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PLoS ONE, ISSN 1932-6203, 01/2017, Volume 12, Issue 1, pp. e0169648 - e0169648
The structural maintenance of chromosome 5/6 complex (Smc5/6) is a restriction factor that represses hepatitis B virus (HBV) transcription. HBV counters this... 
CELLS | NUCLEAR-BODIES | HEPATITIS-B-VIRUS | REPLICATION | DNA | MULTIDISCIPLINARY SCIENCES | GENE-EXPRESSION | EPIGENETIC REGULATION | COMPONENTS | BINDING | HUMANIZED MICE | Autoantigens - metabolism | Hepatitis B - metabolism | Antigens, Nuclear - metabolism | Humans | Hepatitis B - virology | Male | Hepatocytes - metabolism | Autoantigens - genetics | Hepatitis B - immunology | Hepatocytes - cytology | Trans-Activators - genetics | Cell Cycle Proteins - genetics | Promyelocytic Leukemia Protein - metabolism | Nuclear Proteins - genetics | Cytokines - genetics | Hepatitis B virus - immunology | Promyelocytic Leukemia Protein - genetics | Cytokines - metabolism | Cell Cycle Proteins - metabolism | Cells, Cultured | Chromosomal Proteins, Non-Histone | Nuclear Proteins - metabolism | Mice, SCID | Immunity, Innate - immunology | Animals | Antigens, Nuclear - genetics | Virus Replication | Trans-Activators - metabolism | Mice | Immune response | Analysis | Genetic aspects | Hepatitis B virus | Research | Genetic transcription | Hepatitis B | Cell culture | HBX protein | Pathogenesis | Viruses | Infections | Genomes | Degradation | Proteins | Hepatitis | Hepatology | Localization | Bioinformatics | Chromosomes | Deoxyribonucleic acid--DNA | Antigens | Cytokines | Chromosome 5 | Gene expression | Ribonucleic acid--RNA | Immune systems | Hepatocytes | Interferon | Kinetics | X protein | Index Medicus | RNA | Deoxyribonucleic acid | Ribonucleic acid
Journal Article
Journal Article
Science, ISSN 0036-8075, 05/2018, Volume 360, Issue 6388, pp. 558 - 563
Journal Article
Molecular Cell, ISSN 1097-2765, 08/2017, Volume 67, Issue 3, pp. 387 - 399.e5
The DNA-mediated innate immune response underpins anti-microbial defenses and certain autoimmune diseases. Here we used immunoprecipitation, mass spectrometry,... 
HEXIM1 | DNA-PK | innate immune response | herpesvirus | paraspeckles | cGAS | NEAT1 | interferon stimulatory DNA | DEFENSE | PROTEIN | INHIBITION | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSCRIPTION | SENSOR | POLYMERASE-II | 7SK RNA | BINDING | GMP-AMP SYNTHASE | P-TEFB | CELL BIOLOGY | Human Umbilical Vein Endothelial Cells - metabolism | Humans | Octamer Transcription Factors - immunology | Intracellular Signaling Peptides and Proteins - metabolism | Herpesvirus 8, Human - immunology | RNA, Long Noncoding - immunology | PTB-Associated Splicing Factor - genetics | RNA Interference | Calcium-Binding Proteins - immunology | Octamer Transcription Factors - genetics | Nucleotidyltransferases - metabolism | Intracellular Signaling Peptides and Proteins - genetics | Signal Transduction | Membrane Proteins - genetics | RNA-Binding Proteins - immunology | PTB-Associated Splicing Factor - metabolism | Nuclear Matrix-Associated Proteins - metabolism | PTB-Associated Splicing Factor - immunology | DNA - metabolism | Host-Pathogen Interactions | Nuclear Matrix-Associated Proteins - genetics | HeLa Cells | RNA-Binding Proteins - metabolism | Calcium-Binding Proteins - genetics | RNA-Binding Proteins - genetics | Multiprotein Complexes | Human Umbilical Vein Endothelial Cells - immunology | Intracellular Signaling Peptides and Proteins - immunology | Human Umbilical Vein Endothelial Cells - virology | Interferon Regulatory Factor-3 - genetics | Ku Autoantigen - genetics | Transfection | HEK293 Cells | Membrane Proteins - metabolism | Nuclear Proteins - genetics | Octamer Transcription Factors - metabolism | Interferon Regulatory Factor-3 - immunology | Calcium-Binding Proteins - metabolism | DNA - immunology | Nuclear Matrix-Associated Proteins - immunology | Ku Autoantigen - immunology | Membrane Proteins - immunology | Nuclear Proteins - metabolism | Ku Autoantigen - metabolism | RNA, Long Noncoding - genetics | Immunity, Innate | Nuclear Proteins - immunology | DNA - genetics | Interferon Regulatory Factor-3 - metabolism | Nucleotidyltransferases - genetics | Protein Binding | Nucleotidyltransferases - immunology | RNA, Long Noncoding - metabolism | RNA sequencing | Immune response | RNA | DNA | Genetic research | Interferon | Biological response modifiers | Mass spectrometry | Index Medicus | Human Umbilical Vein Endothelial Cells | Nuclear Matrix-Associated Proteins | Herpesvirus 8, Human | RNA-Binding Proteins | Life Sciences | Interferon Regulatory Factor-3 | Genetics | Calcium-Binding Proteins | Intracellular Signaling Peptides and Proteins | PTB-Associated Splicing Factor | Nuclear Proteins | Membrane Proteins | Nucleotidyltransferases | Ku Autoantigen | Octamer Transcription Factors | RNA, Long Noncoding
Journal Article
Molecular Cell, ISSN 1097-2765, 12/2007, Volume 28, Issue 5, pp. 823 - 837
Tandem PHD and bromodomains are often found in chromatin-associated proteins and have been shown to cooperate in gene silencing. Each domain can bind... 
PROTEINS | DNA | LOCALIZATION | RECOGNITION | RING | BIOCHEMISTRY & MOLECULAR BIOLOGY | ZINC-FINGER PROTEINS | COMPLEXES | TRANSCRIPTIONAL REPRESSION | SUMO MODIFICATION | KAP-1 COREPRESSOR | BINDING | CONTRIBUTES | CELL BIOLOGY | Chromatin - metabolism | Autoantigens - metabolism | Mi-2 Nucleosome Remodeling and Deacetylase Complex | Saccharomyces cerevisiae - genetics | Humans | Protein Methyltransferases - genetics | RING Finger Domains | Tripartite Motif-Containing Protein 28 | Autoantigens - genetics | Bone Neoplasms - pathology | Protein Methyltransferases - metabolism | Repressor Proteins - antagonists & inhibitors | Bone Neoplasms - metabolism | DNA-Binding Proteins - metabolism | Saccharomyces cerevisiae - metabolism | Kidney - metabolism | Transcription, Genetic | Bone Neoplasms - genetics | DNA Helicases - genetics | Osteosarcoma - metabolism | Repressor Proteins - metabolism | DNA-Binding Proteins - antagonists & inhibitors | Histone Deacetylases - genetics | Small Ubiquitin-Related Modifier Proteins - metabolism | Cells, Cultured | Gene Expression Regulation | Gene Silencing | Ubiquitin-Protein Ligases - metabolism | Adenosine Triphosphatases - metabolism | Repressor Proteins - genetics | Histone Deacetylases - metabolism | Ubiquitin-Conjugating Enzymes - genetics | DNA-Binding Proteins - genetics | DNA Helicases - metabolism | Two-Hybrid System Techniques | Ubiquitin-Conjugating Enzymes - metabolism | Adenosine Triphosphatases - genetics | Protein Processing, Post-Translational | Osteosarcoma - genetics | Lysine - chemistry | Ubiquitin-Protein Ligases - genetics | Osteosarcoma - pathology | Saccharomyces cerevisiae - growth & development | Index Medicus
Journal Article
Molecular Biology of the Cell, ISSN 1059-1524, 10/2009, Volume 20, Issue 19, pp. 4194 - 4204
Journal Article
Journal Article
Nature Medicine, ISSN 1078-8956, 04/2012, Volume 18, Issue 4, pp. 529 - 537
New cancer therapies are likely to arise from an in-depth understanding of the signaling networks influencing tumor initiation, progression and metastasis. We... 
MEDICINE, RESEARCH & EXPERIMENTAL | PROTEIN | METASTASIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | NOONAN-SYNDROME | CELL BIOLOGY | GENE | STEM-CELL | MYELOID-LEUKEMIA | DIFFERENTIATION | MUTATIONS | IN-VITRO PROPAGATION | DUCTAL CARCINOMA | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - metabolism | Autoantigens - metabolism | Cell Proliferation | Oligonucleotide Array Sequence Analysis | Homeodomain Proteins - metabolism | Humans | Caspase 3 - metabolism | Receptor, ErbB-2 - metabolism | Ki-67 Antigen - metabolism | Gene Expression Profiling | Flow Cytometry | Time Factors | Platelet Endothelial Cell Adhesion Molecule-1 - metabolism | Female | Membrane Proteins - metabolism | Gene Expression Regulation, Neoplastic - drug effects | Tumor Cells, Cultured | Gene Expression Regulation, Neoplastic - physiology | Computational Biology | Transcription Factors - genetics | Mice, SCID | src Homology Domains - physiology | Cell Adhesion Molecules - metabolism | Proto-Oncogene Proteins c-myc - metabolism | Disease Progression | Homeodomain Proteins - genetics | Transcription Factors - metabolism | Animals | Breast Neoplasms - pathology | Cell Polarity - physiology | Doxycycline - pharmacology | Luminescent Proteins - genetics | Signal Transduction - physiology | Mice | Proto-Oncogene Proteins c-myc - genetics | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - genetics | Cell Transformation, Neoplastic - pathology | Luminescent Proteins - metabolism | Mitogen-Activated Protein Kinases - metabolism | RNA, Small Interfering - metabolism | Zinc Finger E-box-Binding Homeobox 1 | Transcription factors | Care and treatment | Phosphatases | Physiological aspects | Development and progression | Genetic aspects | Breast cancer | Research | Proteins | Signal transduction | Cellular biology | Gene expression | Index Medicus
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 08/2012, Volume 32, Issue 32, pp. 11095 - 11108
Journal Article
Oncogene, ISSN 0950-9232, 02/2015, Volume 34, Issue 7, pp. 826 - 837
Nucleolin (NCL) participates in DNA transcription, ribosomal biogenesis and the regulation of RNA stability. However, the contribution of NCL to tumor... 
TARGET | APOPTOSIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL BIOLOGY | LUNG-CANCER | IN-VITRO | ONCOLOGY | GASTRIC-CARCINOMA | PROSTATE-CANCER CELLS | GENETICS & HEREDITY | PROTEINS | BINDING | PROGRESSION | MATRILYSIN MMP-7 | Kruppel-Like Factor 6 | Proto-Oncogene Proteins c-cbl - metabolism | Humans | Lung Neoplasms - metabolism | Male | RNA, Messenger - metabolism | Autoantigens - genetics | RNA, Neoplasm - metabolism | Neoplasm Metastasis | Matrix Metalloproteinase 7 - metabolism | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Matrix Metalloproteinase 9 - genetics | Proteolysis | Hypoxia-Inducible Factor 1, alpha Subunit - genetics | Cell Cycle Proteins - metabolism | Receptor Protein-Tyrosine Kinases - metabolism | RNA Stability - genetics | Mice, Nude | RNA, Neoplasm - genetics | Mice | Kruppel-Like Transcription Factors - genetics | RNA-Binding Proteins - metabolism | RNA-Binding Proteins - genetics | Autoantigens - metabolism | Gene Expression Regulation, Neoplastic | Lung Neoplasms - pathology | Phosphoproteins - metabolism | Kruppel-Like Transcription Factors - metabolism | Cell Cycle Proteins - genetics | Female | Nuclear Proteins - genetics | Lung Neoplasms - genetics | Proto-Oncogene Proteins - metabolism | Proto-Oncogene Proteins c-cbl - genetics | Matrix Metalloproteinase 9 - biosynthesis | RNA, Messenger - genetics | Nuclear Proteins - metabolism | Proto-Oncogene Proteins - genetics | Phosphoproteins - genetics | Transcription Factors - genetics | Gene Expression Regulation, Enzymologic | Proteins - genetics | Transcription Factors - metabolism | Matrix Metalloproteinase 7 - genetics | Animals | Proteins - metabolism | Receptor Protein-Tyrosine Kinases - genetics | Adaptor Proteins, Signal Transducing - genetics | Aged | Adaptor Proteins, Signal Transducing - metabolism | RNA | Phosphoproteins | Physiological aspects | Development and progression | Genetic aspects | Health aspects | Metalloproteins | Tumors | Signal transduction | Protein expression | Tumorigenesis | Lung cancer | Index Medicus
Journal Article
Molecular Biology of the Cell, ISSN 1059-1524, 10/2009, Volume 20, Issue 19, pp. 4194 - 4204
We previously used a human artificial chromosome ( HAC) with a synthetic kinetochore that could be targeted with chromatin modifiers fused to tetracycline... 
KAP-1 | DNA-BINDING | COMPLEX | DOMAIN |