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Journal of Neurochemistry, ISSN 0022-3042, 07/2001, Volume 78, Issue 1, pp. 109 - 120
One of the pathophysiological features of Alzheimer's disease is astrocytosis around senile plaques. Reactive astrocytes may produce proinflammatory mediators,... 
astrocytosis
Journal Article
Neuroscience Letters, ISSN 0304-3940, 07/2016, Volume 626, pp. 48 - 53
Aquaporin-1 (AQP1) is a water channel expressed in the choroid plexus and participates in forming cerebrospinal fluid. Interestingly, reactive astrocytes also... 
Water homeostasis | Neuron | Astrocyte | Reactive astrocytosis
Journal Article
JOURNAL OF NUCLEAR MEDICINE, ISSN 0161-5505, 04/2018, Volume 59, Issue 4, pp. 671 - 674
Clinical PET studies using F-18-THK5351 have demonstrated significant tracer retention in sites susceptible to tau burden in Alzheimer disease (AD). However,... 
imaging-pathology correlation | HUMAN BRAIN | ASTROCYTOSIS | MONOAMINE-OXIDASE-B | tau | Alzheimer's disease | AUTORADIOGRAPHY | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | PET
Journal Article
JOURNAL OF NUCLEAR MEDICINE, ISSN 0161-5505, 01/2012, Volume 53, Issue 1, pp. 37 - 46
Astrocytes colocalize with fibrillar amyloid-beta (A beta) plaques in postmortem Alzheimer disease (AD) brain tissue. It is therefore of great interest to... 
DIAGNOSIS | astrocytosis | Alzheimer disease | MAO-B | monoamine oxidase B | CLINICAL PROGRESSION | amyloid | POSITRON-EMISSION-TOMOGRAPHY | MICROGLIA | MONOAMINE-OXIDASE-B | HUMAN-BRAIN | mild cognitive impairment | HEALTH | INHIBITOR | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | PET
Journal Article
ALZHEIMERS RESEARCH & THERAPY, ISSN 1758-9193, 03/2017, Volume 9
Background: F-18-THK5351 is a quinoline-derived tau imaging agent with high affinity to paired helical filaments (PHF). However, high levels of F-18-THK5351... 
F-18-THK5351 tau tracer | Selegiline | ASTROCYTOSIS | ALZHEIMERS-DISEASE | MAO-B | MILD COGNITIVE IMPAIRMENT | NEUROSCIENCES | CLINICAL NEUROLOGY | POSITRON-EMISSION-TOMOGRAPHY | Monoamine oxidase-B | AMYLOID-BETA | IN-VIVO | L-DEPRENYL | Alzheimer's disease | Positron emission tomography | PET | PROGRESSIVE SUPRANUCLEAR PALSY
Journal Article
Frontiers in Neuroscience, ISSN 1662-453X, 07/2019, Volume 13
Neurodegenerative diseases have mainly been associated with neuronal death. Recent investigations have shown that astroglia may modulate neuroinflammation in... 
[11C]deuterodeprenyl | astrocytosis | Sulforhodamine 101 | astrocyte tracer | PET radiopharmaceutical | [18F]2B-SRF101
Journal Article
Neurologia, ISSN 0213-4853, 03/2015, Volume 30, Issue 2, pp. 119 - 129
Introduction: Astrocytes have been considered mere supporting cells in the CNS. However, we now know that astrocytes are actively involved in many of the... 
Astrocytosis | Astrocyte | Neurodegenerative diseases | Glia | Neurodegeneration | Glial fibrillary acidic protein
Journal Article
Frontiers in neuroscience, ISSN 1662-4548, 2019, Volume 13, p. 297
Neural repair after stroke involves initiation of a cellular proliferative program in the form of angiogenesis, neurogenesis, and molecular growth signals in... 
Journal Article
Neuropharmacology, ISSN 0028-3908, 02/2011, Volume 60, Issue 2-3, pp. 223 - 234
Locus coeruleus degeneration and reduced central noradrenaline content is an early feature of Alzheimer's disease. In transgenic mouse models of Alzheimer's... 
Fluparoxan | Memory | β-Amyloid | Astrocytosis | Alzheimer's disease | Noradrenaline | Alpha2 adrenoceptor antagonist
Journal Article
Brain, ISSN 0006-8950, 03/2016, Volume 139, Issue 3, pp. 922 - 936
Journal Article
Journal of Nuclear Medicine, ISSN 0161-5505, 01/2012, Volume 53, Issue 1, pp. 37 - 46
Journal Article
Brain, ISSN 0006-8950, 12/2018, Volume 141, Issue 12, pp. 3415 - 3427
The role of inflammation in dementia with Lewy bodies is unclear. Surendranathan et al. report that microglial activation is elevated in mild disease, before... 
Inflammation | Cytokines | Neurodegeneration | Dementia with Lewy bodies | Microglia | dementia with Lewy bodies | COMPOUND-B | ASTROCYTOSIS | ALZHEIMERS-DISEASE | neurodegeneration | NEUROSCIENCES | CLINICAL NEUROLOGY | DEGENERATION | NEURONAL FUNCTION | inflammation | NEUROINFLAMMATION | MOUSE MODEL | cytokines | microglia | PET | PARKINSONS-DISEASE | Original
Journal Article
Brain, ISSN 0006-8950, 03/2016, Volume 139, Issue 3, pp. 922 - 936
See Schott and Fox (doi: 10.1093/brain/awv405 ) for a scientific commentary on this article. The relationships between pathophysiological processes in... 
astrocytosis | 11 C-Pittsburgh compound B | Original | autosomal dominant Alzheimer’s disease | 11 C-deuterium-L-deprenyl | 18 F-fluorodeoxyglucose
Journal Article
Journal of Neuropathology & Experimental Neurology, ISSN 0022-3069, 02/2019, Volume 78, Issue 2, pp. 123 - 129
Abstract Selective neuronal death in neurodegenerative disorders represents the final step of a cascade of events, including neuroinflammation,... 
Parkinsonism | Mitochondrial dysfunction | MRI | Selective neuronal degeneration | 3-Nitropropionic acid | Bilateral striatal necrosis | Reactive astrocytosis | TOXIN 3-NITROPROPIONIC ACID | PATHOLOGY | ASTROCYTES | NEUROSCIENCES | CLINICAL NEUROLOGY | PATHOGENESIS | IN-VITRO | NEURONS | GLIA | HUNTINGTONS-DISEASE | EXPRESSION | BRAIN
Journal Article
Proceedings of the National Academy of Sciences, ISSN 0027-8424, 03/2013, Volume 110, Issue 10, pp. 4069 - 4074
Journal Article