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Nature medicine, ISSN 1546-170X, 2016, Volume 22, Issue 10, pp. 1101 - 1107
Journal Article
PloS one, ISSN 1932-6203, 2015, Volume 10, Issue 11, pp. e0142340 - e0142340
.... Here, we used an adeno-associated viral vector-based mouse model of early-stage AD-type tauopathy to investigate effects of the mTOR inhibitor and autophagy stimulator rapamycin on the tau-driven... 
MAMMALIAN TARGET | IN-VITRO | STIMULATION | MULTIDISCIPLINARY SCIENCES | MEMORY IMPAIRMENT | DISEASE | TAU | ENTORHINAL CORTEX NEURONS | TOXICITY | AUTOPHAGY | PATHOLOGY | Microglia - metabolism | Entorhinal Cortex - metabolism | Humans | tau Proteins - metabolism | Male | Hippocampus - drug effects | Neurodegenerative Diseases - drug therapy | TOR Serine-Threonine Kinases - antagonists & inhibitors | Synapses - metabolism | Dentate Gyrus - drug effects | Perforant Pathway - metabolism | Neurons - metabolism | Phosphorylation - drug effects | Neurons - drug effects | Disease Models, Animal | Synapses - drug effects | Dentate Gyrus - metabolism | Microglia - drug effects | Alzheimer Disease - drug therapy | Axons - drug effects | Axons - metabolism | Memory, Long-Term - drug effects | Entorhinal Cortex - drug effects | Neurodegenerative Diseases - metabolism | Sirolimus - pharmacology | Hippocampus - metabolism | Tauopathies - metabolism | Animals | Perforant Pathway - drug effects | Alzheimer Disease - metabolism | Mice | Tauopathies - drug therapy | TOR protein | Brain | Phosphorylation | Toxicity | Activation | mRNA | Kinases | Autophagy | Neurotoxicity | Neurodegeneration | Rodents | Long term memory | Degeneration | Inhibition | Alzheimer's disease | Neurodegenerative diseases | Neurons | Astrocytes | Rapamycin | Inflammation | Substrates | Microglia | Pathology | Cortex (entorhinal) | Dentate gyrus | Gliosis | Inhibitors | Tau protein | Mutation | Hippocampus | Phagocytosis | Synapses | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 03/2016, Volume 11, Issue 3, p. e0152163
.... Methodology and Principal Findings We examined the effect of addition of poly-IC and IL-33 on the differentiation and maturation of oligodendrocyte precursor cells (OPC) cultured in vitro... 
RESPONSES | EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS | IN-VITRO | ACTIVATED PROTEIN-KINASE | MULTIPLE-SCLEROSIS | DEMYELINATION | PRELIMINARY TRIAL | MULTIDISCIPLINARY SCIENCES | TOLL-LIKE RECEPTORS | INJURY | CENTRAL-NERVOUS-SYSTEM | Oligodendroglia - metabolism | Transcription, Genetic - drug effects | Corpus Callosum - metabolism | Myelin Sheath - drug effects | Stem Cells - metabolism | Myelin Sheath - metabolism | Neuroglia - drug effects | Cell Nucleus - metabolism | Oligodendroglia - drug effects | Cell Polarity - drug effects | p38 Mitogen-Activated Protein Kinases - metabolism | Phosphorylation - drug effects | Real-Time Polymerase Chain Reaction | Wound Healing - drug effects | Lysophosphatidylcholines - pharmacology | Poly I-C - pharmacology | Myelin Basic Protein - metabolism | Cells, Cultured | Corpus Callosum - drug effects | Toll-Like Receptor 3 - agonists | Recombinant Proteins - pharmacology | Enzyme Activation - drug effects | Toll-Like Receptor 3 - metabolism | Rats, Sprague-Dawley | Up-Regulation - drug effects | Macrophages - metabolism | Phenotype | Animals | Cell Differentiation - drug effects | Intercellular Signaling Peptides and Proteins - pharmacology | Models, Biological | Interleukin-33 - metabolism | Stem Cells - drug effects | Macrophages - drug effects | Neuroglia - metabolism | Cell Nucleus - drug effects | Physiological aspects | Toll-like receptors | Genetic aspects | Immune response | Research | Interleukins | Phosphorylation | Multiple sclerosis | Spinal cord | Transcription | Genes | Central nervous system | Nervous system | Macrophages | Recovery | Glial stem cells | Recruitment | Demyelination | Rodents | Autocrine signalling | Repair | Cytokines | Myelin | Pharmacology | Gene expression | Chemical compounds | Corpus callosum | TLR3 protein | Axons | Neurology | Myelination | Neurological complications | Differentiation
Journal Article
PLoS ONE, ISSN 1932-6203, 2011, Volume 6, Issue 3, p. e17328
Repairing trauma to the central nervous system by replacement of glial support cells is an increasingly attractive therapeutic strategy. We have focused on the... 
GLIAL-RESTRICTED PRECURSORS | GAP-JUNCTIONS | GLUTAMATE TRANSPORTERS | OLIGODENDROCYTE PROGENITORS | MULTIDISCIPLINARY SCIENCES | EMBRYONIC STEM-CELLS | LOCOMOTOR RECOVERY | AXONAL REGENERATION | REACTIVE ASTROCYTES | CENTRAL-NERVOUS-SYSTEM | ADULT-RAT-BRAIN | Neurons - pathology | Recovery of Function - drug effects | Humans | Motor Activity - drug effects | Stem Cells - cytology | Glial Fibrillary Acidic Protein - metabolism | Neuroglia - drug effects | Neuroglia - cytology | Cytoprotection - drug effects | Recovery of Function - physiology | Female | Astrocytes - transplantation | Neurons - drug effects | Spinal Cord Injuries - therapy | Bone Morphogenetic Proteins - pharmacology | Ciliary Neurotrophic Factor - pharmacology | Astrocytes - cytology | Astrocytes - drug effects | Cell Survival - drug effects | Rats | Rats, Sprague-Dawley | Cell Shape - drug effects | Cell Movement - drug effects | Animals | Cell Differentiation - drug effects | Stem Cells - drug effects | Spinal Cord Injuries - physiopathology | Graft Survival - drug effects | Ciliary neurotrophic factor | Bone morphogenetic proteins | Spinal cord injuries | Spinal cord | Transcription factors | Transplants & implants | Central nervous system | Conservation | Recovery of function | Homeostasis | Nervous system | Transplantation | Neurosurgery | Spinal cord injury | Recovery | Proteins | Pain | Rodents | Injuries | Cell survival | Neurons | Astrocytes | Fetuses | Maintenance | Laminates | Gene expression | Survival | Trauma | Feet | Medicine | Regeneration | Adenoviruses | Morphology | Stem cells | Differentiation | Apoptosis | Osteoprogenitor cells | Axonogenesis | Therapeutic applications | Embryos | Glial stem cells | Neuronal-glial interactions | Foot | Neural stem cells
Journal Article
Nature neuroscience, ISSN 1546-1726, 2012, Volume 15, Issue 5, pp. 746 - 753
Endocannabinoid mediated spike timing-dependent depression (t-LTD) is crucially involved in the development of the sensory neocortex. t-LTD at excitatory... 
Astrocytes/drug effects | Electric Stimulation | Rats, Wistar | 2-Amino-5-phosphonovalerate/pharmacology | Calcium/metabolism | Synapses/drug effects | Time Factors | Naphthalenes/pharmacology | Sodium Channel Blockers/pharmacology | Thalamus/cytology | Long-Term Synaptic Depression/drug effects | Animals, Newborn | Calcium Channel Blockers/pharmacology | Excitatory Amino Acid Antagonists/pharmacology | Dizocilpine Maleate/pharmacology | Excitatory Postsynaptic Potentials/drug effects | Probability | Rats | Benzoxazines/pharmacology | Biophysics | Signal Transduction/drug effects | Neocortex/cytology | Patch-Clamp Techniques | Animals | Glutamic Acid/metabolism | Morpholines/pharmacology | Pyrazoles/pharmacology | Piperidines/pharmacology | Tetrodotoxin/pharmacology | In Vitro Techniques | Receptor, Cannabinoid, CB1/antagonists & inhibitors | D-SERINE | NEUROTRANSMITTER RELEASE | INHIBITORY SYNAPSES | PYRAMIDAL CELLS | SYNAPTIC-TRANSMISSION | RAT SOMATOSENSORY CORTEX | LONG-TERM POTENTIATION | GLIAL-CELLS | PRESYNAPTIC NMDA | NEUROSCIENCES | PLASTICITY | Calcium - metabolism | 2-Amino-5-phosphonovalerate - pharmacology | Long-Term Synaptic Depression - drug effects | Excitatory Postsynaptic Potentials - drug effects | Piperidines - pharmacology | Tetrodotoxin - pharmacology | Pyrazoles - pharmacology | Astrocytes - drug effects | Long-Term Synaptic Depression - physiology | Synapses - drug effects | Synapses - physiology | Morpholines - pharmacology | Sodium Channel Blockers - pharmacology | Synapses - ultrastructure | Excitatory Amino Acid Antagonists - pharmacology | Calcium Channel Blockers - pharmacology | Naphthalenes - pharmacology | Astrocytes - ultrastructure | Astrocytes - physiology | Signal Transduction - drug effects | Benzoxazines - pharmacology | Thalamus - cytology | Neocortex - cytology | Signal Transduction - physiology | Glutamic Acid - metabolism | Receptor, Cannabinoid, CB1 - antagonists & inhibitors | Dizocilpine Maleate - pharmacology | Methyl aspartate | Depression, Mental | Physiological aspects | Genetic aspects | Research | Risk factors | Synapses
Journal Article
Nature Communications, ISSN 2041-1723, 04/2015, Volume 6, Issue 1, p. 6761
Journal Article
Science, ISSN 0036-8075, 03/2012, Volume 335, Issue 6075, pp. 1503 - 1506
Journal Article
PloS one, ISSN 1932-6203, 2012, Volume 7, Issue 6, p. e38381
...) is one of the major extracts obtained from Salvia miltiorrhiza BUNGE, which has anti-inflammatory and anti-apoptotic effects on many diseases... 
GLIAL APOPTOSIS | TUMOR-NECROSIS-FACTOR | CYTOKINES | INHIBITION | MULTIDISCIPLINARY SCIENCES | FACTOR-KAPPA-B | TRANSCRIPTION FACTOR | EXPRESSION | ASTROCYTES | FACTOR-ALPHA | CELL-DEATH | Inflammation - pathology | Spinal Cord - drug effects | Spinal Cord Injuries - drug therapy | Recovery of Function - drug effects | Apoptosis - drug effects | Spinal Cord Injuries - complications | Aging - drug effects | Astrocytes - pathology | Male | NF-kappa B - metabolism | Spinal Cord Injuries - pathology | Inflammation - complications | Inflammation - drug therapy | Spinal Cord - pathology | Inflammation Mediators - metabolism | Neutrophil Infiltration - drug effects | Biomarkers - metabolism | Astrocytes - drug effects | Cytokines - metabolism | Wounds and Injuries - pathology | Diterpenes, Abietane - therapeutic use | Spinal Cord - enzymology | Wounds and Injuries - complications | Rats | Wounds and Injuries - physiopathology | Rats, Sprague-Dawley | Aging - pathology | Diterpenes, Abietane - pharmacology | Animals | MAP Kinase Signaling System - drug effects | Wounds and Injuries - drug therapy | Spinal Cord - physiopathology | Spinal Cord Injuries - physiopathology | Oxidative Stress - drug effects | Inflammation - physiopathology | Nitric Oxide Synthase Type II - metabolism | Spinal cord injuries | Apoptosis | Oxidative stress | Spinal cord | Bcl-2 protein | Inflammatory response | Spinal cord injury | Kinases | Caspase-3 | Interleukin 6 | Pathways | Rodents | Tumor necrosis factor-TNF | Peroxidase | Inhibition | Redox properties | Edema | NF-κB protein | Damage assessment | Cytokines | Astrocytes | Caspase | MAP kinase | Pharmacology | Inflammation | Tumor necrosis factor-α | Trauma | Nitric-oxide synthase | Signaling | Injury prevention | Nitric oxide | Infiltration
Journal Article
PloS one, ISSN 1932-6203, 2011, Volume 6, Issue 7, p. e22735
Journal Article
Nature (London), ISSN 1476-4687, 2011, Volume 476, Issue 7361, pp. 458 - 461
Journal Article