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Annals of Internal Medicine, ISSN 0003-4819, 04/2004, Volume 140, Issue 7, pp. 533 - I61
Journal Article
Cancer Chemotherapy and Pharmacology, ISSN 0344-5704, 7/2013, Volume 72, Issue 1, pp. 139 - 146
This phase I clinical trial evaluated the safety, tolerability, and pharmacokinetics of high-dose intravenous (i.v.) ascorbic acid as a monotherapy in patients... 
Ascorbic acid | Medicine & Public Health | Phase I clinical trial | Oncology | Cancer Research | Pharmacology/Toxicology | Pharmacokinetics | Cancer | VITAMIN-C | VITRO | PANCREATIC-CANCER | GEMCITABINE | CELL-DEATH | OF-LIFE QUESTIONNAIRE | ONCOLOGY | PRECLINICAL MODELS | PHARMACOLOGY & PHARMACY | EUROPEAN-ORGANIZATION | ORTHOMOLECULAR TREATMENT | CARCINOMA | Neoplasms - metabolism | Drug Resistance, Multiple | Humans | Middle Aged | Half-Life | Ascorbic Acid - pharmacokinetics | Drug Resistance, Neoplasm | Male | Metabolic Clearance Rate | Ascorbic Acid - adverse effects | Dose-Response Relationship, Drug | Antineoplastic Agents, Phytogenic - administration & dosage | Neoplasms - blood | Ascorbic Acid - therapeutic use | Adult | Female | Antineoplastic Agents, Phytogenic - therapeutic use | Antineoplastic Agents, Phytogenic - pharmacokinetics | Antineoplastic Agents, Phytogenic - adverse effects | Ascorbic Acid - administration & dosage | Disease Progression | Neoplasms - drug therapy | Antioxidants - therapeutic use | Antioxidants - administration & dosage | Quality of Life | Antioxidants - adverse effects | Aged | Infusions, Intravenous | Antioxidants - pharmacokinetics | Neoplasm Staging | Neoplasms - pathology | Cohort Studies | Care and treatment | Cancer patients | Vitamin C | Clinical trials | Product development | Consulting services | Original
Journal Article
Journal Article
Journal Article
Food Chemistry, ISSN 0308-8146, 04/2015, Volume 173, pp. 1187 - 1194
Journal Article
Journal Article
Free Radical Biology and Medicine, ISSN 0891-5849, 10/2016, Volume 99, pp. 451 - 462
Despite recent evidence for an anti-tumour role for high-dose ascorbate, potential mechanisms of action are still unclear. At mM concentrations that are... 
Lewis lung carcinoma | Mouse model | Pharmacokinetics | Hypoxia-inducible factor-1 | Vitamin C | HYPOXIA-INDUCIBLE FACTOR | VITAMIN-C PHARMACOKINETICS | BIOCHEMISTRY & MOLECULAR BIOLOGY | PANCREATIC-CANCER | I CLINICAL-TRIAL | SUPPLEMENTAL ASCORBATE | INTRACELLULAR ASCORBATE | TERMINAL HUMAN CANCER | COLORECTAL-CANCER | SUPPORTIVE TREATMENT | ENDOCRINOLOGY & METABOLISM | HYDROGEN-PEROXIDE | Sodium-Coupled Vitamin C Transporters - metabolism | Antioxidants - metabolism | Gene Expression Regulation, Neoplastic | Ascorbic Acid - pharmacokinetics | Hypoxia-Inducible Factor 1, alpha Subunit - antagonists & inhibitors | Vascular Endothelial Growth Factor A - metabolism | Vascular Endothelial Growth Factor A - antagonists & inhibitors | Vascular Endothelial Growth Factor A - genetics | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Isoenzymes - metabolism | Female | Antineoplastic Agents - pharmacokinetics | Antineoplastic Agents - pharmacology | Ascorbic Acid - blood | Drug Administration Schedule | Signal Transduction | Hypoxia-Inducible Factor 1, alpha Subunit - genetics | Isoenzymes - genetics | Injections, Intraperitoneal | Sodium-Coupled Vitamin C Transporters - genetics | Antioxidants - pharmacology | Carcinoma, Lewis Lung - metabolism | Carcinoma, Lewis Lung - drug therapy | Mice, Knockout | Animals | Carcinoma, Lewis Lung - genetics | Ascorbic Acid - pharmacology | Antineoplastic Agents - blood | Carcinoma, Lewis Lung - pathology | Mice | Antioxidants - pharmacokinetics | Physiological aspects | Care and treatment | Endothelial growth factors | Analysis | Liver | Cancer | Lung cancer | High performance liquid chromatography
Journal Article
Journal of Advanced Veterinary and Animal Research, ISSN 2311-7710, 2019, Volume 6, Issue 4, pp. 481 - 485
Objective: We performed a randomized two-way crossover study to evaluate the pharmacokinetic profiles of two high-dose ascorbic acid (AA) after IV infusion in... 
ascorbic acid; dog; pharmacokinetics
Journal Article