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Cancer Cell, ISSN 1535-6108, 09/2014, Volume 26, Issue 3, pp. 414 - 427
MYC proteins are major drivers of cancer yet are considered undruggable because their DNA binding domains are composed of two extended alpha helices with no... 
MECHANISM | ONCOLOGY | HISTONE H3 | PHOSPHORYLATION | N-MYC | DFG FLIP | MLN8237 | THERAPEUTIC TARGETS | A KINASE | NEUROBLASTOMA | SMALL-MOLECULE INHIBITOR | CELL BIOLOGY | Phosphorylation | Area Under Curve | Allosteric Regulation | Humans | Crystallography, X-Ray | Structure-Activity Relationship | Aurora Kinase A - antagonists & inhibitors | Aurora Kinase A - metabolism | Pyrimidines - chemistry | Aurora Kinase A - chemistry | Phenylurea Compounds - chemistry | Proteolysis | Antineoplastic Agents - pharmacokinetics | Antineoplastic Agents - pharmacology | N-Myc Proto-Oncogene Protein | Phenylurea Compounds - pharmacokinetics | Neuroblastoma - pathology | Cell Survival - drug effects | Catalytic Domain | Oncogene Proteins - chemistry | Protein Structure, Secondary | Oncogene Proteins - metabolism | Models, Molecular | Nuclear Proteins - metabolism | Pyrimidines - pharmacology | Antineoplastic Agents - chemistry | Mice, SCID | Nuclear Proteins - chemistry | Xenograft Model Antitumor Assays | Animals | Tumor Burden - drug effects | Mice, Nude | Neuroblastoma - drug therapy | Cell Line, Tumor | Pyrimidines - pharmacokinetics | Mice, Inbred NOD | Mice | Phenylurea Compounds - pharmacology | Protein Processing, Post-Translational | S Phase Cell Cycle Checkpoints - drug effects | Proteins | DNA-ligand interactions | Analysis | Protein binding
Journal Article
CELL CYCLE, ISSN 1538-4101, 04/2012, Volume 11, Issue 8, pp. 1490 - 1495
The events of cell division are regulated by a complex interplay between kinases and phosphatases. Cyclin-dependent kinases (Cdks), Polo-like kinases (Plks)... 
CHROMOSOME BI-ORIENTATION | CELL-CYCLE REGULATION | centromere | Bora | Polo | Plk1 | BETA-TRCP | POLO-LIKE-KINASE-1 | PROTEIN-KINASE | mitosis | TRCP-DEPENDENT DEGRADATION | CELL BIOLOGY | kinase | MITOTIC ENTRY | INCENP | kinetochore | phosphatase | Aurora B | Aurora A | AURORA-A
Journal Article
Frontiers in Oncology, ISSN 2234-943X, 2015, Volume 5, p. 278
The Aurora kinase family comprises of cell cycle-regulated serine/threonine kinases important for mitosis. Their activity and protein expression are cell cycle... 
Hematologic diseases | Small molecules | Aurora kinase | Neuroblastoma | Kinase inhibitors | Chromosomes | Hematologic Diseases | kinase inhibitors | small molecules
Journal Article
Journal Article