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Nature Medicine, ISSN 1078-8956, 01/2015, Volume 21, Issue 1, pp. 47 - 54
Journal Article
Nucleic Acids Research, ISSN 0305-1048, 03/2017, Volume 45, Issue 5, pp. 2294 - 2306
Journal Article
Nature Medicine, ISSN 1078-8956, 06/2008, Volume 14, Issue 6, pp. 648 - 655
The Ashwell receptor, the major lectin of hepatocytes, rapidly clears from blood circulation glycoproteins bearing glycan ligands that include galactose and... 
MEDICINE, RESEARCH & EXPERIMENTAL | RESPIRATORY-TRACT | LIGAND-BINDING | BIOCHEMISTRY & MOLECULAR BIOLOGY | MAJOR SUBUNIT | GLYCOPROTEINS | MICE LACKING | CELL BIOLOGY | NEURAMINIDASE | STREPTOCOCCUS-PNEUMONIAE | PLATELET SIALIC-ACID | SURFACE | LIVER ASIALOGLYCOPROTEIN RECEPTOR | Blood Platelets - pathology | Pneumococcal Infections - metabolism | Hemostasis - physiology | Humans | Asialoglycoproteins - blood | Hepatocytes - metabolism | Thrombocytopenia - microbiology | Asialoglycoproteins - pharmacokinetics | Asialoglycoprotein Receptor - metabolism | Fluorescent Antibody Technique, Indirect | Disease Models, Animal | von Willebrand Factor - metabolism | Asialoglycoprotein Receptor - genetics | Mice, Inbred C57BL | Pneumococcal Infections - pathology | Asialoglycoprotein Receptor - blood | Thrombocytopenia - pathology | Mice, Knockout | Homozygote | Animals | Blood Coagulation Disorders - pathology | Metabolic Clearance Rate - genetics | Blood Platelets - metabolism | Blood Coagulation Disorders - blood | Protein Binding | Ligands | Hepatocytes - chemistry | Mice | Mutation | Blood Platelets - microbiology | Care and treatment | Patient outcomes | Glycoproteins | Research | Thrombosis | Blood clot | Risk factors | Complications and side effects | Von Willebrand factor | Lectins | Physiological aspects | Sepsis | Genetic aspects | Drug therapy | Health aspects | Medical research | Infections | Blood diseases | Liver | Blood clots
Journal Article
Journal Article
Journal Article
Journal Article
Nucleic Acid Therapeutics, ISSN 2159-3337, 06/2018, Volume 28, Issue 3, pp. 119 - 127
Oligonucleotide therapeutics have emerged as a third distinct platform for drug discovery within the pharmaceutical industry. Five oligonucleotide-based drugs... 
sinusoidal endothelial cells | Stabilins | asialoglycoprotein receptor | hepatocytes | RNA, Small Interfering - genetics | Glycoconjugates - metabolism | Phosphorothioate Oligonucleotides - genetics | Humans | Oligonucleotides, Antisense - metabolism | Hepatocytes - metabolism | Acetylgalactosamine - metabolism | Endocytosis | Hepatocytes - cytology | Cell Engineering - methods | HEK293 Cells | Asialoglycoprotein Receptor - metabolism | Scavenger Receptors, Class A - genetics | Cell Adhesion Molecules, Neuronal - metabolism | Kupffer Cells - metabolism | Gene Transfer Techniques | Asialoglycoprotein Receptor - genetics | Kupffer Cells - cytology | Endothelial Cells - metabolism | Liver - metabolism | Cell Adhesion Molecules, Neuronal - genetics | Animals | Oligonucleotides, Antisense - genetics | Endothelial Cells - cytology | Phosphorothioate Oligonucleotides - metabolism | Liver - cytology | Mice | Scavenger Receptors, Class A - metabolism | RNA, Small Interfering - metabolism | RAT-LIVER | MEDICINE, RESEARCH & EXPERIMENTAL | CHEMISTRY, MEDICINAL | BIOCHEMISTRY & MOLECULAR BIOLOGY | SILENCING IN-VIVO | HUMAN HYALURONAN RECEPTOR | HIGH-AFFINITY LIGAND | ENDOSOMAL TRAFFICKING | RECOGNITION SYSTEM | ALTERNATIVELY ACTIVATED MACROPHAGES | SINUSOIDAL ENDOTHELIAL-CELLS | MOLECULAR-WEIGHT PROTEIN | Drugs | Lymphatic system | Liver | Oligonucleotides | Antisense oligonucleotides | Biochemistry | Metabolism | Proteins | Lipoproteins | Oxygen atoms | Hepatocytes | Rodents | Extracellular matrix | Ligands | Phosphorothioate | Sulfur | Pharmaceutical industry | Binding sites
Journal Article
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Journal Article