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Cancer Science, ISSN 1347-9032, 09/2014, Volume 105, Issue 9, pp. 1220 - 1227
Although it is known that ataxia‐telangiectasia mutated (ATM) and interleukin 6 (IL‐6) contribute to multiple drug resistance... 
interleukin 6 | multiple drug resistance | chemotherapy | Ataxia‐telangiectasia mutated | NF‐kappaB | Interleukin 6 | Chemotherapy | NF-kappaB | Ataxia-telangiectasia mutated | Multiple drug resistance | CELLS | SERUM INTERLEUKIN-6 | MECHANISMS | IL-6 | FIBROBLASTS | OVEREXPRESSION | CISPLATIN | ONCOLOGY | PREDICTS SURVIVAL | ATM | EXPRESSION | ATP Binding Cassette Transporter, Sub-Family G, Member 2 | Ataxia Telangiectasia Mutated Proteins - metabolism | Nitriles - pharmacology | Humans | Gene Expression Regulation, Neoplastic | Myeloid Cell Leukemia Sequence 1 Protein - metabolism | bcl-X Protein - genetics | Drug Resistance, Neoplasm | NF-kappa B - metabolism | Neoplasm Proteins - metabolism | Sulfones - pharmacology | Lung Neoplasms | Proto-Oncogene Proteins c-bcl-2 - metabolism | ATP-Binding Cassette Transporters - genetics | Interleukin-6 - physiology | ATP-Binding Cassette Transporters - metabolism | Antineoplastic Agents - pharmacology | p38 Mitogen-Activated Protein Kinases - metabolism | Neoplasm Proteins - genetics | Gene Expression | NF-kappa B - antagonists & inhibitors | Imidazoles - pharmacology | Cisplatin - pharmacology | Myeloid Cell Leukemia Sequence 1 Protein - genetics | p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors | Cell Line, Tumor | Pyridines - pharmacology | bcl-X Protein - metabolism | Camptothecin - pharmacology | Proto-Oncogene Proteins c-bcl-2 - genetics | Camptothecin | Flow cytometry | Biotechnology | Phosphorylation | Laboratories | Lung cancer | DNA damage | Chemoresistance | Drug resistance | Kinases | Cancer therapies | Proteins | Cell cycle | Fibroblasts | Ataxia | Deoxyribonucleic acid--DNA | Cytokines | Tumor cell lines | Cisplatin | Investigations | Gene amplification | Stem cells | Protein expression | Apoptosis | Original
Journal Article
Blood, ISSN 1528-0020, 2012, Volume 119, Issue 6, pp. 1490 - 1500
Ataxia-telangiectasia mutated (ATM) plays a central role in DNA damage responses, and its loss leads to development of T-cell malignancies... 
OXIDATIVE STRESS | AUTOPHAGY GENE | BECLIN-1 | HEMATOPOIETIC STEM-CELLS | TUMOR-SUPPRESSOR | DJ-1 | IONIZING-RADIATION | HEMATOLOGY | CANCER | ATM-DEFICIENT MICE | PARKINSONS-DISEASE | Reactive Oxygen Species - metabolism | Thymocytes - metabolism | Humans | Immunoblotting | Autophagy | Lymphoma, T-Cell - metabolism | DNA-Binding Proteins - metabolism | Mitochondria - genetics | RNA Interference | Adenosine Triphosphate - metabolism | Tumor Suppressor Proteins - genetics | Membrane Potential, Mitochondrial | Apoptosis Regulatory Proteins - genetics | Cell Cycle Proteins - genetics | Membrane Proteins - metabolism | Protein-Serine-Threonine Kinases - metabolism | Fibroblasts - metabolism | Ataxia Telangiectasia - physiopathology | Beclin-1 | Microscopy, Electron, Transmission | Thymocytes - ultrastructure | Gene Expression | Tumor Suppressor Proteins - metabolism | Membrane Proteins - genetics | Mice, Inbred C57BL | Cell Cycle Proteins - metabolism | Cells, Cultured | Kaplan-Meier Estimate | Oxygen Consumption | Protein-Serine-Threonine Kinases - genetics | Ataxia Telangiectasia - metabolism | Mitochondria - metabolism | Ataxia Telangiectasia Mutated Proteins | DNA-Binding Proteins - genetics | Lymphoma, T-Cell - genetics | Reverse Transcriptase Polymerase Chain Reaction | Apoptosis Regulatory Proteins - metabolism | Mice, Knockout | Animals | Ataxia Telangiectasia - genetics | Fibroblasts - cytology | Mice | Mitochondria - physiology | Lymphoid Neoplasia
Journal Article
EMBO reports, ISSN 1469-221X, 08/2009, Volume 10, Issue 8, pp. 887 - 893
Ataxia telangiectasia mutated (ATM), the deficiency of which causes a severe neurodegenerative disease, is a crucial mediator for the DNA damage response (DDR... 
topoisomerase | ATM | R‐loop | transcription | DNA double‐strand break | RNA-POLYMERASE-II | R-loop | PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | DNA double-strand break | DAMAGE | CELL-DEATH | CELL BIOLOGY | REPAIR | CLEAVAGE COMPLEXES | PATHWAY | CAMPTOTHECIN | OPINION | Nucleic Acid Synthesis Inhibitors - pharmacology | Humans | Intracellular Signaling Peptides and Proteins - metabolism | Dichlororibofuranosylbenzimidazole - pharmacology | DNA Breaks, Double-Stranded | DNA-Binding Proteins - metabolism | Flow Cytometry | Neurons - metabolism | Neurons - drug effects | Protein-Serine-Threonine Kinases - metabolism | Lymphocytes - metabolism | Tumor Suppressor Proteins - metabolism | DNA Topoisomerases, Type I - metabolism | Alpha-Amanitin - pharmacology | Cell Cycle Proteins - metabolism | Cells, Cultured | Enzyme Inhibitors - pharmacology | Rats | Nuclear Proteins - metabolism | Ataxia Telangiectasia Mutated Proteins | Microscopy, Confocal | Transcription, Genetic - physiology | Animals | Signal Transduction - drug effects | Lymphocytes - drug effects | Trans-Activators - metabolism | Histones - metabolism | Transcription, Genetic - genetics | Tumor Suppressor p53-Binding Protein 1 | Camptothecin - pharmacology | Microscopy, Fluorescence | Ribonuclease H - metabolism | Proteins | Signal transduction | Cellular biology | Molecular biology | Gene expression | DNA damage | Index Medicus | Scientific Report
Journal Article
PloS one, ISSN 1932-6203, 2011, Volume 6, Issue 9, p. e25454
.... Ataxia Telangiectasia Mutated (ATM) Kinase, which functions as the primary sensor and transducer of DNA damage signal, has been demonstrated to play an important role in the DDR and cancer prevention... 
CELLS | REPAIR | METHYLATION | PROTEIN | GENE | MULTIDISCIPLINARY SCIENCES | DOUBLE-STRAND BREAKS | HOMOLOGOUS RECOMBINATION | MUTATIONS | MICRORNA EXPRESSION | CHECKPOINTS | Tumor Suppressor Proteins - metabolism | Recombinational DNA Repair - genetics | Humans | Cell Cycle Proteins - metabolism | Protein-Serine-Threonine Kinases - genetics | 3' Untranslated Regions - genetics | Radiation Tolerance - genetics | Signal Transduction - genetics | Ataxia Telangiectasia Mutated Proteins | DNA-Binding Proteins - genetics | Down-Regulation - genetics | DNA-Binding Proteins - metabolism | Breast Neoplasms - genetics | Breast Neoplasms - pathology | Tumor Suppressor Proteins - genetics | Cell Cycle Proteins - genetics | Cell Line, Tumor | DNA Damage - genetics | Adult | Cell Cycle Checkpoints - genetics | Female | MicroRNAs - genetics | Protein-Serine-Threonine Kinases - metabolism | Prevention | DNA damage | DNA | Ataxia telangiectasia | Ataxia | DNA repair | Cancer | Transcription factors | Radiosensitivity | Laboratories | Genes | Biological evolution | Homologous recombination | Homology | Biochemistry | Kinases | Cell adhesion & migration | Proteins | Homologous recombination repair | Signal transduction | Cell cycle | Damage | Repair | Deoxyribonucleic acid--DNA | Breast cancer | siRNA | Substrates | Augmentation | Medicine | Molecular modelling | 3' Untranslated regions | MicroRNAs | Regulatory mechanisms (biology) | Irradiation | Ataxia telangiectasia mutated protein | Mutation | Apoptosis | Deoxyribonucleic acid
Journal Article
The Journal of experimental medicine, ISSN 1540-9538, 2013, Volume 210, Issue 2, pp. 233 - 239
...) induced by the RAG endonuclease during V(D)J recombination activate the Ataxia Telangiectasia mutated (ATM... 
MEDICINE, RESEARCH & EXPERIMENTAL | MDC1 | B-CELL-DEVELOPMENT | LIGHT-CHAIN | GENES | TRANSCRIPTION | V(D)J RECOMBINATION | DOUBLE-STRAND BREAKS | ATM | MECHANISMS | IMMUNOLOGY | INTERLEUKIN-7 | Homeodomain Proteins - metabolism | Intracellular Signaling Peptides and Proteins - metabolism | Mice, 129 Strain | RNA, Messenger - metabolism | DNA Breaks, Double-Stranded | DNA-Binding Proteins - metabolism | Intracellular Signaling Peptides and Proteins - deficiency | Cell Cycle Proteins - immunology | Base Sequence | Tumor Suppressor Proteins - genetics | Cell Cycle Proteins - genetics | Gene Rearrangement, B-Lymphocyte, Light Chain | Intracellular Signaling Peptides and Proteins - genetics | B-Lymphocytes - metabolism | Protein-Serine-Threonine Kinases - metabolism | Tumor Suppressor Proteins - metabolism | DNA-Binding Proteins - immunology | Signal Transduction | RNA, Messenger - genetics | Cell Cycle Proteins - metabolism | Protein-Serine-Threonine Kinases - genetics | Ataxia Telangiectasia Mutated Proteins | DNA-Binding Proteins - genetics | Immunoglobulin kappa-Chains - metabolism | Tumor Suppressor Proteins - immunology | Mice, Knockout | Histones - deficiency | Immunoglobulin kappa-Chains - genetics | Animals | B-Lymphocytes - immunology | Histones - genetics | Models, Biological | Alleles | Protein-Serine-Threonine Kinases - immunology | Mice | Histones - metabolism | Brief Definitive Report
Journal Article
Journal Article
Nature cell biology, ISSN 1476-4679, 2015, Volume 17, Issue 10, pp. 1259 - 1269
Journal Article