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Molecular Medicine, ISSN 1076-1551, 2014, Volume 20, Issue 1, pp. 215 - 220
Journal Article
Annual Review of Physiology, ISSN 0066-4278, 03/2009, Volume 72, Issue 1, pp. 625 - 645
The Per-Arnt-Sim (PAS) domain is conserved across the kingdoms of life and found in an ever-growing list of proteins. This domain can bind to and sense... 
Toxicology | Mouse | Dioxin | Channel | Genetics | Hypoxia | Circadian | toxicology | hypoxia | HYPOXIA-INDUCIBLE FACTOR | PHYSIOLOGY | PAS-B DOMAIN | channel | TISSUE-SPECIFIC EXPRESSION | DNA-BINDING ACTIVITY | HEAT-SHOCK-PROTEIN | mouse | circadian | dioxin | genetics | ARYL-HYDROCARBON RECEPTOR | RESPONSIVE TRANSCRIPTION FACTOR | HELIX-LOOP-HELIX | SUPRACHIASMATIC CIRCADIAN CLOCK | ENDOTHELIAL GROWTH-FACTOR | Period Circadian Proteins - chemistry | Basic Helix-Loop-Helix Transcription Factors - classification | Polycyclic Aromatic Hydrocarbons - toxicity | Humans | Adaptation, Physiological - drug effects | Aryl Hydrocarbon Receptor Nuclear Translocator - chemistry | Dioxins - toxicity | Period Circadian Proteins - genetics | Adaptation, Physiological - genetics | Mammals - physiology | Amino Acid Sequence | Period Circadian Proteins - physiology | Basic Helix-Loop-Helix Transcription Factors - physiology | Basic Helix-Loop-Helix Transcription Factors - genetics | Period Circadian Proteins - classification | Aryl Hydrocarbon Receptor Nuclear Translocator - physiology | Adaptation, Physiological - physiology | Terminology as Topic | Circadian Rhythm - physiology | Animals | Signal Transduction - drug effects | Hypoxia - pathology | Environment | Aryl Hydrocarbon Receptor Nuclear Translocator - genetics | Aryl Hydrocarbon Receptor Nuclear Translocator - classification | Basic Helix-Loop-Helix Transcription Factors - chemistry | Circadian rhythms | Polycyclic aromatic hydrocarbons | Analysis | Physiological aspects | Research | Adaptation (Physiology) | Xenobiotics
Journal Article
Molecular Endocrinology, ISSN 0888-8809, 02/2008, Volume 22, Issue 2, pp. 304 - 316
Journal Article
Journal Article
Journal of Experimental Medicine, ISSN 0022-1007, 12/2012, Volume 209, Issue 13, pp. 2441 - 2453
mTORC1 (mammalian target of rapamycin complex 1) controls transcriptional programs that determine CD8(+) cytolytic T cell (CTL) fate. In some cell systems,... 
MAMMALIAN TARGET | RAPAMYCIN | SURVIVAL | MEDICINE, RESEARCH & EXPERIMENTAL | EFFECTOR FUNCTIONS | L-SELECTIN | ACTIVATION | KINASE | RECEPTOR | DIFFERENTIATION | IMMUNOLOGY | LYMPHOCYTES | CD8-Positive T-Lymphocytes - cytology | TOR Serine-Threonine Kinases - metabolism | Multiprotein Complexes | Phosphatidylinositol 3-Kinases - metabolism | Aryl Hydrocarbon Receptor Nuclear Translocator - metabolism | Hypoxia-Inducible Factor 1 - metabolism | Cell Movement - physiology | Hypoxia-Inducible Factor 1 - genetics | Mechanistic Target of Rapamycin Complex 1 | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Mice, Mutant Strains | CD8-Positive T-Lymphocytes - metabolism | Proto-Oncogene Proteins c-akt - metabolism | Cell Differentiation - physiology | 3-Phosphoinositide-Dependent Protein Kinases | Protein-Serine-Threonine Kinases - metabolism | Receptors, Antigen, T-Cell - metabolism | Hypoxia-Inducible Factor 1, alpha Subunit - genetics | Mice, Inbred C57BL | Receptors, Chemokine - metabolism | Gene Expression Regulation | Protein-Serine-Threonine Kinases - genetics | Mice, Transgenic | Phosphatidylinositol 3-Kinases - genetics | Animals | Proteins - metabolism | Glucose - metabolism | Glycolysis | Interleukin-2 - pharmacology | Aryl Hydrocarbon Receptor Nuclear Translocator - genetics | Chemokines - metabolism | Mice | CD8-Positive T-Lymphocytes - immunology
Journal Article
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 01/2012, Volume 7, Issue 1, p. e29545
The activated AHR/ARNT complex (AHRC) regulates the expression of target genes upon exposure to environmental contaminants such as... 
RECRUITMENT | PROTEIN ARNT | COACTIVATOR | ACTIVATION | SYNERGISTIC INDUCTION | BIOLOGY | GENE-EXPRESSION | BINDING ACTIVITY | DIOXIN RECEPTOR | TRANSCRIPTIONAL RESPONSE | 2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN | Transcription, Genetic - drug effects | Aryl Hydrocarbon Receptor Nuclear Translocator - deficiency | Humans | RNA, Messenger - genetics | Aryl Hydrocarbon Receptor Nuclear Translocator - metabolism | RNA, Messenger - metabolism | Gene Knockdown Techniques | Phenotype | Signal Transduction - drug effects | Polychlorinated Dibenzodioxins - pharmacology | Cell Line, Tumor | Receptors, Aryl Hydrocarbon - metabolism | Estrogen Receptor alpha - metabolism | Aryl Hydrocarbon Receptor Nuclear Translocator - genetics | Cell Proliferation - drug effects | Estrogens - metabolism | Herbicides | Dioxin | Genes | Estrogen | Phenols | Genetic aspects | Genetic transcription | Cancer | Cell proliferation | Health sciences | Transcription factors | Estrogens | Crosstalk | Hydrocarbons | Estrogen receptors | Dioxins | TCDD | Recruitment | Proteins | Toxicology | Aromatic compounds | Rodents | Physiology | Naphthoflavone | Endometrium | Deoxyribonucleic acid--DNA | Cytokines | Breast cancer | siRNA | Roles | Tumor cell lines | Gene expression | Gene silencing | Signaling | Presenilin 2 | Contaminants | Cell lines | Stem cells | Hypoxia | Ligands | Deoxyribonucleic acid | DNA
Journal Article
Nature, ISSN 0028-0836, 2016, Volume 539, Issue 7627, pp. 112 - 117
Clear cell renal cell carcinoma (ccRCC) is characterized by inactivation of the von Hippel-Lindau tumour suppressor gene (VHL)(1,2). Because no other gene is... 
HIF-2-ALPHA | INHIBITION | RNA | PAS-B DOMAIN | MULTIDISCIPLINARY SCIENCES | IN-VIVO | TUMOR-SUPPRESSOR GENE | HIF2-ALPHA | HYPOXIA-INDUCIBLE FACTOR-2 | TRANSCRIPTION FACTOR | EXPRESSION | Sulfones - therapeutic use | Kidney Neoplasms - genetics | Humans | Gene Expression Regulation, Neoplastic | Carcinoma, Renal Cell - genetics | Male | Kidney Neoplasms - metabolism | Aryl Hydrocarbon Receptor Nuclear Translocator - metabolism | Molecular Targeted Therapy | Sulfones - pharmacology | Indans - therapeutic use | Erythropoietin - blood | Sunitinib | Basic Helix-Loop-Helix Transcription Factors - metabolism | Female | Indoles - pharmacology | Indans - administration & dosage | Carcinoma, Renal Cell - drug therapy | Pyrroles - therapeutic use | Binding Sites | Reproducibility of Results | Basic Helix-Loop-Helix Transcription Factors - genetics | Carcinoma, Renal Cell - pathology | Basic Helix-Loop-Helix Transcription Factors - antagonists & inhibitors | Mice, SCID | Xenograft Model Antitumor Assays | Carcinoma, Renal Cell - metabolism | Pyrroles - pharmacology | Animals | Cell Transformation, Neoplastic | Cell Line, Tumor | Erythropoietin - antagonists & inhibitors | Indoles - therapeutic use | Kidney Neoplasms - pathology | Mice, Inbred NOD | Aryl Hydrocarbon Receptor Nuclear Translocator - genetics | Mice | Mutation | Kidney Neoplasms - drug therapy | Drug Resistance, Neoplasm - drug effects | Indans - pharmacology | Sulfones - administration & dosage | Physiological aspects | Molecular targeted therapy | Transcription factors | Carcinoma, Renal cell | Methods | kidney cancer | HIF-1β (F446L) | RCC | patient-derived xenograft | EPAS1 | HIF-2α (G323E) | renal cancer | ARNT
Journal Article
Journal Article
Molecular and Cellular Biology, ISSN 0270-7306, 07/2017, Volume 37, Issue 13
Journal Article
Journal Article