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Journal of Immunology, ISSN 0022-1767, 09/2015, Volume 195, Issue 5, pp. 1939 - 1943
Detection of intracellular DNA triggers activation of the stimulator of IFN genes dependent IFN-stimulatory DNA (ISD) pathway, which is essential for antiviral... 
CYCLIC GMP-AMP | INTRACELLULAR DNA | LUPUS | DENDRITIC CELLS | GENE | DNA EXONUCLEASE TREX1 | CYTOSOLIC DNA | INNATE IMMUNE SENSOR | MUTATIONS | IMMUNOLOGY | RETROVIRUSES | Nucleotides, Cyclic - metabolism | Phosphoproteins - immunology | Exodeoxyribonucleases - immunology | Interferon-beta - immunology | Nervous System Malformations - immunology | Gene Expression - drug effects | Autoantibodies - blood | Humans | Immunoblotting | Interferons - immunology | Phosphoproteins - metabolism | Inflammation - metabolism | Nervous System Malformations - metabolism | Autoimmune Diseases of the Nervous System - genetics | Gene Expression - immunology | Interferon-beta - genetics | Exodeoxyribonucleases - genetics | Nucleotidyltransferases - metabolism | Autoimmune Diseases of the Nervous System - metabolism | Nervous System Malformations - genetics | Macrophages - immunology | Disease Models, Animal | Fibroblasts - metabolism | Interferons - pharmacology | Mice, Inbred C57BL | Cells, Cultured | Inflammation - immunology | Phosphoproteins - genetics | Reverse Transcriptase Polymerase Chain Reaction | Mice, Knockout | Autoimmune Diseases of the Nervous System - immunology | Autoantibodies - immunology | Macrophages - metabolism | Animals | Interferon-beta - metabolism | Embryo, Mammalian - cytology | Fibroblasts - drug effects | Exodeoxyribonucleases - metabolism | Inflammation - genetics | Nucleotidyltransferases - genetics | Fibroblasts - immunology | Macrophages - drug effects | Nucleotidyltransferases - immunology | Nucleotides, Cyclic - immunology | Index Medicus | Abridged Index Medicus
Journal Article
LANCET NEUROLOGY, ISSN 1474-4422, 01/2010, Volume 9, Issue 1, pp. 67 - 76
Background Some encephalitides or seizure disorders once thought idiopathic now seem to be immune mediated. We aimed to describe the clinical features of one... 
RESPONSES | BACLOFEN | TISSUE | GLOBUS-PALLIDUS | TRAFFICKING | MICE | CHANNELS | EPILEPSY | SYNAPTIC PLASTICITY | NMDAR ENCEPHALITIS | CLINICAL NEUROLOGY | Neurons - pathology | Rats, Wistar | Autoantibodies - blood | Humans | Middle Aged | Paraneoplastic Syndromes, Nervous System - immunology | Male | Seizures - metabolism | Autoimmune Diseases of the Nervous System - pathology | Lung Neoplasms | Brain - metabolism | Limbic Encephalitis - pathology | Paraneoplastic Syndromes, Nervous System - therapy | Limbic Encephalitis - therapy | Seizures - pathology | Receptors, GABA-B - immunology | Immunoglobulin G - immunology | Paraneoplastic Syndromes, Nervous System - pathology | Antigens, Surface - metabolism | Adult | Autoantibodies - analysis | Female | Immunoglobulin G - analysis | Neurons - metabolism | Autoimmune Diseases of the Nervous System - metabolism | Limbic Encephalitis - immunology | Cell Line | Receptors, GABA-B - genetics | Cells, Cultured | Neurons - immunology | Rats | Seizures - therapy | Autoimmune Diseases of the Nervous System - immunology | Autoantibodies - cerebrospinal fluid | Limbic Encephalitis - metabolism | Animals | Seizures - immunology | Brain - pathology | Aged | Autoimmune Diseases of the Nervous System - therapy | Antigens, Surface - immunology | Brain - immunology | Receptors, GABA-B - metabolism | Index Medicus | MEDICIN OCH HÄLSOVETENSKAP | MEDICAL AND HEALTH SCIENCES
Journal Article
The EMBO Journal, ISSN 0261-4189, 04/2016, Volume 35, Issue 8, pp. 831 - 844
Journal Article
Journal Article
PLoS Pathogens, ISSN 1553-7366, 12/2011, Volume 7, Issue 12, pp. e1002425 - e1002425
Myeloid blood cells are largely resistant to infection with human immunodeficiency virus type 1 (HIV-1). Recently, it was reported that Vpx from HIV-2/SIVsm... 
DOMAIN | HUMAN DENDRITIC CELLS | INNATE IMMUNE-RESPONSE | MONOCYTES | MICROBIOLOGY | RESTRICTION | SAMHD1 | REPLICATION | VIROLOGY | IMMUNODEFICIENCY-VIRUS TYPE-1 | EXPRESSION | PARASITOLOGY | VPX | Immunoprecipitation | Humans | SAM Domain and HD Domain-Containing Protein 1 | Immunoblotting | Mutation, Missense | Lipopolysaccharide Receptors - metabolism | Tandem Mass Spectrometry | Flow Cytometry | Transfection | Nervous System Malformations - metabolism | Autoimmune Diseases of the Nervous System - virology | Autoimmune Diseases of the Nervous System - genetics | Autoimmune Diseases of the Nervous System - metabolism | Nervous System Malformations - genetics | HIV-1 - metabolism | Genetic Predisposition to Disease - genetics | Enzyme-Linked Immunosorbent Assay | Cell Separation | HIV Infections - genetics | Myeloid Cells - virology | Monomeric GTP-Binding Proteins - genetics | Reverse Transcriptase Polymerase Chain Reaction | Monomeric GTP-Binding Proteins - deficiency | Nervous System Malformations - virology | Microscopy, Confocal | Myeloid Cells - metabolism | Prevention | Aicardi syndrome | Disease susceptibility | Genetic aspects | Research | T cells | Health aspects | HIV infection | Risk factors | Proteins | Peptides | Microscopy | Genes | Interferon | Mutation | Autoimmune diseases | Mass spectrometry | Patients | Viral infections | Index Medicus
Journal Article
Nature Immunology, ISSN 1529-2908, 01/2019, Volume 20, Issue 1, pp. 18 - 28
Cyclic GMP-AMP synthase (cGAS) is a key sensor responsible for cytosolic DNA detection. Here we report that GTPase-activating protein SH3 domain-binding... 
SYNTHASE | 2ND-MESSENGER | CYCLIC GMP-AMP | IFI16 | GROWTH | INNATE IMMUNE SENSOR | IMMUNOLOGY | Neuroprotective Agents - therapeutic use | RNA Helicases - metabolism | Autoantigens - metabolism | Poly-ADP-Ribose Binding Proteins - metabolism | Cytosol - immunology | Humans | Poly-ADP-Ribose Binding Proteins - antagonists & inhibitors | Multiprotein Complexes - metabolism | Nervous System Malformations - metabolism | Autoimmune Diseases of the Nervous System - genetics | Clustered Regularly Interspaced Short Palindromic Repeats | HEK293 Cells | Catechin - therapeutic use | RNA Helicases - genetics | RNA Recognition Motif Proteins - antagonists & inhibitors | Exodeoxyribonucleases - genetics | Nucleotidyltransferases - metabolism | Autoimmune Diseases of the Nervous System - metabolism | Nervous System Malformations - genetics | RNA Recognition Motif Proteins - metabolism | DNA Helicases - genetics | Disease Models, Animal | DNA - immunology | Poly-ADP-Ribose Binding Proteins - genetics | DNA - metabolism | Phosphoproteins - genetics | Autoimmune Diseases of the Nervous System - drug therapy | RNA Helicases - antagonists & inhibitors | Mice, Knockout | DNA Helicases - metabolism | Animals | Autoantigens - immunology | Interferons - metabolism | Nervous System Malformations - drug therapy | Protein Binding | Cytosol - metabolism | Catechin - analogs & derivatives | Mice | RNA Recognition Motif Proteins - genetics | DNA Helicases - antagonists & inhibitors | HeLa Cells | Promoters (Genetics) | Research | DNA-ligand interactions | Transferases | AMP | Therapeutic applications | Medical treatment | Epigallocatechin-3-gallate | Activation | Gene expression | Proteins | Epigallocatechin gallate | GTPase-activating protein | Cyclic GMP | Interferon | Inhibition | Autoimmune diseases | Deoxyribonucleic acid--DNA | Guanosinetriphosphatase | Index Medicus
Journal Article
The EMBO Journal, ISSN 0261-4189, 09/2013, Volume 32, Issue 18, pp. 2454 - 2462
Journal Article
Lancet Neurology, The, ISSN 1474-4422, 2013, Volume 12, Issue 12, pp. 1159 - 1169
Journal Article
Annals of the Rheumatic Diseases, ISSN 0003-4967, 01/2014, Volume 74, Issue 3, pp. e17 - e17
Journal Article