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Biochemical pharmacology, ISSN 0006-2952, 2017, Volume 139, pp. 71 - 81
.... Andrographolide was isolated as a major bioactive constituent of A. paniculata in 1951, and since 1984, andrographolide and its analogs have been scrutinized with modern drug discovery approach for anti-inflammatory properties... 
Hepatitis | NF-κB | Autoimmune | Neurodegeneration | Nrf2 | Asthma | OXIDATIVE STRESS | ALZHEIMERS-DISEASE | COGNITIVE IMPAIRMENT | CELL-CYCLE ARREST | PROTECTIVE ACTIVITY | IN-VITRO | NF-kappa B | INDUCED PULMONARY-FIBROSIS | SIGNALING PATHWAY | PHARMACOLOGY & PHARMACY | COMBINATION KAN-JANG | NF-KAPPA-B | Liver Cirrhosis - immunology | Humans | Drugs, Investigational - therapeutic use | NF-E2-Related Factor 2 - agonists | Protective Agents - chemistry | Neurodegenerative Diseases - drug therapy | Hepatitis - drug therapy | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Hepatitis - metabolism | Pneumonia - immunology | Autoimmune Diseases - metabolism | Autoimmune Diseases - drug therapy | Diterpenes - pharmacology | Chemical and Drug Induced Liver Injury - prevention & control | NF-kappa B p50 Subunit - antagonists & inhibitors | NF-kappa B p50 Subunit - metabolism | Autoimmune Diseases - prevention & control | Chemical and Drug Induced Liver Injury - immunology | Signal Transduction - drug effects | Chemical and Drug Induced Liver Injury - metabolism | Models, Biological | NF-E2-Related Factor 2 - metabolism | Oxidative Stress - drug effects | Pneumonia - metabolism | Drugs, Investigational - adverse effects | Drugs, Investigational - pharmacology | Dermatitis - immunology | Neurodegenerative Diseases - prevention & control | Protective Agents - metabolism | Anti-Inflammatory Agents, Non-Steroidal - chemistry | Hypoxia-Inducible Factor 1, alpha Subunit - antagonists & inhibitors | Protective Agents - therapeutic use | Neurodegenerative Diseases - immunology | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Drugs, Investigational - chemistry | Hepatitis - prevention & control | Drug Design | Liver Cirrhosis - metabolism | Diterpenes - chemistry | Liver Cirrhosis - drug therapy | Diterpenes - therapeutic use | Liver Cirrhosis - prevention & control | Autoimmune Diseases - immunology | Dermatitis - prevention & control | Neurodegenerative Diseases - metabolism | Animals | Anti-Inflammatory Agents, Non-Steroidal - adverse effects | Pneumonia - drug therapy | Anti-Inflammatory Agents, Non-Steroidal - therapeutic use | NF-kappa B p50 Subunit - chemistry | Hepatitis - immunology | Diterpenes - adverse effects | Dermatitis - drug therapy | Dermatitis - metabolism | Antioxidants | Medical colleges | Lead compounds | Drug discovery | Anti-inflammatory drugs | Analysis | Index Medicus
Journal Article
The Lancet (British edition), ISSN 0140-6736, 2009, Volume 373, Issue 9678, pp. 1905 - 1917
...) expression, raised macrophage migration inhibitory factor, and increased P-glycoprotein-mediated drug efflux... 
Internal Medicine | RHEUMATOID-ARTHRITIS | MEDICINE, GENERAL & INTERNAL | OBSTRUCTIVE PULMONARY-DISEASE | HISTONE DEACETYLASE ACTIVITY | MIGRATION INHIBITORY FACTOR | ULCERATIVE-COLITIS | REGULATORY T-CELLS | RECEPTOR-BETA | RELATIVE CORTICOSTEROID INSENSITIVITY | BLOOD MONONUCLEAR-CELLS | RESPIRATORY-DISTRESS-SYNDROME | Transcription Factor AP-1 - drug effects | Glucocorticoids - therapeutic use | Transcriptional Activation - genetics | Transcription Factor AP-1 - genetics | Humans | Macrophage Migration-Inhibitory Factors - immunology | Transcriptional Activation - drug effects | Transcription Factor AP-1 - immunology | Histone Deacetylases - immunology | Transcriptional Activation - immunology | ATP-Binding Cassette, Sub-Family B, Member 1 - drug effects | Calcineurin Inhibitors | Macrophage Migration-Inhibitory Factors - genetics | Inflammation - drug therapy | Phosphodiesterase 4 Inhibitors | Anti-Inflammatory Agents - therapeutic use | Mitogen-Activated Protein Kinases - immunology | Genetic Predisposition to Disease - genetics | NF-kappa B - antagonists & inhibitors | Histone Deacetylases - genetics | Macrophage Migration-Inhibitory Factors - drug effects | Repressor Proteins - genetics | Histone Deacetylase 2 | Drug Resistance - drug effects | Inflammation - immunology | Asthma - drug therapy | ATP-Binding Cassette, Sub-Family B, Member 1 - immunology | Drug Resistance - genetics | ATP-Binding Cassette, Sub-Family B, Member 1 - genetics | Drug Resistance - immunology | Repressor Proteins - immunology | Histone Deacetylases - drug effects | Mitogen-Activated Protein Kinases - genetics | Repressor Proteins - drug effects | Mitogen-Activated Protein Kinases - drug effects | Pulmonary Disease, Chronic Obstructive - drug therapy | Corticosteroids | Dosage and administration | Inflammation | Research | Drug resistance | Drug therapy | Health aspects | Complications and side effects | Risk factors | Inflammatory bowel disease | Proteins | Respiratory distress syndrome | Asthma | Steroids
Journal Article
CNS Drugs, ISSN 1172-7047, 2008, Volume 22, Issue 1, pp. 27 - 47
Journal Article
Current medicinal chemistry, ISSN 0929-8673, 2018, Volume 25, Issue 7, pp. 814 - 838
.... Moreover, the efficacy of the combination of flavonoids with drugs or other natural nontoxic compounds was also reviewed. Methods... 
Flavonoids | autophagy | infectious diseases | hepatic diseases | cancer | cardiovascular diseases | neurodegenerative disorders | diabetes | HEPATOCELLULAR-CARCINOMA CELLS | OXIDATIVE STRESS | CHEMISTRY, MEDICINAL | APIGENIN-INDUCED APOPTOSIS | FATTY LIVER-DISEASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | BREAST-CANCER CELLS | ROTENONE-INDUCED NEUROTOXICITY | REACTIVE OXYGEN | HELICOBACTER-PYLORI INFECTION | A VIRUS-INFECTION | PHARMACOLOGY & PHARMACY | CELL-DEATH INDUCTION | Diabetes Mellitus - pathology | Influenza, Human - pathology | Cardiovascular Diseases - drug therapy | Humans | Liver Diseases - pathology | Stomach Ulcer - pathology | Osteoporosis - drug therapy | Cardiovascular Diseases - pathology | Neurodegenerative Diseases - drug therapy | Leishmaniasis - pathology | Autophagy - drug effects | Flavonoids - pharmacology | Influenza, Human - drug therapy | Neurodegenerative Diseases - pathology | Diabetes Mellitus - drug therapy | Stomach Ulcer - drug therapy | Leishmaniasis - drug therapy | Asthma - drug therapy | Neoplasms - drug therapy | Osteoporosis - pathology | Cell Proliferation - drug effects | Liver Diseases - drug therapy | Neoplasms - pathology | Asthma - pathology | Flavonoids - chemistry | Deregulation | Identification methods | Homeostasis | Autophagy | Neuromodulation | Modulators | Metabolites | Heart diseases | Vector-borne diseases | Liver diseases | Cell survival | Neurodegenerative diseases | Invasiveness | Medical treatment | Leishmaniasis | Survival | Diseases | Side effects | Cell death | Ulcers | Influenza | Documents | In vivo methods and tests | Diabetes | Cardiovascular diseases | Phagocytosis | Cancer
Journal Article
Drugs, ISSN 0012-6667, 8/2017, Volume 77, Issue 12, pp. 1295 - 1311
Journal Article
New England Journal of Medicine, ISSN 0028-4793, 03/2009, Volume 360, Issue 10, pp. 1002 - 1014
Current estimates suggest that as many as 300 million people worldwide have asthma and atopy. Yet despite the persistently high prevalence of disease, the most... 
MEDICINE, GENERAL & INTERNAL | CHURG-STRAUSS-SYNDROME | LEUKOTRIENE RECEPTOR ANTAGONIST | DOSE FLUTICASONE PROPIONATE | ACTING BETA-AGONIST | COMBINATION THERAPY | EOSINOPHILIC INFLAMMATION | INHALED CORTICOSTEROIDS | DOUBLE-BLIND | PERSISTENT ASTHMA | AIRWAY SMOOTH-MUSCLE | Smooth muscle | Airway management | Drug therapy | Mortality | Asthma
Journal Article
Journal Article
Journal Article
Journal Article
Expert Opinion on Therapeutic Targets, ISSN 1744-7631, 2007, Volume 11, Issue 5, pp. 613 - 624
IL-6 plays a pivotal role in immune responses and certain oncologic conditions. The intense investigation of its biological activity and function led to the... 
cytokine | inflammation | colon cancer | soluble receptor | trans-signalling | rheumatoid arthritis | IL-6 | Soluble | Colon cancer | Receptor | Rheumatoid arthritis | Cytokine | Inflammation | Trans-signalling | RHEUMATOID-ARTHRITIS | CROHNS-DISEASE | SIGNAL-TRANSDUCING RECEPTOR | NECROSIS-FACTOR-ALPHA | T-CELL | INFLAMMATORY-BOWEL-DISEASE | SOLUBLE INTERLEUKIN-6 RECEPTOR | IN-VIVO | ANTI-INTERLEUKIN-6 MONOCLONAL-ANTIBODY | PHARMACOLOGY & PHARMACY | IL-6 RECEPTOR | Neoplasms - metabolism | Receptors, Interleukin-6 - chemistry | Interleukin-6 - antagonists & inhibitors | Alternative Splicing | Colonic Neoplasms - drug therapy | Humans | Recombinant Fusion Proteins - therapeutic use | Male | Antineoplastic Agents - therapeutic use | Receptors, Interleukin-6 - antagonists & inhibitors | Drug Delivery Systems | Cell Line - drug effects | Cytokine Receptor gp130 - physiology | Inflammation - metabolism | Arthritis, Rheumatoid - drug therapy | Inflammation - drug therapy | Interleukin-6 - physiology | Anti-Inflammatory Agents - therapeutic use | Antineoplastic Agents - pharmacology | Colitis - drug therapy | Colitis - immunology | Drug Evaluation, Preclinical | Autoimmune Diseases - metabolism | Autoimmune Diseases - drug therapy | Disease Models, Animal | Anti-Inflammatory Agents - pharmacology | Receptors, Interleukin-6 - genetics | Solubility | Transforming Growth Factor beta - physiology | Clinical Trials as Topic | Asthma - drug therapy | Neoplasms - drug therapy | Receptors, Interleukin-6 - physiology | Animals | Signal Transduction - drug effects | Arthritis - drug therapy | Mice | Leukocytes - metabolism
Journal Article