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Drug Metabolism and Disposition, ISSN 0090-9556, 01/2010, Volume 38, Issue 1, pp. 92 - 99
The aim of the current study is to identify the human cytochrome P450 (P450) isoforms involved in the two oxidative steps in the bioactivation of clopidogrel... 
MECHANISM-BASED INHIBITION | ANTIAGGREGATING ACTIVITY | POLYMORPHISMS | TICLOPIDINE | PHARMACOKINETICS | HEALTHY-SUBJECTS | PHARMACOLOGY & PHARMACY | PRASUGREL | PHARMACODYNAMICS | MONOCLONAL-ANTIBODIES | ATORVASTATIN | Microsomes - metabolism | Humans | Aryl Hydrocarbon Hydroxylases - genetics | Cytochrome P-450 Enzyme System - metabolism | Sulfaphenazole - pharmacology | Microsomes - drug effects | Cytochrome P-450 CYP3A - genetics | Cytochrome P-450 CYP1A2 - genetics | Antibodies - immunology | Omeprazole - pharmacology | Microsomes, Liver - enzymology | Platelet Aggregation Inhibitors - pharmacokinetics | Ticlopidine - pharmacokinetics | Oxidoreductases, N-Demethylating - metabolism | Aryl Hydrocarbon Hydroxylases - immunology | Oxidation-Reduction | Enzyme Inhibitors - pharmacology | Ticlopidine - analogs & derivatives | Oxidoreductases, N-Demethylating - immunology | Cytochrome P-450 CYP3A - metabolism | Cell Line, Tumor | Cytochrome P-450 Enzyme System - genetics | Theophylline - pharmacology | Kinetics | Cytochrome P-450 CYP2C9 | Theophylline - analogs & derivatives | Oxidoreductases, N-Demethylating - genetics | Glutathione - metabolism | Ketoconazole - pharmacology | Biotransformation - physiology | Cytochrome P-450 CYP1A2 Inhibitors | Microsomes, Liver - drug effects | Ticlopidine - metabolism | NADP - metabolism | Platelet Aggregation Inhibitors - metabolism | Cytochrome P-450 CYP3A - immunology | Cell Line | Aryl Hydrocarbon Hydroxylases - antagonists & inhibitors | Cytochrome P-450 CYP1A2 - immunology | Biocatalysis | Mephenytoin - analogs & derivatives | Cytochrome P-450 CYP1A2 - metabolism | Aryl Hydrocarbon Hydroxylases - metabolism | Mephenytoin - pharmacology | Antibodies - pharmacology | Cytochrome P-450 CYP3A Inhibitors | Cytochrome P-450 CYP2C19 | Clopidogrel | Cytochrome P-450 CYP2B6
Journal Article
Clinical Pharmacology & Therapeutics, ISSN 0009-9236, 05/2005, Volume 77, Issue 5, pp. 341 - 352
Cytochrome P450 (CYP) 2C9 has been a relatively neglected member of the human CYP2C family. Over the period from 2000 through 2003, PubMed searches with the... 
Cytochrome P-450 CYP2C8 | Aryl Hydrocarbon Hydroxylases - antagonists & inhibitors | Pharmacogenetics | Humans | Aryl Hydrocarbon Hydroxylases - genetics | Polymorphism, Genetic - genetics | Polymorphism, Genetic - drug effects | Aryl Hydrocarbon Hydroxylases - metabolism
Journal Article
Journal of Thrombosis and Haemostasis, ISSN 1538-7933, 11/2006, Volume 4, Issue 11, pp. 2508 - 2509
HEMATOLOGY | PERIPHERAL VASCULAR DISEASE | Ticlopidine - pharmacology | Humans | Aryl Hydrocarbon Hydroxylases - genetics | Ticlopidine - antagonists & inhibitors | Male | Mixed Function Oxygenases - metabolism | Omeprazole - antagonists & inhibitors | Phosphoproteins - metabolism | Coronary Disease - metabolism | Protein Processing, Post-Translational - drug effects | Coronary Disease - complications | Platelet Aggregation Inhibitors - pharmacology | Female | Omeprazole - pharmacology | Microfilament Proteins - metabolism | Aspirin - pharmacology | Phosphorylation - drug effects | Aspirin - antagonists & inhibitors | Aryl Hydrocarbon Hydroxylases - antagonists & inhibitors | Platelet Function Tests - methods | Enzyme Inhibitors - pharmacology | Angioplasty - methods | Mixed Function Oxygenases - antagonists & inhibitors | Cell Adhesion Molecules - metabolism | Ticlopidine - analogs & derivatives | Aryl Hydrocarbon Hydroxylases - metabolism | Platelet Activation - genetics | Thrombosis - metabolism | Angioplasty - adverse effects | Coronary Disease - genetics | Drug Antagonism | Cytochrome P-450 CYP2C19 | Thrombosis - etiology | Thrombosis - genetics | Aged | Platelet Activation - drug effects | Polymorphism, Single Nucleotide | Coronary Disease - surgery | Mixed Function Oxygenases - genetics | Phosphorylation | Enzyme Inhibitors | Angioplasty | Cell Adhesion Molecules | Mixed Function Oxygenases | Life Sciences | Coronary Disease | Phosphoproteins | Platelet Function Tests | Aspirin | Thrombosis | Ticlopidine | Omeprazole | Human health and pathology | Microfilament Proteins | Platelet Activation | Platelet Aggregation Inhibitors | Protein Processing, Post-Translational | Aryl Hydrocarbon Hydroxylases
Journal Article
Circulation, ISSN 0009-7322, 08/2012, Volume 126, Issue 9, pp. 1087 - 1098
Background-Pulmonary arterial hypertension (PAH) is a hyperproliferative vascular disorder observed predominantly in women. Estrogen is a potent mitogen in... 
Hypertension | Animal | Estrogens | Models | Cardiovascular diseases | Metabolism | Pulmonary | models animal | SEROTONIN TRANSPORTER | CARDIAC & CARDIOVASCULAR SYSTEMS | hypertension pulmonary | P450CYP1B1 | estrogens | cardiovascular diseases | P4501B1 CYP1B1 | HYPOXIA | BREAST-CANCER | IN-VIVO | ESTRADIOL | GENE-EXPRESSION | PERIPHERAL VASCULAR DISEASE | metabolism | MICE | 2-METHOXYESTRADIOL | Up-Regulation | Aryl Hydrocarbon Hydroxylases - biosynthesis | Humans | Aryl Hydrocarbon Hydroxylases - genetics | Myocytes, Smooth Muscle - pathology | Male | Stilbenes - pharmacology | Hypertension, Pulmonary - chemically induced | Lung - enzymology | Cell Hypoxia | Hydroxyestrones - toxicity | Aryl Hydrocarbon Hydroxylases - physiology | Female | Estrogens - metabolism | Myocytes, Smooth Muscle - metabolism | Estradiol - pharmacology | Hypertension, Pulmonary - enzymology | Aryl Hydrocarbon Hydroxylases - antagonists & inhibitors | Cells, Cultured - drug effects | Lung - pathology | Hydroxyestrones - pharmacology | Enzyme Induction | Hypoxia - complications | Hypertrophy, Right Ventricular - enzymology | Reverse Transcriptase Polymerase Chain Reaction | Pulmonary Artery - enzymology | Mice, Knockout | Animals | Aryl Hydrocarbon Hydroxylases - deficiency | Hydroxyestrones - metabolism | Cytochrome P-450 CYP1B1 | Cells, Cultured - metabolism | Mice | Chronic Disease | Hypertension, Pulmonary - etiology | Hypertension, Pulmonary - pathology | Pulmonary Artery - pathology | Physiological aspects | Development and progression | Research | Pulmonary hypertension | Cytochrome P-450 | Estrogen
Journal Article
PLoS ONE, ISSN 1932-6203, 2011, Volume 6, Issue 3, p. e17979
EGFR-MEK-ERK signaling pathway has an established role in promoting malignant growth and disease progression in human cancers. Therefore identification of... 
TRANSCRIPTION FACTORS | HUMAN MALIGNANCIES | GASTRIC-CANCER | PATHWAY | GROWTH | BIOLOGY | GENE-EXPRESSION | ACUTE MYELOID-LEUKEMIA | ONCOGENIC ACTIVITY | EGFR | FAMILY | Promoter Regions, Genetic | Aryl Hydrocarbon Hydroxylases - antagonists & inhibitors | Humans | Aryl Hydrocarbon Hydroxylases - genetics | Molecular Sequence Data | MAP Kinase Kinase 1 - metabolism | MAP Kinase Kinase 2 - metabolism | DNA Methylation | Base Sequence | DNA | Steroid Hydroxylases - antagonists & inhibitors | Cell Line, Tumor | Proto-Oncogene Protein c-ets-1 - physiology | Polymorphism, Single Nucleotide | Steroid Hydroxylases - genetics | Chromatin | Phosphatases | RNA | Luciferase | Cancer cells | Development and progression | Cancer | Biotechnology | Transcription factors | Ets-1 protein | Immunoprecipitation | Target recognition | Phosphoprotein phosphatase | Leukemia | Stimulation | Biology | Kinases | Phosphatase | Proteins | Angiogenesis | Signal transduction | Evolutionary conservation | Rodents | DNA methylation | Inhibition | Deoxyribonucleic acid--DNA | CpG islands | Antigens | Sequences | Medical technology | Epidermal growth factor receptors | Cloning | Extracellular signal-regulated kinase | Gene expression | Signaling | Hospitals | Inhibitors | Mutagenesis | Adenoviruses | Regulatory mechanisms (biology) | Protein phosphatase | Mutation | Binding sites | Data processing | siRNA | Promoters | Basic Medicine | Steroid Hydroxylases: antagonists & inhibitors | MAP Kinase Kinase 1: metabolism | Medical and Health Sciences | Medicin och hälsovetenskap | Aryl Hydrocarbon Hydroxylases: antagonists & inhibitors | Aryl Hydrocarbon Hydroxylases: genetics | Steroid Hydroxylases: genetics | Medicinsk genetik | Medical Genetics | Medicinska och farmaceutiska grundvetenskaper | Proto-Oncogene Protein c-ets-1: physiology | MAP Kinase Kinase 2: metabolism | Deoxyribonucleic acid
Journal Article
Drug Metabolism and Disposition, ISSN 0090-9556, 08/2007, Volume 35, Issue 8, pp. 1400 - 1407
The elimination process of the endothelin receptor antagonist bosentan (Tracleer) in humans is entirely dependent on metabolism mediated by two cytochrome P450... 
PHARMACOKINETICS | METABOLISM | HEALTHY MALE-SUBJECTS | PHARMACOLOGY & PHARMACY | ANION TRANSPORTING POLYPEPTIDES | HUMAN LIVER | RIFAMYCIN SV | EXPRESSION | DISPOSITION | ENDOTHELIN RECEPTOR ANTAGONIST | DRUG-DRUG INTERACTION | Cytochrome P-450 CYP2C9 | Organic Anion Transporters, Sodium-Independent - genetics | Estradiol - analogs & derivatives | Organic Anion Transporters, Sodium-Independent - antagonists & inhibitors | Cricetulus | Cytochrome P-450 Enzyme Inhibitors | Cyclosporine - pharmacology | Cytochrome P-450 CYP3A | Humans | Warfarin - metabolism | Cytochrome P-450 Enzyme System - metabolism | Dehydroepiandrosterone Sulfate - metabolism | Sulfones - pharmacology | Organic Anion Transporters - metabolism | Pyrimidines - chemistry | Pyrimidines - metabolism | Sildenafil Citrate | Organic Anion Transporters - genetics | Bosentan | Drug Interactions | Organic Anion Transporters, Sodium-Independent - metabolism | Biological Transport - drug effects | Molecular Structure | Solute Carrier Organic Anion Transporter Family Member 1B3 | CHO Cells | Estradiol - metabolism | Aryl Hydrocarbon Hydroxylases - antagonists & inhibitors | Cricetinae | Organic Anion Transporters - antagonists & inhibitors | Sulfonamides - chemistry | Purines - pharmacology | Enzyme Inhibitors - pharmacology | Piperazines - pharmacology | Sulfonamides - pharmacokinetics | Aryl Hydrocarbon Hydroxylases - metabolism | Animals | Estrone - analogs & derivatives | Estrone - metabolism | Sulfonamides - metabolism | Liver-Specific Organic Anion Transporter 1 | Rifampin - pharmacology
Journal Article
Pharmacology and Therapeutics, ISSN 0163-7258, 2010, Volume 126, Issue 1, pp. 9 - 20
Journal Article
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 09/2004, Volume 351, Issue 11, pp. 1089 - 1096
Journal Article
Journal Article