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arylacetamide deacetylase (48) 48
humans (46) 46
pharmacology & pharmacy (37) 37
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hydrolysis (26) 26
carboxylic ester hydrolases - metabolism (22) 22
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biochemistry & molecular biology (18) 18
carboxylesterase (18) 18
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human arylacetamide deacetylase (15) 15
microsomes, liver - enzymology (15) 15
pharmacokinetics (14) 14
liver (13) 13
mice (13) 13
carboxylic ester hydrolases - genetics (12) 12
liver - enzymology (12) 12
microsomes, liver - metabolism (12) 12
carboxylesterase - metabolism (11) 11
female (11) 11
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carboxylic ester hydrolases - antagonists & inhibitors (9) 9
human liver (9) 9
kinetics (9) 9
physiological aspects (9) 9
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enzyme inhibitors - pharmacology (8) 8
hormone-sensitive lipase (8) 8
lipase (8) 8
molecular sequence data (8) 8
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rats (8) 8
drug metabolism (7) 7
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esterases - metabolism (7) 7
expression (7) 7
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liver - metabolism (7) 7
mice, inbred c57bl (7) 7
microsomes, liver - drug effects (7) 7
substrate-specificity (7) 7
toxicology (7) 7
acetylation (6) 6
cell line (6) 6
drug hydrolysis (6) 6
esterase (6) 6
human liver-microsomes (6) 6
metabolic-activation (6) 6
metabolites (6) 6
rats, sprague-dawley (6) 6
recombinant proteins - metabolism (6) 6
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young adult (6) 6
amidohydrolases - metabolism (5) 5
atherosclerosis (5) 5
clopidogrel (5) 5
dose-response relationship, drug (5) 5
hepatocytes - metabolism (5) 5
lipids (5) 5
proteins (5) 5
rat (5) 5
tissue distribution (5) 5
adolescent (4) 4
amidohydrolases - genetics (4) 4
biophysics (4) 4
carboxylesterase - antagonists & inhibitors (4) 4
cells (4) 4
endoplasmic-reticulum (4) 4
fatty acids (4) 4
flutamide hydrolysis (4) 4
hepatocytes - enzymology (4) 4
hydrolase (4) 4
in vitro techniques (4) 4
in-vitro (4) 4
inhibitors (4) 4
isoenzymes - metabolism (4) 4
lipid droplets (4) 4
phenacetin (4) 4
sequence homology, amino acid (4) 4
triacylglycerol (4) 4
analysis (3) 3
base sequence (3) 3
blotting, western (3) 3
carboxylesterase - genetics (3) 3
cell biology (3) 3
cynomolgus monkey (3) 3
cytochrome p-450 (3) 3
cytochrome p450 (3) 3
deacetylation (3) 3
dna, complementary - genetics (3) 3
dogs (3) 3
drug interactions (3) 3
drug-induced toxicity (3) 3
esterases (3) 3
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European Journal of Pharmaceutical Sciences, ISSN 0928-0987, 10/2015, Volume 78, pp. 47 - 53
Journal Article
Journal Article
Frontiers in Pharmacology, ISSN 1663-9812, 11/2017, Volume 8, pp. 846 - 846
Journal Article
Journal of Veterinary Medical Science, ISSN 0916-7250, 2015
Arylacetamide deacetylase (AADAC), a microsomal serine esterase, hydrolyzes drugs, such as flutamide, phenacetin and rifampicin. Because AADAC has not been... 
genome | cynomolgus monkey | drug metabolism | arylacetamide deacetylase | tissue expression
Journal Article
Biochemical Pharmacology, ISSN 0006-2952, 11/2012, Volume 84, Issue 9, pp. 1196 - 1206
Journal Article
Journal of Hepatology, ISSN 0168-8278, 2013, Volume 59, Issue 2, pp. 336 - 343
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Yaoxue Xuebao, ISSN 0513-4870, 02/2018, Volume 53, Issue 2, pp. 177 - 185
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 10/2001, Volume 276, Issue 43, pp. 39522 - 39532
Journal Article
by Lu, DY and Dong, D and Liu, Z and Wang, YF and Wu, BJ
EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY, ISSN 1742-5255, 07/2015, Volume 11, Issue 7, pp. 1029 - 1040
Objective: The aim of this article is to elucidate the metabolic pathways of BJ-B11, a heat shock protein 90 inhibitor, in human liver microsomes (HLM) and... 
APOPTOSIS | HSP90 INHIBITOR | HUMAN ARYLACETAMIDE DEACETYLASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | HUMAN CARBOXYLESTERASES | DISCOVERY | IN-VITRO | POTENT | PHARMACOKINETICS | BJ-B11 | GYP metabolism | TISSUE DISTRIBUTION | arylacetamide deacetylase | PHARMACOLOGY & PHARMACY | TOXICOLOGY | hydrolysis | DRUG-METABOLISM
Journal Article
Journal of Pharmaceutical Sciences, ISSN 0022-3549, 02/2019, Volume 108, Issue 2, pp. 1027 - 1034
In liver microsomes, selexipag (NS-304; ACT-293987) mainly undergoes hydrolytic removal of the sulfonamide moiety by carboxylesterase 1 (CES1) to yield the... 
oxidation | enzymes | prodrugs | hydrolysis | intestinal metabolism | microsomes | ACTIVATION | CHEMISTRY, MEDICINAL | PROTEIN | ARYLACETAMIDE DEACETYLASE | EGASYN | CHEMISTRY, MULTIDISCIPLINARY | ISOZYMES | SUBSTRATE-SPECIFICITY | METABOLISM | PROSTACYCLIN RECEPTOR AGONIST | PHARMACOLOGY & PHARMACY | EXPRESSION
Journal Article
Journal Article
Drug metabolism and disposition: the biological fate of chemicals, ISSN 0090-9556, 05/2019, Volume 47, Issue 8, pp. 843 - 853
Journal Article
Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 07/2000, Volume 294, Issue 1, pp. 80 - 87
Journal Article
Journal Article
Yakugaku Zasshi, ISSN 0031-6903, 11/2015, Volume 135, Issue 11, pp. 1235 - 1244
Journal Article