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Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 04/2001, Volume 276, Issue 17, pp. 13750 - 13755
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 03/1998, Volume 101, Issue 5, pp. 1163 - 1174
Transcription factors of the NF-kappa B/Rel family are critical for inducible expression of multiple genes involved in inflammatory responses, Sulfasalazine... 
Inflammatory bowel disease | NF-κB | Therapy | SW620 | AP1 | RHEUMATOID-ARTHRITIS | MEDICINE, RESEARCH & EXPERIMENTAL | TRANSCRIPTIONAL ACTIVATION | METABOLITES | PHOSPHORYLATION | therapy | ULCERATIVE-COLITIS | ACTIVE MOIETY | ALPHA | CELL-LINES | 5-AMINOSALICYLIC ACID | inflammatory bowel disease | NF-kappa B | SODIUM-SALICYLATE | Phosphorylation | Anti-Infective Agents - pharmacology | Humans | Tumor Necrosis Factor-alpha - genetics | NF-kappa B - metabolism | Sulfasalazine - pharmacology | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Cystine - pharmacology | Thiocarbamates - pharmacology | Transfection | Recombination, Genetic | Phorbol Esters - pharmacology | Proline - pharmacology | Colonic Diseases - drug therapy | Aspirin - pharmacology | Cystine - analogs & derivatives | Fluorescent Antibody Technique, Indirect | NF-kappa B - antagonists & inhibitors | Proline - analogs & derivatives | Anti-Inflammatory Agents - pharmacology | Cells, Cultured | Epithelial Cells | Antioxidants - pharmacology | Recombinant Proteins - pharmacology | Blotting, Western | Sulfapyridine - pharmacology | Tumor Necrosis Factor-alpha - pharmacology | Colonic Diseases - immunology | Immunosuppression | Mesalamine - pharmacology | Transcription Factor AP-1 - antagonists & inhibitors | NF-kappa B - genetics | Plasmids | Lipopolysaccharides - pharmacology | Index Medicus | Abridged Index Medicus
Journal Article
Journal of the American College of Cardiology, ISSN 0735-1097, 09/2019, Volume 74, Issue 12, p. 1618
This focus seminar will take the reader through the history and pivotal trials that have formed the current state-of-the-art management for acute coronary... 
Heart failure | Occlusion | Anticoagulants | Cardiac arrhythmia | Aspirin | Stroke | Heart attacks | Mortality | Coronary artery | Disorders | Cardiovascular disease | Pharmacology | Angina pectoris | Thrombosis | Heart rate | Reperfusion | Ischemia | Medical prognosis | Coronary vessels | Electrocardiography | Embolization | Blood pressure | Inhibition | Statins
Journal Article
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 09/2014, Volume 34, Issue 9, pp. 2078 - 2085
OBJECTIVE—In a phase III clinical trial (PLATelet inhibition and patient Outcomes, PLATO), ticagrelor provided better clinical outcomes than clopidogrel in... 
adenosine | aspirin | cyclooxygenase | platelet aggregation inhibitors | ISCHEMIA/REPERFUSION INJURY | ACUTE CORONARY SYNDROMES | PLATO | COMBINATION | ATORVASTATIN | ISCHEMIA-REPERFUSION INJURY | CLOPIDOGREL | PLATELET INHIBITION | PERIPHERAL VASCULAR DISEASE | CARDIOPROTECTION | HEMATOLOGY | Receptor, Adenosine A1 - physiology | Ticlopidine - therapeutic use | Nitric Oxide Synthase Type III - biosynthesis | Adenosine A1 Receptor Antagonists - pharmacology | Male | Receptor, Adenosine A2A - physiology | Cardiotonic Agents - therapeutic use | Cyclooxygenase 2 - biosynthesis | Myocardial Reperfusion Injury - pathology | Cyclooxygenase 2 - genetics | Adenosine - therapeutic use | Myocardial Infarction - pathology | Enzyme Induction - drug effects | Nitric Oxide Synthase Type III - physiology | Aspirin - pharmacology | Myocardial Reperfusion Injury - drug therapy | Drug Evaluation, Preclinical | Pyrazoles - pharmacology | Cyclooxygenase 2 Inhibitors - pharmacology | Rats | Cyclooxygenase 2 - physiology | Adenosine - pharmacology | Cardiotonic Agents - pharmacology | Nitric Oxide Synthase Type III - genetics | Rats, Sprague-Dawley | Ticlopidine - analogs & derivatives | Triazoles - pharmacology | Up-Regulation - drug effects | Adenosine A2 Receptor Antagonists - pharmacology | Animals | Myocardial Infarction - drug therapy | Adenosine - analogs & derivatives | Adenosine - physiology | 6-Ketoprostaglandin F1 alpha - metabolism | Quinazolines - pharmacology | Lipoxins - metabolism | Myocardial Reperfusion Injury - prevention & control | Index Medicus
Journal Article
FASEB Journal, ISSN 0892-6638, 03/2006, Volume 20, Issue 3, pp. 542 - 544
It is widely believed that the potencies of nonsteroid anti-inflammatory drugs ( NSAIDs) as inhibitors of cyclooxygenase ( COX) are influenced by protein... 
SITE | MECHANISM | BIOCHEMISTRY & MOLECULAR BIOLOGY | nonsteroid anti-inflammatory drugs | coxibs | PROSTAGLANDIN H-2 SYNTHASE | CELL BIOLOGY | CYCLO-OXYGENASE-2 | THERAPY | FLUID | NONSTEROIDAL ANTIINFLAMMATORY DRUGS | BIOLOGY | prostaglandins | SELECTIVITY | Organic Chemicals - cerebrospinal fluid | Humans | Naproxen - pharmacology | Synovial Fluid - metabolism | Pyrazoles - cerebrospinal fluid | Sodium Salicylate - pharmacology | Lactones - pharmacology | Aspirin - cerebrospinal fluid | Cell Line - drug effects | Calcium - physiology | Pyrazoles - blood | Organic Chemicals - pharmacology | Dinoprostone - cerebrospinal fluid | Diclofenac - cerebrospinal fluid | Aspirin - pharmacology | Sulfones - cerebrospinal fluid | Aspirin - blood | Thiazines - blood | Sulfonamides - pharmacology | Indomethacin - cerebrospinal fluid | Indomethacin - pharmacology | Cyclooxygenase 1 - drug effects | Cyclooxygenase Inhibitors - adverse effects | Cyclooxygenase Inhibitors - blood | Diclofenac - pharmacology | Thiazoles - blood | Thromboxane A2 - blood | Cerebrospinal Fluid Proteins - pharmacology | Dinoprostone - biosynthesis | Lactones - cerebrospinal fluid | Blood Platelets - enzymology | Cyclooxygenase 2 Inhibitors - cerebrospinal fluid | Sodium Salicylate - cerebrospinal fluid | Sulfones - pharmacology | Blood Proteins - pharmacology | Cyclooxygenase 2 Inhibitors - adverse effects | Sulfonamides - blood | Lactones - blood | Naproxen - cerebrospinal fluid | Sodium Salicylate - blood | Thiazines - pharmacology | Cyclooxygenase 2 Inhibitors - blood | Cyclooxygenase Inhibitors - cerebrospinal fluid | Blood Platelets - drug effects | Sulfones - blood | Organic Chemicals - blood | Ionophores - pharmacology | Pyrazoles - pharmacology | Sulfonamides - cerebrospinal fluid | Cyclooxygenase 2 Inhibitors - pharmacology | Thiazoles - cerebrospinal fluid | Celecoxib | Diclofenac - blood | Dinoprostone - blood | Naproxen - blood | Organ Specificity | Calcimycin - pharmacology | Cyclooxygenase Inhibitors - pharmacology | Indomethacin - blood | Protein Binding | Thiazines - cerebrospinal fluid | Thiazoles - pharmacology | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 03/2013, Volume 8, Issue 3, pp. e59281 - e59281
Platelets play an important role in thrombosis and in neo-vascularisation as they release and produce factors that both promote and suppress angiogenesis.... 
ACTIVATION | ALPHA-GRANULES | PROSTACYCLIN | MULTIDISCIPLINARY SCIENCES | NITRIC-OXIDE | GROWTH-FACTOR | ANGIOGENESIS INHIBITOR | PROTEINS | PLASMINOGEN | CARCINOMA | ENDOSTATIN | Endothelium, Vascular - cytology | Humans | Culture Media, Conditioned - pharmacology | Endothelium, Vascular - drug effects | Valerates - pharmacology | Cell Hypoxia | S-Nitrosoglutathione - pharmacology | Platelet Aggregation Inhibitors - pharmacology | Epoprostenol - pharmacology | Collagen - pharmacology | Platelet Aggregation - drug effects | Aspirin - pharmacology | Blood Platelets - drug effects | Vascular Endothelial Growth Factor A - pharmacology | Cell Line | Adenine - analogs & derivatives | Angiogenesis Inhibitors - pharmacology | Adenine - pharmacology | Peptides - pharmacology | Platelet Glycoprotein GPIIb-IIIa Complex - antagonists & inhibitors | Cell Movement - drug effects | Blood Platelets - metabolism | Endothelial Cells - cytology | Angiostatins - pharmacology | Endothelial Cells - drug effects | Aspirin | Collagen | Hostages | Comparative analysis | Vascular endothelial growth factor | Thrombosis | Blood clot | Endothelium | Prostacyclin | Acetylsalicylic acid | Cell adhesion & migration | Vascularization | Proteins | Angiogenesis | Cell growth | Blood platelets | Thromboembolism | Pharmaceutical sciences | Glutathione | Gold | Immunoglobulins | Research & development--R&D | Pharmacology | Platelet aggregation | Electron microscopy | Organelles | Endothelial cells | Blood clots | Inhibitors | Acids | Microscopy | Granular materials | Nitric oxide | Pharmacy | Hypoxia | Granules | Kinetics | Angiostatin | Immunofluorescence | Platelets | Cell migration | Cancer | Index Medicus | Research & development | R&D
Journal Article
Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 02/2012, Volume 340, Issue 2, pp. 422 - 432
Phospho-nonsteroidal anti-inflammatory drugs (phospho-NSAIDs) are novel NSAID derivatives with improved anticancer activity and reduced side effects in... 
Organophosphates - metabolism | Indomethacin - analogs & derivatives | Naproxen - analogs & derivatives | Humans | Naproxen - pharmacology | Phenylglyoxal - analogs & derivatives | Indomethacin - metabolism | Valproic Acid - analogs & derivatives | Anti-Inflammatory Agents, Non-Steroidal - blood | Naproxen - metabolism | Organophosphorus Compounds - metabolism | Valproic Acid - pharmacology | Ibuprofen - analogs & derivatives | Aspirin - metabolism | Nitrophenols - therapeutic use | Organophosphorus Compounds - pharmacology | Anti-Inflammatory Agents, Non-Steroidal - metabolism | Aspirin - pharmacology | Carboxylesterase - antagonists & inhibitors | Valproic Acid - metabolism | Cell Survival - drug effects | Organophosphates - blood | Enzyme Inhibitors - pharmacology | Organophosphorus Compounds - therapeutic use | Stomach Neoplasms - drug therapy | Ibuprofen - metabolism | Indomethacin - pharmacology | Aspirin - analogs & derivatives | Mice, Nude | Carboxylesterase - genetics | Cell Line, Tumor | Mice | Mice, Inbred BALB C | Kinetics | Organophosphates - therapeutic use | Stomach Neoplasms - pathology | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Sulindac - metabolism | Transfection | Nitrophenols - pharmacology | HEK293 Cells | Inhibitory Concentration 50 | Female | Sulindac - blood | Carboxylic Ester Hydrolases - genetics | Carboxylic Ester Hydrolases - antagonists & inhibitors | Ibuprofen - pharmacology | Phenylglyoxal - pharmacology | Sulindac - therapeutic use | Carboxylesterase - metabolism | Hydrolysis | Organophosphates - pharmacology | Xenograft Model Antitumor Assays | Sulindac - analogs & derivatives | Drug Therapy, Combination - methods | Animals | Anti-Inflammatory Agents, Non-Steroidal - therapeutic use | Drug Interactions - physiology | Organophosphorus Compounds - blood | Sulindac - pharmacology | Carboxylic Ester Hydrolases - metabolism | Index Medicus | Metabolism, Transport, and Pharmacogenomics
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 12/2001, Volume 345, Issue 25, pp. 1809 - 1817
Journal Article
Journal Article
Journal Article
Journal Article
Journal of Natural Products, ISSN 0163-3864, 11/2002, Volume 65, Issue 11, pp. 1517 - 1521
A rapid semi-homogeneous cyclooxygenase-2 (COX-2) enzymatic assay using scintillation proximity assay (SPA) technology was developed, and 49 ubiquitous plant... 
RESVERATROL | CHEMISTRY, MEDICINAL | CYCLOOXYGENASE-2 | ACID | PROSTAGLANDIN BIOSYNTHESIS | NITRIC-OXIDE SYNTHASE | PHENOLIC-COMPOUNDS | MACROPHAGES | IDENTIFICATION | DISCOVERY | PLANT SCIENCES | PHARMACOLOGY & PHARMACY | PHORBOL ESTER | Acrolein - analogs & derivatives | Triterpenes - pharmacology | Dinoprostone - biosynthesis | Cyclooxygenase 2 | Alkaloids - isolation & purification | Oleanolic Acid - pharmacology | Nitrobenzenes - pharmacology | Lactones - pharmacology | Dose-Response Relationship, Drug | Syzygium - chemistry | Terpenes - pharmacology | Terpenes - chemistry | Isoenzymes - metabolism | Inhibitory Concentration 50 | Biological Assay | Steroids - pharmacology | Flavonoids - pharmacology | Aspirin - pharmacology | Catalysis | Sulfones | Steroids - chemistry | Acrolein - pharmacology | Pyrogallol - pharmacology | Plants, Medicinal - chemistry | Alkaloids - pharmacology | Terpenes - isolation & purification | Cinnamomum zeylanicum - chemistry | Anthraquinones - isolation & purification | Models, Molecular | Eugenol - pharmacology | Sulfonamides - pharmacology | Indomethacin - pharmacology | Cyclooxygenase Inhibitors - pharmacology | Animals | Cyclooxygenase 2 Inhibitors | Prostaglandin-Endoperoxide Synthases - metabolism | Steroids - isolation & purification | Anthraquinones - pharmacology | Flavonoids - isolation & purification | Kinetics | Anthraquinones - chemistry | Flavonoids - chemistry | Alkaloids - chemistry | Index Medicus | Pharmaceutical Sciences | Basic Medicine | PHARMACY | Medical and Health Sciences | Medicin och hälsovetenskap | Medicinska och farmaceutiska grundvetenskaper | FARMACI | Farmaceutiska vetenskaper
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 06/2004, Volume 24, Issue 26, pp. 5922 - 5930
We used a model system in which dopaminergic (DA) neurons from embryonic rat mesencephalon undergo spontaneous and selective degeneration as they develop in... 
Excitability | GDNF | Sodium | Channel | Trophic | Dopaminergic | TYROSINE-HYDROXYLASE | POTASSIUM CHANNELS | NEUROTROPHIC FACTOR | channel | trophic | NEUROSCIENCES | sodium | CYCLIC-AMP | excitability | CALCIUM-CHANNELS | SIGNALING PATHWAY | MEMBRANE-PROPERTIES | CENTRAL-NERVOUS-SYSTEM | dopaminergic | SMALL-CONDUCTANCE | PARKINSONS-DISEASE | Mesencephalon - cytology | Sodium-Potassium-Exchanging ATPase - physiology | Rats, Wistar | Apoptosis - drug effects | gamma-Aminobutyric Acid - metabolism | Cells, Cultured - cytology | Neurons - cytology | Sodium Channels - physiology | Apamin - pharmacology | Nerve Growth Factors - pharmacology | Neuroprotective Agents - pharmacology | Glial Cell Line-Derived Neurotrophic Factor | Ion Transport - drug effects | Neurons - metabolism | Aspirin - pharmacology | Tetrodotoxin - pharmacology | Neurons - drug effects | Dopamine - metabolism | Ouabain - pharmacology | Potassium Channel Blockers - pharmacology | Sodium - pharmacology | Cells, Cultured - drug effects | Nerve Tissue Proteins - physiology | Nifedipine - pharmacology | Sodium-Potassium-Exchanging ATPase - antagonists & inhibitors | Biological Transport, Active - drug effects | Rats | Sodium Channel Blockers - pharmacology | Sodium Channels - drug effects | Calcium Channel Blockers - pharmacology | Nerve Tissue Proteins - drug effects | Veratridine - pharmacology | Scorpion Venoms - pharmacology | Animals | Calcium Channels, T-Type - drug effects | Serotonin - metabolism | Calcium Channel Agonists - pharmacology | Cells, Cultured - metabolism | Potassium Channels, Calcium-Activated - antagonists & inhibitors | Ion Channel Gating | Sodium - physiology | Index Medicus | Tetrodotoxin | Neuroprotective Agents | Veratridine | Mesencephalon | Neurons and Cognition | Ouabain | Calcium Channel Agonists | Calcium Channels, T-Type | Potassium Channels, Calcium-Activated | Life Sciences | Biological Transport, Active | Sodium-Potassium-Exchanging ATPase | Ion Transport | Potassium Channel Blockers | gamma-Aminobutyric Acid | Aspirin | Apamin<