone marrow | Cultured cells | Transplantation | Aryl hydrocarbon receptors | Hematopoietic stem cells | Blood | EX-VIVO EXPANSION | ENGRAFTMENT | MULTIDISCIPLINARY SCIENCES | BONE-MARROW | BIOLOGY | MICE | UMBILICAL-CORD BLOOD | BINDING | TRANSPLANTATION | Antigens, CD34 - analysis | Cell Proliferation | Receptors, Aryl Hydrocarbon - antagonists & inhibitors | Species Specificity | Cell Count | Humans | Aryl Hydrocarbon Hydroxylases - genetics | Antigens, CD - analysis | Multipotent Stem Cells - drug effects | Hematopoiesis | Polychlorinated Dibenzodioxins - pharmacology | Hematopoietic Stem Cells - physiology | Receptors, Aryl Hydrocarbon - metabolism | Multipotent Stem Cells - physiology | Hematopoietic Stem Cells - drug effects | Signal Transduction | Purines - metabolism | Purines - pharmacology | Cells, Cultured | Hematopoietic Stem Cell Transplantation | Hematopoietic Stem Cells - metabolism | Mice, SCID | AC133 Antigen | Aryl Hydrocarbon Hydroxylases - metabolism | Cell Lineage | Animals | Multipotent Stem Cells - cytology | Small Molecule Libraries | Hematopoietic Stem Cells - cytology | Cytochrome P-450 CYP1B1 | Mice, Inbred NOD | Mice | Glycoproteins - analysis | Cytokines - pharmacology | Peptides - analysis | Physiological aspects | Arylation | Human | Receptors | Aromatic compounds | Modulation | Hydrocarbons | Derivatives | Culture | Index Medicus
Journal Article
Drug Metabolism and Disposition, ISSN 0090-9556, 01/2010, Volume 38, Issue 1, pp. 92 - 99
The aim of the current study is to identify the human cytochrome P450 (P450) isoforms involved in the two oxidative steps in the bioactivation of clopidogrel... 
MECHANISM-BASED INHIBITION | ANTIAGGREGATING ACTIVITY | POLYMORPHISMS | TICLOPIDINE | PHARMACOKINETICS | HEALTHY-SUBJECTS | PHARMACOLOGY & PHARMACY | PRASUGREL | PHARMACODYNAMICS | MONOCLONAL-ANTIBODIES | ATORVASTATIN | Microsomes - metabolism | Humans | Aryl Hydrocarbon Hydroxylases - genetics | Cytochrome P-450 Enzyme System - metabolism | Sulfaphenazole - pharmacology | Microsomes - drug effects | Cytochrome P-450 CYP3A - genetics | Cytochrome P-450 CYP1A2 - genetics | Antibodies - immunology | Omeprazole - pharmacology | Microsomes, Liver - enzymology | Platelet Aggregation Inhibitors - pharmacokinetics | Ticlopidine - pharmacokinetics | Oxidoreductases, N-Demethylating - metabolism | Aryl Hydrocarbon Hydroxylases - immunology | Oxidation-Reduction | Enzyme Inhibitors - pharmacology | Ticlopidine - analogs & derivatives | Oxidoreductases, N-Demethylating - immunology | Cytochrome P-450 CYP3A - metabolism | Cell Line, Tumor | Cytochrome P-450 Enzyme System - genetics | Theophylline - pharmacology | Kinetics | Cytochrome P-450 CYP2C9 | Theophylline - analogs & derivatives | Oxidoreductases, N-Demethylating - genetics | Glutathione - metabolism | Ketoconazole - pharmacology | Biotransformation - physiology | Cytochrome P-450 CYP1A2 Inhibitors | Microsomes, Liver - drug effects | Ticlopidine - metabolism | NADP - metabolism | Platelet Aggregation Inhibitors - metabolism | Cytochrome P-450 CYP3A - immunology | Cell Line | Aryl Hydrocarbon Hydroxylases - antagonists & inhibitors | Cytochrome P-450 CYP1A2 - immunology | Biocatalysis | Mephenytoin - analogs & derivatives | Cytochrome P-450 CYP1A2 - metabolism | Aryl Hydrocarbon Hydroxylases - metabolism | Mephenytoin - pharmacology | Antibodies - pharmacology | Cytochrome P-450 CYP3A Inhibitors | Cytochrome P-450 CYP2C19 | Clopidogrel | Cytochrome P-450 CYP2B6 | Index Medicus
Journal Article
Nature, ISSN 0028-0836, 07/2003, Volume 424, Issue 6947, pp. 464 - 468
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 08/2004, Volume 279, Issue 34, pp. 35630 - 35637
Journal Article
Blood, ISSN 0006-4971, 07/2013, Volume 122, Issue 3, pp. 376 - 385
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 01/2009, Volume 360, Issue 4, pp. 363 - 375
In a cohort of 2208 patients who presented with acute myocardial infarction and were treated with clopidogrel, single-nucleotide polymorphisms in five genes... 
MEDICINE, GENERAL & INTERNAL | PERCUTANEOUS CORONARY INTERVENTION | HEALTHY JAPANESE SUBJECTS | CONTROLLED TRIAL | MYOCARDIAL-INFARCTION | DUODENAL ENTEROCYTES | OF-FUNCTION POLYMORPHISM | SEQUENCE VARIATIONS | ST-SEGMENT ELEVATION | DRUG RESPONSE | P-GLYCOPROTEIN | Myocardial Infarction - genetics | Myocardial Infarction - epidemiology | Follow-Up Studies | Ticlopidine - pharmacology | Ticlopidine - therapeutic use | Humans | Middle Aged | Aryl Hydrocarbon Hydroxylases - genetics | Male | Angioplasty, Balloon, Coronary | Myocardial Infarction - therapy | Cytochrome P-450 CYP3A - genetics | Receptors, Purinergic P2 - genetics | Receptors, Purinergic P2Y12 | Ticlopidine - adverse effects | Platelet Aggregation Inhibitors - pharmacology | Female | Integrin beta3 - genetics | Registries | Stroke - epidemiology | Platelet Aggregation - drug effects | Platelet Aggregation Inhibitors - therapeutic use | Platelet Aggregation Inhibitors - adverse effects | Mortality | Genotype | Combined Modality Therapy | Ticlopidine - analogs & derivatives | Aryl Hydrocarbon Hydroxylases - metabolism | Polymorphism, Genetic | ATP-Binding Cassette, Sub-Family B, Member 1 - genetics | Cytochrome P-450 CYP2C19 | ATP Binding Cassette Transporter, Sub-Family B | Aged | Mutation | Complications and side effects | Usage | Analysis | Clopidogrel | Cardiovascular diseases | Genetic polymorphisms | Risk factors | Heart attacks | Biomedical research | Angina pectoris | Acute coronary syndromes | Kinases | Index Medicus | Abridged Index Medicus
Journal Article
Circulation, ISSN 0009-7322, 02/2010, Volume 121, Issue 4, pp. 512 - 518
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 01/2012, Volume 122, Issue 1, pp. 178 - 191
Journal Article
Journal Article
Journal of Thrombosis and Haemostasis, ISSN 1538-7933, 12/2007, Volume 5, Issue 12, pp. 2429 - 2436
Background:  Thienopyridines are metabolized to active metabolites that irreversibly inhibit the platelet P2Y 12 adenosine diphosphate receptor. The... 
clopidogrel | prasugrel | receptor | P2Y | platelet function | thienopyridines | cytochrome P450 enzymes | Prasugrel | Cytochrome P450 enzymes | Platelet function | Thienopyridines | Clopidogrel | MYOCARDIAL-INFARCTION | STENT THROMBOSIS | ANTIPLATELET THERAPY | ATHEROTHROMBOTIC EVENTS | INCREASED RISK | P2Y receptor | THIENOPYRIDINE P2Y INHIBITOR | PERIPHERAL VASCULAR DISEASE | ST-SEGMENT ELEVATION | HEMATOLOGY | CORONARY-ARTERY-DISEASE | PLATELET REACTIVITY | ACTIVE METABOLITE | Cytochrome P-450 CYP2C9 | Prasugrel Hydrochloride | Ticlopidine - pharmacology | Area Under Curve | Humans | Middle Aged | Aryl Hydrocarbon Hydroxylases - genetics | Male | Mixed Function Oxygenases - metabolism | Reference Values | Thiophenes - blood | Platelet Aggregation Inhibitors - blood | Receptors, Purinergic P2Y12 | Platelet Aggregation Inhibitors - pharmacology | Adult | Female | Platelet Aggregation - drug effects | Platelet Aggregation Inhibitors - pharmacokinetics | Retrospective Studies | Ticlopidine - pharmacokinetics | Piperazines - pharmacokinetics | Blood Platelets - drug effects | Piperazines - blood | Purinergic P2 Receptor Antagonists | Thiophenes - pharmacology | Genotype | Clinical Trials as Topic | Piperazines - pharmacology | Ticlopidine - analogs & derivatives | Aryl Hydrocarbon Hydroxylases - metabolism | Polymorphism, Genetic | Cross-Over Studies | Thiophenes - pharmacokinetics | Phenotype | Prodrugs - pharmacokinetics | Blood Platelets - metabolism | Cytochrome P-450 CYP2C19 | Receptors, Purinergic P2 - metabolism | Mixed Function Oxygenases - genetics | Prodrugs - pharmacology | Research Design | Ticlopidine - blood | Adenosine diphosphate | Genetic aspects | Metabolites | Cytochrome P-450 | Index Medicus
Journal Article