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1. Full Text B cell survival, surface BCR and BAFFR expression, CD74 metabolism, and CD8- dendritic cells require the intramembrane endopeptidase SPPl2A
by Bergmann, Hannes and Yabas, Mehmet and Short, Alanna and Miosge, Lisa and Barthel, Nadine and Teh, Charis E and Roots, Carla M and Bull, Katherine R and Jeelall, Yogesh and Horikawa, Keisuke and Whittle, Belinda and Balakishnan, Bhavani and Sjollema, Geoff and Bertram, Edward M and Mackay, Fabienne and Rimmer, Andrew J and Cornall, Richard J and Field, Matthew A and Andrews, T. Daniel and Goodnow, Christopher C and Enders, Anselm
The Journal of experimental medicine, ISSN 0022-1007, 01/2013, Volume 210, Issue 1, pp. 31 - 40
Immunology | Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine | Receptors, Fc - metabolism | Dendritic Cells - physiology | Aspartic Acid Endopeptidases - genetics | Proto-Oncogene Proteins c-bcl-2 - metabolism | Mice, Mutant Strains | B-Lymphocyte Subsets - immunology | Histocompatibility Antigens Class II - metabolism | Membrane Proteins - metabolism | B-Cell Activation Factor Receptor - genetics | Cell Survival | Membrane Proteins - genetics | Immunity, Humoral - genetics | Mice, Inbred C57BL | Gene Expression Regulation | B-Lymphocytes - physiology | B-Cell Activation Factor Receptor - metabolism | CD8 Antigens - metabolism | Animals | B-Cell Activating Factor - metabolism | B-Cell Activating Factor - genetics | Aspartic Acid Endopeptidases - metabolism | CD8 Antigens - genetics | Receptors, Fc - genetics | Mice | Antigens, Differentiation, B-Lymphocyte - metabolism | Proto-Oncogene Proteins c-bcl-2 - genetics | Index Medicus | 309 | Brief Definitive Report
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2. Full Text Inhibition of GSK3β-mediated BACE1 expression reduces Alzheimer-associated phenotypes
by Ly, Philip T.T and Wu, Yili and Zou, Haiyan and Wang, Ruitao and Zhou, Weihui and Kinoshita, Ayae and Zhang, Mingming and Yang, Yi and Cai, Fang and Woodgett, James and Song, Weihong
The Journal of clinical investigation, ISSN 0021-9738, 01/2013, Volume 123, Issue 1, pp. 224 - 235
Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine | Amyloid Precursor Protein Secretases - genetics | Aspartic Acid Endopeptidases - biosynthesis | Humans | Glycogen Synthase Kinase 3 beta | NF-kappa B - metabolism | Aspartic Acid Endopeptidases - genetics | Alzheimer Disease - pathology | Amyloid beta-Protein Precursor - metabolism | HEK293 Cells | Disease Models, Animal | Plaque, Amyloid - enzymology | Plaque, Amyloid - pathology | Glycogen Synthase Kinase 3 - antagonists & inhibitors | Signal Transduction - genetics | Alzheimer Disease - enzymology | Glycogen Synthase Kinase 3 - metabolism | Mice, Knockout | Plaque, Amyloid - genetics | Gene Expression Regulation, Enzymologic | Amyloid Precursor Protein Secretases - metabolism | Amyloid beta-Protein Precursor - genetics | Animals | Glycogen Synthase Kinase 3 - genetics | NF-kappa B - genetics | Aspartic Acid Endopeptidases - metabolism | Mice | Enzyme Activation | Transcription, Genetic - genetics | Alzheimer Disease - genetics | Amyloid Precursor Protein Secretases - biosynthesis | Index Medicus | Abridged Index Medicus
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3. Full Text The S8 serine, C1A cysteine and A1 aspartic protease families in Arabidopsis
by Beers, Eric P and Jones, Alan M and Dickerman, Allan W
Phytochemistry (Oxford), ISSN 0031-9422, 2004, Volume 65, Issue 1, pp. 43 - 58
Arabidopsis thaliana | Cysteine protease | Aspartic protease | Crucifereae | Papain | Serine protease | Pepsin | Subtilisin | Fundamental and applied biological sciences. Psychology | Enzymes | Biological and medical sciences | Metabolism | Plant physiology and development | Cysteine Endopeptidases - chemistry | Amino Acid Sequence | Aspartic Acid Endopeptidases - chemistry | Arabidopsis - enzymology | Molecular Sequence Data | Serine Endopeptidases - chemistry | Aspartic Acid Endopeptidases - genetics | Phylogeny | Sequence Alignment | Cysteine Endopeptidases - metabolism | Aspartic Acid Endopeptidases - metabolism | Cysteine Endopeptidases - genetics | Databases, Protein | Serine Endopeptidases - genetics | Serine Endopeptidases - metabolism | Genetic Structures | Embryonic development | Thiols | Genomics | Family | Thrombin | Amino acids | Cellular signal transduction | Index Medicus
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4. Full Text The expression of microRNA miR-107 decreases early in Alzheimer's disease and may accelerate disease progression through regulation of β-site amyloid precursor protein-cleaving enzyme 1
by Wang, Wang-Xia and Rajeev, Bernard W and Stromberg, Arnold J and Ren, Na and Tang, Guiliang and Huang, Qingwei and Rigoutsos, Isidore and Nelson, Peter T
The Journal of neuroscience, ISSN 0270-6474, 01/2008, Volume 28, Issue 5, pp. 1213 - 1223
Noncoding | miRNAs | Microarray | In situ | Alzheimer's | BACE | Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Aspartic Acid Endopeptidases - physiology | Amyloid Precursor Protein Secretases - genetics | Amyloid Precursor Protein Secretases - physiology | Gene Expression Regulation - genetics | Humans | Male | MicroRNAs - biosynthesis | Alzheimer Disease - enzymology | Aspartic Acid Endopeptidases - genetics | Disease Progression | Alzheimer Disease - pathology | Amyloid Precursor Protein Secretases - metabolism | Time Factors | Aspartic Acid Endopeptidases - metabolism | Aged, 80 and over | Female | Aged | MicroRNAs - genetics | MicroRNAs - physiology | Alzheimer Disease - genetics | Index Medicus | microarray | noncoding | in situ
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5. Full Text Signal Peptidases
by Paetzel, Mark and Karla, Andrew and Strynadka, Natalie C. J and Dalbey, Ross E
Chemical reviews, ISSN 0009-2665, 12/2002, Volume 102, Issue 12, pp. 4549 - 4580
Physical Sciences | Chemistry | Chemistry, Multidisciplinary | Science & Technology | Metalloendopeptidases - genetics | Aspartic Acid Endopeptidases - chemistry | Substrate Specificity | Metalloendopeptidases - metabolism | Serine Endopeptidases - chemistry | Aspartic Acid Endopeptidases - genetics | Protein Sorting Signals | Bacterial Proteins | Membrane Proteins | Aspartic Acid Endopeptidases - metabolism | Metalloendopeptidases - chemistry | Serine Endopeptidases - genetics | Plant Proteins | Serine Endopeptidases - metabolism | Enzymes | Proteases | Research | Proteins | Peptides | Index Medicus
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6. Full Text A Diet Enriched with the Omega-3 Fatty Acid Docosahexaenoic Acid Reduces Amyloid Burden in an Aged Alzheimer Mouse Model
by Lim, Giselle P and Calon, Frederic and Morihara, Takashi and Yang, Fusheng and Teter, Bruce and Ubeda, Oliver and Salem, Norman, Jr and Frautschy, Sally A and Cole, Greg M
The Journal of neuroscience, ISSN 0270-6474, 03/2005, Volume 25, Issue 12, pp. 3032 - 3040
Polyunsaturated fatty acid | APP | DHA | Alzheimer | Secretase | Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Enzyme-Linked Immunosorbent Assay - methods | Prealbumin - genetics | Central Nervous System - metabolism | Male | Statistics as Topic | RNA, Messenger - metabolism | Apolipoproteins E - metabolism | Diagnostic Imaging - methods | Dose-Response Relationship, Drug | Alzheimer Disease - diet therapy | Amyloid - metabolism | Aspartic Acid Endopeptidases | Reverse Transcriptase Polymerase Chain Reaction - methods | Amyloid Precursor Protein Secretases | Amyloid beta-Peptides - metabolism | Amyloid beta-Protein Precursor - metabolism | Fatty Acids - metabolism | Disease Models, Animal | Endopeptidases - metabolism | Blotting, Western - methods | Peptide Fragments - metabolism | Plaque, Amyloid - pathology | Administration, Oral | Mice, Transgenic | Docosahexaenoic Acids - administration & dosage | Immunohistochemistry - methods | Docosahexaenoic Acids - pharmacology | Amyloid beta-Protein Precursor - genetics | Animals | Endopeptidases - genetics | Analysis of Variance | Prealbumin - metabolism | Apolipoproteins E - genetics | Alzheimer Disease - metabolism | Central Nervous System - drug effects | Dietary Fats, Unsaturated - administration & dosage | Mice | Index Medicus | Aβ | Neurobiology of Disease | secretase | polyunsaturated fatty acid
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7. Full Text The endosome-associated deubiquitinating enzyme USP8 regulates BACE1 enzyme ubiquitination and degradation
by Yeates, Eniola Funmilayo Aduke and Tesco, Giuseppina
The Journal of biological chemistry, ISSN 0021-9258, 07/2016, Volume 291, Issue 30, pp. 15753 - 15766
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Amyloid Precursor Protein Secretases - genetics | Endopeptidases - metabolism | Humans | Lysosomes - genetics | Adaptor Proteins, Vesicular Transport - genetics | Endosomal Sorting Complexes Required for Transport - metabolism | Endosomal Sorting Complexes Required for Transport - genetics | Aspartic Acid Endopeptidases - genetics | Ubiquitin Thiolesterase - genetics | Adaptor Proteins, Vesicular Transport - metabolism | Protein Transport - genetics | Amyloid Precursor Protein Secretases - metabolism | Ubiquitination | Amyloid beta-Protein Precursor - genetics | Endopeptidases - genetics | Lysosomes - metabolism | Proteolysis | Aspartic Acid Endopeptidases - metabolism | Alzheimer Disease - metabolism | Amyloid beta-Protein Precursor - metabolism | Cell Line, Tumor | Ubiquitin Thiolesterase - metabolism | Alzheimer Disease - genetics | Index Medicus | deubiquitylation (deubiquitination) | Alzheimer disease | Protein Synthesis and Degradation | β-secretase 1 (BACE1) | amyloid-β (AB) | lysosome | trafficking | protein degradation
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8. Full Text Plasmepsin V licenses Plasmodium proteins for export into the host erythrocyte
by Russo, Ilaria and Oksman, Anna and Babbitt, Shalon and Muralidharan, Vasant and Butler, Tamira and Goldberg, Daniel E
Nature (London), ISSN 0028-0836, 02/2010, Volume 463, Issue 7281, pp. 632 - 636
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Infectious diseases | Malaria | Parasitic diseases | Protozoal diseases | Biological and medical sciences | Human protozoal diseases | Medical sciences | Plasmodium falciparum - enzymology | Humans | Malaria, Falciparum - pathology | Endoplasmic Reticulum - metabolism | Substrate Specificity | Aspartic Acid Endopeptidases - genetics | Pepstatins - pharmacology | HIV Protease Inhibitors - pharmacology | Malaria, Falciparum - blood | Multiprotein Complexes - metabolism | Protozoan Proteins - metabolism | Genes, Dominant | Biocatalysis - drug effects | Plasmodium falciparum - genetics | Plasmids - genetics | Malaria, Falciparum - metabolism | Erythrocytes - cytology | Plasmodium falciparum - metabolism | Protozoan Proteins - chemistry | Endoplasmic Reticulum - enzymology | Protein Structure, Tertiary | Aspartic Acid Endopeptidases - chemistry | Aspartic Acid Endopeptidases - antagonists & inhibitors | Genes, Essential | Protein Sorting Signals | Amino Acid Motifs | Antimalarials - pharmacology | Protein Transport | Malaria, Falciparum - parasitology | Phenotype | Animals | Aspartic Acid Endopeptidases - metabolism | Erythrocytes - metabolism | Proteomics | Plasmodium falciparum - pathogenicity | Protein Binding | Erythrocytes - parasitology | Plasmodium falciparum | Research | Proteases | Erythrocytes | Proteins | Genotype & phenotype | Mass spectrometry | International trade | Enzymes | Protease | Parasites | Endoplasmic reticulum | Exports | Index Medicus
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9. Full Text Twenty Years of the Alzheimer’s Disease Amyloid Hypothesis: A Genetic Perspective
by Tanzi, Rudolph E and Bertram, Lars
Cell (Cambridge), ISSN 0092-8674, 2005, Volume 120, Issue 4, pp. 545 - 555
Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Alzheimer Disease - etiology | Endopeptidases - metabolism | Alzheimer Disease - physiopathology | Chromosomes, Human, Pair 21 - metabolism | Humans | Protein Denaturation - physiology | Chromosomes, Human, Pair 21 - genetics | Mutation - genetics | Protein Denaturation - genetics | Amyloid beta-Protein Precursor - genetics | Endopeptidases - genetics | Amyloid beta-Peptides - genetics | Aspartic Acid Endopeptidases | Alzheimer Disease - metabolism | Amyloid Precursor Protein Secretases | Amyloid beta-Peptides - metabolism | Amyloid beta-Protein Precursor - metabolism | Alzheimer Disease - genetics | Prevention | Genetic aspects | Research | Alzheimer's disease | Amyloid beta-protein | Index Medicus
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