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autophagy (79) 79
science & technology (71) 71
life sciences & biomedicine (68) 68
animals (62) 62
cell biology (55) 55
humans (53) 53
autophagosome (39) 39
autophagosomes - metabolism (37) 37
proteins (28) 28
autophagy - drug effects (23) 23
mice (23) 23
lysosomes - metabolism (20) 20
phagocytosis (19) 19
biochemistry & molecular biology (17) 17
lysosome (17) 17
autophagosomes (16) 16
autophagy - genetics (16) 16
biology (16) 16
cancer (16) 16
autophagosomes - enzymology (15) 15
autophagosomes - drug effects (14) 14
signal transduction (14) 14
autophagy-related proteins - metabolism (13) 13
cell line, tumor (13) 13
male (13) 13
microtubule-associated proteins - metabolism (13) 13
autophagosomes - ultrastructure (12) 12
autophagy - physiology (12) 12
lysosomes - enzymology (12) 12
binding (11) 11
cell line (11) 11
phagosomes - metabolism (11) 11
rats (11) 11
apoptosis (10) 10
calcium (10) 10
kinases (10) 10
lysosomes (10) 10
phosphorylation (10) 10
protein binding (10) 10
signal transduction - drug effects (10) 10
transfection (10) 10
biochemistry (9) 9
bioscience (9) 9
cell (9) 9
cells, cultured (9) 9
cycle (9) 9
green fluorescent proteins - metabolism (9) 9
landes (9) 9
membrane proteins - metabolism (9) 9
organogenesis (9) 9
proteolysis (9) 9
time factors (9) 9
acid phosphatase - metabolism (8) 8
lc3 (8) 8
lysosomes - drug effects (8) 8
microscopy, fluorescence (8) 8
microtubule-associated proteins - genetics (8) 8
models, biological (8) 8
phagosomes (8) 8
phagosomes - ultrastructure (8) 8
physiology (8) 8
protein transport (8) 8
saccharomyces cerevisiae proteins - metabolism (8) 8
tor serine-threonine kinases - metabolism (8) 8
yeast (8) 8
amp-activated protein kinases - metabolism (7) 7
cell death (7) 7
enzymes (7) 7
hela cells (7) 7
lysosomes - ultrastructure (7) 7
oncology (7) 7
research article (7) 7
vacuole (7) 7
vacuoles - enzymology (7) 7
autolysosome (6) 6
autophagy-related protein-1 homolog - metabolism (6) 6
autophagy-related proteins (6) 6
autophagy-related proteins - genetics (6) 6
biodegradation (6) 6
cell nucleus - metabolism (6) 6
disease models, animal (6) 6
female (6) 6
gene expression (6) 6
health aspects (6) 6
hek293 cells (6) 6
medicine (6) 6
mice, inbred c57bl (6) 6
mice, knockout (6) 6
molecular biology (6) 6
mutation (6) 6
phagosomes - enzymology (6) 6
phosphatidylinositol phosphates - metabolism (6) 6
recombinant proteins - genetics (6) 6
research paper (6) 6
rna interference (6) 6
saccharomyces cerevisiae - enzymology (6) 6
vesicular transport proteins - metabolism (6) 6
vps34 (6) 6
adaptor proteins, signal transducing - metabolism (5) 5
ampk (5) 5
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1. Full Text Phosphatidylinositol‐3‐phosphate in the regulation of autophagy membrane dynamics
by Nascimbeni, Anna Chiara and Codogno, Patrice and Morel, Etienne
The FEBS journal, ISSN 1742-464X, 05/2017, Volume 284, Issue 9, pp. 1267 - 1278
endosome | PI3P | autophagosome | lysosome | membrane trafficking | Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Endoplasmic Reticulum - enzymology | Class II Phosphatidylinositol 3-Kinases - metabolism | Phosphatidylinositol Phosphates - metabolism | Endosomes - physiology | Membrane Microdomains - enzymology | Autophagosomes - physiology | Humans | Autophagosomes - enzymology | Endoplasmic Reticulum - physiology | Class III Phosphatidylinositol 3-Kinases - metabolism | Lysosomes - enzymology | Adaptor Proteins, Vesicular Transport - metabolism | Autophagy | Lysosomes - physiology | Organelle Biogenesis | Animals | Models, Biological | Endosomes - enzymology | Membrane Microdomains - physiology | Beclin-1 - metabolism | Autophagy-Related Proteins - metabolism | Second Messenger Systems | Phosphates | Phospholipids | Protein binding | Membranes | Phagosomes | Lipids | Biosynthesis | Kinases | Machinery | Proteins | Lipid kinase | Membrane trafficking | Endoplasmic reticulum | Phagocytosis | Index Medicus
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2. Full Text Rab2 promotes autophagic and endocytic lysosomal degradation
by Lörincz, Péter and Tóth, Sarolta and Benkö, Péter and Lakatos, Zsolt and Boda, Attila and Glatz, Gábor and Zobel, Martina and Bisi, Sara and Hegedüs, Krisztina and Takáts, Szabolcs and Scita, Giorgio and Juhász, Gábor
The Journal of cell biology, ISSN 0021-9525, 07/2017, Volume 216, Issue 7, pp. 1937 - 1947
Life Sciences & Biomedicine | Science & Technology | Cell Biology | Humans | Autophagosomes - enzymology | Lysosomes - enzymology | rab GTP-Binding Proteins - genetics | Drosophila Proteins - metabolism | Autophagy | Drosophila melanogaster - genetics | Breast Neoplasms - enzymology | Endocytosis | Transfection | RNA Interference | Proteolysis | Female | rab2 GTP-Binding Protein - metabolism | rab GTP-Binding Proteins - metabolism | Membrane Fusion | Signal Transduction | Animals, Genetically Modified | Animals | Breast Neoplasms - genetics | Breast Neoplasms - pathology | rab2 GTP-Binding Protein - genetics | Cell Line, Tumor | Drosophila melanogaster - enzymology | Endosomes - enzymology | Drosophila Proteins - genetics | Cellular proteins | Autophagy (Cytology) | Genetic aspects | Gene expression | Health aspects | Biodegradation | Cargo | Yeast | Maturation | Phagosomes | Lysosomes | Guanosine triphosphatases | Tethering | Breast cancer | Cells | Degradation | Guanosine triphosphate | Fruit flies | Binding sites | Endosomes | Index Medicus
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3. Full Text Trehalose induces autophagy via lysosomal-mediated TFEB activation in models of motoneuron degeneration
by Rusmini, Paola and Cortese, Katia and Crippa, Valeria and Cristofani, Riccardo and Cicardi, Maria Elena and Ferrari, Veronica and Vezzoli, Giulia and Tedesco, Barbara and Meroni, Marco and Messi, Elio and Piccolella, Margherita and Galbiati, Mariarita and Garrè, Massimiliano and Morelli, Elena and Vaccari, Thomas and Poletti, Angelo
Autophagy, ISSN 1554-8627, 04/2019, Volume 15, Issue 4, pp. 631 - 651
autophagy | neurodegeneration | spinal and bulbar muscular atrophy | TFEB | Amyotrophic lateral sclerosis | motoneuron diseases | trehalose | lactulose | calcineurin | protein quality control | lysosomes | melibiose | galectin-3 | Life Sciences & Biomedicine | Science & Technology | Cell Biology | RNA, Small Interfering - genetics | Calcium - metabolism | Microtubule-Associated Proteins - metabolism | Humans | Autophagosomes - enzymology | Lysosomes - enzymology | Amyotrophic Lateral Sclerosis - drug therapy | Autophagy - drug effects | Motor Neurons - pathology | Motor Neurons - ultrastructure | Neuroprotection - drug effects | Autophagosomes - drug effects | Calcineurin - genetics | Cell Nucleus - metabolism | Lysosomes - metabolism | Trehalose - analogs & derivatives | Cell Differentiation | Membrane Proteins - metabolism | Autophagy - genetics | Autophagy-Related Proteins - genetics | Sequestosome-1 Protein - metabolism | Induced Pluripotent Stem Cells - metabolism | Induced Pluripotent Stem Cells - pathology | Lysosomes - drug effects | Induced Pluripotent Stem Cells - enzymology | Unfolded Protein Response - genetics | Membrane Proteins - genetics | Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - chemistry | Induced Pluripotent Stem Cells - ultrastructure | Signal Transduction - genetics | Autophagosomes - metabolism | Bulbo-Spinal Atrophy, X-Linked - metabolism | Motor Neurons - enzymology | Neuroprotection - genetics | Bulbo-Spinal Atrophy, X-Linked - drug therapy | Down-Regulation - genetics | Lysosomes - ultrastructure | Motor Neurons - metabolism | Animals | Signal Transduction - drug effects | Amyotrophic Lateral Sclerosis - metabolism | Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - genetics | Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - metabolism | Mice | Autophagy-Related Proteins - metabolism | Calcineurin - metabolism | RNA, Small Interfering - metabolism | Trehalose - pharmacology | Index Medicus
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4. Full Text The ER-Localized Transmembrane Protein EPG-3/VMP1 Regulates SERCA Activity to Control ER-Isolation Membrane Contacts for Autophagosome Formation
by Zhao, Yan G and Chen, Yong and Miao, Guangyan and Zhao, Hongyu and Qu, Wenyan and Li, Dongfang and Wang, Zheng and Liu, Nan and Li, Lin and Chen, She and Liu, Pingsheng and Feng, Du and Zhang, Hong
Molecular cell, ISSN 1097-2765, 09/2017, Volume 67, Issue 6, pp. 974 - 989.e6
VMP1 | membrane contact | SERCA | autophagosome | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Intracellular Membranes - enzymology | Phosphatidylinositol Phosphates - metabolism | Humans | Proteolipids - metabolism | Autophagosomes - enzymology | Caenorhabditis elegans Proteins - metabolism | Cercopithecus aethiops | Autophagy-Related Protein-1 Homolog - metabolism | Intracellular Signaling Peptides and Proteins - metabolism | Transfection | RNA Interference | HEK293 Cells | Muscle Proteins - metabolism | Membrane Proteins - metabolism | Lipid Droplets - metabolism | Intracellular Signaling Peptides and Proteins - genetics | Calcium-Binding Proteins - metabolism | Endoplasmic Reticulum - enzymology | Sarcoplasmic Reticulum Calcium-Transporting ATPases - metabolism | Animals, Genetically Modified | Caenorhabditis elegans - genetics | Membrane Proteins - genetics | Genotype | Phenotype | Animals | CRISPR-Cas Systems | HeLa Cells | Sarcoplasmic Reticulum Calcium-Transporting ATPases - genetics | Autophagy-Related Protein-1 Homolog - genetics | COS Cells | Caenorhabditis elegans Proteins - genetics | Caenorhabditis elegans - enzymology | Calcium-binding proteins | Cells | Adenosine triphosphatase | Index Medicus
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5. Full Text Phosphoglycerate Kinase 1 Phosphorylates Beclin1 to Induce Autophagy
by Qian, Xu and Li, Xinjian and Cai, Qingsong and Zhang, Chuanbao and Yu, Qiujing and Jiang, Yuhui and Lee, Jong-Ho and Hawke, David and Wang, Yugang and Xia, Yan and Zheng, Yanhua and Jiang, Bing-Hua and Liu, David X and Jiang, Tao and Lu, Zhimin
Molecular cell, ISSN 1097-2765, 03/2017, Volume 65, Issue 5, pp. 917 - 931.e6
ARD1 | autophagy | tumor | PGK1 | mTOR | Beclin1 | VPS34 | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Glioblastoma - enzymology | Glutamine - deficiency | Phosphorylation | Cell Proliferation | TOR Serine-Threonine Kinases - metabolism | Humans | Autophagosomes - enzymology | Brain Neoplasms - pathology | Autophagy | Tumor Hypoxia | TOR Serine-Threonine Kinases - genetics | Transfection | Glioblastoma - genetics | RNA Interference | Time Factors | HEK293 Cells | Female | Acetylation | Phosphoglycerate Kinase - genetics | Brain Neoplasms - enzymology | Signal Transduction | N-Terminal Acetyltransferase A - genetics | Brain Neoplasms - genetics | Class III Phosphatidylinositol 3-Kinases - metabolism | Tumor Burden | Autophagosomes - pathology | Animals | N-Terminal Acetyltransferase A - metabolism | Class III Phosphatidylinositol 3-Kinases - genetics | Mice, Nude | Glioblastoma - pathology | Beclin-1 - genetics | Cell Line, Tumor | N-Terminal Acetyltransferase E - genetics | Protein Binding | Beclin-1 - metabolism | N-Terminal Acetyltransferase E - metabolism | Phosphoglycerate Kinase - metabolism | Enzymes | Medical colleges | Gliomas | Pancreatic cancer | Brain tumors | Physiological aspects | Phospholipids | Protein kinases | Glutamine | Index Medicus
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6. Full Text Pacer Mediates the Function of Class III PI3K and HOPS Complexes in Autophagosome Maturation by Engaging Stx17
by Cheng, Xiawei and Ma, Xiuling and Ding, Xianming and Li, Lin and Jiang, Xiao and Shen, Zhirong and Chen, She and Liu, Wei and Gong, Weihua and Sun, Qiming
Molecular cell, ISSN 1097-2765, 03/2017, Volume 65, Issue 6, pp. 1029 - 1043.e5
Stx-17 | UVRAG | PI3KC3 | Rubicon | Vps34 | Beclin1 | Pacer | HOPS | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Protein Aggregates | Salmonella typhimurium - growth & development | Vesicular Transport Proteins - metabolism | Humans | Autophagosomes - enzymology | Lysosomes - enzymology | Intracellular Signaling Peptides and Proteins - metabolism | Autophagy | Transfection | RNA Interference | Time Factors | Tumor Suppressor Proteins - genetics | HEK293 Cells | Qa-SNARE Proteins - genetics | Protein Interaction Domains and Motifs | Lipid Droplets - metabolism | Autophagy-Related Proteins - genetics | Intracellular Signaling Peptides and Proteins - genetics | Tumor Suppressor Proteins - metabolism | Membrane Fusion | Signal Transduction | Vesicular Transport Proteins - genetics | Class III Phosphatidylinositol 3-Kinases - metabolism | Hep G2 Cells | Host-Pathogen Interactions | Qa-SNARE Proteins - metabolism | Protein Binding | Endosomes - enzymology | Enzyme Activation | HeLa Cells | Autophagy-Related Proteins - metabolism | Hepatocytes - enzymology | Molecular biology | Medical colleges | Health aspects | Index Medicus
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7. Full Text Copper is an essential regulator of the autophagic kinases ULK1/2 to drive lung adenocarcinoma
by Tsang, Tiffany and Posimo, Jessica M and Gudiel, Andrea A and Cicchini, Michelle and Feldser, David M and Brady, Donita C
Nature cell biology, ISSN 1465-7392, 04/2020, Volume 22, Issue 4, pp. 412 - 424
Life Sciences & Biomedicine | Science & Technology | Cell Biology | Fibroblasts - enzymology | Cell Proliferation | Adenocarcinoma of Lung - pathology | Proto-Oncogene Proteins p21(ras) - genetics | Humans | Autophagosomes - enzymology | Gene Expression Regulation, Neoplastic | Lung Neoplasms - pathology | Autophagy-Related Protein 5 - genetics | Autophagy-Related Protein-1 Homolog - metabolism | Intracellular Signaling Peptides and Proteins - metabolism | Adenocarcinoma of Lung - genetics | Proto-Oncogene Proteins p21(ras) - deficiency | Copper - metabolism | Autophagy - genetics | Intracellular Signaling Peptides and Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | Lung Neoplasms - genetics | Amino Acid Sequence | Lung Neoplasms - enzymology | Signal Transduction | Cell Survival | Protein-Serine-Threonine Kinases - genetics | Copper Transporter 1 - genetics | Adenocarcinoma of Lung - enzymology | Fibroblasts - pathology | Mice, Knockout | Sequence Homology, Amino Acid | Xenograft Model Antitumor Assays | Sequence Alignment | Animals | Autophagy-Related Protein 5 - deficiency | Cell Line, Tumor | Copper Transporter 1 - deficiency | Mice | Autophagy-Related Protein-1 Homolog - genetics | Adenocarcinoma | Autophagy (Cytology) | Enzymes | Lung cancer | Oncology, Experimental | Development and progression | Research | Physiological aspects | Regulation | Copper | Health aspects | Protein kinases | Cancer | Binding | Transition metals | Starvation | Intracellular signalling | Kinases | Autophagy | Survival | Signaling | Lungs | Chelation | Mutation | Transporter | Phagocytosis | Tumors | Index Medicus
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8. Full Text Visualization of Atg3 during autophagosome formation in Saccharomyces cerevisiae
by Ngu, Meipin and Hirata, Eri and Suzuki, Kuninori
The Journal of biological chemistry, ISSN 0021-9258, 03/2015, Volume 290, Issue 13, pp. 8146 - 8153
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Green Fluorescent Proteins - metabolism | Vacuoles - enzymology | Autophagy-Related Proteins | Intracellular Membranes - enzymology | Phagosomes - enzymology | Autophagy | Recombinant Fusion Proteins - metabolism | Protein Transport | Phosphatidylethanolamines | Ubiquitin-Conjugating Enzymes - metabolism | Saccharomyces cerevisiae Proteins - metabolism | Saccharomyces cerevisiae - enzymology | Microscopy, Fluorescence | Index Medicus | Biodegradation | Atg3 | Atg8 Lipidation | Yeast | Organelle | Isolation Membrane | Autophagosome | Saccharomyces cerevisiae | Cell Biology
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9. Full Text A STRIPAK complex mediates axonal transport of autophagosomes and dense core vesicles through PP2A regulation
by Neisch, Amanda L and Neufeld, Thomas P and Hays, Thomas S
The Journal of cell biology, ISSN 0021-9525, 02/2017, Volume 216, Issue 2, pp. 441 - 461
Axonal Transport | Axons - enzymology | Autophagosomes - enzymology | Multiprotein Complexes - genetics | Drosophila Proteins - metabolism | Drosophila melanogaster - genetics | Recombinant Fusion Proteins - metabolism | Multiprotein Complexes - metabolism | Transfection | RNA Interference | Protein Interaction Domains and Motifs | Secretory Vesicles - enzymology | Dyneins - metabolism | Cell Line | Signal Transduction | Animals, Genetically Modified | Protein Phosphatase 2 - genetics | Genotype | Nerve Tissue Proteins - genetics | Nerve Tissue Proteins - metabolism | Phenotype | Animals | Adaptor Proteins, Signal Transducing - genetics | Protein Phosphatase 2 - metabolism | Drosophila melanogaster - enzymology | Presynaptic Terminals - metabolism | Protein Binding | Recombinant Fusion Proteins - genetics | Drosophila Proteins - genetics | Dyneins - genetics | Mutation | Adaptor Proteins, Signal Transducing - metabolism | Microscopy, Fluorescence | Proteins | Homeostasis | Cellular biology | Neurodegeneration | Neurons | Autophagy | Index Medicus
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