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1. Full Text First detection of TR34 L98H and TR46 Y121F T289A Cyp51 mutations in aspergillus fumigatus isolates in the United States
by Wiederhold, Nathan P and Gil, Veronica Garcia and Gutierrez, Felipe and Lindner, Jonathan R and Albataineh, Mohammad T and McCarthy, Dora I and Sanders, Carmita and Fan, Hongxin and Fothergill, Annette W and Sutton, Deanna A
Journal of Clinical Microbiology, ISSN 0095-1137, 01/2016, Volume 54, Issue 1, pp. 168 - 171
Azole resistance in Aspergillus fumigatus is an increasing problem. The TR34 L98H and TR46 Y121F T289A mutations that can occur in patients without previous... 
CELL TRANSPLANT RECIPIENTS | GLOBAL BURDEN | GENE | CHRONIC PULMONARY ASPERGILLOSIS | ITRACONAZOLE RESISTANCE | AZOLE RESISTANCE | ENVIRONMENT | SURVEILLANCE | MICROBIOLOGY | TR46/Y121F/T289A | IDENTIFICATION | Antifungal Agents - pharmacology | Aspergillus fumigatus - drug effects | Sterol 14-Demethylase - genetics | United States | Humans | Aspergillus fumigatus - enzymology | Mutation, Missense | Aspergillus fumigatus - genetics | Azoles - pharmacology | Microbial Sensitivity Tests | Aspergillus fumigatus - isolation & purification | Aspergillosis - microbiology | Drug Resistance, Fungal | Index Medicus | Mycology
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2. Full Text Structure-functional characterization of cytochrome P450 Sterol 14α-Demethylase (CYP51B) from aspergillus fumigatus and molecular basis for the development of antifungal drugs
by Hargrove, Tatiana Y and Wawrzak, Zdzislaw and Lamb, David C and Guengerich, F. Peter and Lepesheva, Galina I
Journal of Biological Chemistry, ISSN 0021-9258, 09/2015, Volume 290, Issue 39, pp. 23916 - 23934
Aspergillus fumigatus is the opportunistic fungal pathogen that predominantly affects the immunocompromised population and causes 600,000 deaths/year. The... 
CONSERVATION | INHIBITION | RECOGNITION | TRYPANOSOMA-CRUZI | BIOCHEMISTRY & MOLECULAR BIOLOGY | RESISTANCE | SUBSTRATE PREFERENCES | CONFORMATIONAL DYNAMICS | IDENTIFICATION | BINDING | FUNGAL-INFECTIONS | Fungal Proteins - chemistry | Protein Structure, Tertiary | Cytochrome P-450 Enzyme System - chemistry | Aspergillus fumigatus - enzymology | Cytochrome P-450 Enzyme System - genetics | Voriconazole - chemistry | Fungal Proteins - antagonists & inhibitors | Structure-Activity Relationship | Catalysis | Fungal Proteins - genetics | Aspergillus fumigatus - genetics | Drug Resistance, Fungal | Aspergillus | x-ray crystallography | enzyme inhibitor | sterol | drug design | sterol 14alpha-demethylase (CYP51) | cytochrome P450 | antifungal drugs | Enzymology
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3. Full Text The fumagillin biosynthetic gene cluster in Aspergillus fumigatus encodes a cryptic terpene cyclase involved in the formation of β-trans-bergamotene
by Lin, Hsiao-Ching and Chooi, Yit-Heng and Dhingra, Sourabh and Xu, Wei and Calvo, Ana M and Tang, Yi
Journal of the American Chemical Society, ISSN 0002-7863, 03/2013, Volume 135, Issue 12, pp. 4616 - 4619
Fumagillin 1 is a meroterpenoid from Aspergillus fumigatus that is known for its anti-angiogenic activity by binding to human methionine aminopeptidase 2. The... 
OVALICIN | PATHWAY | POLYKETIDE SYNTHASE | PYROPHOSPHATE | MAGNETIC-RESONANCE | INHIBITORS | IDENTIFICATION | METAP-2 | RECONSTITUTION | CHEMISTRY, MULTIDISCIPLINARY | CYCLIZATION | Fatty Acids, Unsaturated - genetics | Cyclohexanes - metabolism | Multigene Family | Polyketide Synthases - metabolism | Sesquiterpenes - metabolism | Aspergillus fumigatus - enzymology | Genes, Fungal | Aspergillus fumigatus - metabolism | Fatty Acids, Unsaturated - metabolism | Aspergillus fumigatus - genetics | Polyketide Synthases - genetics | terpene cyclase | prenyltransferase | polyketide | genome mining | meroterpenoids
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4. Full Text Rapid Induction of Multiple Resistance Mechanisms in Aspergillus fumigatus during Azole Therapy: a Case Study and Review of the Literature
by Simone M. T. Camps and Jan W. M. van der Linden and Yi Li and Ed J. Kuijper and Jaap T. van Dissel and Paul E. Verweij and Willem J. G. Melchers
Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 01/2012, Volume 56, Issue 1, pp. 10 - 16
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VORICONAZOLE | IN-VITRO | POSACONAZOLE | ITRACONAZOLE RESISTANCE | SUSCEPTIBILITY | DRUGS | ANTIFUNGAL AGENTS | MICROBIOLOGY | PHARMACOLOGY & PHARMACY | PATIENT | MUTATIONS | GENE CYP51A | Aspergillus fumigatus - drug effects | Sputum - microbiology | Triazoles - administration & dosage | Humans | Middle Aged | Aspergillus fumigatus - enzymology | Cytochrome P-450 Enzyme System - metabolism | Molecular Sequence Data | Microbial Sensitivity Tests | Time Factors | Female | Itraconazole - administration & dosage | Aspergillosis - drug therapy | Amino Acid Sequence | Mutagenesis, Site-Directed | Drug Resistance, Fungal - drug effects | Models, Molecular | Genotype | Mutation Rate | Drug Resistance, Fungal - genetics | Fungal Proteins - genetics | Aspergillus fumigatus - genetics | Phenotype | Aspergillosis - microbiology | Cytochrome P-450 Enzyme System - genetics | Polymorphism, Single Nucleotide | Antifungal Agents - administration & dosage | Amino Acid Substitution | Fungal Proteins - metabolism | Mechanisms of Resistance
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5. Full Text GH16 and GH81 family β‐(1,3)‐glucanases in Aspergillus fumigatus are essential for conidial cell wall morphogenesis
by Mouyna, Isabelle and Aimanianda, Vishukumar and Hartl, Lukas and Prevost, Marie‐christine and Sismeiro, Odile and Dillies, Marie‐Agnès and Jagla, Bernd and Legendre, Rachel and Coppee, Jean‐Yves and Latgé, Jean‐Paul
Cellular Microbiology, ISSN 1462-5814, 09/2016, Volume 18, Issue 9, pp. 1285 - 1293
The fungal cell wall is a rigid structure because of fibrillar and branched β‐(1,3)‐glucan linked to chitin. Softening of the cell wall is an essential... 
MOLECULAR CHARACTERIZATION | TRANSFORMATION | CANDIDA-ALBICANS | GENE | ESCHERICHIA-COLI | MICROBIOLOGY | SEPARATION | ENDO-1,3-BETA-GLUCANASE | SACCHAROMYCES-CEREVISIAE | NUCLEOTIDE-SEQUENCE | SCHIZOSACCHAROMYCES-POMBE | CELL BIOLOGY | Aspergillus fumigatus - ultrastructure | Glycoside Hydrolases - physiology | Aspergillus fumigatus - enzymology | Spores, Fungal - growth & development | Glycosylation | Cell Wall - enzymology | Spores, Fungal - enzymology | Morphogenesis | Fungal Proteins - physiology | Spores, Fungal - ultrastructure | Aspergillus fumigatus - growth & development | Carbohydrate Conformation | Cell Wall - ultrastructure | Cell Wall | Life Sciences | Microbiology and Parasitology | Glycoside Hydrolases | Spores, Fungal | Mycology | Fungal Proteins | Aspergillus fumigatus
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6. Full Text A New Aspergillus fumigatus Resistance Mechanism Conferring In Vitro Cross-Resistance to Azole Antifungals Involves a Combination of cyp51A Alterations
by E. Mellado and G. Garcia-Effron and L. Alcázar-Fuoli and W. J. G. Melchers and P. E. Verweij and M. Cuenca-Estrella and J. L. Rodríguez-Tudela
Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 06/2007, Volume 51, Issue 6, pp. 1897 - 1904
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EBURICOL 14-ALPHA-DEMETHYLASE CYP51 | INVASIVE ASPERGILLOSIS | REDUCED SUSCEPTIBILITY | 14-ALPHA-STEROL DEMETHYLASE CYP51A | CANDIDA-ALBICANS | ITRACONAZOLE RESISTANCE | CYTOCHROME-P450 14-ALPHA-DEMETHYLASE | AMINO-ACID SUBSTITUTIONS | MICROBIOLOGY | PHARMACOLOGY & PHARMACY | AMPHOTERICIN-B | FILAMENTOUS FUNGI | Antifungal Agents - pharmacology | Aspergillus fumigatus - drug effects | Fungal Proteins - chemistry | Humans | Aspergillus fumigatus - enzymology | Cytochrome P-450 Enzyme System - metabolism | Genotype | Drug Resistance, Fungal - genetics | Fungal Proteins - genetics | Aspergillus fumigatus - genetics | Azoles - pharmacology | Microbial Sensitivity Tests | Cytochrome P-450 Enzyme System - chemistry | Cytochrome P-450 Enzyme System - genetics | Tandem Repeat Sequences - genetics | Amino Acid Substitution | Fungal Proteins - metabolism | Mechanisms of Resistance
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7. Full Text Deletion of the α-(1,3)-Glucan Synthase Genes Induces a Restructuring of the Conidial Cell Wall Responsible for the Avirulence of Aspergillus fumigatus
by Beauvais, Anne and Bozza, Silvia and Kniemeyer, Olaf and Formosa, Céline and Balloy, Viviane and Henry, Christine and Roberson, Robert W and Dague, Etienne and Chignard, Michel and Brakhage, Axel A and Romani, Luigina and Latgé, Jean-Paul
PLoS Pathogens, ISSN 1553-7366, 11/2013, Volume 9, Issue 11, p. e1003716
alpha-(1,3)-Glucan is a major component of the cell wall of Aspergillus fumigatus, an opportunistic human fungal pathogen. There are three genes (AGS1, AGS2... 
PHAGOCYTOSIS | COMPLEMENT | PROTEOME | MICROBIOLOGY | IMMUNE RECOGNITION | FAMILY | ADHESION | INVASIVE ASPERGILLOSIS | VIROLOGY | GROWTH | ENHANCEMENT | POLYMORPHONUCLEAR | PARASITOLOGY | Aspergillosis - enzymology | Humans | Aspergillosis - genetics | Aspergillus fumigatus - enzymology | Cell Wall - genetics | Cell Wall - enzymology | Fungal Proteins - genetics | Aspergillus fumigatus - genetics | Spores, Fungal - enzymology | Aspergillus fumigatus - pathogenicity | Mice, Knockout | Fungal Polysaccharides - genetics | Glucosyltransferases - metabolism | Animals | Aspergillosis - pathology | Gene Deletion | Fungal Polysaccharides - biosynthesis | Spores, Fungal - genetics | Fungal Proteins - metabolism | Glucosyltransferases - genetics | Mycology | Fungal Proteins | Fungal Polysaccharides | Cell Wall | Life Sciences | Microbiology and Parasitology | Spores, Fungal | Aspergillosis | Glucosyltransferases | Aspergillus fumigatus
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8. Full Text Crystal structure of the new investigational drug candidate VT-1598 in complex with Aspergillus fumigatus sterol 14α-demethylase provides insights into its broad-spectrum Antifungal Activity
by Hargrove, Tatiana Y and Garvey, Edward P and Hoekstra, William J and Yates, Christopher M and Wawrzak, Zdzislaw and Rachakonda, Girish and Villalta, Fernando and Lepesheva, Galina I and Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 07/2017, Volume 61, Issue 7
Within the past few decades, the incidence and complexity of human fungal infections have increased, and therefore, the need for safer and more efficient,... 
VT-1598 | Fungal infections | Inhibition | Sterol 14α-demethylase (CYP51) | Aspergillus fumigatus | X-ray structure | HUMAN ENZYME | TRYPANOSOMA-CRUZI | CHAGAS-DISEASE | CANDIDIASIS | inhibition | MICROBIOLOGY | INVASIVE FUNGAL-INFECTIONS | HIGHLY POTENT INHIBITOR | fungal infections | CYP51 | MURINE MODEL | IN-VITRO | sterol 14 alpha-demethylase (CYP51) | PHARMACOLOGY & PHARMACY | ALBICANS | Antifungal Agents - pharmacology | Aspergillus fumigatus - drug effects | Fluconazole - pharmacology | Drugs, Investigational - pharmacology | Tetrazoles - pharmacology | Voriconazole - pharmacology | Sterol 14-Demethylase - genetics | Aspergillus fumigatus - enzymology | Aspergillus fumigatus - genetics | Ketoconazole - pharmacology | Candida albicans - genetics | Microbial Sensitivity Tests | Triazoles - pharmacology | Candida albicans - drug effects | Pyridines - pharmacology | Sterol 14-Demethylase - metabolism | Candida albicans - enzymology
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9. Full Text Structural and biochemical characterization of the dual substrate recognition of the (R)‐selective amine transaminase from Aspergillus fumigatus
by Skalden, Lilly and Thomsen, Maren and Höhne, Matthias and Bornscheuer, Uwe T and Hinrichs, Winfried
FEBS Journal, ISSN 1742-464X, 01/2015, Volume 282, Issue 2, pp. 407 - 415
Chiral amines are important precursors for the pharmaceutical and fine‐chemical industry. In order to guide protein engineering of transaminases to improve... 
gabaculine | dual substrate recognition | X‐ray structure | pyridoxal‐5′‐phosphate | amine transaminase | pyridoxal-5′-phosphate | X-ray structure | OPTICALLY-ACTIVE AMINES | ASYMMETRIC-SYNTHESIS | SPECIFICITY | MECHANISM | BIOCHEMISTRY & MOLECULAR BIOLOGY | CRYSTAL-STRUCTURES | pyridoxal-5 '-phosphate | CHIRAL AMINES | ENZYME | ASPARTATE-AMINOTRANSFERASE | OMEGA-TRANSAMINASES | Amines - chemistry | Pyruvic Acid - chemistry | Aspergillus fumigatus - enzymology | Transaminases - metabolism | Substrate Specificity | Crystallography, X-Ray | Transaminases - chemistry | Amines - metabolism | Cyclohexanecarboxylic Acids - chemistry | Phosphates | Enzymes | Amines | Analysis | Crystals | Chemical properties | Enantiomers | Structure | Fungi | Biochemistry | Microbiology | Substrates
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10. Full Text Isolation, purification and characterization of 5′-phosphodiesterase from Aspergillus fumigatus
by Luo, Zhiting and Fan, Yingying and Li, Qiuxia and Han, Bing and Liu, Yang and Li, Shubo and Qiu, Hua and Pang, Zongwen
PLoS ONE, ISSN 1932-6203, 10/2017, Volume 12, Issue 10, p. e0186011
5'-Phosphodiesterase (5'-PDE) catalyzes the hydrolysis of ribonucleic acid to obtain a mixture of ribonucleotides, such as 5'-guanosine monophosphate and... 
NUCLEOTIDES | PROTEIN | PENICILLIUM-CITRINUM | RNA | SAFETY EVALUATION | MULTIDISCIPLINARY SCIENCES | BARLEY | HYDROLYSIS | NUCLEASE P1 | Hydrolysis | Phosphoric Diester Hydrolases - isolation & purification | Molecular Weight | Phosphoric Diester Hydrolases - metabolism | Aspergillus fumigatus - enzymology | Protein Conformation | Catalysis | Phosphoric Diester Hydrolases - chemistry | Enzyme activity | Guanosine | Biochemistry | Iron | pH effects | Molecular weight | Proteins | Toxicology | Enzymatic activity | Imidazole | pH | Life sciences | Copper | Localization | Chemical synthesis | Food | Phosphodiesterase | Enzymes | Barley | Purification | Adenosine monophosphate | AMP | Fermentation | Zinc | Chromatography | Studies | Ribonucleotides | Methods
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11. Full Text Azole Resistance Profile of Amino Acid Changes in Aspergillus fumigatus CYP51A Based on Protein Homology Modeling
by Eveline Snelders and Anna Karawajczyk and Gijs Schaftenaar and Paul E. Verweij and Willem J. G. Melchers
Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 06/2010, Volume 54, Issue 6, pp. 2425 - 2430
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IN-VITRO | MECHANISM | STEROL 14-ALPHA-DEMETHYLASE | ANTIFUNGALS | CROSS-RESISTANCE | MICROBIOLOGY | PHARMACOLOGY & PHARMACY | ITRACONAZOLE | EXPRESSION | BINDING | LANOSTEROL 14-ALPHA-DEMETHYLASE | INSIGHTS | Antifungal Agents - pharmacology | Aspergillus fumigatus - drug effects | Fungal Proteins - chemistry | Humans | Aspergillus fumigatus - enzymology | Models, Molecular | Tandem Repeat Sequences | Drug Resistance, Fungal - genetics | Fungal Proteins - genetics | Mutation, Missense | Aspergillus fumigatus - genetics | Azoles - pharmacology | Cytochrome P-450 Enzyme System - chemistry | Cytochrome P-450 Enzyme System - genetics | Genes, Fungal | Protein Conformation | Structural Homology, Protein | In Vitro Techniques | Amino Acid Substitution | Mechanisms of Resistance
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12. Full Text Functional analysis of the superoxide dismutase family in Aspergillus fumigatus
by Lambou, Karine and Lamarre, Claude and Beau, Rémi and Dufour, Nicolas and Latge, Jean-Paul
Molecular Microbiology, ISSN 0950-382X, 02/2010, Volume 75, Issue 4, pp. 910 - 923
P>Reactive oxidant species produced by phagocytes have been reported as being involved in the killing of Aspergillus fumigatus. Fungal superoxide dismutases... 
TRANSFORMATION | OXIDATIVE STRESS | INVASIVE ASPERGILLOSIS | CANDIDA-ALBICANS | BIOCHEMISTRY & MOLECULAR BIOLOGY | RESISTANCE GENE PTRA | MICROBIOLOGY | CRYPTOCOCCUS-NEOFORMANS | IMMUNE HUMAN SERA | VIRULENCE | SACCHAROMYCES-CEREVISIAE | EXPRESSION | Superoxide Dismutase - genetics | Virulence Factors - genetics | Aspergillus fumigatus - enzymology | Spores, Fungal - growth & development | Aspergillus fumigatus - genetics | Aspergillus fumigatus - pathogenicity | Superoxide Dismutase - chemistry | Vitamin K 3 - pharmacology | Mycelium - metabolism | Animals | Spores, Fungal - metabolism | Aspergillosis - microbiology | Superoxides - metabolism | Female | Aspergillus fumigatus - growth & development | Mice | Kinetics | Mutation | Superoxide Dismutase - metabolism | Mycoses | Superoxide dismutase | Superoxide | Fungi | Enzymes | Genotype & phenotype | Microbiology | Genomics
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13. Full Text Aspergillus fumigatus protein phosphatase PpzA is involved in iron assimilation, secondary metabolite production, and virulence
by Manfiolli, Adriana Oliveira and Castro, Patrícia Alves and Reis, Thaila Fernanda and Dolan, Stephen and Doyle, Sean and Jones, Gary and Riaño Pachón, Diego M and Ulaş, Mevlüt and Noble, Luke M and Mattern, Derek J and Brakhage, Axel A and Valiante, Vito and Silva‐Rocha, Rafael and Bayram, Ozgur and Goldman, Gustavo H
Cellular Microbiology, ISSN 1462-5814, 12/2017, Volume 19, Issue 12, p. n/a
Metal restriction imposed by mammalian hosts during an infection is a common mechanism of defence to reduce or avoid the pathogen infection. Metals are... 
Metabolomics | Phosphoprotein Phosphatases - metabolism | Virulence | Aspergillus fumigatus - enzymology | Gene Expression Profiling | Proteome - analysis | Aspergillus fumigatus - genetics | Aspergillus fumigatus - pathogenicity | Iron - metabolism | Secondary Metabolism | Animals | Phosphoprotein Phosphatases - genetics | Gene Deletion | Invasive Pulmonary Aspergillosis - microbiology | Mass Spectrometry | Chromatography, Liquid | Aspergillus fumigatus - metabolism | Mice | Invasive Pulmonary Aspergillosis - pathology | Disease Models, Animal | Metabolites | Mass spectrometry | Phosphatases
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14. Full Text Catalases of Aspergillus fumigatus
by Sophie Paris and Deborah Wysong and Jean-Paul Debeaupuis and Kazutoshi Shibuya and Bruno Philippe and Richard D. Diamond and Jean-Paul Latgé
Infection and Immunity, ISSN 0019-9567, 06/2003, Volume 71, Issue 6, pp. 3551 - 3562
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DEFICIENT MUTANTS | INFECTIOUS DISEASES | OXIDATIVE STRESS | GENE | INVITRO | PURIFICATION | HOST-DEFENSE | REGULATED CATALASE | NIDULANS | IMMUNOLOGY | VIRULENCE | NEUROSPORA-CRASSA | Amino Acid Sequence | Fungal Proteins - physiology | Phenotype | Catalase - genetics | Catalase - physiology | Humans | Mycelium - enzymology | Aspergillus fumigatus - enzymology | Cloning, Molecular | Molecular Sequence Data | Catalase - chemistry | Fungal and Parasitic Infections
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15. Full Text Sph3 is a glycoside hydrolase required for the biosynthesis of galactosaminogalactan in aspergillus fumigatus
by Bamford, Natalie C and Snarr, Brendan D and Gravelat, Fabrice N and Little, Dustin J and Lee, Mark J and Zacharias, Caitlin A and Chabot, Josée C and Geller, Alexander M and Baptista, Stefanie D and Baker, Perrin and Robinson, Howard and Howell, P. Lynne and Sheppard, Donald C
Journal of Biological Chemistry, ISSN 0021-9258, 11/2015, Volume 290, Issue 46, pp. 27438 - 27450
Aspergillus fumigatus is the most virulent species within the Aspergillus genus and causes invasive infections with high mortality rates. The exopolysaccharide... 
ALGINATE LYASE | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | EVOLUTIONARY CONSERVATION | SEQUENCE | CLASSIFICATION | CONSURF | CATALYTIC MECHANISM | IDENTIFICATION | BIOFILM FORMATION | POLYSACCHARIDE | Fungal Proteins - chemistry | Glycoside Hydrolases - physiology | Glycoside Hydrolases - genetics | Aspergillus fumigatus - enzymology | Coccidioidin - genetics | Polysaccharides - genetics | Molecular Sequence Data | Crystallography, X-Ray | Cell Wall - enzymology | Polysaccharides - biosynthesis | Conserved Sequence | Glycoside Hydrolases - chemistry | Aspergillus fumigatus - metabolism | Catalysis | Amino Acid Sequence | Catalytic Domain | Coccidioidin - chemistry | Coccidioidin - physiology | Fungal Proteins - genetics | Aspergillus fumigatus - pathogenicity | Hydrolysis | Fungal Proteins - physiology | Sequence Alignment | Protein Conformation | Mutation | Index Medicus | Aspergillus | glycoside hydrolase | in vivo imaging | polysaccharide | biofilm | crystal structure | mutagenesis in vitro | Glycobiology and Extracellular Matrices | galactosaminogalactan | carbohydrate biosynthesis | Sph3
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16. Full Text An alternative route to cyclic terpenes by reductive cyclization in iridoid biosynthesis
by Geu-Flores, Fernando and Sherden, Nathaniel H and Glenn, Weslee S and Courdavault, Vincent and Burlat, Vincent and O’connor, Sarah E and Glenn, Weslee S and Courdavault, Vincent and Burlat, Vincent and Wu, Cen and Nims, Ezekiel and Wu, Cen and Cui, Yuehua and Cui, Yuehua and O'Connor, Sarah E
Nature, ISSN 0028-0836, 12/2012, Volume 491, Issue 7427, pp. 138 - 142
The iridoids comprise a large family of distinctive bicyclic monoterpenes that possess a wide range of pharmacological activities, including anticancer,... 
ALKALOID BIOSYNTHESIS | METABOLISM | MECHANISM | CATHARANTHUS-ROSEUS | VINDOLINE | SUSPENSION-CULTURES | SECOIRIDOIDS | MULTIDISCIPLINARY SCIENCES | GENES | PROGESTERONE 5-BETA-REDUCTASE | IRIDANE SKELETON FORMATION | Plant Extracts - chemistry | Biocatalysis | Catharanthus - enzymology | Oxidoreductases - metabolism | Plants, Medicinal - enzymology | Aspergillus fumigatus - enzymology | Molecular Sequence Data | Substrate Specificity | Iridoids - metabolism | Cycloaddition Reaction | Catharanthus - metabolism | Biological Products - chemistry | Iridoids - chemistry | Cyclization | Plant Leaves - genetics | Plant Leaves - metabolism | Plants, Medicinal - genetics | Monoterpenes - metabolism | Biological Products - metabolism | Aspergillus fumigatus - metabolism | Catharanthus - genetics | NADP - metabolism | Plant Leaves - enzymology | Plants, Medicinal - metabolism | Iridoids | Chemical properties | Research | Health aspects | Proteins | Enzymes | Biosynthesis
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