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1. Full Text Cell cycle proteins as promising targets in cancer therapy
by Otto, Tobias and Sicinski, Piotr
Nature Reviews Cancer, ISSN 1474-175X, 01/2017, Volume 17, Issue 2, pp. 93 - 115
Cancer is characterized by uncontrolled tumour cell proliferation resulting from aberrant activity of various cell cycle proteins. Therefore, cell cycle... 
INVESTIGATIONAL AURORA KINASE | PHASE-II TRIAL | POLO-LIKE-KINASE | EARLY EMBRYONIC-DEVELOPMENT | DINACICLIB SCH 727965 | ADVANCED SOLID TUMORS | ONCOLOGY | PREVENTS TUMOR-GROWTH | VOLASERTIB BI 6727 | DEPENDENT KINASE INHIBITOR | SMALL-MOLECULE INHIBITOR | Cyclin-Dependent Kinase 6 - antagonists & inhibitors | Humans | Checkpoint Kinase 1 - physiology | Aurora Kinase A - antagonists & inhibitors | Cyclin-Dependent Kinase 2 - physiology | Cell Cycle Proteins - antagonists & inhibitors | Protein-Tyrosine Kinases - physiology | Aurora Kinase A - physiology | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Cyclin-Dependent Kinase 4 - antagonists & inhibitors | Proto-Oncogene Proteins - antagonists & inhibitors | Signal Transduction | Protein-Serine-Threonine Kinases - physiology | Checkpoint Kinase 1 - antagonists & inhibitors | Clinical Trials as Topic | Neoplasms - drug therapy | Animals | Cyclin-Dependent Kinase 4 - physiology | Nuclear Proteins - antagonists & inhibitors | Proto-Oncogene Proteins - physiology | Cyclin-Dependent Kinase 2 - antagonists & inhibitors | Cyclin-Dependent Kinase 6 - physiology | Nuclear Proteins - physiology | Cell Cycle Proteins - physiology | Protein-Tyrosine Kinases - antagonists & inhibitors | Proteins | Care and treatment | Usage | MicroRNA | Cell cycle | Research | Cancer
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2. Full Text Size matters! Aurora A controls Drosophila larval development
by Vaufrey, Lucie and Balducci, Christine and Lafont, René and Prigent, Claude and Le Bras, Stéphanie
Developmental Biology, ISSN 0012-1606, 08/2018, Volume 440, Issue 2, pp. 88 - 98
In metazoans, organisms arising from a fertilized egg, the embryo will develop through multiple series of cell divisions, both symmetric and asymmetric,... 
Larval development coordination | Drosophila | Aurora A kinase | EMBRYONIC-DEVELOPMENT | BODY-SIZE | SELF-RENEWAL | DEVELOPMENTAL BIOLOGY | PROLIFERATION ACTIVATION | PROTHORACIC GLAND | GROWTH | TUMOR-SUPPRESSOR | CELL-CYCLE | A KINASE | ASYMMETRIC DIVISION | Protein-Serine-Threonine Kinases - physiology | Larva - metabolism | Cell Cycle Proteins - metabolism | Protein-Serine-Threonine Kinases - genetics | Drosophila Proteins - metabolism | Aurora Kinase A - metabolism | Brain - metabolism | Cell Division - physiology | Drosophila Proteins - physiology | Animals | Spindle Apparatus - metabolism | Aurora Kinase A - physiology | Neurogenesis - physiology | Drosophila - embryology | Cell Differentiation | Neurons - metabolism | Drosophila - metabolism | Drosophila Proteins - genetics | Genetic Pleiotropy - genetics | Larva - physiology | Neural Stem Cells - metabolism | Aurora Kinase A - genetics | Loss of Function Mutation - genetics | Life Sciences | Genetics
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3. Full Text Aurora-A recruitment and centrosomal maturation are regulated by a Golgi-activated pool of Src during G2
by Barretta, Maria Luisa and Spano, Daniela and D'Ambrosio, Chiara and Cervigni, Romina Ines and Scaloni, Andrea and Corda, Daniela and Colanzi, Antonino
Nature Communications, ISSN 2041-1723, 05/2016, Volume 7, Issue 1, p. 11727
The Golgi apparatus is composed of stacks of cisternae laterally connected by tubules to form a ribbon-like structure. At the onset of mitosis, the Golgi... 
MITOSIS | GRASP65 | COMPLEX | MITOTIC ENTRY | PHOSPHORYLATION | MULTIDISCIPLINARY SCIENCES | KINASE | FRAGMENTATION | MAMMALIAN-CELLS | ORGANELLE | CYCLE | Phosphorylation | G2 Phase - physiology | Humans | src-Family Kinases - antagonists & inhibitors | Rats | Sulfonamides - pharmacology | Tyrosine - metabolism | Animals | Aurora Kinase A - physiology | RNA Interference | Thymidine - pharmacology | Chromosome Segregation - physiology | Centrosome - physiology | Golgi Apparatus - metabolism | Indoles - pharmacology | S Phase - drug effects | src-Family Kinases - physiology | HeLa Cells | Aurora Kinase A - genetics | RNA, Small Interfering - metabolism | Tyrosine | Fracture mechanics | Maturation | Mitosis | Centrosomes | Tubules | Ductile-brittle transition | Heredity | Kinases | Recruitment | Fragmentation | Cell cycle | Stacks | Localization | Golgi cells
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4. Full Text The potential role of the NEK6, AURKA, AURKB, and PAK1 genes in adenomatous colorectal polyps and colorectal adenocarcinoma
by Kasap, Elmas and Kasap, Elmas and Gerceker, Emre and Gerceker, Emre and Boyacıoglu, Seda Örenay and Boyacıoglu, Seda Örenay and Yuceyar, Hakan and Yuceyar, Hakan and Yıldırm, Hatice and Yıldırm, Hatice and Ayhan, Semin and Ayhan, Semin and Korkmaz, Mehmet and Korkmaz, Mehmet
Tumor Biology, ISSN 1010-4283, 3/2016, Volume 37, Issue 3, pp. 3071 - 3080
Colorectal adenomatous polyp (CRAP) is a major risk factor for the development of sporadic colorectal cancer (CRC). Histone modifications are one of the... 
PAK1 | Biomedicine | Colorectal adenocarcinoma | NEK6 | Cancer Research | Histone modification | Colorectal adenomatous polyp | Epigenetic | AURKB | AURKA | HDAC INHIBITORS | AURORA KINASE | CANCER | EPIGENETICS | ONCOLOGY | INFLAMMATION | EXPRESSION | Aurora Kinase B - genetics | Adenocarcinoma - pathology | p21-Activated Kinases - genetics | Colorectal Neoplasms - genetics | Humans | Middle Aged | Male | Adenomatous Polyposis Coli - pathology | Aurora Kinase A - physiology | NIMA-Related Kinases - genetics | Adult | Female | NIMA-Related Kinases - physiology | Adenocarcinoma - genetics | Aged | p21-Activated Kinases - physiology | Adenomatous Polyposis Coli - genetics | Colorectal Neoplasms - pathology | Aurora Kinase B - physiology | Aurora Kinase A - genetics | Adenocarcinoma | Epigenetic inheritance | Enzymes | Polyps (Pathology) | Analysis | Genes | Colorectal cancer | Genetic research | Development and progression | Genetic aspects | Gene expression | Cancer
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5. Full Text N-Myc Drives Neuroendocrine Prostate Cancer Initiated from Human Prostate Epithelial Cells
by Lee, John K and Phillips, John W and Smith, Bryan A and Park, Jung Wook and Stoyanova, Tanya and McCaffrey, Erin F and Baertsch, Robert and Sokolov, Artem and Meyerowitz, Justin G and Mathis, Colleen and Cheng, Donghui and Stuart, Joshua M and Shokat, Kevan M and Gustafson, W. Clay and Huang, Jiaoti and Witte, Owen N
Cancer Cell, ISSN 1535-6108, 04/2016, Volume 29, Issue 4, pp. 536 - 547
amplification and overexpression are common in neuroendocrine prostate cancer (NEPC). However, the impact of aberrant N-Myc expression in prostate... 
INACTIVATION | ORIGIN | ONCOLOGY | ADENOCARCINOMA | C-MYC | STEM-CELL | DIFFERENTIATION | IDENTIFICATION | CARCINOMA | EXPRESSION | BASAL-CELLS | CELL BIOLOGY | Adenocarcinoma - pathology | Epithelial Cells - metabolism | Humans | Neoplasm Proteins - physiology | Gene Expression Regulation, Neoplastic | Laser Capture Microdissection | Male | Antineoplastic Agents - therapeutic use | Genes, myc | Aurora Kinase A - antagonists & inhibitors | Molecular Targeted Therapy | Recombinant Fusion Proteins - metabolism | Exome | Neoplasm Metastasis | Proto-Oncogene Proteins c-myc - physiology | Prostatic Neoplasms - genetics | Aurora Kinase A - physiology | Neoplastic Stem Cells - metabolism | Cell Transformation, Neoplastic - genetics | Neoplastic Stem Cells - pathology | Adenocarcinoma - genetics | Neoplasm Proteins - genetics | Neuroendocrine Tumors - pathology | Prostatic Neoplasms - pathology | Transduction, Genetic | Neoplasm Invasiveness | Phenylurea Compounds - therapeutic use | Epithelial Cells - pathology | Proto-Oncogene Proteins c-akt - physiology | Mice, SCID | Azepines - therapeutic use | Neuroendocrine Tumors - genetics | Orchiectomy | Xenograft Model Antitumor Assays | Animals | Protein Kinase Inhibitors - therapeutic use | Pyrimidines - therapeutic use | Cell Line, Tumor | Mice, Inbred NOD | Enzyme Activation | Molecular biology | Health aspects | Prostate cancer | Stem cells | Medical genetics | Cell death
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6. Full Text Aurora kinase a is required for hematopoiesis but is dispensable for murine megakaryocyte endomitosis and differentiation
by Goldenson, Benjamin and Kirsammer, Gina and Stankiewicz, Monika J and Wen, Qiang Jeremy and Crispino, John D
Blood, ISSN 0006-4971, 03/2015, Volume 125, Issue 13, pp. 2141 - 2150
Aurora kinase A (AURKA) is a therapeutic target in acute megakaryocytic leukemia. However, its requirement in normal hematopoiesis and megakaryocyte... 
SURVIVIN | REGENERATION | GATA-1 | CELL-CYCLE | MICE | SUPPRESSION | HEMATOLOGY | POLYPLOIDIZATION | DEFICIENCY | Adult Stem Cells - physiology | Polyploidy | Mice, Inbred C57BL | Cells, Cultured | Hematopoiesis - genetics | Mice, Transgenic | Megakaryocytes - physiology | Mitosis - genetics | Thrombopoiesis - genetics | Cell Differentiation - genetics | Animals | Aurora Kinase A - physiology | Mice | Platelets and Thrombopoiesis
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7. Full Text Biology of Aurora A kinase: Implications in cancer manifestation and therapy
by Karthigeyan, Dhanasekaran and Prasad, Sallekoppal B. Benaka and Shandilya, Jayasha and Agrawal, Shipra and Kundu, Tapas K
Medicinal Research Reviews, ISSN 0198-6325, 09/2011, Volume 31, Issue 5, pp. 757 - 793
The Aurora A kinase belongs to serine/threonine group of kinases, well known for its role in cell cycle, especially in the regulation of mitosis. Numerous... 
checkpoint | centrosome dynamics | kinase inhibitors | tumorigenesis | phosphorylation | Checkpoint | Phosphorylation | Tumorigenesis | Kinase inhibitors | Centrosome dynamics | CHEMISTRY, MEDICINAL | CRYSTAL-STRUCTURE | OVARIAN-CANCER | I DOSE-ESCALATION | PROTEIN-KINASES | SMALL-MOLECULE INHIBITOR | MITOTIC SPINDLE | B KINASE | GENE-EXPRESSION | PHARMACOLOGY & PHARMACY | A KINASE | CELL-CYCLE | Genomic Instability | Neoplasms - etiology | Humans | Neoplasms - diagnosis | Aurora Kinase A - antagonists & inhibitors | Neoplasms - drug therapy | Polymorphism, Genetic | Gene Expression Regulation, Enzymologic | Animals | Aurora Kinase A - physiology | Aurora Kinase A - chemistry | Protein Kinase Inhibitors - therapeutic use | Signal Transduction - physiology | Genes, Tumor Suppressor | Aurora Kinase A - genetics
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8. Full Text Aurora A plays a dual role in migration and survival of human glioblastoma cells according to the CXCL12 concentration
by Willems, Estelle and Dedobbeleer, Matthias and Digregorio, Marina and Lombard, Arnaud and Goffart, Nicolas and Lumapat, Paul Noel and Lambert, Jeremy and Van den Ackerveken, Priscilla and Szpakowska, Martyna and Chevigné, Andy and Scholtes, Felix and Rogister, Bernard
Oncogene, ISSN 0950-9232, 01/2019, Volume 38, Issue 1, pp. 73 - 87
Primary glioblastoma is the most frequent human brain tumor in adults and is generally fatal due to tumor recurrence. We previously demonstrated that... 
INITIATING CELLS | ACTIVATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | PROLIFERATION | TEMOZOLOMIDE | CELL BIOLOGY | SUBVENTRICULAR ZONES | STEM-LIKE CELLS | INHIBITION | ONCOLOGY | GENETICS & HEREDITY | CENTRAL-NERVOUS-SYSTEM | A KINASE | RADIOTHERAPY | Chemokine CXCL12 - physiology | Glioblastoma - enzymology | Lateral Ventricles - pathology | Phosphorylation | Humans | Neoplasm Proteins - physiology | Brain Neoplasms - pathology | LIM Domain Proteins - biosynthesis | MAP Kinase Signaling System | Heterografts | Aurora Kinase A - physiology | Brain Neoplasms - enzymology | Signal Transduction | Cell Survival | Neoplasm Invasiveness | Cell Movement - drug effects | Receptors, CXCR4 - physiology | Animals | Chemokine CXCL12 - pharmacology | Glioblastoma - pathology | Cell Line, Tumor | LIM Domain Proteins - genetics | Mice | Protein Processing, Post-Translational | Enzyme Activation | Enzymes | Care and treatment | Development and progression | Genetic aspects | Regulation | Glioblastoma multiforme | Phosphotransferases | Health aspects | Vimentin | Cdc42 protein | CXCL12 protein | Cell survival | Brain tumors | Glioblastoma | Extracellular signal-regulated kinase | Guanine nucleotide-binding protein | Subventricular zone | CXCR4 protein | Actin | Xenografts | Cytoskeleton | Glioblastoma cells | Cell migration | Guanosinetriphosphatase | Target validation | Cancer stem cells | CNS cancer | Cancer microenvironment
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9. Full Text Targeting Aurora kinase-A downregulates cell proliferation and angiogenesis in neuroblastoma
by Romain, Carmelle and Paul, Pritha and Kim, Kwang Woon and Lee, Sora and Qiao, Jingbo and Chung, Dai H
Journal of Pediatric Surgery, ISSN 0022-3468, 2014, Volume 49, Issue 1, pp. 159 - 165
Abstract Purpose Aurora kinase A (AURKA) overexpression is associated with poor prognosis in neuroblastoma and has been described to upregulate VEGF in gastric... 
Pediatrics | Surgery | N-Myc | Angiogenesis | Neuroblastoma | AURKA | SURGERY | INHIBITOR MLN8237 | GROWTH | VEGF EXPRESSION | PEDIATRICS | HYBRIDIZATION | CANCER | LINES | Human Umbilical Vein Endothelial Cells | Vascular Endothelial Growth Factor A - biosynthesis | Humans | Neoplasm Proteins - physiology | Neuroblastoma - enzymology | Neoplasm Proteins - antagonists & inhibitors | Protein Transport - drug effects | Vascular Endothelial Growth Factor A - metabolism | Aurora Kinase A - antagonists & inhibitors | Molecular Targeted Therapy | Vascular Endothelial Growth Factor A - genetics | Neovascularization, Pathologic - etiology | Neovascularization, Pathologic - enzymology | Proto-Oncogene Proteins c-myc - physiology | Aurora Kinase A - physiology | Antineoplastic Agents - pharmacology | Gene Expression Regulation, Neoplastic - drug effects | Neuroblastoma - pathology | Tumor Stem Cell Assay | RNA, Small Interfering - pharmacology | Pyrimidines - pharmacology | Cell Adhesion - drug effects | Cell Division - drug effects | Azepines - pharmacology | RNA, Neoplasm - biosynthesis | Neuroblastoma - blood supply | Neovascularization, Pathologic - drug therapy | Neuroblastoma - drug therapy | Cell Line, Tumor | Protein Kinase Inhibitors - pharmacology | In Vitro Techniques | Vascular endothelial growth factor
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10. Full Text Phosphatases: providing safe passage through mitotic exit
by Gerlich, Daniel W and Wurzenberger, Claudia
Nature Reviews Molecular Cell Biology, ISSN 1471-0072, 08/2011, Volume 12, Issue 8, pp. 469 - 482
The mitosis-to-interphase transition involves dramatic cellular reorganization from a state that supports chromosome segregation to a state that complies with... 
PROTEIN PHOSPHATASE | XENOPUS EGG EXTRACTS | AURORA-B KINASE | ANAPHASE-PROMOTING COMPLEX/CYCLOSOME | BUDDING YEAST | HUMAN CDC14A PHOSPHATASE | CHROMOSOMAL PASSENGER COMPLEX | CELL-CYCLE PROGRESSION | SACCHAROMYCES-CEREVISIAE | SPINDLE-ASSEMBLY CHECKPOINT | CELL BIOLOGY | Protein Phosphatase 1 - physiology | Anaphase-Promoting Complex-Cyclosome | Protein Phosphatase 2 - physiology | Saccharomyces cerevisiae - physiology | Interphase - physiology | Protein-Serine-Threonine Kinases - physiology | Ubiquitin-Protein Ligase Complexes - physiology | Humans | Aurora Kinases | Phosphoric Monoester Hydrolases - physiology | Saccharomyces cerevisiae - cytology | Neoplasms - therapy | Animals | Mitosis - physiology | Models, Biological | Proto-Oncogene Proteins - physiology | Cell Cycle - physiology | Cyclin B1 - physiology | Saccharomyces cerevisiae Proteins - physiology | Neoplasms - pathology | Cell Cycle Proteins - physiology | CDC2 Protein Kinase - physiology | Protein Tyrosine Phosphatases - physiology | Spindle (Cell division) | Phosphorylation | Phosphatases | Mitosis | Cellular control mechanisms | Genetic aspects | Research | Properties | Protein kinases
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