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Molecular Cell, ISSN 1097-2765, 05/2016, Volume 62, Issue 4, pp. 491 - 506
ULK1 and ULK2 are thought to be essential for initiating autophagy, and -deficient mice die perinatally of autophagy-related defects. Therefore, we used a... 
SEROTONIN TRANSPORTER | BIOGENESIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | EXIT SITES | EXPORT | NEURONS | AUTOPHAGOSOME FORMATION | ULK1 | COMPONENT | HOMOLOG | PROTEINS | CELL BIOLOGY | Golgi Apparatus - enzymology | Protein-Serine-Threonine Kinases - deficiency | Fibroblasts - enzymology | Phosphorylation | Vesicular Transport Proteins - metabolism | Autophagy-Related Protein 7 - metabolism | Humans | Brain - enzymology | Caenorhabditis elegans Proteins - metabolism | Homeostasis | Male | Autophagy-Related Protein-1 Homolog - metabolism | Golgi Apparatus - pathology | Mice, 129 Strain | Autophagy | Endoplasmic Reticulum - pathology | Transfection | RNA Interference | Time Factors | HEK293 Cells | Female | Nuclear Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | Endoplasmic Reticulum - enzymology | Caenorhabditis elegans - genetics | Mice, Inbred C57BL | Vesicular Transport Proteins - genetics | Protein-Serine-Threonine Kinases - genetics | Genotype | Nuclear Proteins - metabolism | Unfolded Protein Response | Autophagy-Related Protein 7 - genetics | Mice, Knockout | Protein Transport | Carrier Proteins - genetics | Phenotype | Animals | Autophagy-Related Protein-1 Homolog - deficiency | COP-Coated Vesicles - enzymology | Carrier Proteins - metabolism | Brain - pathology | Nerve Degeneration | Autophagy-Related Protein-1 Homolog - genetics | Caenorhabditis elegans - enzymology | Proteins | Neurons | Phosphoproteins | Cells
Journal Article
The FEBS Journal, ISSN 1742-464X, 05/2017, Volume 284, Issue 9, pp. 1267 - 1278
Journal Article
Journal Article
Circulation: Heart Failure, ISSN 1941-3289, 12/2017, Volume 10, Issue 12
BACKGROUND: Sustained inflammation in the heart is sufficient to provoke left ventricular dysfunction and left ventricular remodeling. Although inflammation... 
autophagy | tumor necrosis factor | inflammation | myocarditis | ubiquitin | APOPTOSIS | ISCHEMIA/REPERFUSION INJURY | CARDIAC & CARDIOVASCULAR SYSTEMS | UBIQUITIN-PROTEASOME SYSTEM | CELL-DEATH | CARDIOMYOCYTE DEATH | DISEASE | DYSFUNCTION | HUMAN HEART | TRANSGENIC MICE | Protein Aggregates | Tumor Necrosis Factor-alpha - metabolism | Up-Regulation | Cardiomyopathy, Dilated - pathology | Ventricular Function, Left | Cardiomyopathy, Dilated - enzymology | Heart Failure - enzymology | Humans | Tumor Necrosis Factor-alpha - genetics | Autophagosomes - enzymology | Myosin Heavy Chains - genetics | Autophagy | Myocytes, Cardiac - enzymology | Ubiquitination | Ventricular Remodeling | Time Factors | Ventricular Dysfunction, Left - genetics | Heart Ventricles - enzymology | Inflammation Mediators - metabolism | Ventricular Dysfunction, Left - pathology | Ventricular Dysfunction, Left - enzymology | Heart Ventricles - pathology | Disease Models, Animal | Cardiomyopathy, Dilated - genetics | Promoter Regions, Genetic | Genetic Predisposition to Disease | Mice, Transgenic | Heart Failure - pathology | Mechanistic Target of Rapamycin Complex 1 - metabolism | Protein Aggregation, Pathological | Ventricular Dysfunction, Left - physiopathology | Autophagosomes - pathology | Myocytes, Cardiac - pathology | Phenotype | Animals | Cardiomyopathy, Dilated - physiopathology | Heart Ventricles - physiopathology | Proteasome Endopeptidase Complex - metabolism | proteasome | Inflammatory Heart Disease | Heart Failure | Myocardial Biology | Basic Science Research
Journal Article
Molecular Cell, ISSN 1097-2765, 09/2017, Volume 67, Issue 6, pp. 974 - 989.e6
Journal Article
Molecular Cell, ISSN 1097-2765, 03/2017, Volume 65, Issue 6, pp. 1029 - 1043.e5
Journal Article
Molecular Cell, ISSN 1097-2765, 03/2017, Volume 65, Issue 5, pp. 917 - 931.e6
Autophagy is crucial for maintaining cell homeostasis. However, the precise mechanism underlying autophagy initiation remains to be defined. Here, we... 
ARD1 | autophagy | tumor | PGK1 | mTOR | Beclin1 | VPS34 | BREAST-CANCER | NUCLEOTIDE SYNTHESIS | METABOLISM | SIGNALING PATHWAY | PROTEIN-KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | PHOSPHATIDYLINOSITOL 3-KINASE COMPLEXES | GROWTH | TUMOR-CELLS | BETA-CATENIN | TUMORIGENESIS | CELL BIOLOGY | Glioblastoma - enzymology | Glutamine - deficiency | Phosphorylation | Cell Proliferation | TOR Serine-Threonine Kinases - metabolism | Humans | Autophagosomes - enzymology | Brain Neoplasms - pathology | Autophagy | Tumor Hypoxia | TOR Serine-Threonine Kinases - genetics | Transfection | Glioblastoma - genetics | RNA Interference | Time Factors | HEK293 Cells | Female | Acetylation | Phosphoglycerate Kinase - genetics | Brain Neoplasms - enzymology | Signal Transduction | N-Terminal Acetyltransferase A - genetics | Brain Neoplasms - genetics | Class III Phosphatidylinositol 3-Kinases - metabolism | Tumor Burden | Autophagosomes - pathology | Animals | N-Terminal Acetyltransferase A - metabolism | Class III Phosphatidylinositol 3-Kinases - genetics | Mice, Nude | Glioblastoma - pathology | Beclin-1 - genetics | Cell Line, Tumor | N-Terminal Acetyltransferase E - genetics | Protein Binding | Beclin-1 - metabolism | N-Terminal Acetyltransferase E - metabolism | Phosphoglycerate Kinase - metabolism | Enzymes | Medical colleges | Gliomas | Pancreatic cancer | Brain tumors | Physiological aspects | Phospholipids | Protein kinases | Glutamine
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 12/2009, Volume 390, Issue 3, pp. 963 - 970
Phosphatidylinositol (PI) kinases are at the heart of one of the major pathways of intracellular signal transduction. Herein, we present the first report on a... 
Trypanosomatids | Inhibitors | Phosphatidylinositol kinases | Phosphatidylinositol-related kinases | SIGNALING PATHWAYS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CHAGAS-DISEASE | CELL-GROWTH | ENDOCYTOSIS | BIOPHYSICS | COMPARATIVE GENOMICS | TOR | PHOSPHOINOSITIDE 3-KINASES | AUTOPHAGOSOME FORMATION | ATM | KINASES | Trypanosomatina - growth & development | Humans | Molecular Sequence Data | Trypanocidal Agents - chemistry | Phylogeny | Trypanosoma brucei brucei - enzymology | Autophagy | Trypanosoma cruzi - enzymology | Trypanosomatina - drug effects | Leishmania infantum - growth & development | Enzyme Inhibitors - chemistry | Leishmania major - growth & development | Drug Design | Leishmania braziliensis - enzymology | 1-Phosphatidylinositol 4-Kinase - classification | Trypanosoma brucei brucei - growth & development | Cytokinesis - drug effects | 1-Phosphatidylinositol 4-Kinase - genetics | Amino Acid Sequence | Leishmania braziliensis - drug effects | Leishmania major - drug effects | Enzyme Inhibitors - pharmacology | 1-Phosphatidylinositol 4-Kinase - antagonists & inhibitors | Trypanocidal Agents - isolation & purification | Leishmania braziliensis - growth & development | Trypanosoma brucei brucei - drug effects | Enzyme Inhibitors - isolation & purification | Leishmania infantum - enzymology | Trypanosomatina - enzymology | Cell Membrane - enzymology | Androstadienes - chemistry | Lysine - genetics | Leishmania major - enzymology | Trypanosoma cruzi - growth & development | Androstadienes - pharmacology | Trypanocidal Agents - pharmacology | Leishmania infantum - drug effects | Trypanosoma cruzi - drug effects | Phosphatidylinositol | Phosphotransferases
Journal Article
The Plant Cell, ISSN 1040-4651, 9/2013, Volume 25, Issue 9, pp. 3434 - 3449
Vacuoles are multifunctional organelles essential for the sessile lifestyle of plants. Despite their central functions in cell growth, storage, and... 
Tonoplast | Sterols | RESEARCH ARTICLES | Fluorescence | Plants | Root tips | Endoplasmic reticulum | Vacuoles | Plant cells | Seedlings | Daughter cells | ROOT-TIP CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | PLANT-CELLS | V-ATPASE ACTIVITY | PLANT SCIENCES | CELL BIOLOGY | MULTIVESICULAR BODIES | MERISTEMATIC CELLS | TRANS-GOLGI NETWORK | DYNAMIC ORGANELLE | AUTOPHAGOSOME FORMATION | H+-ATPASE | TONOPLAST TRANSPORTERS | Meristem - enzymology | Arabidopsis - physiology | Sterols - metabolism | Arabidopsis - enzymology | Meristem - physiology | Endoplasmic Reticulum - metabolism | Plant Roots - genetics | Inorganic Pyrophosphatase - metabolism | Plant Roots - ultrastructure | Recombinant Fusion Proteins | Arabidopsis Proteins - metabolism | Plant Roots - physiology | Meristem - genetics | Plants, Genetically Modified | Genes, Reporter | Arabidopsis Proteins - genetics | Adenosine Triphosphatases - metabolism | Arabidopsis - ultrastructure | Lipid Metabolism | Meristem - ultrastructure | Protein Transport | Arabidopsis - genetics | Inorganic Pyrophosphatase - genetics | Plant Roots - enzymology | Vacuoles - metabolism | Golgi Apparatus - metabolism | Adenosine Triphosphatases - genetics | Hydrogen-Ion Concentration | Arabidopsis thaliana | Physiological aspects | Biosynthesis | Research | Biological Sciences | Naturvetenskap | Botanik | Biokemi och molekylärbiologi | Biologiska vetenskaper | Botany | Biochemistry and Molecular Biology | Natural Sciences | Cellbiologi | Cell Biology
Journal Article
Journal of Pharmacy and Pharmacology, ISSN 0022-3573, 02/2018, Volume 70, Issue 2, pp. 259 - 267
Objectives This study aimed to investigate the protective effect of gastrodin (GAS) on myocardial cells with hypoxia/reoxygenation (H/R) injury in neonatal... 
gastrodin | mammalian target of rapamycin | PI3K‐Akt pathway | hypoxia/reoxygenation injury | PI3K-Akt pathway | APOPTOSIS | REPERFUSION | ISCHEMIA | DEATH | MEDICINE | HEART | NEURONS | PHARMACOLOGY & PHARMACY | STRESS | Phosphorylation | TOR Serine-Threonine Kinases - metabolism | Microtubule-Associated Proteins - metabolism | Autophagosomes - enzymology | Male | Autophagy-Related Protein-1 Homolog - metabolism | Autophagy - drug effects | Myocardial Reperfusion Injury - enzymology | Dose-Response Relationship, Drug | Myocytes, Cardiac - enzymology | Autophagosomes - drug effects | Myocardial Reperfusion Injury - pathology | Benzyl Alcohols - pharmacology | Female | Proto-Oncogene Proteins c-akt - metabolism | Phosphatidylinositol 3-Kinase - metabolism | Sequestosome-1 Protein - metabolism | Cytoprotection | Animals, Newborn | Cell Survival - drug effects | Glucosides - pharmacology | Cells, Cultured | Rats, Sprague-Dawley | Autophagosomes - pathology | Myocytes, Cardiac - pathology | Animals | Myocytes, Cardiac - drug effects | Signal Transduction - drug effects | Cell Proliferation - drug effects | Myocardial Reperfusion Injury - prevention & control | TOR protein | Cell proliferation | Neonates | Rats | AKT protein | Activation | Rapamycin | Gene expression | Autophagy | 1-Phosphatidylinositol 3-kinase | Cell activation | Injury prevention | Inhibitors | Rodents | Hypoxia | Inhibition | Viability | Phagocytosis
Journal Article