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1. Full Text Temozolomide chemotherapy alone versus radiotherapy alone for malignant astrocytoma in the elderly: the NOA-08 randomised, phase 3 trial
by Wick, Wolfgang, Prof and Platten, Michael, Prof and Meisner, Christoph, PhD and Felsberg, Jörg, MD and Tabatabai, Ghazaleh, MD and Simon, Matthias, MD and Nikkhah, Guido, Prof and Papsdorf, Kirsten, MD and Steinbach, Joachim P, Prof and Sabel, Michael, MD and Combs, Stephanie E, MD and Vesper, Jan, MD and Braun, Christian, MD and Meixensberger, Jürgen, Prof and Ketter, Ralf, MD and Mayer-Steinacker, Regine, MD and Reifenberger, Guido, Prof and Weller, Michael, Prof and German Canc Soc and NOA-08 Study Group of Neuro-oncology Working Group (NOA) of German Cancer Society
Lancet Oncology, The, ISSN 1470-2045, 2012, Volume 13, Issue 7, pp. 707 - 715
Summary Background Radiotherapy is the standard care in elderly patients with malignant astrocytoma and the role of primary chemotherapy is poorly defined. We... 
Hematology, Oncology and Palliative Medicine | OLDER PATIENTS | ONCOLOGY | PROMOTER METHYLATION | NEWLY-DIAGNOSED GLIOBLASTOMA | CONCOMITANT | CLASSIFICATION | PATTERNS | MULTIFORME | CARE | ADJUVANT TEMOZOLOMIDE | Astrocytoma - radiotherapy | Promoter Regions, Genetic | Dacarbazine - therapeutic use | Humans | DNA Repair Enzymes - genetics | Isocitrate Dehydrogenase - genetics | Male | Brain Neoplasms - drug therapy | Antineoplastic Agents, Alkylating - therapeutic use | Disease-Free Survival | DNA Methylation | DNA Modification Methylases - genetics | Tumor Suppressor Proteins - genetics | Astrocytoma - drug therapy | Dacarbazine - analogs & derivatives | Aged, 80 and over | Female | Aged | Brain Neoplasms - mortality | Brain Neoplasms - radiotherapy | Astrocytoma - mortality | Care and treatment | Oncology, Experimental | Radiation | Aged patients | Research | Antineoplastic agents | Radiotherapy | Biometry | Antimitotic agents | Chemotherapy | Nuclear radiation | Gliomas | Product development | Temozolomide | Cancer | Tumors
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2. Radiological and clinical outcome following stereotactic biopsy and radiotherapy for low-grade insular astrocytomas
by Shankar, A and Rajshekhar, V
Radiological and clinical outcome following stereotactic biopsy and radiotherapy for low-grade insular astrocytomas, 12/2003
Thirty patients with low-grade (WHO Grade II) astrocytomas involving the insula, who had undergone stereotactic biopsy followed by radiotherapy, were followed... 
Insula, Astrocytoma, Stereotaxy, Radiotherapy
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3. Full Text Radiotherapy for Glioblastoma in the Elderly
by Keime-Guibert, Florence and Chinot, Olivier and Taillandier, Luc and Cartalat-Carel, Stéphanie and Frenay, Marc and Kantor, Guy and Guillamo, Jean-Sébastien and Jadaud, Eric and Colin, Philippe and Bondiau, Pierre-Yves and Meneï, Philippe and Loiseau, Hugues and Bernier, Valérie and Honnorat, Jérôme and Barrié, Maryline and Mokhtari, Karima and Mazeron, Jean-Jacques and Bissery, Anne and Delattre, Jean-Yves and Assoc French Speaking Neuro Oncolo and Association of French-Speaking Neuro-Oncologists
The New England Journal of Medicine, ISSN 0028-4793, 04/2007, Volume 356, Issue 15, pp. 1527 - 1535
This trial compared radiotherapy plus supportive care with supportive care alone in patients with glioblastoma who were 70 years of age or older. As compared... 
MALIGNANT GLIOMA | IRRADIATION | MEDICINE, GENERAL & INTERNAL | OLDER PATIENTS | CLINICAL-TRIALS | ASTROCYTOMAS | QUALITY-OF-LIFE | CANCER-TREATMENT TRIALS | MULTIFORME | RADIATION-THERAPY | AGE | Radiotherapy Dosage | Astrocytoma - radiotherapy | Astrocytoma - therapy | Humans | Proportional Hazards Models | Male | Glioblastoma - radiotherapy | Glioblastoma - therapy | Brain Neoplasms - therapy | Survival Analysis | Aged, 80 and over | Quality of Life | Female | Aged | Brain Neoplasms - mortality | Brain Neoplasms - radiotherapy | Glioblastoma - mortality | Astrocytoma - mortality | Cognition - radiation effects | Aged patients | Usage | Drug therapy | Radiotherapy | Glioblastoma multiforme | Survival analysis | Radiation therapy | Brain cancer | Older people | Standards | Quality of life
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4. Full Text Fasting Enhances the Response of Glioma to Chemo- and Radiotherapy
by Safdie, Fernando and Brandhorst, Sebastian and Wei, Min and Wang, Weijun and Lee, Changhan and Hwang, Saewon and Conti, Peter S and Chen, Thomas C and Longo, Valter D
PLoS ONE, ISSN 1932-6203, 09/2012, Volume 7, Issue 9, p. e44603
Background: Glioma, including anaplastic astrocytoma and glioblastoma multiforme (GBM) are among the most commonly diagnosed malignant adult brain tumors. GBM... 
CELLS | GLIOBLASTOMA | PROTECTION | GLUCOSE | MULTIDISCIPLINARY SCIENCES | CONCOMITANT | CANCER-RISK | MALIGNANT GLIOMAS | 2-DEOXY-D-GLUCOSE | CHEMOTHERAPY | TEMOZOLOMIDE | Astrocytoma - radiotherapy | Neoplasm Transplantation | Body Weight | Dacarbazine - therapeutic use | Brain Neoplasms - pathology | Luminescence | Antineoplastic Agents, Alkylating - pharmacology | Male | Glioblastoma - radiotherapy | Glioma - radiotherapy | Astrocytoma - pathology | Glioma - pathology | Astrocytoma - drug therapy | Dacarbazine - analogs & derivatives | Brain Neoplasms - radiotherapy | Insulin-Like Growth Factor I - therapeutic use | Fasting | Mice, Inbred C57BL | Rats | Brain Neoplasms - drug therapy | Animals | Glioblastoma - pathology | Cell Line, Tumor | Mice | Blood Glucose - metabolism | Glioblastoma - drug therapy | Glioma - drug therapy | Chemotherapy | Gliomas | Blood sugar | Development and progression | Temozolomide | Radiotherapy | Health aspects | Cancer | Short term | Brain | Cell culture | Animal models | Insulin-like growth factor I | Brain tumors | Brain cancer | Glioblastoma | Insulin-like growth factors | Cancer therapies | Mimicry | Angiogenesis | Metabolites | Surgery | Glioma cells | DNA methylation | Bone marrow | Physiology | Drug dosages | Astrocytoma | Deoxyribonucleic acid--DNA | Sensitizing | Starvation | Cell survival | Tumor cells | Invasiveness | Melanoma | Radio | Radiation therapy | Metabolism | Insulin | Glioblastoma multiforme | Survival | Gerontology | Blood circulation | In vivo methods and tests | Tumors | Deoxyribonucleic acid | DNA
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5. Full Text Astrocytoma cells interconnect to resist radiotherapy
by Malkki, Hemi
Nature Reviews Clinical Oncology, ISSN 1759-4774, 01/2016, Volume 13, Issue 1, pp. 3 - 3
Pharmacology, Experimental | Patient outcomes | Oncology, Experimental | Research | Radiotherapy | Drug resistance | Health aspects | Astrocytoma | Cancer
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6. Full Text Astrocytoma cells interconnect to resist radiotherapy
by Malkki, Hemi
Nature Reviews Neurology, ISSN 1759-4758, 12/2015, Volume 11, Issue 12, pp. 668 - 668
Care and treatment | Pharmacology, Experimental | Patient outcomes | Research | Drug resistance | Radiotherapy | Astrocytoma
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7. Full Text Long-term efficacy of early versus delayed radiotherapy for low-grade astrocytoma and oligodendroglioma in adults: the EORTC 22845 randomised trial
by van den Bent, MJ and Afra, D and de Witte, O and Hassel, M Ben and Schraub, S and Hoang-Xuan, K and Malmström, P-O and Collette, L and Piérart, M and Mirimanoff, R and Karim, ABMF and EORTC Radiotherapy Grp and EORTC Brain Tumor Grp and UK Med Res Council and EORTC Radiotherapy and Brain Tumor Groups and the UK Medical Research Council and Onkologi och Patologi, MV and Oncology and Pathology, Kamprad Lab and Lund University and Oncology and Pathology, MV and Lunds universitet and Onkologi och Patologi, Kampradlab
The Lancet, ISSN 0140-6736, 2005, Volume 366, Issue 9490, pp. 985 - 990
Postoperative policies of “wait-and-see” and radiotherapy for low-grade glioma are poorly defined. A trial in the mid 1980s established the radiation dose. In... 
PROGNOSTIC FACTORS | MALIGNANT GLIOMA | MEDICINE, GENERAL & INTERNAL | EUROPEAN ORGANIZATION | QUALITY-OF-LIFE | PROCARBAZINE | CHEMOTHERAPY | RADIATION-THERAPY | TEMOZOLOMIDE | Radiotherapy Dosage | Astrocytoma - radiotherapy | Oligodendroglioma - mortality | Humans | Middle Aged | Male | Survival Rate | Oligodendroglioma - radiotherapy | Disease Progression | Central Nervous System Neoplasms - radiotherapy | Disease-Free Survival | Adolescent | Adult | Female | Aged | Astrocytoma - mortality | Central Nervous System Neoplasms - mortality | Evaluation | Care and treatment | Radiotherapy | Gliomas | Usage | Diagnosis | Astrocytoma | Therapy | Adults | Long term health care | Brain cancer | Clinical outcomes | Radiation | Medical and Health Sciences | Medicin och hälsovetenskap
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8. Full Text Radiotherapy in the Management of Paediatric Low-Grade Gliomas
by Ajithkumar, T and Taylor, R and Kortmann, R.D
Clinical Oncology, ISSN 0936-6555, 03/2019, Volume 31, Issue 3, pp. 151 - 161
Paediatric low-grade (World Health Organization grade I–II) gliomas (LGGs) represent a spectrum of primary central nervous system tumours. Local tumour control... 
radiotherapy | proton therapy | Low-grade gliomas | systemic treatment | GAMMA-KNIFE RADIOSURGERY | OPTIC PATHWAY | FRACTIONATED STEREOTACTIC RADIOTHERAPY | RADIATION-THERAPY | PROTON RADIATION | ONCOLOGY | RADIOGRAPHIC RESPONSE | TERM-FOLLOW-UP | PILOCYTIC ASTROCYTOMA | FUTURE STRATEGIES | CLINICAL-OUTCOMES | Pediatrics | Chemotherapy | Hospitals | Gliomas | Radiation | Radiotherapy | Cancer
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9. Full Text Immediate post-radiotherapy changes in malignant glioma can mimic tumor progression
by De Wit, M.C.Y and De Bruin, H.G and Eijkenboom, W and Sillevis Smitt, P.A.E and Van Den Bent, M.J
Neurology, ISSN 0028-3878, 08/2004, Volume 63, Issue 3, pp. 535 - 537
To determine the frequency of progressive MRI lesions shortly after radiotherapy for glioma with spontaneous improvement or stabilization, the authors studied... 
PHASE-II | CLINICAL NEUROLOGY | RADIATION-THERAPY | Procarbazine - administration & dosage | Astrocytoma - radiotherapy | Antineoplastic Combined Chemotherapy Protocols - administration & dosage | Follow-Up Studies | Humans | Middle Aged | Brain Neoplasms - pathology | Gadolinium | Male | Glioma - radiotherapy | Brain Neoplasms - surgery | Patient Selection | Astrocytoma - pathology | Clinical Trials, Phase III as Topic - standards | Glioma - pathology | Astrocytoma - drug therapy | Dacarbazine - analogs & derivatives | Vincristine - administration & dosage | Female | Chemotherapy, Adjuvant | Brain Neoplasms - radiotherapy | Dacarbazine - administration & dosage | Diagnosis, Differential | Brain Edema - etiology | Brain Edema - pathology | Combined Modality Therapy | Brain Neoplasms - drug therapy | Cranial Irradiation | Disease Progression | Artifacts | Magnetic Resonance Imaging | Dexamethasone - therapeutic use | Contrast Media | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Brain Edema - drug therapy | Temozolomide | Lomustine - administration & dosage | Glioma - drug therapy | Astrocytoma - surgery | Cohort Studies
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10. Full Text Pattern of Failure After Limited Margin Radiotherapy and Temozolomide for Glioblastoma
by McDonald, Mark W., M.D and Shu, Hui-Kuo G., M.D., Ph.D and Curran, Walter J., M.D., F.A.C.R and Crocker, Ian R., M.D., F.A.C.R
International Journal of Radiation Oncology, Biology, Physics, ISSN 0360-3016, 2011, Volume 79, Issue 1, pp. 130 - 136
Purpose To evaluate the pattern of failure after limited margin radiotherapy for glioblastoma. Methods and Materials We analyzed 62 consecutive patients with... 
Radiology | Hematology, Oncology and Palliative Medicine | Pattern of failure | Radiation therapy | Glioblastoma | Margin | NEWLY-DIAGNOSED GLIOBLASTOMA | ASTROCYTOMAS | MULTIFORME | RADIATION-THERAPY | MALIGNANT GLIOMA | DOSE-ESCALATION | IRRADIATION | ONCOLOGY | CONFORMAL RADIOTHERAPY | RECURRENCE | HIGH-GRADE GLIOMAS | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | Follow-Up Studies | Radiotherapy Planning, Computer-Assisted - methods | Humans | Middle Aged | Brain Neoplasms - pathology | Male | Tomography, X-Ray Computed | Antineoplastic Agents - therapeutic use | Glioblastoma - radiotherapy | Brain Neoplasms - surgery | Neoplasm Recurrence, Local - pathology | Young Adult | Treatment Failure | Dacarbazine - analogs & derivatives | Adult | Dose Fractionation | Female | Brain Neoplasms - mortality | Brain Neoplasms - radiotherapy | Oxides - administration & dosage | Dacarbazine - administration & dosage | Tumor Burden | Brain Neoplasms - drug therapy | Disease Progression | Glioblastoma - surgery | Disease-Free Survival | Magnetic Resonance Imaging | Arsenicals - administration & dosage | Glioblastoma - pathology | Adolescent | Aged | Combined Modality Therapy - methods | Glioblastoma - drug therapy | Neoplasm Staging | Glioblastoma - mortality | Radiotherapy | Glioblastoma multiforme | Temozolomide | temozolomide | Cavities | Radiation | Arsenic trioxide | imaging | Tumors | GLIOMAS | ARSENIC COMPOUNDS | OXYGEN COMPOUNDS | NEOPLASMS | ARSENIC OXIDES | FAILURES | ANTINEOPLASTIC DRUGS | MEDICINE | NUCLEAR MEDICINE | CHALCOGENIDES | NERVOUS SYSTEM DISEASES | DISEASES | THERAPY | DRUGS | RADIOLOGY AND NUCLEAR MEDICINE | RADIOTHERAPY | OXIDES | RADIOLOGY
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11. Full Text Secondary basal cell carcinoma of scalp after radiotherapy: A case report
by Chen, Frank and Yang, Sheau-Fang and Chen, Chien-Hung and Lieu, Ann-Shung and Cheng, Shih-Tsung and Huang, Ming-Yii and Lee, Hsin-Hua
Medicine, ISSN 0025-7974, 09/2018, Volume 97, Issue 36, p. e12170
Rationale: Radiotherapy (RT) is widely used for both malignant and benign tumors in order to reduce the risk of recurrence, to promote tumor control, and to... 
BCC | CNS tumor | RISK | TUMORS | 2ND CANCERS | IRRADIATION | MEDICINE, GENERAL & INTERNAL | THERAPY | astrocytoma | radiotherapy | secondary cancer | SKIN | EXPOSURE | MALIGNANT NEOPLASMS | Neoplasms, Radiation-Induced - surgery | Astrocytoma - therapy | Brain Neoplasms - diagnostic imaging | Humans | Male | Neoplasms, Second Primary - surgery | Carcinoma, Basal Cell - diagnosis | Neoplasm Recurrence, Local - diagnostic imaging | Skin Neoplasms - diagnosis | Carcinoma, Basal Cell - etiology | Adult | Neoplasms, Radiation-Induced - pathology | Skin Neoplasms - surgery | Skin Neoplasms - pathology | Diagnosis, Differential | Neoplasm Recurrence, Local - therapy | Carcinoma, Basal Cell - pathology | Astrocytoma - diagnostic imaging | Neoplasms, Second Primary - diagnosis | Neoplasms, Second Primary - etiology | Carcinoma, Basal Cell - surgery | Scalp | Brain Neoplasms - therapy | Skin Neoplasms - etiology | Neoplasms, Second Primary - pathology | Development and progression | Care and treatment | Basal cell carcinoma | Radiotherapy | Patient outcomes | Methods
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12. Full Text Treatment outcomes of radiotherapy for primary spinal cord glioma
by Choi, Seo Hee and Yoon, Hong In and Yi, Seong and Park, Jong Won and Cho, JaeHo and Shin, Dong Ah and Ha, Yoon and Kim, Dong-Seok and Kim, Se Hoon and Lee, Seung-Koo and Chang, Jong Hee and Suh, Chang-Ok
Strahlentherapie und Onkologie, ISSN 0179-7158, 02/2019, Volume 195, Issue 2, pp. 164 - 174
PurposeSpinal cord gliomas are rare, and there is no consensus on the optimal radiotherapy (RT) regimen. Herein, we investigated therapeutic outcomes in spinal... 
Craniospinal irradiation | Spinal cord | High-grade glioma | Glioma | Radiotherapy | Meningeal carcinomatosis | MANAGEMENT | PROGNOSTIC-FACTORS | REIRRADIATION | ASTROCYTOMAS | TUMORS | GLIOBLASTOMA | ONCOLOGY | CENTRAL-NERVOUS-SYSTEM | SURGICAL RESECTION | MUTATIONS | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | EPIDEMIOLOGY
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13. Full Text One and done: A week of radiotherapy for glioblastoma
by Knisely, Jonathan P.S
Journal of Clinical Oncology, ISSN 0732-183X, 12/2015, Volume 33, Issue 35, pp. 4129 - 4130
GLIOMAS | PHASE-II TRIAL | CLINICAL-TRIAL | IMRT | ONCOLOGY | MALIGNANT ASTROCYTOMA | OLDER | MULTIFORME | RADIATION-THERAPY | TEMOZOLOMIDE | Female | Male | Frail Elderly | Brain Neoplasms - radiotherapy | Glioblastoma - radiotherapy | Humans
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14. Full Text Galectin-1 is a poor prognostic factor in patients with glioblastoma multiforme after radiotherapy
by Chou, Shang-Yu and Yen, Shao-Lun and Huang, Chao-Cheng and Huang, Eng-Yen
BMC Cancer, ISSN 1471-2407, 01/2018, Volume 18, Issue 1, pp. 105 - 8
Background: Galectin-1, a radioresistance marker, was found in our previous study to be a prognostic factor for cervical cancer. The aim of current study is to... 
Adjuvant radiotherapy | Galectin-1 | Glioblastoma multiforme | Radioresistant marker | ASTROCYTOMA | CELLS | RAS | NEWLY-DIAGNOSED GLIOBLASTOMA | GLIOMA | THERAPY-ONCOLOGY-GROUP | PHASE-II | RADIATION-THERAPY | TEMOZOLOMIDE | ONCOLOGY | GROWTH | Immunohistochemistry | Usage | Care and treatment | Prognosis | Oncology, Experimental | Radiation | Research | Radiotherapy | Methylation | Cervical cancer | Cancer
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15. Full Text Nimotuzumab in combination with radiotherapy in high grade glioma patients
: A single institution experience
by Solomon, Maria Teresa and Miranda, Nederlay and Jorrín, Eugenia and Chon, Ivonne and Marinello, Jorge Juan and Alert, José and Lorenzo-Luaces, Patricia and Crombet, Tania
Cancer Biology & Therapy, ISSN 1538-4047, 05/2014, Volume 15, Issue 5, pp. 504 - 509
Nimotuzumab, a humanized antibody targeting epidermal growth factor receptor, has potent anti-proliferative, anti-angiogenic, and pro-apoptotic effects in... 
radiotherapy | glioblastoma multiforme | high grade glioma | nimotuzumab | monoclonal antibody | anaplastic astrocytoma | Monoclonal antibody | Radiotherapy | Glioblastoma multiforme | Anaplastic astrocytoma | Nimotuzumab | High grade glioma | TRIALS | GLIOBLASTOMA-MULTIFORME | MONOCLONAL-ANTIBODY | CANCER | GROWTH-FACTOR RECEPTOR | TARGETED THERAPIES | ONCOLOGY | MALIGNANT GLIOMAS | SURGICAL RESECTION | BINDING | EXPRESSION | Astrocytoma - radiotherapy | Antibodies, Monoclonal, Humanized - therapeutic use | Humans | Middle Aged | Brain Neoplasms - pathology | Male | Antineoplastic Agents - therapeutic use | Combined Modality Therapy | Brain Neoplasms - drug therapy | Glioblastoma - radiotherapy | Young Adult | Disease-Free Survival | Astrocytoma - pathology | Neoplasm Grading | Glioblastoma - pathology | Astrocytoma - drug therapy | Adult | Female | Aged | Brain Neoplasms - radiotherapy | Glioblastoma - drug therapy | Index Medicus | Clinical Study
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16. Full Text Recurrence Pattern After Temozolomide Concomitant With and Adjuvant to Radiotherapy in Newly Diagnosed Patients With Glioblastoma: Correlation With MGMT Promoter Methylation Status
by Alba A. Brandes and Alicia Tosoni and Enrico Franceschi and Guido Sotti and Giampiero Frezza and Pietro Amistà and Luca Morandi and Federica Spagnolli and Mario Ermani
Journal of Clinical Oncology, ISSN 0732-183X, 03/2009, Volume 27, Issue 8, pp. 1275 - 1279
Purpose The aim of the present study was to evaluate factors predicting the recurrence pattern after the administration of temozolomide (TMZ), initially... 
SURVIVAL | TRIAL | ONCOLOGY | CONFORMAL RADIOTHERAPY | GLIOMA | LIMITED-VOLUME IRRADIATION | MALIGNANT ASTROCYTOMAS | FAILURE | MULTIFORME | CHEMOTHERAPY | Promoter Regions, Genetic | Dacarbazine - therapeutic use | Humans | Middle Aged | Neoplasm Recurrence, Local - therapy | DNA Repair Enzymes - genetics | Brain Neoplasms - genetics | Male | Combined Modality Therapy | Glioblastoma - therapy | DNA Methylation | DNA Modification Methylases - genetics | Glioblastoma - genetics | Tumor Suppressor Proteins - genetics | Brain Neoplasms - therapy | Dacarbazine - analogs & derivatives | Adult | Female | Aged | Radiotherapy, Adjuvant
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