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Journal Article
Journal of allergy and clinical immunology, ISSN 0091-6749, 2013, Volume 131, Issue 2, pp. 501 - 511.e1
Background Sphingosine-1-phosphate (S1P), which is produced by 2 sphingosine kinase (SphK) isoenzymes, SphK1 and SphK2, has been implicated in IgE-mediated... 
Allergy and Immunology | airway hyperresponsiveness | asthma | nuclear factor κB | mast cells | sphingosine kinase | Sphingosine-1-phosphate | IMMUNITY | FC-EPSILON-RI | nuclear factor kappa B | FACTOR-KAPPA-B | IMMUNOLOGY | MULTIPLE FEATURES | REGULATES MUCIN PRODUCTION | RESPONSES | CYTOKINE PRODUCTION | ALLERGY | GENE-EXPRESSION | MICE | Tumor Necrosis Factor-alpha - metabolism | Lysophospholipids - metabolism | Asthma - metabolism | Bronchial Hyperreactivity - drug therapy | Humans | Goblet Cells - drug effects | NF-kappa B - metabolism | Amino Alcohols - pharmacology | Interferon-gamma - metabolism | Interleukins - metabolism | Inflammation - metabolism | Inflammation - drug therapy | Methacholine Chloride - pharmacology | Mast Cells - metabolism | Bronchial Hyperreactivity - metabolism | Female | Chemokine CCL2 - metabolism | Hyperplasia - drug therapy | Lung - metabolism | Sphingosine - metabolism | Hyperplasia - metabolism | Asthma - enzymology | Immunoglobulin E - metabolism | Mice, Inbred C57BL | Cells, Cultured | Ovalbumin - pharmacology | Asthma - drug therapy | Goblet Cells - metabolism | Mast Cells - drug effects | Asthma - chemically induced | Phosphotransferases (Alcohol Group Acceptor) - metabolism | Bronchial Hyperreactivity - enzymology | Phosphotransferases (Alcohol Group Acceptor) - antagonists & inhibitors | Bronchial Hyperreactivity - pathology | Sphingosine - analogs & derivatives | Animals | Lung - drug effects | Mice | Bronchoalveolar Lavage Fluid - chemistry | Phosphates | Medical colleges | Isoenzymes | Analysis | Sphingosine | Inflammation | Asthma | Studies | Cytokines | Lungs | Rodents | Kinases | Laboratory animals | Allergies
Journal Article
The Journal of immunology (1950), ISSN 1550-6606, 2009, Volume 183, Issue 10, pp. 6469 - 6477
Alternatively activated macrophages (AAM) play a crucial role in type 2 immunity. Mice deficient in ST2, a receptor for the latest member of the IL-1 family,... 
IL-1-LIKE CYTOKINE IL-33 | IMMUNE-RESPONSE | ST2 RECEPTOR | EFFECTOR FUNCTION | MAST-CELLS | IN-VIVO | INDUCED ARTHRITIS | ALVEOLAR MACROPHAGES | INTERLEUKIN-1 RECEPTOR | IMMUNOLOGY | T-CELLS | Interleukin-1 Receptor-Like 1 Protein | Asthma - metabolism | Epithelial Cells - metabolism | Ovalbumin - immunology | Humans | Middle Aged | Chemokine CCL24 - metabolism | Interleukin-13 - immunology | Male | Interleukins - metabolism | Receptors, Interleukin - metabolism | Signal Transduction - immunology | Inflammation - metabolism | Interleukins - immunology | Asthma - immunology | Chemokine CCL17 - immunology | Adult | Female | Interleukin-4 - genetics | Macrophages, Alveolar - immunology | Recombinant Proteins - metabolism | Cell Polarity - immunology | Lung - pathology | Receptors, Interleukin - immunology | Interleukin-33 | Macrophage Activation - immunology | Receptors, Interleukin-1 - immunology | Interleukin-4 - metabolism | Receptors, Interleukin-4 - metabolism | Inflammation - immunology | Receptors, Interleukin-4 - immunology | Interleukin-13 - metabolism | Chemokine CCL24 - immunology | Receptors, Interleukin - genetics | Mice, Knockout | Receptors, Interleukin-1 - metabolism | Interleukin-4 - immunology | Animals | Eosinophilia - immunology | Recombinant Proteins - immunology | Epithelial Cells - immunology | Receptors, Interleukin-4 - genetics | Mice | Mice, Inbred BALB C | Macrophages, Alveolar - metabolism | Chemokine CCL17 - metabolism | Lung - immunology
Journal Article
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2016, Volume 138, Issue 1, pp. 130 - 141.e9
Journal Article
Scientific Reports, ISSN 2045-2322, 08/2014, Volume 4, Issue 1, p. 5865
In a murine model of allergic asthma, we found that Tyk-2((-/-)) asthmatic mice have induced peribronchial collagen deposition, mucosal type mast cells in the... 
INFLAMMATION IN-VIVO | TGF-BETA | INTERLEUKIN-17 | TYK2-DEFICIENT MICE | MULTIDISCIPLINARY SCIENCES | REGULATORY T-CELLS | AIRWAY INFLAMMATION | PHENOTYPE | EXPRESSION | HYPERRESPONSIVENESS | IL-21 | Asthma - metabolism | Cell Proliferation | Ovalbumin - immunology | TYK2 Kinase - metabolism | Th2 Cells - immunology | Interleukin-17 - pharmacology | Recombinant Proteins - biosynthesis | CD4-Positive T-Lymphocytes - immunology | T-Lymphocytes, Helper-Inducer - drug effects | Th17 Cells - metabolism | T-Lymphocytes, Helper-Inducer - immunology | Asthma - immunology | Th17 Cells - cytology | Cell Differentiation | Lung - metabolism | Disease Models, Animal | T-Lymphocytes, Helper-Inducer - metabolism | Cytokines - metabolism | CD4-Positive T-Lymphocytes - cytology | Interleukin-17 - genetics | Th2 Cells - cytology | Recombinant Proteins - genetics | Recombinant Proteins - pharmacology | Th2 Cells - metabolism | Mice, Knockout | Interleukin-17 - metabolism | Suppressor of Cytokine Signaling 3 Protein | Phenotype | Animals | Th17 Cells - immunology | Mice | Mice, Inbred BALB C | Suppressor of Cytokine Signaling Proteins - metabolism | TYK2 Kinase - genetics | Asthma - pathology | Animal models | Mucosa | Helper cells | Effector cells | Lymphocytes T | Interleukin 6 | Interleukin 4 | Interleukin 5 | Interleukin 3 | Rodents | Interleukin 21 | CD25 antigen | Foxp3 protein | Interleukin 9 | Immunoregulation | Interleukin 13 | Asthma | CD4 antigen | Lungs | Interferon regulatory factor 4 | Collagen | Interleukin 10 | Mast cells | Autoimmune diseases | Cancer
Journal Article
Journal of allergy and clinical immunology, ISSN 0091-6749, 2013, Volume 131, Issue 2, pp. 549 - 561
Background Allergic rhinitis (AR) and asthma are 2 entities of allergic airway diseases that frequently occur together, which is referred to as united airways... 
Allergy and Immunology | pathogen associated molecular pattern | allergic asthma | innate immunity | house dust mite | Allergic rhinitis | reactive oxygen species | epithelium | β-glucans | dual oxidase 2 | Toll-like receptor | ACTIVATION | beta-glucans | DENDRITIC CELLS | IMMUNOLOGY | DECTIN-1 | RHINITIS | TOLL-LIKE RECEPTOR-2 | RESPONSES | EPITHELIAL-CELLS | ALLERGY | INFLAMMATION | LIPID RAFTS | ASTHMA | Asthma - metabolism | Epithelial Cells - metabolism | Reactive Oxygen Species - metabolism | Rhinitis, Allergic | NADPH Oxidases - metabolism | Hypersensitivity - immunology | NADPH Oxidases - immunology | Lipopolysaccharides - immunology | Rhinitis, Allergic, Perennial - metabolism | Hypersensitivity - metabolism | Reactive Oxygen Species - immunology | Respiratory Mucosa - immunology | Asthma - immunology | Lung - metabolism | Nasal Mucosa - metabolism | beta-Glucans - immunology | Respiratory System - immunology | Rhinitis, Allergic, Perennial - immunology | Toll-Like Receptor 4 - immunology | Toll-Like Receptor 2 - metabolism | Toll-Like Receptor 4 - metabolism | Immunity, Innate - immunology | beta-Glucans - metabolism | Animals | Nasal Mucosa - immunology | Respiratory System - metabolism | Epithelial Cells - immunology | Toll-Like Receptor 2 - immunology | Mice | Respiratory Mucosa - metabolism | Dual Oxidases | Lung - immunology | Pyroglyphidae - immunology | Medical colleges | Asthma | Lipids | Gene expression | Allergies | Immune system
Journal Article
The Journal of clinical investigation, ISSN 0021-9738, 2012, Volume 122, Issue 7, pp. 2590 - 2600
Journal Article
Journal Article
PloS one, ISSN 1932-6203, 2008, Volume 3, Issue 10, pp. e3331 - e3331
Journal Article
Journal of the American College of Nutrition, ISSN 1541-1087, 2002, Volume 21, Issue 6, pp. 495 - 505
Among the fatty acids, it is the omega-3 polyunsaturated fatty acids (PUFA) which possess the most potent immunomodulatory activities, and among the omega-3... 
background diet | inflammation | IL-1 | cardiovascular disease and major depression autoimmune diseases | omega-6/omega-3 ratio | TNF | IL-6 | Inflammation | Autoimmune diseases | Cardiovascular disease and major depression autoimmune diseases | Background diet | Cardiovascular disease and major depression | Omega-6/omega-3 ratio | autoimmune diseases | C-REACTIVE PROTEIN | RHEUMATOID-ARTHRITIS | CORONARY-ARTERY DISEASE | DIETARY FISH-OIL | ULCERATIVE-COLITIS | MAJOR DEPRESSION | cardiovascular disease and major depression | TUMOR-NECROSIS-FACTOR | PLASMA-FIBRINOGEN CONCENTRATION | NUTRITION & DIETETICS | ACUTE MYOCARDIAL-INFARCTION | CARDIOVASCULAR RISK-FACTORS | Fatty Acids, Omega-6 | Asthma - metabolism | Depressive Disorder, Major - metabolism | Humans | Inflammatory Bowel Diseases - immunology | Autoimmune Diseases - diet therapy | Inflammatory Bowel Diseases - metabolism | Depressive Disorder, Major - immunology | Arthritis, Rheumatoid - metabolism | Asthma - diet therapy | Fatty Acids, Omega-3 - physiology | Inflammation - diet therapy | Inflammation - metabolism | Asthma - immunology | Psoriasis - metabolism | Anti-Inflammatory Agents - administration & dosage | Fish Oils - administration & dosage | Autoimmune Diseases - metabolism | Fatty Acids, Omega-3 - administration & dosage | Psoriasis - therapy | Psoriasis - immunology | Depressive Disorder, Major - diet therapy | Fatty Acids, Omega-3 - metabolism | Cardiovascular Diseases - metabolism | Eicosapentaenoic Acid - metabolism | Fatty Acids, Unsaturated - metabolism | Inflammatory Bowel Diseases - diet therapy | Arthritis, Rheumatoid - diet therapy | Cardiovascular Diseases - immunology | Animals | alpha-Linolenic Acid - metabolism | Arthritis, Rheumatoid - immunology | Fish Oils - chemistry | Cytokines - biosynthesis | Docosahexaenoic Acids - metabolism | Prostaglandins - metabolism
Journal Article
Scientific reports, ISSN 2045-2322, 2016, Volume 6, Issue 1, p. 21810
Protein arginine methyltransferase 1 (PRMT1) catalyzes methylation of histones and other cellular proteins, and thus regulates gene transcription and protein... 
PROTEIN METHYLATION | ARGININE METHYLTRANSFERASE 1 | INHIBITION | ACTIVATOR | MULTIDISCIPLINARY SCIENCES | TRANSCRIPTION | GROWTH-FACTOR | KAPPA-B | SIGNAL TRANSDUCER | Interleukin-1beta - pharmacology | Humans | Phosphatidylethanolamine Binding Protein - metabolism | NF-kappa B - metabolism | Protein Inhibitors of Activated STAT - metabolism | STAT6 Transcription Factor - genetics | Vascular Endothelial Growth Factor A - metabolism | Interleukin-1beta - genetics | Recombinant Proteins - biosynthesis | RNA, Messenger - metabolism | Vascular Endothelial Growth Factor A - genetics | Repressor Proteins - antagonists & inhibitors | Interleukin-4 - pharmacology | RNA Interference | Cyclooxygenase 2 - genetics | Interleukin-1beta - metabolism | Protein Inhibitors of Activated STAT - genetics | STAT6 Transcription Factor - antagonists & inhibitors | Phosphorylation - drug effects | Binding Sites | Real-Time Polymerase Chain Reaction | Repressor Proteins - metabolism | Fibroblasts - metabolism | Phosphatidylethanolamine Binding Protein - antagonists & inhibitors | A549 Cells | NF-kappa B - antagonists & inhibitors | Repressor Proteins - genetics | STAT6 Transcription Factor - metabolism | Blotting, Western | Small Ubiquitin-Related Modifier Proteins - antagonists & inhibitors | Signal Transduction - drug effects | Fibroblasts - cytology | Pneumonia - metabolism | RNA, Small Interfering - metabolism | Epithelial Cells - metabolism | Immunoprecipitation | Pneumonia - pathology | Protein-Arginine N-Methyltransferases - antagonists & inhibitors | Recombinant Proteins - isolation & purification | Small Ubiquitin-Related Modifier Proteins - genetics | Lung - metabolism | Protein-Arginine N-Methyltransferases - genetics | Interleukin-4 - genetics | Epithelial Cells - cytology | Protein Inhibitors of Activated STAT - antagonists & inhibitors | Promoter Regions, Genetic | Lung - pathology | Small Ubiquitin-Related Modifier Proteins - metabolism | Interleukin-4 - metabolism | Cells, Cultured | Recombinant Proteins - pharmacology | Protein-Arginine N-Methyltransferases - metabolism | Up-Regulation - drug effects | Phosphatidylethanolamine Binding Protein - genetics | Cyclooxygenase 2 - metabolism | Microscopy, Fluorescence | Immunohistochemistry | NF-κB protein | Transcription | Epithelial cells | Protein arginine methyltransferase | Epithelium | Kinases | Western blotting | Asthma | Proteins | Signal transduction | Interleukin 4 | Arginine | Stat6 protein | Fibroblasts | Histones | DNA methylation
Journal Article