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American Journal of Physiology - Heart and Circulatory Physiology, ISSN 0363-6135, 10/2007, Volume 293, Issue 4, pp. 2210 - 2218
Targeting cannabinoid-2 (CB2) receptors with selective agonists may represent a novel therapeutic avenue in various inflammatory diseases, but the mechanisms... 
Adhesion molecules | Inflammation | RhoA | Endothelial activation | C-REACTIVE PROTEIN | CARDIAC & CARDIOVASCULAR SYSTEMS | PHYSIOLOGY | MOLECULE EXPRESSION | ATHEROSCLEROSIS | NECROSIS-FACTOR-ALPHA | KNOCKOUT MICE | endothelial activation | CANNABINOID RECEPTORS | inflammation | adhesion molecules | NITRIC-OXIDE | THERAPEUTIC TARGETS | PERIPHERAL VASCULAR DISEASE | POTENTIAL ROLE | CB2 RECEPTOR ACTIVATION | Inflammation - chemically induced | Leukocyte Rolling - drug effects | Tumor Necrosis Factor-alpha - metabolism | Receptor, Cannabinoid, CB2 - agonists | Humans | Male | Monocytes - metabolism | NF-kappa B - metabolism | rhoA GTP-Binding Protein - metabolism | Aorta - metabolism | RNA, Messenger - metabolism | Receptor, Cannabinoid, CB2 - genetics | Coronary Vessels - metabolism | Lipopolysaccharides | Dose-Response Relationship, Drug | Inflammation - metabolism | Anti-Inflammatory Agents - therapeutic use | Chemokine CCL2 - metabolism | Disease Models, Animal | Coronary Vessels - drug effects | Anti-Inflammatory Agents - pharmacology | Endothelial Cells - metabolism | Aorta - drug effects | Mice, Inbred C57BL | Cells, Cultured | Cannabinoids - pharmacology | Monocytes - drug effects | Receptor, Cannabinoid, CB1 - metabolism | Receptor, Cannabinoid, CB2 - metabolism | Cannabinoids - therapeutic use | Intercellular Adhesion Molecule-1 - metabolism | Animals | Signal Transduction - drug effects | Inflammation - prevention & control | Mice | Vascular Cell Adhesion Molecule-1 - metabolism | Endothelial Cells - drug effects
Journal Article
Circulation research, ISSN 1524-4571, 2015, Volume 116, Issue 7, pp. 1231 - 1244
Journal Article
Nature (London), ISSN 1476-4687, 2016, Volume 535, Issue 7611, pp. 303 - 307
Cellular mechanisms that mediate steatohepatitis, an increasingly prevalent condition in the Western world for which no therapies are available, are poorly... 
Fatty Liver/genetics | Cholesterol, HDL/metabolism | Atherosclerosis/genetics | Male | Lipoproteins, HDL/deficiency | Ubiquitination | Proteolysis | Diet, High-Fat | Liver X Receptors | Female | Protein Stability | Cholesterol, Dietary/metabolism | Lipogenesis/genetics | Orphan Nuclear Receptors/genetics | Receptors, LDL/deficiency | Gene Expression Regulation | Lipoproteins, LDL/metabolism | ATP Binding Cassette Transporter, Subfamily G, Member 5 | ATP-Binding Cassette Transporters/metabolism | ATP Binding Cassette Transporter, Subfamily G, Member 8 | Sterol Regulatory Element Binding Protein 1/metabolism | Lipoproteins/metabolism | Phosphatidylcholines/biosynthesis | Animals | Hepatocytes/metabolism | Fatty Acids, Unsaturated/metabolism | Ligands | ATP Binding Cassette Transporter 1/metabolism | Mice | Bile Acids and Salts/metabolism | FATTY LIVER-DISEASE | REVERSE CHOLESTEROL TRANSPORT | ER STRESS | MULTIDISCIPLINARY SCIENCES | ELEMENT-BINDING PROTEIN-1C | IN-VIVO | ALPHA | X-RECEPTOR | MICE | OXIDATION-PRODUCTS | INTESTINAL EPITHELIAL-CELLS | Lipoproteins, HDL - genetics | Atherosclerosis - genetics | Cholesterol, Dietary - metabolism | Phosphatidylcholines - biosynthesis | Lipoproteins, HDL - metabolism | Fatty Liver - therapy | Hepatocytes - metabolism | Orphan Nuclear Receptors - metabolism | Phosphatidylcholines - metabolism | ATP Binding Cassette Transporter 1 - metabolism | Atherosclerosis - therapy | Lipogenesis - genetics | Lipoproteins - metabolism | Receptors, LDL - deficiency | ATP-Binding Cassette Transporters - metabolism | Lipoproteins, HDL - deficiency | Lipoproteins, LDL - metabolism | Sterol Regulatory Element Binding Protein 1 - metabolism | Fatty Liver - genetics | Receptors, LDL - genetics | Cholesterol, HDL - metabolism | Fatty Liver - prevention & control | Bile Acids and Salts - metabolism | Fatty Acids, Unsaturated - metabolism | Orphan Nuclear Receptors - genetics | ATP Binding Cassette Transporter, Sub-Family G, Member 8 | Atherosclerosis - prevention & control | ATP Binding Cassette Transporter, Sub-Family G, Member 5 | Proteolipids | Transcription factors | Lipoproteins | Liver diseases | Atherosclerosis | Genetic aspects | Blood lipoproteins | Properties | Ubiquitin-proteasome system | Health aspects | Risk factors | Proteins | Diet | Liver | Gene expression | Cholesterol
Journal Article
Cell metabolism, ISSN 1550-4131, 2005, Volume 1, Issue 2, pp. 107 - 119
.... Here, we developed mice with targeted mutations in two related adipocyte FABPs, aP2 and mal1, to resolve their role in systemic lipid, glucose, and energy metabolism... 
LEPTIN | OXIDATION | TARGETED DISRUPTION | GLUCOSE | ENDOCRINOLOGY & METABOLISM | MUSCLE | MICE | TNF-ALPHA | WEIGHT | INDUCED INSULIN-RESISTANCE | APOLIPOPROTEIN-E | CELL BIOLOGY | Fatty Acid-Binding Proteins | Phosphorylation | Body Weight | Adipose Tissue - cytology | Multienzyme Complexes - metabolism | Adipocytes - cytology | Immunoblotting | RNA, Messenger - metabolism | AMP-Activated Protein Kinases | Oxygen - metabolism | Tissue Distribution | Adipose Tissue - metabolism | Time Factors | Fatty Acids - metabolism | Protein-Serine-Threonine Kinases - metabolism | Cytokines - metabolism | Liver - metabolism | Mice, Inbred C57BL | Gene Expression Regulation | Insulin Resistance | Diabetes Mellitus - metabolism | Lipid Metabolism | Mice, Transgenic | Inflammation | Macrophages - cytology | Obesity - metabolism | Triglycerides - metabolism | Insulin - metabolism | Macrophages - metabolism | Phenotype | Animals | Carrier Proteins - metabolism | Adipocytes - metabolism | Glucose - metabolism | Stearoyl-CoA Desaturase - metabolism | Receptor, Insulin - metabolism | Arteriosclerosis - metabolism | Mice | Mutation | Type 2 diabetes | Obesity | Glucose | Macrophages | Fatty acids | Dextrose | Glucose metabolism | Atherosclerosis | Physiological aspects | Insulin resistance | Binding proteins | Public health | Protein binding | Diabetes therapy
Journal Article
Cell metabolism, ISSN 1550-4131, 2013, Volume 17, Issue 5, pp. 695 - 708
Diabetes is a major risk factor for atherosclerosis. Although atherosclerosis is initiated by deposition of cholesterol-rich lipoproteins in the artery wall,... 
DIABETES-MELLITUS | PLAQUE REGRESSION | INSULIN-RESISTANCE | ADVANCED GLYCATION ENDPRODUCTS | ENDOCRINOLOGY & METABOLISM | LEUKOCYTE COUNT | RECEPTOR | STEM-CELL PROLIFERATION | APOE(-/-) MICE | DEFICIENT MICE | G-CSF | CELL BIOLOGY | Leukocytes - pathology | Humans | Diabetes Mellitus, Type 1 - metabolism | Male | Monocytes - metabolism | NF-kappa B - metabolism | Leukocytosis - metabolism | Coronary Disease - metabolism | Bone Marrow - metabolism | Hyperglycemia - pathology | Monocytes - pathology | Diabetes Mellitus, Experimental - metabolism | Neutrophils - metabolism | Receptor for Advanced Glycation End Products | Leukocytosis - pathology | Neutrophils - pathology | Myeloid Progenitor Cells - metabolism | Atherosclerosis - pathology | Myelopoiesis - physiology | Cytokines - metabolism | Mice, Inbred C57BL | Diabetes Mellitus, Type 1 - pathology | Myeloid Progenitor Cells - pathology | Atherosclerosis - metabolism | Hyperglycemia - metabolism | Coronary Disease - pathology | Animals | Bone Marrow - pathology | Glycation End Products, Advanced - metabolism | Glucose - metabolism | Mice | Leukocytes - metabolism | Receptors, Immunologic - metabolism | Hyperglycemia | Type 1 diabetes | Atherosclerosis | Development and progression | Universities and colleges | Blood lipids | Coronary heart disease | Medicine, Preventive | Cholesterol | Preventive health services
Journal Article
Diabetes care, ISSN 1935-5548, 2010, Volume 33, Issue 4, pp. 861 - 868
Journal Article
Cell metabolism, ISSN 1550-4131, 2012, Volume 15, Issue 5, pp. 665 - 674
Nonalcoholic fatty liver disease (NAFLD) is associated with increased cardiovascular and liver-related mortality. NAFLD is characterized by both triglyceride... 
RAT-LIVER | RISK-FACTORS | MACROPHAGE APOPTOSIS | PROTEIN-KINASE | ENDOCRINOLOGY & METABOLISM | HMG-COA REDUCTASE | STEATOHEPATITIS | 3-HYDROXY-3-METHYLGLUTARYL COENZYME | PREVALENCE | MICRORNA EXPRESSION | MODULATION | CELL BIOLOGY | Sirtuin 1 - metabolism | Up-Regulation | Cholesterol - blood | Humans | Middle Aged | Sterol Esterase - metabolism | Male | MicroRNAs - metabolism | Desmosterol - metabolism | Cardiovascular Diseases - genetics | Cholesterol - genetics | Sirtuin 1 - genetics | Case-Control Studies | Phosphorylation - genetics | Hydroxymethylglutaryl CoA Reductases - metabolism | Adenylate Kinase - metabolism | Non-alcoholic Fatty Liver Disease | Sterol O-Acyltransferase - metabolism | Adult | Female | Lipid Metabolism - genetics | Sterol Regulatory Element Binding Protein 2 - genetics | Sterol Regulatory Element Binding Protein 2 - metabolism | Fatty Liver - genetics | Receptors, LDL - genetics | Gene Expression | Fatty Liver - metabolism | Cardiovascular Diseases - metabolism | Fatty Liver - blood | Liver - metabolism | Receptors, LDL - metabolism | Cholesterol - metabolism | Cholesterol, LDL - genetics | Phenotype | Sterol Esterase - genetics | Desmosterol - blood | Cholesterol, LDL - metabolism | MicroRNAs - genetics | Sterol O-Acyltransferase - genetics | Adenylate Kinase - genetics | Hydroxymethylglutaryl CoA Reductases - genetics | Enzymes | Liver diseases | Low density lipoproteins | Genes | Esters | Triglycerides | Cholesterol | MicroRNA | Fatty liver | Blood cholesterol | Physiological aspects | Hydrolases | Blood lipids | Health aspects | Statins | atherosclerosis | Nonalcoholic steatohepatitis | cholesterol | Nonalcoholic fatty liver disease | fatty liver | lipogenesis | hypercholesterolemia | HMG CoA reductase
Journal Article
Seminars in immunopathology, ISSN 1863-2300, 2011, Volume 34, Issue 1, pp. 43 - 62
The interaction of coagulation factors with the perivascular environment affects the development of disease in ways that extend beyond their traditional roles... 
Autoimmunity | Complement receptor 3 | Multiple sclerosis | Stroke | Alzheimer’s disease | Internal Medicine | Macrophages | Blood brain barrier | Inflammatory disease | Microglia | Biomedicine | Immunology | Rheumatoid arthritis | CD11b/CD18 | Atherosclerosis | Plasminogen | Anticoagulant therapy | Alzheimer's disease | ALZHEIMERS-DISEASE | IMMUNOLOGY | PATHOLOGY | GAMMA-C-DOMAIN | BINDING-SITE | CENTRAL-NERVOUS-SYSTEM | MULTIPLE-SCLEROSIS LESIONS | CRYSTAL-STRUCTURE | BLOOD-BRAIN-BARRIER | INTEGRIN ALPHA(M)BETA | PROTEASE-ACTIVATED RECEPTORS | PERIPHERAL ARTERIAL-DISEASE | Colitis - genetics | Humans | Brain Injuries - metabolism | Arthritis, Rheumatoid - metabolism | Bacterial Infections - genetics | Inflammation - metabolism | Blood Coagulation - immunology | Muscular Dystrophy, Duchenne - immunology | Alzheimer Disease - immunology | Fibrinogen - immunology | Thromboplastin - immunology | Pulmonary Fibrosis - immunology | Vascular Diseases - genetics | Brain Injuries - genetics | Thrombin - genetics | Kidney Diseases - immunology | Arthritis, Rheumatoid - genetics | Neoplasms - immunology | Colitis - metabolism | Muscular Dystrophy, Duchenne - genetics | Bacterial Infections - metabolism | Neoplasms - metabolism | Pulmonary Fibrosis - genetics | Spinal Cord Injuries - genetics | Kidney Diseases - genetics | Stroke - genetics | Brain Injuries - immunology | Neoplasms - genetics | Bacterial Infections - immunology | Pulmonary Fibrosis - metabolism | Colitis - immunology | Thrombin - immunology | Stroke - immunology | Kidney Diseases - metabolism | Multiple Sclerosis - metabolism | Vascular Diseases - immunology | Spinal Cord Injuries - metabolism | Multiple Sclerosis - genetics | Inflammation - immunology | Fibrinogen - genetics | Stroke - metabolism | Animals | Thromboplastin - genetics | Alzheimer Disease - metabolism | Fibrinogen - metabolism | Inflammation - genetics | Multiple Sclerosis - immunology | Blood Coagulation - genetics | Spinal Cord Injuries - immunology | Muscular Dystrophy, Duchenne - metabolism | Thrombin - metabolism | Thromboplastin - metabolism | Alzheimer Disease - genetics | Arthritis, Rheumatoid - immunology | Vascular Diseases - metabolism | Nervous system diseases | Bacterial infections | Oncology, Experimental | Thrombin | Inflammation | Anticoagulants (Medicine) | Research | Rheumatoid factor | Fibrin | Fibrinogen | Genetic research | Colitis | Cancer | Traumatic brain injury | Coagulation | Tissue factor | hemostasis | Spinal cord injury | Inflammatory diseases | Kidney | Signal transduction | Duchenne's muscular dystrophy | Neurodegenerative diseases | Therapeutic applications | Thrombosis | Coagulation factors | Infection | Molecular modelling | Fibrosis | Brain injury
Journal Article
Nature communications, ISSN 2041-1723, 2015, Volume 6, Issue 1, p. 6498
Journal Article