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1. Full Text Neuroprotection with a new kynurenic acid analog in the four-vessel occlusion model of ischemia
by Gellért, Levente and Fuzik, János and Göblös, Anikó and Sárközi, Kitti and Marosi, Máté and Kis, Zsolt and Farkas, Tamás and Szatmári, István and Fülöp, Ferenc and Vécsei, László and Toldi, József
European Journal of Pharmacology, ISSN 0014-2999, 2011, Volume 667, Issue 1, pp. 182 - 187
Global forebrain ischemia results in damage to the pyramids in the CA1 hippocampal subfield, which is particularly vulnerable to excitotoxic processes.... 
4VO model | Kynurenine | Neuroprotection | Ischemic brain damage | MANIPULATION | VIVO | VULNERABILITY | STROKE | IN-VITRO | PRETREATMENT | PHARMACOLOGY & PHARMACY | RAT HIPPOCAMPUS | ANTAGONISTS | DERIVATIVES | BRAIN | Neuroprotective Agents - therapeutic use | Electric Stimulation | Rats, Wistar | Cell Count | Male | Kynurenic Acid - therapeutic use | CA1 Region, Hippocampal - drug effects | CA1 Region, Hippocampal - pathology | Neuroprotective Agents - pharmacology | Long-Term Potentiation - drug effects | Kynurenic Acid - analogs & derivatives | Kynurenic Acid - pharmacology | Disease Models, Animal | Synapses - drug effects | Neuroprotective Agents - chemistry | Synapses - physiology | Rats | Brain Ischemia - physiopathology | Brain Ischemia - etiology | Animals | Brain Ischemia - drug therapy | Brain Ischemia - pathology | Carotid Arteries - surgery | CA1 Region, Hippocampal - physiopathology | In Vitro Techniques | Methyl aspartate | Brain damage | Ischemia | Glycine | Analysis | Drugs | Occlusion | Preservation | Long-term potentiation | Cognitive ability | Clinical trials | Forebrain | N-Methyl-D-aspartic acid receptors | Antagonists | Glutamic acid receptors | Neuroprotective agents | Reperfusion | Pyramidal cells | Excitotoxicity | Kynurenic acid | Hippocampus | Synapses
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2. Full Text Phosphine-Catalyzed [3+2] Cycloadditions of 2-Phenyl-4-Arylidene-5(4H)-Oxazolones with Allenoate: A Concise Synthesis of Aspartic Acid Analogues
by Zou, You-Quan and Li, Chao and Rong, Jian and Yan, Hao and Chen, Jia-Rong and Xiao, Wen-Jing
Synlett, ISSN 0936-5214, 04/2011, Volume 2011, Issue 7, pp. 1000 - 1004
Abstract A Ph 3 P-catalyzed [3+2] cycloaddition of 2-phenyl-4-arylidene-5(4H)-oxazolones with benzyl 2,3-butadienoate has been developed for the efficient... 
letter | aspartic acid analogues | organocatalysis | phosphine | cycloaddition | benzyl 2,3-butadienoate | SULFUR YLIDES | ENANTIOSELECTIVE SYNTHESIS | NITROGEN-HETEROCYCLES | CHEMISTRY, ORGANIC | ALPHA-AMINO-ACIDS | FUNCTIONALIZED CYCLOPENTENES | BETA-AMINOPHOSPHINE LIGANDS | GLUTAMATE-RECEPTOR | METATHESIS/INTRAMOLECULAR-HYDROARYLATION SEQUENCE | STEREOSELECTIVE-SYNTHESIS | ELECTRON-DEFICIENT OLEFINS
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3. Full Text Efficient synthesis of fluorothiosparfosic acid analogues with potential antitumoral activity
by Pfund, Emmanuel and Lequeux, Thierry and Masson, Serge and Vazeux, Michel and Cordi, Alex and Pierre, Alain and Serre, Valérie and Hervé, Guy
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 2005, Volume 13, Issue 16, pp. 4921 - 4928
Ester thioPALA(FF), prepared in one step, showed a remarkable cytotoxic activity towards murine leukemia L1210 cell. In this paper, we describe a short... 
Sparfosic acid | ATCase | L1210 | PALA | Difluorophosphonates | N-(PHOSPHONACETYL)-L-ASPARTATE PALA | DESIGN | CHEMISTRY, MEDICINAL | L-ASPARTATE PALA | PHOSPHONATE ANALOGS | BIOCHEMISTRY & MOLECULAR BIOLOGY | sparfosic acid | SENSITIVITY | CHEMISTRY, ORGANIC | TRANSCARBAMYLASE | PROLIFERATION | PHOSPHOLIPID ANALOGS | difluorophosphonates | INHIBITORS | MURINE TUMORS | Leukemia L1210 - drug therapy | Antineoplastic Agents - chemical synthesis | Enzyme Inhibitors - pharmacology | Phosphonoacetic Acid - analogs & derivatives | Enzyme Inhibitors - chemical synthesis | Aspartate Carbamoyltransferase - antagonists & inhibitors | Phosphonoacetic Acid - chemical synthesis | Phosphonoacetic Acid - pharmacology | Animals | Aspartic Acid - chemical synthesis | Thioacetamide - chemical synthesis | Thioacetamide - chemistry | Antineoplastic Agents - pharmacology | Aspartic Acid - analogs & derivatives | Aspartic Acid - pharmacology | Drug Screening Assays, Antitumor | Research | Heterocyclic compounds | Leukemia | Oncology, Experimental | Cancer
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4. Full Text Characterization of Novel Aryl-Ether, Biaryl, and Fluorene Aspartic Acid and Diaminopropionic Acid Analogs as Potent Inhibitors of the High-Affinity Glutamate Transporter EAAT2
by John Dunlop and H. Beal McIlvain and Tikva A. Carrick and Brian Jow and Qiang Lu and Dianne Kowal and Steven Lin and Alexander Greenfield and Cristina Grosanu and Kristi Fan and Robert Petroski and John Williams and Alan Foster and John Butera
Molecular Pharmacology, ISSN 0026-895X, 10/2005, Volume 68, Issue 4, pp. 974 - 982
In this study, we describe the pharmacological characterization of novel aryl-ether, biaryl, and fluorene aspartic acid and diaminopropionic acid analogs as... 
BLOCKERS | BETA-HYDROXYASPARTATE DERIVATIVES | BENZYLOXYASPARTATE | SUBTYPES | SUBSTRATE | PHARMACOLOGY & PHARMACY | AGENTS | RAT-BRAIN | RECEPTORS | EXPRESSION | GLT-1 | Propionates - pharmacology | Cell Line | Propionates - chemistry | Synaptosomes - drug effects | Cricetinae | Synaptosomes - physiology | Excitatory Amino Acid Transporter 2 - antagonists & inhibitors | Humans | Xenopus laevis | Models, Molecular | Rats | Animals | Aspartic Acid - analogs & derivatives | Aspartic Acid - pharmacology | CHO Cells
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5. Full Text β-Sulfonamido Functionalized Aspartate Analogues as Excitatory Amino Acid Transporter Inhibitors: Distinct Subtype Selectivity Profiles Arising from Subtle Structural Differences
by Hansen, Jacob C and Bjørn-Yoshimoto, Walden E and Bisballe, Niels and Nielsen, Birgitte and Jensen, Anders A and Bunch, Lennart
Journal of Medicinal Chemistry, ISSN 0022-2623, 10/2016, Volume 59, Issue 19, pp. 8771 - 8786
In this study inspired by previous work on 3-substituted Asp analogues, we designed and synthesized a total of 32 beta-sulfonamide Asp analogues and... 
BLOCKERS | CHEMISTRY, MEDICINAL | BENZYLOXYASPARTATE | CHEMOENZYMATIC SYNTHESIS | PHARMACOLOGICAL CHARACTERIZATION | EAAT1 | HYDROXYASPARTATE DERIVATIVES | MECHANISMS | AFFINITY GLUTAMATE TRANSPORTER | RECEPTORS | MODULATION | Glutamate Plasma Membrane Transport Proteins - metabolism | Sulfonamides - chemistry | Humans | Excitatory Amino Acid Transporter 1 - metabolism | Sulfonamides - pharmacology | Glutamate Plasma Membrane Transport Proteins - antagonists & inhibitors | Excitatory Amino Acid Transporter 1 - antagonists & inhibitors | Excitatory Amino Acid Transporter 3 - metabolism | Excitatory Amino Acid Transporter 3 - antagonists & inhibitors | HEK293 Cells | Biological Transport - drug effects | Aspartic Acid - analogs & derivatives | Aspartic Acid - pharmacology | Index Medicus
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6. Full Text Trans-spinal direct current enhances corticospinal output and stimulation-evoked release of glutamate analog, D-2,3-3H-aspartic acid
by Zaghloul Ahmed and Andrzej Wieraszko
Journal of Applied Physiology, ISSN 8750-7587, 05/2012, Volume 112, Issue 9, pp. 1576 - 1592
Trans-spinal direct current (tsDC) stimulation is a modulator of spinal excitability and can influence cortically elicited muscle contraction in a... 
Spinal cord | Glutamate | Direct current | Motor cortex | Plasticity | Calcium - metabolism | Male | Muscle, Skeletal - innervation | Motor Activity | Cerebral Cortex - metabolism | Synaptic Transmission | Cerebral Cortex - physiopathology | Behavior, Animal | Evoked Potentials, Motor | Pyramidal Tracts - physiopathology | Time Factors | Pyramidal Tracts - metabolism | Female | Spinal Cord Injuries - therapy | Muscle Strength | Disease Models, Animal | Spinal Cord Injuries - metabolism | Animals | Muscle Contraction | Electric Stimulation Therapy - methods | Glutamic Acid - analogs & derivatives | Long-Term Potentiation | Aspartic Acid - metabolism | Glutamic Acid - metabolism | Mice | Spinal Cord Injuries - physiopathology | Aspartic Acid - analogs & derivatives | Spinal Cord Injuries - psychology
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7. Full Text Antipsychotic Treatment Resistance in Schizophrenia Associated with Elevated Glutamate Levels but Normal Dopamine Function
by Demjaha, Arsime and Egerton, Alice and Murray, Robin M and Kapur, Shitij and Howes, Oliver D and Stone, James M and McGuire, Philip K
Biological Psychiatry, ISSN 0006-3223, 2014, Volume 75, Issue 5, pp. e11 - e13
Psychiatry | SYNTHESIS CAPACITY | PSYCHIATRY | PSYCHOSIS | DYSFUNCTION | NEUROSCIENCES | PET | STRIATUM | BRAIN | Protons | Schizophrenia - metabolism | Magnetic Resonance Spectroscopy | Humans | Dihydroxyphenylalanine - analogs & derivatives | Male | Positron-Emission Tomography | Dihydroxyphenylalanine - pharmacokinetics | Schizophrenia - diagnostic imaging | Analysis of Variance | Antipsychotic Agents - therapeutic use | Aspartic Acid - metabolism | Female | Glutamic Acid - metabolism | Aspartic Acid - analogs & derivatives | Schizophrenia - drug therapy | Dopamine - metabolism
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8. Full Text A Guide to the Metabolic Pathways and Function of Metabolites Observed in Human Brain 1H Magnetic Resonance Spectra
by Rae, Caroline D
Neurochemical Research, ISSN 0364-3190, 1/2014, Volume 39, Issue 1, pp. 1 - 36
The current knowledge of the normal biochemistry of compounds that give rise to resonances in human brain proton magnetic resonance spectra measureable at... 
Neurochemistry | Biochemistry, general | Neurology | Neurosciences | γ-Aminobutyric acid | Biomedicine | Lactate | Choline | Creatine | Cell Biology | N -acetylaspartate | myo-inositol | N-acetylaspartate | Brain - metabolism | Choline - metabolism | Protons | Magnetic Resonance Spectroscopy | Metabolic Networks and Pathways | Inositol - metabolism | gamma-Aminobutyric Acid - metabolism | Humans | Lactic Acid - metabolism | Creatine - metabolism | Aspartic Acid - metabolism | Aspartic Acid - analogs & derivatives
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9. Full Text 2-Hydroxyglutarate detection by magnetic resonance spectroscopy in IDH-mutated patients with gliomas
by Choi, Changho and Ganji, Sandeep K and DeBerardinis, Ralph J and Hatanpaa, Kimmo J and Rakheja, Dinesh and Kovacs, Zoltan and Yang, Xiao-Li and Mashimo, Tomoyuki and Raisanen, Jack M and Marin-Valencia, Isaac and Pascual, Juan M and Madden, Christopher J and Mickey, Bruce E and Malloy, Craig R and Bachoo, Robert M and Maher, Elizabeth A
Nature Medicine, ISSN 1078-8956, 04/2012, Volume 18, Issue 4, pp. 624 - 629
Mutations in isocitrate dehydrogenases 1 and 2 (IDH1 and IDH2) have been shown to be present in most World Health Organization grade 2 and grade 3 gliomas in... 
Choline - metabolism | Magnetic Resonance Spectroscopy | Glutarates | Humans | Brain - enzymology | Brain Neoplasms - genetics | Isocitrate Dehydrogenase - genetics | Male | Statistics as Topic | Mutation - genetics | Brain Neoplasms - metabolism | Glioma - metabolism | Glioma - genetics | Algorithms | Creatine - metabolism | Brain Mapping | Aspartic Acid - metabolism | Female | Aspartic Acid - analogs & derivatives | Enzymes | Medical imaging | Mutation | Gene expression | Brain cancer | Spectrum analysis
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10. Full Text Inhibition of Mycobacterium tuberculosis dihydrodipicolinate synthase by alpha-ketopimelic acid and its other structural analogues
by Shrivastava, Priyanka and Navratna, Vikas and Silla, Yumnam and Dewangan, Rikeshwer P and Pramanik, Atreyi and Chaudhary, Sarika and Rayasam, Geethavani and Kumar, Anuradha and Gopal, Balasubramanian and Ramachandran, Srinivasan
Scientific Reports, ISSN 2045-2322, 09/2016, Volume 6, Issue 1, p. 30827
The Mycobacterium tuberculosis dihydrodipicolinate synthase (Mtb-dapA) is an essential gene. Mtb-DapA catalyzes the aldol condensation between pyruvate and... 
PROTEIN | L-LYSINE | MECHANISM | CRYSTAL-STRUCTURE | BIOSYNTHESIS | MULTIDISCIPLINARY SCIENCES | ESCHERICHIA-COLI | DIAMINOPIMELATE PATHWAY | KEY ENZYME | CRYSTALLOGRAPHY | IDENTIFICATION | Pyruvic Acid - chemistry | Crystallography, X-Ray | Bridged-Ring Compounds - metabolism | Recombinant Proteins - biosynthesis | Mycobacterium tuberculosis - drug effects | Recombinant Proteins - isolation & purification | Bridged-Ring Compounds - chemistry | Bridged-Ring Compounds - pharmacology | Inhibitory Concentration 50 | Pyruvic Acid - metabolism | Hydro-Lyases - metabolism | Hydro-Lyases - genetics | Binding Sites | Ketones - pharmacology | Bacterial Proteins - antagonists & inhibitors | Catalytic Domain | Bacterial Proteins - genetics | Enzyme Inhibitors - pharmacology | Recombinant Proteins - genetics | Enzyme Activation - drug effects | Molecular Dynamics Simulation | Hydrogen Bonding | Hydro-Lyases - antagonists & inhibitors | Mycobacterium tuberculosis - enzymology | Ketones - chemistry | Aspartic Acid - metabolism | Bacterial Proteins - metabolism | Molecular Docking Simulation | Aspartic Acid - analogs & derivatives | Aspartic Acid - chemistry | Kinetics | Ketones - metabolism | Competition | Dihydrodipicolinate synthase | Tuberculosis | Pyruvic acid | Mass spectroscopy | Abundance | Liquid chromatography | Dihydrodipicolinate reductase | Hydrogen bonding | Reductase | Crystal structure
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11. Full Text Crystal Structures of the Iron-Sulfur Cluster-Dependent Quinolinate Synthase in Complex with Dihydroxyacetone Phosphate, Iminoaspartate Analogues, and Quinolinate
by Fenwick, Michael K and Ealick, Steven E and Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Biochemistry, ISSN 0006-2960, 08/2016, Volume 55, Issue 30, pp. 4135 - 4139
The quinolinate synthase of prokaryotes and photosynthetic eukaryotes, NadA, contains a [4Fe-4S] cluster with unknown function. We report crystal structures of... 
NAD | ENZYME | ACID | MECHANISM | BIOCHEMISTRY & MOLECULAR BIOLOGY | ESCHERICHIA-COLI | TRIOSEPHOSPHATE ISOMERASE | METHYLGLYOXAL SYNTHASE | SYNTHETASE | L-ASPARTATE OXIDASE | CLASS-II | Catalytic Domain | Archaeal Proteins - chemistry | Models, Molecular | Crystallography, X-Ray | Protein Conformation | Quinolinic Acid - chemistry | Aspartic Acid - analogs & derivatives | Aspartic Acid - chemistry | Iron-Sulfur Proteins - chemistry | Dihydroxyacetone Phosphate - chemistry | Multienzyme Complexes - chemistry | Pyrococcus horikoshii - enzymology | BASIC BIOLOGICAL SCIENCES | INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
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12. Full Text N-Acetylaspartate in the CNS: From neurodiagnostics to neurobiology
by Moffett, John R and Ross, Brian and Arun, Peethambaran and Madhavarao, Chikkathur N and Namboodiri, Aryan M.A
Progress in Neurobiology, ISSN 0301-0082, 2007, Volume 81, Issue 2, pp. 89 - 131
The brain is unique among organs in many respects, including its mechanisms of lipid synthesis and energy production. The nervous system-specific metabolite... 
Canavan disease | Lipid synthesis | Myelination | Energy metabolism | Dysmyelination | Aspartoacylase | Acetyl coenzyme A | Acetate | N-acetyl- l-aspartic acid | NAA | N-acetyl-l-aspartic acid | ACETYL-L-ASPARTATE | PROTON MR SPECTROSCOPY | acetyl coenzyme A | METABOTROPIC GLUTAMATE RECEPTORS | N-acetyl-L-aspartic acid | MILD COGNITIVE IMPAIRMENT | NEUROSCIENCES | acetate | aspartoacylase | lipid synthesis | MAGNETIC-RESONANCE-SPECTROSCOPY | TRAUMATIC BRAIN-INJURY | MOLECULAR WATER PUMP | myelination | PELIZAEUS-MERZBACHER-DISEASE | CENTRAL-NERVOUS-SYSTEM | dysmyelination | L-ASPARTIC ACID | energy metabolism | Central Nervous System - metabolism | Humans | Central Nervous System - pathology | Lipid Metabolism | Canavan Disease - etiology | Aspartic Acid - genetics | Animals | Canavan Disease - metabolism | Energy Metabolism | Metabolic Networks and Pathways | Canavan Disease - genetics | Aspartic Acid - analysis | Aspartic Acid - metabolism | Aspartic Acid - analogs & derivatives | Physiological aspects | Enzymes
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