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atrogin-1 (293) 293
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animals (182) 182
atrophy (133) 133
male (121) 121
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muscle, skeletal - metabolism (101) 101
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gene-expression (85) 85
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skp cullin f-box protein ligases - metabolism (74) 74
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ubiquitin-protein ligases - genetics (39) 39
muscle, skeletal - drug effects (37) 37
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phosphorylation (34) 34
physiological aspects (34) 34
proteasome endopeptidase complex - metabolism (34) 34
ubiquitin-proteasome pathway (33) 33
neurosciences (32) 32
endocrinology & metabolism (31) 31
mice, inbred c57bl (31) 31
analysis (30) 30
atrogin-1/mafbx (30) 30
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skeletal-muscle atrophy (30) 30
rats, wistar (29) 29
insulin (28) 28
muscular atrophy - genetics (28) 28
proto-oncogene proteins c-akt - metabolism (28) 28
autophagy (27) 27
forkhead transcription factors - metabolism (27) 27
muscle fibers, skeletal - metabolism (27) 27
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rats, sprague-dawley (21) 21
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in-vivo (20) 20
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muscular atrophy - etiology (20) 20
protein biosynthesis (20) 20
rodents (20) 20
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FASEB Journal, ISSN 0892-6638, 11/2008, Volume 22, Issue 11, pp. 3836 - 3845
Heat shock protein 70 (Hsp70) is a highly conserved and ubiquitous protein that is reported to provide cytoprotection in various cell types and tissues.... 
Immobilization | Atrogin-1/MAFbx | MuRF1 | DISUSE ATROPHY | OXIDATIVE STRESS | ACTIVATION | immobilization | PROTEIN | UBIQUITIN LIGASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | SOLEUS MUSCLE | CELL BIOLOGY | DEPENDENT PROTEOLYSIS | MESSENGER-RNA | BIOLOGY | GENE-EXPRESSION | DEGRADATION | atrogin-1/MAFbx | Research Communications | atrogin-1 | MAFbx
Journal Article
Journal of Microbiology and Biotechnology, ISSN 1017-7825, 2018, Volume 28, Issue 4, pp. 520 - 526
Conessine, a steroidal alkaloid, is a potent histamine H3 antagonist with antimalarial activity. We recently reported that conessine treatment interferes with... 
Conessine | FoxO3a | atrogin-1 | muscle atrophy | MuRF1
Journal Article
American Journal of Physiology - Cell Physiology, ISSN 0363-6143, 09/2012, Volume 303, Issue 5, pp. C512 - C529
Journal Article
FASEB Journal, ISSN 0892-6638, 01/2011, Volume 25, Issue 1, pp. 99 - 110
Cachectic muscle wasting is a frequent complication of many inflammatory conditions, due primarily to excessive muscle catabolism. However, the pathogenesis... 
Autophagosomes | Lactacystin | Atrogin-1/MAFbx | p38 MAPK | 3-Methyladenine | RAT SKELETAL-MUSCLE | BIOCHEMISTRY & MOLECULAR BIOLOGY | NECROSIS-FACTOR-ALPHA | FOXO TRANSCRIPTION FACTORS | lactacystin | CELL BIOLOGY | MESSENGER-RNAS | autophagosomes | PROTEIN-DEGRADATION | SIGNALING PATHWAY | AMINO-ACIDS | IN-VIVO | BIOLOGY | atrogin-1/MAFbx | 3-methyladenine | INNATE IMMUNITY | C2C12 MYOTUBES | SKP Cullin F-Box Protein Ligases - genetics | Ubiquitin - metabolism | Male | Muscle Fibers, Skeletal - drug effects | Muscle Fibers, Skeletal - metabolism | Autophagy - drug effects | Lysosomes - metabolism | RNA Interference | Muscle Proteins - metabolism | p38 Mitogen-Activated Protein Kinases - metabolism | Muscles - metabolism | Phagosomes - drug effects | Cell Line | Muscular Atrophy - metabolism | Mice, Inbred C57BL | Phagosomes - metabolism | Enzyme Inhibitors - pharmacology | Toll-Like Receptor 4 - genetics | Muscular Atrophy - genetics | Imidazoles - pharmacology | SKP Cullin F-Box Protein Ligases - metabolism | Toll-Like Receptor 4 - metabolism | Blotting, Western | Mice, Knockout | Muscle Proteins - genetics | Animals | Signal Transduction - drug effects | Muscles - drug effects | p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors | Lipopolysaccharides - pharmacology | Mice | Pyridines - pharmacology | Proteasome Endopeptidase Complex - metabolism | Research Communications | atrogin-1 | MAFbx
Journal Article
FASEB Journal, ISSN 0892-6638, 10/2009, Volume 23, Issue 10, pp. 3415 - 3423
Heat shock protein 25/27 (Hsp25/27) is a cytoprotective protein that is ubiquitously expressed in most cells, and is up-regulated in response to cellular... 
Immobilization | Atrogin-1/MAFbx | MuRF1 | DISUSE ATROPHY | OXIDATIVE STRESS | ACTIVATION | immobilization | STRESS-PROTEINS | BIOCHEMISTRY & MOLECULAR BIOLOGY | RATS | ALPHA | CELL BIOLOGY | HEAT-SHOCK PROTEINS | BIOLOGY | GENE-EXPRESSION | DEGRADATION | KINASE IKK | atrogin-1/MAFbx | Research Communications | atrogin-1 | MAFbx
Journal Article
Journal of Microbiology and Biotechnology, ISSN 1017-7825, 04/2018, Volume 28, Issue 4, pp. 520 - 526
Conessine, a steroidal alkaloid, is a potent histamine H3 antagonist with antimalarial activity. We recently reported that conessine treatment interferes with... 
Conessine | FoxO3a | Muscle atrophy | Atrogin-1 | MuRF1 | APOPTOSIS | atrogin-1 | PROTEIN-KINASE | MICROBIOLOGY | TUMOR-CELLS | KAPPA-B | UBIQUITIN LIGASES | SKELETAL-MUSCLE | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | GROWTH | muscle atrophy | TRANSCRIPTION FACTOR | MAFBX/ATROGIN-1 | 생물학
Journal Article
Skeletal Muscle, ISSN 2044-5040, 03/2013, Volume 3, Issue 1, pp. 6 - 6
Background: Skeletal muscle mass is determined by the balance between protein synthesis and degradation. Mammalian target of rapamycin complex 1 (mTORC1) is a... 
Atrophy | Tuberous sclerosis complex (TSC) | FoxO | PKB/Akt | MuRF1 | Mammalian target of rapamycin complex 1 (mTORC1) | Atrogin-1/MAFbx | Raptor | Skeletal muscle | Hypertrophy | CELL BIOLOGY | Ligases | Proteolysis | Analysis | Muscles | Tuberous sclerosis | Protein biosynthesis | Health aspects | Life Sciences
Journal Article
The Journal of Poultry Science, ISSN 1346-7395, 2017
The expression of atrogin-1/MAFbx, a muscle-specific E3 ubiquitin ligase, is increased in catabolic conditions that result in muscle atrophy. The expression of... 
IGF-I | chick myotubes | Akt | atrogin-1/MAFbx | FOXO1
Journal Article
by Kim, HE and Rhee, J and Park, S and Yang, J and Chun, JS
OSTEOARTHRITIS AND CARTILAGE, ISSN 1063-4584, 03/2017, Volume 25, Issue 3, pp. 397 - 400
Objective: In a preliminary study, we found that recently identified catabolic regulators of osteoarthritis (OA), including hypoxia-inducible factor (HIF)-2... 
Atrogin-1/FBX032 | Cartilage | Chondrocytes | RHEUMATOLOGY | ORTHOPEDICS | Osteoarthritis | HYPOXIA-INDUCIBLE FACTOR-2-ALPHA | AXIS
Journal Article
JOURNAL OF CELL BIOLOGY, ISSN 0021-9525, 03/2014, Volume 204, Issue 5, pp. 747 - 758
Activation of the PI3K-Akt-Fox0 pathway induces cell growth, whereas its inhibition reduces cell survival and, in muscle, causes atrophy. Here, we report a... 
CADHERIN | PROTEIN-DEGRADATION | GROWTH | MUTATION | CELL-ADHESION | ATROGIN-1 | BETA-CATENIN | UBIQUITIN LIGASES | PHOSPHOINOSITIDE 3-KINASE | EXPRESSION | CELL BIOLOGY
Journal Article
Nature Communications, ISSN 2041-1723, 04/2015, Volume 6, Issue 1, p. 6670
Journal Article
Nucleic Acids Research, ISSN 0305-1048, 11/2018, Volume 46, Issue 20, pp. 10697 - 10708
Abstract Multiple physiopathological and clinical conditions trigger skeletal muscle atrophy through the induction of a group of proteins (atrogenes) that... 
MYOD BINDING | DELTA-EF1 | ZEB | BIOCHEMISTRY & MOLECULAR BIOLOGY | DEGRADATION | HOMOLOG | DIFFERENTIATION | ATROGIN-1 | REPRESSOR | PROTEINS | EXPRESSION | Gene regulation, Chromatin and Epigenetics
Journal Article
Comparative Biochemistry and Physiology, Part A, ISSN 1095-6433, 09/2017, Volume 211, pp. 1 - 6
Adrenaline changes expression of the genes encoding peroxisome proliferator-activated receptor-gamma coactivator-1 alpha (PGC-1α), which is known as a... 
PGC-1α | Chicken | Atrogin-1/MAFbx | Skeletal muscle | β-Adrenergic receptor
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 2010, Volume 392, Issue 1, pp. 1 - 3
Menopause, the age-related loss of ovarian hormone production, promotes increased adiposity and associated metabolic pathology, but molecular mechanisms remain... 
Musclin | Myogenin | Atrogin-1/MAFbx | MuRF-1 | Menopause | Estrogen | ACTIVATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | BETA | OBESITY | BIOPHYSICS | METABOLISM | ACCUMULATION | MAFbx | menopause | Atrogin-1 | myogenin
Journal Article
Experimental Gerontology, ISSN 0531-5565, 10/2019, Volume 126, p. 110711
Skeletal muscle atrophy reduces quality of life and increases morbidity and mortality in patients with chronic conditions. Oxidative stress is a key factor... 
Skeletal muscle atrophy | Immobilization | Oxidative stress | Beta-lapachone | ACTIVATION | DETERMINANT | PREVENTION | INCREASES | DENERVATION | INDUCTION | AUTOPHAGY | MTOR | GERIATRICS & GERONTOLOGY | GROWTH | ATROGIN-1
Journal Article
Journal of Molecular and Cellular Cardiology, ISSN 0022-2828, 01/2019, Volume 126, pp. 1 - 12
Muscle atrophy F-box (MAFbx/atrogin-1), an E3 ubiquitin ligase, is a crucial mediator of skeletal muscle atrophy and cardiac hypertrophy in response to... 
Myocardial infarction | Inflammasome | Muscle atrophy F-box | Cardiac rupture | Neutrophils | ACTIVATION | CARDIAC & CARDIOVASCULAR SYSTEMS | IDENTIFICATION | CELL BIOLOGY | HYPERTROPHY | INHIBITION | MAFBX | INFLAMMATION | ATROGIN-1 | DYSFUNCTION | PROTEINS | EXPRESSION
Journal Article
Cell Metabolism, ISSN 1550-4131, 2007, Volume 6, Issue 6, pp. 458 - 471
Journal Article