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1. Full Text B cell survival, surface BCR and BAFFR expression, CD74 metabolism, and CD8- dendritic cells require the intramembrane endopeptidase SPPl2A
by Bergmann, Hannes and Yabas, Mehmet and Short, Alanna and Miosge, Lisa and Barthel, Nadine and Teh, Charis E and Roots, Carla M and Bull, Katherine R and Jeelall, Yogesh and Horikawa, Keisuke and Whittle, Belinda and Balakishnan, Bhavani and Sjollema, Geoff and Bertram, Edward M and Mackay, Fabienne and Rimmer, Andrew J and Cornall, Richard J and Field, Matthew A and Andrews, T. Daniel and Goodnow, Christopher C and Enders, Anselm
Journal of Experimental Medicine, ISSN 0022-1007, 01/2013, Volume 210, Issue 1, pp. 31 - 40
Druggable proteins required for B lymphocyte survival and immune responses are an emerging source of new treatments for autoimmunity and lymphoid malignancy.... 
MEDICINE, RESEARCH & EXPERIMENTAL | ENDOSOMES | DEFICIENT | MATURE | RECEPTOR | ANTIGEN PRESENTATION | KAPPA-B | PROTEOLYSIS | DIFFERENTIATION | IMMUNOLOGY | INVARIANT-CHAIN | MHC CLASS-II | Receptors, Fc - metabolism | Dendritic Cells - physiology | Aspartic Acid Endopeptidases - genetics | Proto-Oncogene Proteins c-bcl-2 - metabolism | Mice, Mutant Strains | B-Lymphocyte Subsets - immunology | Histocompatibility Antigens Class II - metabolism | Membrane Proteins - metabolism | B-Cell Activation Factor Receptor - genetics | Cell Survival | Membrane Proteins - genetics | Immunity, Humoral - genetics | Mice, Inbred C57BL | Gene Expression Regulation | B-Lymphocytes - physiology | B-Cell Activation Factor Receptor - metabolism | CD8 Antigens - metabolism | Animals | B-Cell Activating Factor - metabolism | B-Cell Activating Factor - genetics | Aspartic Acid Endopeptidases - metabolism | CD8 Antigens - genetics | Receptors, Fc - genetics | Mice | Antigens, Differentiation, B-Lymphocyte - metabolism | Proto-Oncogene Proteins c-bcl-2 - genetics | Index Medicus | 309 | Brief Definitive Report
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2. Full Text Inhibition of GSK3β-mediated BACE1 expression reduces Alzheimer-associated phenotypes
by Ly, Philip T.T and Wu, Yili and Zou, Haiyan and Wang, Ruitao and Zhou, Weihui and Kinoshita, Ayae and Zhang, Mingming and Yang, Yi and Cai, Fang and Woodgett, James and Song, Weihong
Journal of Clinical Investigation, ISSN 0021-9738, 01/2013, Volume 123, Issue 1, pp. 224 - 235
Deposition of amyloid beta protein (A beta) to form neuritic plaques in the brain is the pathological hallmark of Alzheimer's disease (AD). A beta is generated... 
GLYCOGEN-SYNTHASE KINASE-3-BETA | MEDICINE, RESEARCH & EXPERIMENTAL | BETA-SECRETASE ACTIVITY | TUMOR-NECROSIS-FACTOR | SMALL-MOLECULE INHIBITORS | MOUSE MODEL | A-BETA | GENE-EXPRESSION | PRODUCTION IN-VIVO | AMYLOID PRECURSOR PROTEIN | KAPPA-B | Amyloid Precursor Protein Secretases - genetics | Aspartic Acid Endopeptidases - biosynthesis | Humans | Glycogen Synthase Kinase 3 beta | NF-kappa B - metabolism | Aspartic Acid Endopeptidases - genetics | Alzheimer Disease - pathology | Amyloid beta-Protein Precursor - metabolism | HEK293 Cells | Disease Models, Animal | Plaque, Amyloid - enzymology | Plaque, Amyloid - pathology | Glycogen Synthase Kinase 3 - antagonists & inhibitors | Signal Transduction - genetics | Alzheimer Disease - enzymology | Glycogen Synthase Kinase 3 - metabolism | Mice, Knockout | Plaque, Amyloid - genetics | Gene Expression Regulation, Enzymologic | Amyloid Precursor Protein Secretases - metabolism | Amyloid beta-Protein Precursor - genetics | Animals | Glycogen Synthase Kinase 3 - genetics | NF-kappa B - genetics | Aspartic Acid Endopeptidases - metabolism | Mice | Enzyme Activation | Transcription, Genetic - genetics | Alzheimer Disease - genetics | Amyloid Precursor Protein Secretases - biosynthesis | Index Medicus | Abridged Index Medicus
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3. Full Text The expression of microRNA miR-107 decreases early in Alzheimer's disease and may accelerate disease progression through regulation of β-site amyloid precursor protein-cleaving enzyme 1
by Wang, Wang-Xia and Rajeev, Bernard W and Stromberg, Arnold J and Ren, Na and Tang, Guiliang and Huang, Qingwei and Rigoutsos, Isidore and Nelson, Peter T
Journal of Neuroscience, ISSN 0270-6474, 01/2008, Volume 28, Issue 5, pp. 1213 - 1223
MicroRNAs (miRNAs) are small regulatory RNAs that participate in posttranscriptional gene regulation in a sequence-specific manner. However, little is... 
Noncoding | miRNAs | Microarray | In situ | Alzheimer's | BACE | PATHWAYS | NEUROFIBRILLARY TANGLES | TRANSLATIONAL REGULATION | noncoding | NEUROSCIENCES | in situ | MICROARRAY ANALYSIS | PREDICTION | microarray | MESSENGER-RNA | SECRETASE ACTIVITY | BACE INHIBITORS | BRAIN | Aspartic Acid Endopeptidases - physiology | Amyloid Precursor Protein Secretases - genetics | Amyloid Precursor Protein Secretases - physiology | Gene Expression Regulation - genetics | Humans | Male | MicroRNAs - biosynthesis | Alzheimer Disease - enzymology | Aspartic Acid Endopeptidases - genetics | Disease Progression | Alzheimer Disease - pathology | Amyloid Precursor Protein Secretases - metabolism | Time Factors | Aspartic Acid Endopeptidases - metabolism | Aged, 80 and over | Female | Aged | MicroRNAs - genetics | MicroRNAs - physiology | Alzheimer Disease - genetics | Index Medicus
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4. Full Text Genome sequencing and analysis of Aspergillus oryzae
by Fedorova, Natalie D and Cleveland, Thomas E and Iwashita, Kazuhiro and Okada, Kinya and Machida, Masayuki and Asai, Kiyoshi and Takase, Kumiko and Gomi, Katsuya and Koide, Yoshinao and Wortman, Jennifer R and Hata, Yoji and Galagan, James E and Kikuchi, Hisashi and Akita, Osamu and Denning, David W and Terabayashi, Yasunobu and Minetoki, Toshitaka and Komori, Takashi and Kashiwagi, Yutaka and Kato, Yumiko and Nagasaki, Hideki and Kokubun, Akira and Maeyama, Noriko and Takahashi, Mikio and Terai, Goro and Arima, Toshihide and Kobayashi, Tetsuo and Kin, Taishin and Tanaka, Akimitsu and Sawano, Toshihiko and Sakamoto, Kazutoshi and Takeuchi, Michio and Paulsen, Ian and Sano, Motoaki and Suharnan, Sivasundaram and Horikawa, Hiroshi and Anazawa, Hideharu and Ogasawara, Naotake and Kusumoto, Ken-Ichi and Nierman, William C and Oda, Ken and Bennett, Joan W and Nakajima, Tasuku and Kumagai, Toshitaka and Archer, David B and Ichinomiya, Masayuki and Yu, Jiujiang and Gotoh, Osamu and Maeda, Hiroshi and Juvvadi, Praveen Rao and Koyama, Yasuji and Tanaka, Toshihiro and Isono, Katsumi and Kitamoto, Katsuhiko and Igarashi, Rie and Maruyama, Jun-ichi and Yamagata, Youhei and Horiuchi, Hiroyuki and Kuhara, Satoru and Abe, Keietsu and Kato, Masashi and Yamada, Osamu and Bhatnagar, Deepak and Hosoyama, Akira
Nature, ISSN 0028-0836, 12/2005, Volume 438, Issue 7071, pp. 1157 - 1161
The genome of Aspergillus oryzae, a fungus important for the production of traditional fermented foods and beverages in Japan, has been sequenced. The ability... 
TRANSFORMATION | YEAST | HIGH-LEVEL EXPRESSION | EVOLUTION | GENE | DNA | MULTIDISCIPLINARY SCIENCES | PLASMID | FLAVUS | PROGRAM | TAGS | Aspergillus oryzae - genetics | Aspergillus oryzae - enzymology | Chromosomes, Fungal - genetics | Genome, Fungal | Genomics | Synteny | Cytochrome P-450 Enzyme System - genetics | Molecular Sequence Data | Aspartic Acid Endopeptidases - genetics | Phylogeny | Aspergillus oryzae - metabolism | Genes, Fungal - genetics | Fungi | Index Medicus
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5. Full Text Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes
by Seow, Yiqi and Betts, Corinne and Wood, Matthew J A and Lakhal, Samira and Yin, HaiFang and Alvarez-Erviti, Lydia
Nature Biotechnology, ISSN 1087-0156, 04/2011, Volume 29, Issue 4, pp. 341 - 345
To realize the therapeutic potential of RNA drugs, efficient, tissue-specific and nonimmunogenic delivery technologies must be developed. Here we show that... 
BACE1 | CELLS | GENE DELIVERY | RNA | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | PERSPECTIVES | GROWTH | NEURONS | MICE | VECTORS | Exosomes - metabolism | Amyloid Precursor Protein Secretases - genetics | Cell Line | Gene Transfer Techniques | Microglia - metabolism | Lysosomal-Associated Membrane Protein 2 - genetics | Mice, Inbred C57BL | Alzheimer Disease - therapy | Male | Aspartic Acid Endopeptidases - genetics | RNA, Messenger - metabolism | Gene Knockdown Techniques | Brain - metabolism | Rabies virus - metabolism | Animals | Peptides - metabolism | Proteins - metabolism | Membrane Proteins - metabolism | Mice | Neurons - metabolism | Genetic Vectors | RNA, Small Interfering - administration & dosage | Dendritic Cells - metabolism | Research | Membrane proteins | Brain | Biotechnology | Gene therapy | Ribonucleic acid--RNA | Rodents | Index Medicus
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6. Full Text Loss of microRNA Cluster miR-29a/b-1 in Sporadic Alzheimer's Disease Correlates with Increased BACE1/β-Secretase Expression
by Sébastien S. Hébert and Katrien Horré and Laura Nicolaï and Aikaterini S. Papadopoulou and Wim Mandemakers and Asli N. Silahtaroglu and Sakari Kauppinen and André Delacourte and Bart De Strooper
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 4/2008, Volume 105, Issue 17, pp. 6415 - 6420
Although the role of APP and PSEN genes in genetic Alzheimer's disease (AD) cases is well established, fairly little is known about the molecular mechanisms... 
Brain | MicroRNA | Messenger RNA | Neurons | Neuroglia | Antibodies | Gene expression regulation | Amyloids | Alzheimers disease | Three prime untranslated regions | Neurodegeneration | Noncoding RNA | Amyloid | CLEAVING ENZYME-1 | GAMMA | NERVOUS-SYSTEM | BACE1 EXPRESSION | noncoding RNA | BETA-SECRETASE EXPRESSION | MULTIDISCIPLINARY SCIENCES | neurodegeneration | AMYLOID-PRECURSOR-PROTEIN | MISSENSE MUTATIONS | amyloid | GENE | NEURONS | BRAIN | Amyloid Precursor Protein Secretases - genetics | Cell Line | Humans | Up-Regulation - genetics | Gene Expression Profiling | Alzheimer Disease - enzymology | Aspartic Acid Endopeptidases - genetics | Brain - metabolism | Amyloid Precursor Protein Secretases - metabolism | Animals | Gene Expression Regulation, Developmental | Aspartic Acid Endopeptidases - metabolism | Amyloid beta-Peptides - metabolism | Brain - pathology | Mice | MicroRNAs - genetics | Alzheimer Disease - genetics | Index Medicus | Biological Sciences
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7. Full Text Secretome protein enrichment identifies physiological BACE1 protease substrates in neurons
by Kuhn, Peer‐Hendrik and Koroniak, Katarzyna and Hogl, Sebastian and Colombo, Alessio and Zeitschel, Ulrike and Willem, Michael and Volbracht, Christiane and Schepers, Ute and Imhof, Axel and Hoffmeister, Albrecht and Haass, Christian and Roßner, Steffen and Bräse, Stefan and Lichtenthaler, Stefan F
The EMBO Journal, ISSN 0261-4189, 07/2012, Volume 31, Issue 14, pp. 3157 - 3168
Cell surface proteolysis is essential for communication between cells and results in the shedding of membrane‐protein ectodomains. However, physiological... 
bioorthogonal chemistry | click chemistry | Alzheimer's disease | quantitative proteomics | proteases | OLFACTORY SENSORY NEURONS | PERIPHERAL NERVOUS-SYSTEM | BIOCHEMISTRY & MOLECULAR BIOLOGY | AMYLOID PRECURSOR PROTEIN | BETA | CELL BIOLOGY | NEURITE OUTGROWTH | DISEASE | CELL-ADHESION MOLECULES | MICE | BRAIN | PROTEOMICS | Nerve Tissue Proteins - metabolism | Amyloid Precursor Protein Secretases - genetics | Amyloid Precursor Protein Secretases - metabolism | Synapses - secretion | Animals | Neurites - secretion | Aspartic Acid Endopeptidases - metabolism | Substrate Specificity | Mice | Aspartic Acid Endopeptidases - genetics | Nerve Tissue Proteins - genetics | Mice, Knockout | Proteins | Anatomy & physiology | Proteases | Neurons | Substrates | Index Medicus
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8. Full Text Plasmepsin V licenses Plasmodium proteins for export into the host erythrocyte
by Russo, Ilaria and Oksman, Anna and Babbitt, Shalon and Muralidharan, Vasant and Butler, Tamira and Goldberg, Daniel E
Nature, ISSN 0028-0836, 02/2010, Volume 463, Issue 7281, pp. 632 - 636
During their intraerythrocytic development, malaria parasites export hundreds of proteins to remodel their host cell. Nutrient acquisition, cytoadherence and... 
CALPAIN | FALCIPARUM | MULTIDISCIPLINARY SCIENCES | FOOD VACUOLE | TRAFFICKING | ENDOPLASMIC-RETICULUM | MALARIA PARASITES | VIRULENCE | REVEALS | Plasmodium falciparum - enzymology | Humans | Malaria, Falciparum - pathology | Endoplasmic Reticulum - metabolism | Substrate Specificity | Aspartic Acid Endopeptidases - genetics | Pepstatins - pharmacology | HIV Protease Inhibitors - pharmacology | Malaria, Falciparum - blood | Multiprotein Complexes - metabolism | Protozoan Proteins - metabolism | Genes, Dominant | Biocatalysis - drug effects | Plasmodium falciparum - genetics | Plasmids - genetics | Malaria, Falciparum - metabolism | Erythrocytes - cytology | Plasmodium falciparum - metabolism | Protozoan Proteins - chemistry | Endoplasmic Reticulum - enzymology | Protein Structure, Tertiary | Aspartic Acid Endopeptidases - chemistry | Aspartic Acid Endopeptidases - antagonists & inhibitors | Genes, Essential | Protein Sorting Signals | Amino Acid Motifs | Antimalarials - pharmacology | Protein Transport | Malaria, Falciparum - parasitology | Phenotype | Animals | Aspartic Acid Endopeptidases - metabolism | Erythrocytes - metabolism | Proteomics | Plasmodium falciparum - pathogenicity | Protein Binding | Erythrocytes - parasitology | Plasmodium falciparum | Research | Malaria | Proteases | Erythrocytes | Proteins | Genotype & phenotype | Mass spectrometry | International trade | Enzymes | Protease | Parasites | Endoplasmic reticulum | Exports | Index Medicus
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9. Full Text β-site amyloid precursor protein cleaving enzyme 1 levels become elevated in neurons around amyloid plaques: Implications for Alzheimer's disease pathogenesis
by Zhao, Jie and Fu, Yifan and Yasvoina, Marina and Shao, Peizhen and Hitt, Brian and O'Connor, Tracy and Logan, Sreemathi and Maus, Erika and Citron, Martin and Berry, Robert and Binder, Lester and Vassar, Robert
Journal of Neuroscience, ISSN 0270-6474, 04/2007, Volume 27, Issue 14, pp. 3639 - 3649
beta-Site amyloid precursor protein cleaving enzyme 1 (BACE1) (beta-secretase) initiates generation of beta-amyloid (A beta), which plays an early role in... 
β-secretase | 5XFAD | APP transgenic | Neurodegeneration | BACE-Cat1 | Tg2576 | APP | ASPARTYL PROTEASE | MEMORY DEFICITS | neurodegeneration | CLEAVAGE | NEUROSCIENCES | TRANSGENIC TG2576 MICE | BACE1 | beta-secretase | SECRETASE ACTIVITY | A-BETA | EXPRESSION | BRAIN | Aspartic Acid Endopeptidases - physiology | Amyloid Precursor Protein Secretases - genetics | Neurons - pathology | Amyloid Precursor Protein Secretases - physiology | Aspartic Acid Endopeptidases - biosynthesis | Humans | Male | Aspartic Acid Endopeptidases - genetics | Alzheimer Disease - pathology | Aged, 80 and over | Female | Plaque, Amyloid - enzymology | Plaque, Amyloid - pathology | Mice, Inbred C57BL | Mice, Transgenic | Alzheimer Disease - enzymology | Mice, Knockout | Animals | Neurons - enzymology | Amyloid Precursor Protein Secretases - deficiency | Aged | Mice | Alzheimer Disease - genetics | Aspartic Acid Endopeptidases - deficiency | Amyloid Precursor Protein Secretases - biosynthesis | Index Medicus
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10. Full Text Evidence for natural antisense transcript-mediated inhibition of microRNA function
by Faghihi, Mohammad Ali and Zhang, Ming and Huang, Jia and Modarresi, Farzaneh and Van der Brug, Marcel P and Nalls, Michael A and Cookson, Mark R and St-Laurent III, Georges and Wahlestedt, Claes
Genome Biology, ISSN 1474-7596, 05/2010, Volume 11, Issue 5, pp. R56 - R56
Background: MicroRNAs (miRNAs) have the potential to regulate diverse sets of mRNA targets. In addition, mammalian genomes contain numerous natural antisense... 
NONCODING RNA | BACE1 | NERVOUS-SYSTEM | BETA-SECRETASE ACTIVITY | OXIDATIVE STRESS | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | ALZHEIMERS-DISEASE | GENETICS & HEREDITY | GENE-EXPRESSION | MAMMALIAN TRANSCRIPTOME | DRUG TARGET | HIF-1-ALPHA | Amyloid Precursor Protein Secretases - genetics | Luciferases - metabolism | RNA, Untranslated - metabolism | Humans | Brain - enzymology | Molecular Sequence Data | MicroRNAs - metabolism | Aspartic Acid Endopeptidases - genetics | RNA, Messenger - metabolism | RNA, Untranslated - genetics | Oligonucleotides - pharmacology | Base Sequence | Aged, 80 and over | Binding Sites | Cell Line | Reproducibility of Results | RNA, Messenger - genetics | Alzheimer Disease - enzymology | Open Reading Frames - genetics | Sequence Analysis, DNA | Binding, Competitive - drug effects | Brain - drug effects | Amyloid Precursor Protein Secretases - metabolism | Animals | High-Throughput Screening Assays | Aspartic Acid Endopeptidases - metabolism | RNA, Antisense - metabolism | Brain - pathology | Aged | Mice | MicroRNAs - genetics | Alzheimer Disease - genetics | Index Medicus | Research
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11. Full Text Epigenetic regulation of motor neuron cell death through DNA methylation
by Chestnut, Barry A and Chang, Qing and Price, Ann and Lesuisse, Catherine and Wong, Margaret and Martin, Lee J
Journal of Neuroscience, ISSN 0270-6474, 11/2011, Volume 31, Issue 46, pp. 16619 - 16636
DNA methylation is an epigenetic mechanism for gene silencing engaged by DNA methyltransferase (Dnmt)-catalyzed methyl group transfer to cytosine residues in... 
SUBCELLULAR REDISTRIBUTION | PERMEABILITY TRANSITION PORE | WESTERN-BLOT-ANALYSIS | DE-NOVO | SPINAL-CORD | CENTRAL-NERVOUS-SYSTEM | AMYOTROPHIC-LATERAL-SCLEROSIS | METHYLTRANSFERASES DNMT3A | CEREBRAL-ISCHEMIA | NEUROSCIENCES | TRANSGENIC MICE | Propionates - pharmacology | Amyloid Precursor Protein Secretases - genetics | Cytosine - analogs & derivatives | RNA, Small Interfering - genetics | Central Nervous System - metabolism | Age Factors | Apoptosis - drug effects | 5-Methylcytosine - analogs & derivatives | Humans | Caspase 3 - metabolism | Gene Expression Regulation, Developmental - genetics | Apoptosis - genetics | Green Fluorescent Proteins - genetics | Aspartic Acid Endopeptidases - genetics | Central Nervous System - growth & development | Transfection | Epigenomics - methods | Cytosine - metabolism | Tryptophan - analogs & derivatives | Indoles - pharmacology | Superoxide Dismutase - metabolism | Disease Models, Animal | Motor Neurons - physiology | DNA (Cytosine-5-)-Methyltransferase 1 | Enzyme Inhibitors - pharmacology | Gene Expression Regulation, Developmental - drug effects | Sciatic Neuropathy - pathology | Mice, Transgenic | Up-Regulation - genetics | DNA Methylation - genetics | Mutation - genetics | Up-Regulation - drug effects | DNA (Cytosine-5-)-Methyltransferases - genetics | Amyloid Precursor Protein Secretases - metabolism | Amyotrophic Lateral Sclerosis - pathology | Animals | Phthalimides | Aspartic Acid Endopeptidases - metabolism | Mice | Camptothecin - pharmacology | Sciatic Neuropathy - metabolism | Cell Line, Transformed | RNA, Small Interfering - metabolism | Index Medicus | Dnmt-GFP | RG108 | NSC34 cells | mitochondria | DNA methylation | 5-methylcytosine | DNA methyltransferase | axotomy | epigenetics | Hb9-eGFP | Apoptosis
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12. Full Text Expression of a noncoding RNA is elevated in Alzheimer's disease and drives rapid feed-forward regulation of β-secretase
by Sahagan, Barbara G and Finch, Caleb E and Wood, Douglas E and St. Laurent III, Georges and Modarresi, Farzaneh and Faghihi, Mohammad Ali and Kenny, Paul J and Wahlestedt, Claes and Morgan, Todd E and Khalil, Ahmad M
Nature Medicine, ISSN 1078-8956, 07/2008, Volume 14, Issue 7, pp. 723 - 730
Recent efforts have revealed that numerous protein-coding messenger RNAs have natural antisense transcript partners, most of which seem to be noncoding RNAs.... 
MEDICINE, RESEARCH & EXPERIMENTAL | NERVOUS-SYSTEM | OXIDATIVE STRESS | BIOCHEMISTRY & MOLECULAR BIOLOGY | NEUROLOGICAL DISORDERS | AMYLOID PRECURSOR PROTEIN | CEREBROSPINAL-FLUID | SYNAPTIC PLASTICITY | CELL BIOLOGY | BACE1 GENE-EXPRESSION | A-BETA | MITOCHONDRIAL DYSFUNCTION | TRANSGENIC MICE | Alzheimer Disease - etiology | Amyloid Precursor Protein Secretases - genetics | RNA, Untranslated - metabolism | Humans | Middle Aged | Male | Aspartic Acid Endopeptidases - genetics | RNA, Messenger - metabolism | Transfection | Amyloid beta-Peptides - metabolism | Aged, 80 and over | Transcription, Genetic | Neuroblastoma - pathology | Alzheimer Disease - physiopathology | Peptide Fragments - metabolism | RNA, Small Interfering - pharmacology | Gene Expression Regulation | Mice, Transgenic | Alzheimer Disease - enzymology | Amyloid Precursor Protein Secretases - metabolism | Feedback, Physiological | Animals | Aspartic Acid Endopeptidases - metabolism | Alzheimer Disease - metabolism | RNA, Untranslated - analysis | Cell Line, Tumor | Aged | Mice | Models, Genetic | Protein Processing, Post-Translational | Index Medicus
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