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1. Full Text Linked cycles of oxidative decarboxylation of glyoxylate as protometabolic analogs of the citric acid cycle
by Springsteen, Greg and Yerabolu, Jayasudhan Reddy and Nelson, Julia and Rhea, Chandler Joel and Krishnamurthy, Ramanarayanan
Nature communications, ISSN 2041-1723, 12/2018, Volume 9, Issue 1, pp. 91 - 91
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Carbon Dioxide - chemistry | Pyruvic Acid - chemistry | Models, Chemical | Oxidation-Reduction | Glyoxylates - chemistry | Origin of Life | Oxaloacetic Acid - chemistry | Hydrogen Peroxide - chemistry | Metabolic Networks and Pathways | Malonates - chemistry | Decarboxylation | Ammonia - chemistry | Aspartic Acid - chemistry | Kinetics | Hydrogen-Ion Concentration | Tricarboxylic acid cycle | Hydrogen peroxide | Catalysts | Carbon dioxide | Pyruvic acid | Metabolism | Citric acid | Controlled conditions | Ammonia | Acids | Metabolic pathways | Aspartic acid | Carbon sources | Index Medicus
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2. Full Text β‑Sulfonamido Functionalized Aspartate Analogues as Excitatory Amino Acid Transporter Inhibitors: Distinct Subtype Selectivity Profiles Arising from Subtle Structural Differences
by Hansen, Jacob C and Bjørn-Yoshimoto, Walden E and Bisballe, Niels and Nielsen, Birgitte and Jensen, Anders A and Bunch, Lennart
Journal of medicinal chemistry, ISSN 0022-2623, 10/2016, Volume 59, Issue 19, pp. 8771 - 8786
Glutamate Plasma Membrane Transport Proteins - metabolism | Sulfonamides - chemistry | Humans | Excitatory Amino Acid Transporter 1 - metabolism | Sulfonamides - pharmacology | Glutamate Plasma Membrane Transport Proteins - antagonists & inhibitors | Excitatory Amino Acid Transporter 1 - antagonists & inhibitors | Excitatory Amino Acid Transporter 3 - metabolism | Excitatory Amino Acid Transporter 3 - antagonists & inhibitors | HEK293 Cells | Biological Transport - drug effects | Aspartic Acid - analogs & derivatives | Aspartic Acid - pharmacology | Index Medicus
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3. Full Text Trans-spinal direct current enhances corticospinal output and stimulation-evoked release of glutamate analog, D-2,3-3H-aspartic acid
by Zaghloul Ahmed and Andrzej Wieraszko
Journal of Applied Physiology, ISSN 8750-7587, 05/2012, Volume 112, Issue 9, pp. 1576 - 1592
Spinal cord | Glutamate | Direct current | Motor cortex | Plasticity | Calcium - metabolism | Male | Muscle, Skeletal - innervation | Motor Activity | Cerebral Cortex - metabolism | Synaptic Transmission | Cerebral Cortex - physiopathology | Behavior, Animal | Evoked Potentials, Motor | Pyramidal Tracts - physiopathology | Time Factors | Pyramidal Tracts - metabolism | Female | Spinal Cord Injuries - therapy | Muscle Strength | Disease Models, Animal | Spinal Cord Injuries - metabolism | Animals | Muscle Contraction | Electric Stimulation Therapy - methods | Glutamic Acid - analogs & derivatives | Long-Term Potentiation | Aspartic Acid - metabolism | Glutamic Acid - metabolism | Mice | Spinal Cord Injuries - physiopathology | Aspartic Acid - analogs & derivatives | Spinal Cord Injuries - psychology | Index Medicus
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4. Full Text Selective and competitive inhibition of kynurenine aminotransferase 2 by glycyrrhizic acid and its analogues
by Yoshida, Yukihiro and Fujigaki, Hidetsugu and Kato, Koichi and Yamazaki, Kyoka and Fujigaki, Suwako and Kunisawa, Kazuo and Yamamoto, Yasuko and Mouri, Akihiro and Oda, Akifumi and Nabeshima, Toshitaka and Saito, Kuniaki
Scientific reports, ISSN 2045-2322, 07/2019, Volume 9, Issue 1, pp. 10243 - 11
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Competition | Acids | Mental disorders | Isoenzymes | Therapeutic applications | Schizophrenia | N-Methyl-D-aspartic acid receptors | Acetylcholine receptors (nicotinic) | Glutamic acid receptors | Kynurenic acid | Kynurenine-oxoglutarate transaminase | Index Medicus
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5. Full Text Secretory expression and surface display of a new and biologically active single-chain insulin (SCI-59) analog by lactic acid bacteria
by Mao, Ruifeng and Wu, Dongli and Hu, Shimeng and Zhou, Kangping and Wang, Man and Wang, Yefu
Applied microbiology and biotechnology, ISSN 0175-7598, 4/2017, Volume 101, Issue 8, pp. 3259 - 3271
Life Sciences | Biotechnology | Lactic acid bacteria | Microbiology | Single-chain insulin | Surface display | Microbial Genetics and Genomics | Secretory expression | Non-viable bacteria | Life Sciences & Biomedicine | Biotechnology & Applied Microbiology | Science & Technology | Lactococcus lactis - genetics | Signal Transduction | Administration, Oral | Humans | Diabetes Mellitus - drug therapy | Lactococcus lactis - metabolism | Microbial Viability | Drug Delivery Systems | Insulin - metabolism | Biological Transport | Insulin - chemistry | Insulin - analogs & derivatives | Insulin - genetics | Insulin Secretion | Cell Surface Display Techniques - methods | Type 2 diabetes | Enzymes | Drug resistance in microorganisms | Gastrointestinal system | Genetically modified organisms | Bacteria | Aspartic proteinases | Patient compliance | Insulin | Diabetes therapy | Studies | Medical research | Acids | Index Medicus
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6. Full Text Inhibition of Mycobacterium tuberculosis dihydrodipicolinate synthase by alpha-ketopimelic acid and its other structural analogues
by Shrivastava, Priyanka and Navratna, Vikas and Silla, Yumnam and Dewangan, Rikeshwer P and Pramanik, Atreyi and Chaudhary, Sarika and Rayasam, Geethavani and Kumar, Anuradha and Gopal, Balasubramanian and Ramachandran, Srinivasan
Scientific reports, ISSN 2045-2322, 09/2016, Volume 6, Issue 1, pp. 30827 - 30827
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Pyruvic Acid - chemistry | Crystallography, X-Ray | Bridged-Ring Compounds - metabolism | Recombinant Proteins - biosynthesis | Mycobacterium tuberculosis - drug effects | Recombinant Proteins - isolation & purification | Bridged-Ring Compounds - chemistry | Bridged-Ring Compounds - pharmacology | Inhibitory Concentration 50 | Pyruvic Acid - metabolism | Hydro-Lyases - metabolism | Hydro-Lyases - genetics | Binding Sites | Ketones - pharmacology | Bacterial Proteins - antagonists & inhibitors | Catalytic Domain | Bacterial Proteins - genetics | Enzyme Inhibitors - pharmacology | Recombinant Proteins - genetics | Enzyme Activation - drug effects | Molecular Dynamics Simulation | Hydrogen Bonding | Hydro-Lyases - antagonists & inhibitors | Mycobacterium tuberculosis - enzymology | Ketones - chemistry | Aspartic Acid - metabolism | Bacterial Proteins - metabolism | Molecular Docking Simulation | Aspartic Acid - analogs & derivatives | Aspartic Acid - chemistry | Kinetics | Ketones - metabolism | Competition | Dihydrodipicolinate synthase | Tuberculosis | Pyruvic acid | Mass spectroscopy | Abundance | Liquid chromatography | Dihydrodipicolinate reductase | Hydrogen bonding | Crystal structure | Index Medicus
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7. Full Text Crystal Structures of the Iron–Sulfur Cluster-Dependent Quinolinate Synthase in Complex with Dihydroxyacetone Phosphate, Iminoaspartate Analogues, and Quinolinate
by Fenwick, Michael K and Ealick, Steven E and Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Biochemistry (Easton), ISSN 0006-2960, 08/2016, Volume 55, Issue 30, pp. 4135 - 4139
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Catalytic Domain | Archaeal Proteins - chemistry | Models, Molecular | Crystallography, X-Ray | Protein Conformation | Quinolinic Acid - chemistry | Aspartic Acid - analogs & derivatives | Aspartic Acid - chemistry | Iron-Sulfur Proteins - chemistry | Dihydroxyacetone Phosphate - chemistry | Multienzyme Complexes - chemistry | Pyrococcus horikoshii - enzymology | Index Medicus | BASIC BIOLOGICAL SCIENCES | INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
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8. Full Text Acetyl Coenzyme A Analogues as Rationally Designed Inhibitors of Citrate Synthase
by Bello, Davide and Rubanu, Maria Grazia and Bandaranayaka, Nouchali and Götze, Jan P and Bühl, Michael and O'Hagan, David
Chembiochem : a European journal of chemical biology, ISSN 1439-4227, 05/2019, Volume 20, Issue 9, pp. 1174 - 1182
coenzyme A analogues | enzyme inhibition | organo-fluorine chemistry | citrate synthase mechanism | Catalytic Domain | Quantum Theory | Acetyl Coenzyme A - analogs & derivatives | Animals | Hydrogen Bonding | Models, Chemical | Swine | Enzyme Inhibitors - chemistry | Citrate (si)-Synthase - antagonists & inhibitors | Citrate (si)-Synthase - chemistry | Enzyme Inhibitors - chemical synthesis | Acetyl Coenzyme A - chemical synthesis | Aspartate | Thiols | Fluorides | Hydrogen | Analysis | Enzymes | Fluorine | Isomers | Hydrogen bonding | Mimicry | Analogs | Inhibitors | Hydrogen bonds | Biotransformation | Quantum mechanics | Dimethyl sulfoxide | Coenzyme A | Aspartic acid | Fluorination | Basicity | Bonding | Carboxylates | Index Medicus
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9. Full Text Phosphine-Catalyzed [3+2] Cycloadditions of 2-Phenyl-4-Arylidene-5(4H)-Oxazolones with Allenoate: A Concise Synthesis of Aspartic Acid Analogues
by Zou, You-Quan and Li, Chao and Rong, Jian and Yan, Hao and Chen, Jia-Rong and Xiao, Wen-Jing
Synlett, ISSN 0936-5214, 04/2011, Volume 2011, Issue 7, pp. 1000 - 1004
letter | aspartic acid analogues | organocatalysis | phosphine | cycloaddition | benzyl 2,3-butadienoate | Organic chemistry | Chemistry | Heterocyclic compounds with n hetero atom and also o and/or s, se, te hetero atoms | Heterocyclic compounds | Preparations and properties | Exact sciences and technology
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10. Synthesis and Biological Evaluation of Novel 2,3-disubstituted Benzofuran Analogues of GABA as Neurotropic Agents
by Coaviche-Yoval, Arturo and Luna, Héctor and Tovar-Miranda, Ricardo and Soriano-Ursúa, Marvin A and Trujillo-Ferrara, José G
Medicinal chemistry (Shp-sariqah, United Arab Emirates), ISSN 1573-4064, 2019, Volume 15, Issue 1, pp. 77 - 86
seizures | GABA receptor (GABA-R) | molecular docking | pentylenetetrazol (PTZ) | 4-aminopyridine (4-AP) | 2,3-disubstituted benzofurans (BZF) | Pharmacology & Pharmacy | Life Sciences & Biomedicine | Chemistry, Medicinal | Science & Technology | Potentiation | γ-Aminobutyric acid A receptors | Glutamic acid receptors (ionotropic) | Toxicity | Blockage | Receptors | Allosteric properties | Synthesis | Heterocyclic compounds | Rectifiers | Biocompatibility | Seizures | Seizing | γ-Aminobutyric acid B receptors | N-Methyl-D-aspartic acid receptors | Benzodiazepines | Latency | Neurotransmitters | Benzofuran | Ligands | In vivo methods and tests | Glutamatergic transmission | Potassium | Acute toxicity | γ-Aminobutyric acid receptors
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11. Full Text The novel methoxetamine analogs N-ethylnorketamine hydrochloride (NENK), 2-MeO-N-ethylketamine hydrochloride (2-MeO-NEK), and 4-MeO-N-ethylketamine hydrochloride (4-MeO-NEK) elicit rapid antidepressant effects via activation of AMPA and 5-HT2 receptors
by Sayson, Leandro Val and Botanas, Chrislean Jun and Custodio, Raly James Perez and Abiero, Arvie and Kim, Mikyung and Lee, Hyun Jun and Kim, Hee Jin and Yoo, Sung Yeun and Lee, Kun Won and Ryu, Hye Won and Acharya, Srijan and Kim, Kyeong-Man and Lee, Yong Sup and Cheong, Jae Hoon
Psychopharmacology, ISSN 0033-3158, 7/2019, Volume 236, Issue 7, pp. 2201 - 2210
Neurosciences | Biomedicine | Depressive syndrome | Methoxetamine analogs | NMDA receptor antagonists | 5-HT 2 receptors | AMPA receptors | Pharmacology/Toxicology | Psychiatry | Pharmacology & Pharmacy | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | TOR protein | Brain | Glutamic acid receptors (ionotropic) | Activation | mRNA | Mental depression | α-Amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors | Analogs | Diketones | Receptors | Antidepressants | α-Amino-3-hydroxy-5-methyl-4-isoxazole propionic acid | Field tests | Remission | Swimming | Open-field behavior | Quinoxaline | N-Methyl-D-aspartic acid receptors | Quinoxalines | Rapamycin | Serotonin S2 receptors | Prefrontal cortex | Brain-derived neurotrophic factor | Ketamine | Swimming behavior | Affinity | Receptor mechanisms | Glutamatergic transmission | Ketanserin | Index Medicus
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12. Full Text Behavioral economic analysis of the effects of N-substituted benztropine analogs on cocaine self-administration in rats
by Zanettini, Claudio and Zanettini, Claudio and Wilkinson, Derek S and Wilkinson, Derek S and Katz, Jonathan L and Katz, Jonathan L
Psychopharmacology, ISSN 0033-3158, 1/2018, Volume 235, Issue 1, pp. 47 - 58
Essential value | Self-administration | Drug abuse | Neurosciences | Biomedicine | Benztropine analogs | Rats | Cocaine | Demand curves | Pharmacology/Toxicology | Psychiatry | Behavioral economics | Pharmacology & Pharmacy | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Dopamine Uptake Inhibitors - pharmacology | Cocaine-Related Disorders - psychology | Injections, Intraperitoneal | Reinforcement (Psychology) | Male | Methylphenidate - pharmacology | Excitatory Amino Acid Antagonists - pharmacology | Rats, Sprague-Dawley | Reinforcement Schedule | Economics, Behavioral | Self Administration | Animals | Benztropine - analogs & derivatives | Behavior, Animal - drug effects | Cocaine-Related Disorders - economics | Benztropine - pharmacology | Ketamine - pharmacology | Food | Psychological aspects | Benztropine | Dosage and administration | Observations | Drug interactions | Drugs | Economic analysis | Schedules | Dopamine | Glutamic acid receptors (ionotropic) | Exponential functions | N-Methyl-D-aspartic acid receptors | Analogs | Drug self-administration | Ketamine | Animal behavior | Psychopharmacology | Dopamine transporter | Drug dosages | Methylphenidate | Index Medicus
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