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Journal Article
Journal Article
Journal Article
International Endodontic Journal, ISSN 0143-2885, 10/2017, Volume 50, Issue 10, pp. 967 - 975
Journal Article
International Immunopharmacology, ISSN 1567-5769, 11/2013, Volume 17, Issue 3, pp. 638 - 650
Neutrophils play a critical role in the host defense against bacterial and fungal infections, but their inappropriate activation also contributes to tissue... 
Signaling | Receptors | Inflammation | Kinases | Neutrophils | ACTIVATED PROTEIN-KINASE | COLONY-STIMULATING FACTOR | LEUKOCYTE ADHESION DEFICIENCY | IMMUNOLOGY | SRC-FAMILY KINASES | HUMAN POLYMORPHONUCLEAR LEUKOCYTES | HIGH-AFFINITY RECEPTOR | TUMOR-NECROSIS-FACTOR | TOLL-LIKE RECEPTORS | PHARMACOLOGY & PHARMACY | BETA-GAMMA-SUBUNITS | NF-KAPPA-B | Signal Transduction - immunology | Animals | Receptors, Cell Surface - immunology | Humans | Neutrophils - immunology | Selectins - immunology | Mycoses | Lectins | Fc receptors | Integrins | FcR, Fc-receptor | GPI, glycosylphosphatidylinositol anchor | CLEC, C-type lectin | OSCAR, osteoclast-associated receptor | PKB, protein kinase B | DAG, diacyl-glycerol | Tyk2, tyrosine protein kinase 2 | VCAM-1, vascular cell adhesion molecule 1 | ICAM-1, intercellular adhesion molecule 1 | FADD, Fas-associated protein with death domain | IκB, inhibitor of NF-κB | GM-CSF, granulocyte | MyD88, myeloid differentiation protein 88 | TNF, tumor necrosis factor | LTβ, lymphotoxin β | TRADD, TNFR1-associated death domain protein | Abl, Abelson leukemia proto-oncogene | SLP-76, SH2 domain-containing leukocyte protein of 76 kDa | CALDAG-GEFI, calcium and DAG-regulated guanine nucleotide exchange factor I | IL, interleukin | Src, Rous sarcoma virus proto-oncogene | IRF, IFN regulatory factor | RIG, retinoic acid-inducible gene | PLC, phospholipase C | TCR, T-cell receptor | IKK, IκB kinase | ITAM, immunoreceptor tyrosine-based activation motif | CARD, caspase activation and recruitment domain | IP3, inositol-tris-phosphate | CHO, Chinese hamster ovary cells | MKK, MAP kinase kinase | fMLP, formly-Met-Leu-Phe | TRAF, TNF receptor-associated factor | MIP, macrophage inflammatory protein | Rac, Ras-related C3 botulinum toxin substrate | monocyte colony-stimulating factor | PIP3, phosphatidylinositol-3-phosphate | VLA-4, very late antigen 4 (α4β1 integrin) | PAF, platelet activating factor | STAT, signal transducer and activator of transcription | TAK, TGFβ-activated kinase 1 | Mac-1, macrophage antigen 1 (αMβ2 integrin) | FcRγ, Fc-receptor γ-chain | Asc, apoptosis-associated speck-like protein containing a CARD | cIAP, cellular inhibitor of apoptosis | BCR, B-cell receptor | Fgr, Gardner–Rasheed feline sarcoma proto-oncogene | VASP, vasodilator-stimulated phosphoprotein | Hck, hematopoietic cell kinase | TGFβ, transforming growth factor β | Rap, Ras-related protein | SHP-1, SH2 domain-containing protein tyrosine phosphatase 1 | Syk, spleen tyrosine kinase | GPCR, G protein-coupled receptor | G-CSF, granulocyte colony-stimulating factor | TREM, triggering receptor expressed on myeloid cells | DISC, death-inducing signaling complex | MDL-1, myeloid DAP12-associating lectin 1 | C3G, Crk SH3 domain-binding guanine nucleotide exchange factor (RapGEF1) | NF-κB, nuclear factor κB | ERM, ezrin-radixin-moesin | Epac1, exchange protein activated by cyclic AMP 1 | LTB4, leukotriene B4 | Mcl, macrophage C-type lectin | SAP130, Sin3A-associated protein of 130 kDa | SH2, Src-homology 2 domain | MAP kinase, mitogen-activated protein kinase | PSGL-1, P-selectin glycoprotein ligand | PI3K, phoshoinositide-3-kinase | ADAP, adhesion and degranulation promoting adapter protein (Fyb, SLAP-130) | NLRP3, NOD-like receptor family, pyrin domain containing 3 | MDA5, melanoma differentiation-associated protein 5 | TLR, Toll-like receptor | GRK, GPCR kinase | LAD, leukocyte adhesion deficiency | MAPKAP-kinase, MAP kinase-associated protein kinase | ZAP-70, ζ-chain-associated protein of 70 kDa | TRAIL, TNF-related apoptosis-inducing ligand | JNK, c-Jun N-terminal kinase | LFA-1, lymphocyte function-associated receptor 1 (αLβ2 integrin) | ROS, reactive oxygen species | RIP3, receptor-interacting serine-threonine protein kinase 3 | DAP12, DNAX activating protein 12 | IFN, interferon | PIR, paired immunoglobulin-like receptor | PKC, protein kinase C | PAK, p21-activated kinase | ESL-1, E-selectin ligand 1 | GAP, GTPase activating protein | ERK, extracellular signal-regulated kinase | SOCS, suppressor of cytokine signaling | JAK, Janus kinase | RANK, receptor activator of NF-κB | IRAK, IL-1 receptor-associated kinase | NOD, nucleotide-binding oligomerization domain containing protein | CEACAM3, carcinoembryonic antigen-related cell adhesion molecule 3 (CD66b)
Journal Article
Clinical Immunology, ISSN 1521-6616, 11/2019, Volume 208, p. 108232
variants result in reduced enzymatic activity of procaspase-1 and impaired IL-1β release. Despite this, affected individuals can develop systemic... 
Pyroptosome | Pyroptosis | Speck | NLRP3 | Inflammasome | Gasdermin D | Interleukin-1 converting enzyme | Apoptosis-associated speck-like protein containing a CARD (ASC) | IL-1β | Caspase-1
Journal Article
Biochemical Journal, ISSN 0264-6021, 12/2004, Volume 384, Issue 2, pp. 201 - 232
The death morphology commonly known as apoptosis results from a post-translational pathway driven largely by specific limited proteolysis. In the last decade... 
Zymogen | Caspase | Inhibitor | Protease | Inhibitor of apoptosis protein (IAP) | Apoptosis | INDUCED-PROXIMITY MODEL | VIRAL SERPIN CRMA | X-LINKED INHIBITOR | BIOCHEMISTRY & MOLECULAR BIOLOGY | inhibitor of apoptosis protein (IAP) | apoptosis | zymogen | caspase | INTERLEUKIN-1-BETA CONVERTING-ENZYME | protease | PROGRAMMED CELL-DEATH | TOLL-LIKE RECEPTOR-2 | inhibitor | ANTI-APOPTOTIC ACTIVITY | CYTOCHROME-C RELEASE | DEATH-EFFECTOR DOMAIN | SIGNALING COMPLEX DISC | Caspases - physiology | Enzyme Precursors - chemistry | Humans | Models, Molecular | Molecular Sequence Data | Substrate Specificity | Amino Acid Sequence - physiology | Structure-Activity Relationship | Caspase Inhibitors | Enzyme Precursors - metabolism | Animals | Caspases - metabolism | Protein Conformation | Molecular Structure | Caspases - chemistry | Enzyme Activation - physiology | CAD, caspase-activated DNase | FLICE, FADD-like ICE | TNF, tumour necrosis factor | CARD, LRR and NACHT-containing protein | Rip, receptor-interacting protein | DRONC, Drosophila Nedd2-like caspase | CARD-containing ICE-associated kinase | Ipaf | ICAD, inhibitor of CAD | CED, cell death-defective | DFF, DNA fragmentation factor | CARD, caspase-recruitment domain | APAF-1, apoptotic protease activating factor-1 | CLARP, caspase-like apoptosis-regulatory protein | DIABLO, direct IAP-binding protein with low pI | CLAN, ICE-protease-activating factor | RAIDD, caspase-2 and RipK1 domain-containing adaptor with death domain | ICE, interleukin-1β-converting enzyme | NALP1, NACHT, LRR and Pyrin domain containing 1 | ALPS, autoimmune lymphoproliferative syndrome | LRR, leucine-rich repeat | PYD- and CARD-containing molecule | NOD, nucleotide-binding and oligomerization domain-containing protein | NACHT, NTPase-domain named after NAIP, CIITA, HET-E and TP1 | S1, S2, …Sn and S1′, S2′, …Sm′ refer to the cognate pockets on the protease that accept these side chains | PYCARD, apoptosis-associated speck-like protein containing a CARD | PARP, poly(ADP-ribose) polymerase | P1, P2, …Pn and P1′, P2′, …Pm′ designate the side chains in substrates and inhibitors in the N- and C-terminal direction respectively from the P1–P1′ scissile peptide bond | TFPI, tissue factor pathway inhibitor | TLR, Toll-like receptor | serpin, serine protease inhibitor | RING, really interesting new gene | XIAP | DED, death effector domain | Review | PIDD, p53-induced protein with a death domain | TRAIL, TNF-related apoptosis-inducing ligand | IAP, inhibitor of apoptosis protein | NBD, nucleotide-binding domain | ASC | TRAF, TNF receptor-associated factor | BIRC4, X-linked IAP | DD, death domain | Smac, second mitochondrial activator of caspases | DIAP1, Drosophila inhibitor of apoptosis 1 | BIR, baculoviral IAP repeat | IBM, IAP binding motif | TRADD, TNFRSF1A-associated via death domain | CRADD | DISC, death-inducing signalling complex | FADD, Fas (TNFRSF6)-associated via death domain | FLIP, FLICE inhibitory protein | NF-κB, nuclear factor-κB | CARP, caspase-associated RING protein | CrmA, cytokine response modifier A | CARDIAK, Rip-like interacting CLARP kinase | RICK | Rip-associated protein with a death domain | baculoviral IAP repeat-containing 4
Journal Article