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index medicus (86) 86
autophagy (81) 81
cell biology (71) 71
animals (66) 66
humans (64) 64
biochemistry & molecular biology (45) 45
autophagosome (40) 40
proteins (33) 33
autophagosome formation (29) 29
mice (25) 25
autophagosomes - metabolism (23) 23
autophagosomes (21) 21
biochemical research methods (21) 21
autophagy - drug effects (20) 20
lc3 (18) 18
lysosome (17) 17
microtubule-associated proteins - metabolism (17) 17
cancer (16) 16
lysosomes - metabolism (16) 16
phagocytosis (16) 16
apoptosis (15) 15
biology (15) 15
degradation (15) 15
saccharomyces-cerevisiae (15) 15
cell (14) 14
autophagy-related proteins - metabolism (13) 13
binding (13) 13
green fluorescent proteins - metabolism (13) 13
phosphorylation (13) 13
saccharomyces cerevisiae proteins - metabolism (13) 13
transfection (13) 13
yeast (13) 13
autophagosomes - enzymology (12) 12
calcium (12) 12
cell line, tumor (12) 12
cells, cultured (12) 12
hela cells (12) 12
microtubule-associated proteins - genetics (12) 12
protein transport (12) 12
rats (12) 12
autophagy - genetics (11) 11
autophagy - physiology (11) 11
bioscience (11) 11
cell line (11) 11
cycle (11) 11
landes (11) 11
organogenesis (11) 11
protein (11) 11
article (10) 10
biogenesis (10) 10
kinases (10) 10
lysosomes - enzymology (10) 10
male (10) 10
microscopy, fluorescence (10) 10
phagosomes - metabolism (10) 10
research article (10) 10
rna interference (10) 10
signal transduction (10) 10
time factors (10) 10
autophagosomes - drug effects (9) 9
cells (9) 9
female (9) 9
lysosomes (9) 9
selective autophagy (9) 9
endoplasmic-reticulum (8) 8
green fluorescent proteins - genetics (8) 8
mechanisms (8) 8
membrane proteins - metabolism (8) 8
mitochondria (8) 8
models, biological (8) 8
protein binding (8) 8
saccharomyces cerevisiae - enzymology (8) 8
signal transduction - drug effects (8) 8
vacuole (8) 8
vesicular transport proteins - metabolism (8) 8
vps34 (8) 8
acid phosphatase - metabolism (7) 7
ampk (7) 7
atg8 (7) 7
autophagosomes - ultrastructure (7) 7
autophagy-related proteins (7) 7
biochemistry (7) 7
cell death (7) 7
enzymes (7) 7
expression (7) 7
fusion (7) 7
hek293 cells (7) 7
macroautophagy (7) 7
mice, knockout (7) 7
molecular biology - methods (7) 7
mutation (7) 7
phagosomes - enzymology (7) 7
phagosomes - ultrastructure (7) 7
phenotype (7) 7
phosphatidylinositol phosphates - metabolism (7) 7
proteolysis (7) 7
recombinant fusion proteins - metabolism (7) 7
recombinant proteins - genetics (7) 7
saccharomyces cerevisiae proteins - genetics (7) 7
vacuoles - metabolism (7) 7
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1. Full Text The Noncanonical Role of ULK/ATG1 in ER-to-Golgi Trafficking Is Essential for Cellular Homeostasis
by Joo, Joung Hyuck and Wang, Bo and Frankel, Elisa and Ge, Liang and Xu, Lu and Iyengar, Rekha and Li-Harms, XiuJie and Wright, Christopher and Shaw, Timothy I and Lindsten, Tullia and Green, Douglas R and Peng, Junmin and Hendershot, Linda M and Kilic, Fusun and Sze, Ji Ying and Audhya, Anjon and Kundu, Mondira
Molecular Cell, ISSN 1097-2765, 05/2016, Volume 62, Issue 4, pp. 491 - 506
ULK1 and ULK2 are thought to be essential for initiating autophagy, and -deficient mice die perinatally of autophagy-related defects. Therefore, we used a... 
SEROTONIN TRANSPORTER | BIOGENESIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | EXIT SITES | EXPORT | NEURONS | AUTOPHAGOSOME FORMATION | ULK1 | COMPONENT | HOMOLOG | PROTEINS | CELL BIOLOGY | Golgi Apparatus - enzymology | Protein-Serine-Threonine Kinases - deficiency | Fibroblasts - enzymology | Phosphorylation | Vesicular Transport Proteins - metabolism | Autophagy-Related Protein 7 - metabolism | Humans | Brain - enzymology | Caenorhabditis elegans Proteins - metabolism | Homeostasis | Male | Autophagy-Related Protein-1 Homolog - metabolism | Golgi Apparatus - pathology | Mice, 129 Strain | Autophagy | Endoplasmic Reticulum - pathology | Transfection | RNA Interference | Time Factors | HEK293 Cells | Female | Nuclear Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | Endoplasmic Reticulum - enzymology | Caenorhabditis elegans - genetics | Mice, Inbred C57BL | Vesicular Transport Proteins - genetics | Protein-Serine-Threonine Kinases - genetics | Genotype | Nuclear Proteins - metabolism | Unfolded Protein Response | Autophagy-Related Protein 7 - genetics | Mice, Knockout | Protein Transport | Carrier Proteins - genetics | Phenotype | Animals | Autophagy-Related Protein-1 Homolog - deficiency | COP-Coated Vesicles - enzymology | Carrier Proteins - metabolism | Brain - pathology | Nerve Degeneration | Autophagy-Related Protein-1 Homolog - genetics | Caenorhabditis elegans - enzymology | Proteins | Neurons | Phosphoproteins | Cells
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2. Full Text Phosphatidylinositol‐3‐phosphate in the regulation of autophagy membrane dynamics
by Nascimbeni, Anna Chiara and Codogno, Patrice and Morel, Etienne
The FEBS Journal, ISSN 1742-464X, 05/2017, Volume 284, Issue 9, pp. 1267 - 1278
Phosphatidylinositol‐3‐phosphate (PI3P) is a key player in membrane dynamics and trafficking regulation. Most PI3P is associated with endosomal membranes and... 
endosome | PI3P | autophagosome | lysosome | membrane trafficking | LYSOSOME REFORMATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | ISOLATED RAT HEPATOCYTES | SACCHAROMYCES-CEREVISIAE | SELECTIVE AUTOPHAGY | III PHOSPHOINOSITIDE 3-KINASE | RECYCLING ENDOSOMES | BIOGENESIS | ENDOPLASMIC-RETICULUM | COMPLEX FUNCTIONS | LC3 CONJUGATION | Endoplasmic Reticulum - enzymology | Class II Phosphatidylinositol 3-Kinases - metabolism | Phosphatidylinositol Phosphates - metabolism | Endosomes - physiology | Membrane Microdomains - enzymology | Autophagosomes - physiology | Humans | Autophagosomes - enzymology | Endoplasmic Reticulum - physiology | Class III Phosphatidylinositol 3-Kinases - metabolism | Lysosomes - enzymology | Adaptor Proteins, Vesicular Transport - metabolism | Autophagy | Lysosomes - physiology | Organelle Biogenesis | Animals | Models, Biological | Endosomes - enzymology | Membrane Microdomains - physiology | Beclin-1 - metabolism | Autophagy-Related Proteins - metabolism | Second Messenger Systems | Phosphates | Phospholipids | Protein binding | Membranes | Phagosomes | Lipids | Biosynthesis | Kinases | Machinery | Proteins | Lipid kinase | Membrane trafficking | Endoplasmic reticulum | Phagocytosis
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3. Full Text Rab2 promotes autophagic and endocytic lysosomal degradation
by Lörincz, Péter and Tóth, Sarolta and Benkö, Péter and Lakatos, Zsolt and Boda, Attila and Glatz, Gábor and Zobel, Martina and Bisi, Sara and Hegedüs, Krisztina and Takáts, Szabolcs and Scita, Giorgio and Juhász, Gábor
Journal of Cell Biology, ISSN 0021-9525, 07/2017, Volume 216, Issue 7, pp. 1937 - 1947
Rab7 promotes fusion of autophagosomes and late endosomes with lysosomes in yeast and metazoan cells, acting together with its effector, the tethering complex... 
TRANSPORT | TETHERING COMPLEXES | FUSION | BIOGENESIS | GTPASES | DROSOPHILA-MELANOGASTER | TRAFFICKING | SYNTAXIN 17 | PROTEINS | HOPS COMPLEX | CELL BIOLOGY | Humans | Autophagosomes - enzymology | Lysosomes - enzymology | rab GTP-Binding Proteins - genetics | Drosophila Proteins - metabolism | Autophagy | Drosophila melanogaster - genetics | Breast Neoplasms - enzymology | Endocytosis | Transfection | RNA Interference | Proteolysis | Female | rab2 GTP-Binding Protein - metabolism | rab GTP-Binding Proteins - metabolism | Membrane Fusion | Signal Transduction | Animals, Genetically Modified | Animals | Breast Neoplasms - genetics | Breast Neoplasms - pathology | rab2 GTP-Binding Protein - genetics | Cell Line, Tumor | Drosophila melanogaster - enzymology | Endosomes - enzymology | Drosophila Proteins - genetics | Cellular proteins | Autophagy (Cytology) | Genetic aspects | Gene expression | Health aspects
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4. Full Text Impaired Protein Quality Control during Left Ventricular Remodeling in Mice with Cardiac Restricted Overexpression of Tumor Necrosis Factor
by Hartupee, Justin and Szalai, Gabor D and Wang, Wei and Ma, Xiucui and Diwan, Abhinav and Mann, Douglas L
Circulation: Heart Failure, ISSN 1941-3289, 12/2017, Volume 10, Issue 12
BACKGROUND: Sustained inflammation in the heart is sufficient to provoke left ventricular dysfunction and left ventricular remodeling. Although inflammation... 
autophagy | tumor necrosis factor | inflammation | myocarditis | ubiquitin | APOPTOSIS | ISCHEMIA/REPERFUSION INJURY | CARDIAC & CARDIOVASCULAR SYSTEMS | UBIQUITIN-PROTEASOME SYSTEM | CELL-DEATH | CARDIOMYOCYTE DEATH | DISEASE | DYSFUNCTION | HUMAN HEART | TRANSGENIC MICE | Protein Aggregates | Tumor Necrosis Factor-alpha - metabolism | Up-Regulation | Cardiomyopathy, Dilated - pathology | Ventricular Function, Left | Cardiomyopathy, Dilated - enzymology | Heart Failure - enzymology | Humans | Tumor Necrosis Factor-alpha - genetics | Autophagosomes - enzymology | Myosin Heavy Chains - genetics | Autophagy | Myocytes, Cardiac - enzymology | Ubiquitination | Ventricular Remodeling | Time Factors | Ventricular Dysfunction, Left - genetics | Heart Ventricles - enzymology | Inflammation Mediators - metabolism | Ventricular Dysfunction, Left - pathology | Ventricular Dysfunction, Left - enzymology | Heart Ventricles - pathology | Disease Models, Animal | Cardiomyopathy, Dilated - genetics | Promoter Regions, Genetic | Genetic Predisposition to Disease | Mice, Transgenic | Heart Failure - pathology | Mechanistic Target of Rapamycin Complex 1 - metabolism | Protein Aggregation, Pathological | Ventricular Dysfunction, Left - physiopathology | Autophagosomes - pathology | Myocytes, Cardiac - pathology | Phenotype | Animals | Cardiomyopathy, Dilated - physiopathology | Heart Ventricles - physiopathology | Proteasome Endopeptidase Complex - metabolism | proteasome | Inflammatory Heart Disease | Heart Failure | Myocardial Biology | Basic Science Research
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5. Full Text The ER-Localized Transmembrane Protein EPG-3/VMP1 Regulates SERCA Activity to Control ER-Isolation Membrane Contacts for Autophagosome Formation
by Zhao, Yan G and Zhao, Hongyu and Chen, She and Chen, Yong and Miao, Guangyan and Qu, Wenyan and Li, Dongfang and Li, Lin and Wang, Zheng and Liu, Nan and Liu, Pingsheng and Feng, Du and Zhang, Hong
Molecular Cell, ISSN 1097-2765, 09/2017, Volume 67, Issue 6, pp. 974 - 989.e6
During autophagosome formation in mammalian cells, isolation membranes (IMs; autophagosome precursors) dynamically contact the ER. Here, we demonstrated that... 
VMP1 | membrane contact | SERCA | autophagosome | COMPLEX | BIOENERGETICS | ATG16L1 | BIOCHEMISTRY & MOLECULAR BIOLOGY | CALCIUM | SITES | FIP200 | CELL BIOLOGY | Intracellular Membranes - enzymology | Phosphatidylinositol Phosphates - metabolism | Humans | Proteolipids - metabolism | Autophagosomes - enzymology | Caenorhabditis elegans Proteins - metabolism | Cercopithecus aethiops | Autophagy-Related Protein-1 Homolog - metabolism | Intracellular Signaling Peptides and Proteins - metabolism | Transfection | RNA Interference | HEK293 Cells | Muscle Proteins - metabolism | Membrane Proteins - metabolism | Lipid Droplets - metabolism | Intracellular Signaling Peptides and Proteins - genetics | Calcium-Binding Proteins - metabolism | Endoplasmic Reticulum - enzymology | Sarcoplasmic Reticulum Calcium-Transporting ATPases - metabolism | Animals, Genetically Modified | Caenorhabditis elegans - genetics | Membrane Proteins - genetics | Genotype | Phenotype | Animals | CRISPR-Cas Systems | HeLa Cells | Sarcoplasmic Reticulum Calcium-Transporting ATPases - genetics | Autophagy-Related Protein-1 Homolog - genetics | COS Cells | Caenorhabditis elegans Proteins - genetics | Caenorhabditis elegans - enzymology | Calcium-binding proteins | Cells | Adenosine triphosphatase
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6. Full Text Pacer Mediates the Function of Class III PI3K and HOPS Complexes in Autophagosome Maturation by Engaging Stx17
by Cheng, Xiawei and Ma, Xiuling and Ding, Xianming and Li, Lin and Jiang, Xiao and Shen, Zhirong and Chen, She and Liu, Wei and Gong, Weihua and Sun, Qiming
Molecular Cell, ISSN 1097-2765, 03/2017, Volume 65, Issue 6, pp. 1029 - 1043.e5
Class III PI3-kinase (PI3KC3) is essential for autophagy initiation, but whether PI3KC3 participates in other steps of autophagy remains unknown. The HOPS... 
Stx-17 | UVRAG | PI3KC3 | Rubicon | Vps34 | Beclin1 | Pacer | HOPS | RAB7 EFFECTOR | PROTEIN | LYSOSOME FUSION | BIOCHEMISTRY & MOLECULAR BIOLOGY | RUBICON | PHOSPHATIDYLINOSITOL 3-KINASE COMPLEX | SNARE SYNTAXIN 17 | C-VPS COMPLEX | ENDOSOME MATURATION | ATG14L | CELL BIOLOGY | Protein Aggregates | Salmonella typhimurium - growth & development | Vesicular Transport Proteins - metabolism | Humans | Autophagosomes - enzymology | Lysosomes - enzymology | Intracellular Signaling Peptides and Proteins - metabolism | Autophagy | Transfection | RNA Interference | Time Factors | Tumor Suppressor Proteins - genetics | HEK293 Cells | Qa-SNARE Proteins - genetics | Protein Interaction Domains and Motifs | Lipid Droplets - metabolism | Autophagy-Related Proteins - genetics | Intracellular Signaling Peptides and Proteins - genetics | Tumor Suppressor Proteins - metabolism | Membrane Fusion | Signal Transduction | Vesicular Transport Proteins - genetics | Class III Phosphatidylinositol 3-Kinases - metabolism | Hep G2 Cells | Host-Pathogen Interactions | Qa-SNARE Proteins - metabolism | Protein Binding | Endosomes - enzymology | Enzyme Activation | HeLa Cells | Autophagy-Related Proteins - metabolism | Hepatocytes - enzymology | Molecular biology | Medical colleges | Health aspects
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7. Full Text Phosphoglycerate Kinase 1 Phosphorylates Beclin1 to Induce Autophagy
by Qian, Xu and Li, Xinjian and Cai, Qingsong and Zhang, Chuanbao and Yu, Qiujing and Jiang, Bing-Hua and Jiang, Tao and Jiang, Yuhui and Lee, Jong-Ho and Hawke, David and Wang, Yugang and Xia, Yan and Zheng, Yanhua and Liu, David X and Lu, Zhimin
Molecular Cell, ISSN 1097-2765, 03/2017, Volume 65, Issue 5, pp. 917 - 931.e6
Autophagy is crucial for maintaining cell homeostasis. However, the precise mechanism underlying autophagy initiation remains to be defined. Here, we... 
ARD1 | autophagy | tumor | PGK1 | mTOR | Beclin1 | VPS34 | BREAST-CANCER | NUCLEOTIDE SYNTHESIS | METABOLISM | SIGNALING PATHWAY | PROTEIN-KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | PHOSPHATIDYLINOSITOL 3-KINASE COMPLEXES | GROWTH | TUMOR-CELLS | BETA-CATENIN | TUMORIGENESIS | CELL BIOLOGY | Glioblastoma - enzymology | Glutamine - deficiency | Phosphorylation | Cell Proliferation | TOR Serine-Threonine Kinases - metabolism | Humans | Autophagosomes - enzymology | Brain Neoplasms - pathology | Autophagy | Tumor Hypoxia | TOR Serine-Threonine Kinases - genetics | Transfection | Glioblastoma - genetics | RNA Interference | Time Factors | HEK293 Cells | Female | Acetylation | Phosphoglycerate Kinase - genetics | Brain Neoplasms - enzymology | Signal Transduction | N-Terminal Acetyltransferase A - genetics | Brain Neoplasms - genetics | Class III Phosphatidylinositol 3-Kinases - metabolism | Tumor Burden | Autophagosomes - pathology | Animals | N-Terminal Acetyltransferase A - metabolism | Class III Phosphatidylinositol 3-Kinases - genetics | Mice, Nude | Glioblastoma - pathology | Beclin-1 - genetics | Cell Line, Tumor | N-Terminal Acetyltransferase E - genetics | Protein Binding | Beclin-1 - metabolism | N-Terminal Acetyltransferase E - metabolism | Phosphoglycerate Kinase - metabolism | Enzymes | Medical colleges | Gliomas | Pancreatic cancer | Brain tumors | Physiological aspects | Phospholipids | Protein kinases | Glutamine
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8. Full Text The TryPIKinome of five human pathogenic trypanosomatids: Trypanosoma brucei, Trypanosoma cruzi, Leishmania major, Leishmania braziliensis and Leishmania infantum - New tools for designing specific inhibitors
by Bahia, Diana and Oliveira, Luciana Márcia and Lima, Fabio Mitsuo and Oliveira, Priscila and Silveira, José Franco da and Mortara, Renato Arruda and Ruiz, Jerônimo Conceição
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 12/2009, Volume 390, Issue 3, pp. 963 - 970
Phosphatidylinositol (PI) kinases are at the heart of one of the major pathways of intracellular signal transduction. Herein, we present the first report on a... 
Trypanosomatids | Inhibitors | Phosphatidylinositol kinases | Phosphatidylinositol-related kinases | SIGNALING PATHWAYS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CHAGAS-DISEASE | CELL-GROWTH | ENDOCYTOSIS | BIOPHYSICS | COMPARATIVE GENOMICS | TOR | PHOSPHOINOSITIDE 3-KINASES | AUTOPHAGOSOME FORMATION | ATM | KINASES | Trypanosomatina - growth & development | Humans | Molecular Sequence Data | Trypanocidal Agents - chemistry | Phylogeny | Trypanosoma brucei brucei - enzymology | Autophagy | Trypanosoma cruzi - enzymology | Trypanosomatina - drug effects | Leishmania infantum - growth & development | Enzyme Inhibitors - chemistry | Leishmania major - growth & development | Drug Design | Leishmania braziliensis - enzymology | 1-Phosphatidylinositol 4-Kinase - classification | Trypanosoma brucei brucei - growth & development | Cytokinesis - drug effects | 1-Phosphatidylinositol 4-Kinase - genetics | Amino Acid Sequence | Leishmania braziliensis - drug effects | Leishmania major - drug effects | Enzyme Inhibitors - pharmacology | 1-Phosphatidylinositol 4-Kinase - antagonists & inhibitors | Trypanocidal Agents - isolation & purification | Leishmania braziliensis - growth & development | Trypanosoma brucei brucei - drug effects | Enzyme Inhibitors - isolation & purification | Leishmania infantum - enzymology | Trypanosomatina - enzymology | Cell Membrane - enzymology | Androstadienes - chemistry | Lysine - genetics | Leishmania major - enzymology | Trypanosoma cruzi - growth & development | Androstadienes - pharmacology | Trypanocidal Agents - pharmacology | Leishmania infantum - drug effects | Trypanosoma cruzi - drug effects | Phosphatidylinositol | Phosphotransferases
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9. Full Text The Endoplasmic Reticulum Is the Main Membrane Source for Biogenesis of the Lytic Vacuole in Arabidopsis
by Corrado Viotti and Falco Krüger and Melanie Krebs and Christoph Neubert and Fabian Fink and Upendo Lupanga and David Scheuring and Yohann Boutté and Márcia Frescatada-Rosa and Susanne Wolfenstetter and Norbert Sauer and Stefan Hillmer and Markus Grebe and Karin Schumacher and Umeå Plant Science Centre (UPSC) and Institutionen för fysiologisk botanik and Umeå universitet and Teknisk-naturvetenskapliga fakulteten
The Plant Cell, ISSN 1040-4651, 9/2013, Volume 25, Issue 9, pp. 3434 - 3449
Vacuoles are multifunctional organelles essential for the sessile lifestyle of plants. Despite their central functions in cell growth, storage, and... 
Tonoplast | Sterols | RESEARCH ARTICLES | Fluorescence | Plants | Root tips | Endoplasmic reticulum | Vacuoles | Plant cells | Seedlings | Daughter cells | ROOT-TIP CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | PLANT-CELLS | V-ATPASE ACTIVITY | PLANT SCIENCES | CELL BIOLOGY | MULTIVESICULAR BODIES | MERISTEMATIC CELLS | TRANS-GOLGI NETWORK | DYNAMIC ORGANELLE | AUTOPHAGOSOME FORMATION | H+-ATPASE | TONOPLAST TRANSPORTERS | Meristem - enzymology | Arabidopsis - physiology | Sterols - metabolism | Arabidopsis - enzymology | Meristem - physiology | Endoplasmic Reticulum - metabolism | Plant Roots - genetics | Inorganic Pyrophosphatase - metabolism | Plant Roots - ultrastructure | Recombinant Fusion Proteins | Arabidopsis Proteins - metabolism | Plant Roots - physiology | Meristem - genetics | Plants, Genetically Modified | Genes, Reporter | Arabidopsis Proteins - genetics | Adenosine Triphosphatases - metabolism | Arabidopsis - ultrastructure | Lipid Metabolism | Meristem - ultrastructure | Protein Transport | Arabidopsis - genetics | Inorganic Pyrophosphatase - genetics | Plant Roots - enzymology | Vacuoles - metabolism | Golgi Apparatus - metabolism | Adenosine Triphosphatases - genetics | Hydrogen-Ion Concentration | Arabidopsis thaliana | Physiological aspects | Biosynthesis | Research | Biological Sciences | Naturvetenskap | Botanik | Biokemi och molekylärbiologi | Biologiska vetenskaper | Botany | Biochemistry and Molecular Biology | Natural Sciences | Cellbiologi | Cell Biology
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10. Full Text Visualization of Atg3 during autophagosome formation in Saccharomyces cerevisiae
by Ngu, Meipin and Hirata, Eri and Suzuki, Kuninori
Journal of Biological Chemistry, ISSN 0021-9258, 03/2015, Volume 290, Issue 13, pp. 8146 - 8153
Macroautophagy (autophagy) is a highly conserved cellular recycling process involved in degradation of eukaryotic cellular components. During autophagy,... 
YEAST | SYSTEM | MUTANTS | COMPLEX | PROTEIN LIPIDATION | ENZYME | BIOCHEMISTRY & MOLECULAR BIOLOGY | CYTOPLASM | VACUOLE TARGETING PATHWAY | DELIVERY | Green Fluorescent Proteins - metabolism | Vacuoles - enzymology | Autophagy-Related Proteins | Intracellular Membranes - enzymology | Phagosomes - enzymology | Autophagy | Recombinant Fusion Proteins - metabolism | Protein Transport | Phosphatidylethanolamines | Ubiquitin-Conjugating Enzymes - metabolism | Saccharomyces cerevisiae Proteins - metabolism | Saccharomyces cerevisiae - enzymology | Microscopy, Fluorescence | Biodegradation | Atg3 | Atg8 Lipidation | Yeast | Organelle | Isolation Membrane | Autophagosome | Saccharomyces cerevisiae | Cell Biology
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11. Full Text A STRIPAK complex mediates axonal transport of autophagosomes and dense core vesicles through PP2A regulation
by Neisch, Amanda L and Neufeld, Thomas P and Hays, Thomas S
The Journal of cell biology, ISSN 0021-9525, 02/2017, Volume 216, Issue 2, pp. 441 - 461
Autophagy plays an essential role in the cellular homeostasis of neurons, facilitating the clearance of cellular debris. This clearance process is orchestrated... 
Axonal Transport | Axons - enzymology | Autophagosomes - enzymology | Multiprotein Complexes - genetics | Drosophila Proteins - metabolism | Drosophila melanogaster - genetics | Recombinant Fusion Proteins - metabolism | Multiprotein Complexes - metabolism | Transfection | RNA Interference | Protein Interaction Domains and Motifs | Secretory Vesicles - enzymology | Dyneins - metabolism | Cell Line | Signal Transduction | Animals, Genetically Modified | Protein Phosphatase 2 - genetics | Genotype | Nerve Tissue Proteins - genetics | Nerve Tissue Proteins - metabolism | Phenotype | Animals | Adaptor Proteins, Signal Transducing - genetics | Protein Phosphatase 2 - metabolism | Drosophila melanogaster - enzymology | Presynaptic Terminals - metabolism | Protein Binding | Recombinant Fusion Proteins - genetics | Drosophila Proteins - genetics | Dyneins - genetics | Mutation | Adaptor Proteins, Signal Transducing - metabolism | Microscopy, Fluorescence
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12. Full Text Rab proteins of the endoplasmic reticulum: Functions and interactors
by Sandoval, Carolina Ortiz and Simmen, Thomas
Biochemical Society Transactions, ISSN 0300-5127, 12/2012, Volume 40, Issue 6, pp. 1426 - 1432
Whereas most of what we know today about the Ras-related small GTPases of the Rab family stems from observations made on Golgi complex, endosome and plasma... 
Mitochondrion | Endoplasmic reticulum (ER) | Rab | Mitochondria-associated membrane (MAM) | Golgi complex | GTPase | DISSOCIATION INHIBITOR | BIOCHEMISTRY & MOLECULAR BIOLOGY | GOLGI-APPARATUS | mitochondrion | GERANYLGERANYL TRANSFERASE | TRANSPORT | mitochondria-associated membrane (MAM) | GTPASE-ACTIVATING PROTEINS | BINDING PROTEINS | MOLECULAR-CLONING | AUTOPHAGOSOME FORMATION | endoplasmic reticulum (ER) | LIPID DROPLETS | Endoplasmic Reticulum - enzymology | Golgi Apparatus - enzymology | rab GTP-Binding Proteins - metabolism | rab GTP-Binding Proteins - physiology | Animals | Intracellular Membranes - enzymology | Transport Vesicles - enzymology | Transport Vesicles - metabolism | Humans | Endoplasmic Reticulum - metabolism | Golgi Apparatus - metabolism | Protein Transport
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13. SapM-induced fusion blocking of autophagosome-lysosome is depended on interaction with Rab7
by Hu, Dong and Wang, Wan and Zhao, Runpeng and Xu, Xuewei and Xing, Yingru and Ni, Shengfa and Xu, Congjing and Tie, Baoxian and Zhang, Rongbo and Wu, Jing
Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology, ISSN 1007-8738, 09/2016, Volume 32, Issue 9, p. 1178
Objective To study the role of Rab7 in the blockage of autophagosome-lysosome fusion induced by secretory acid phosphatase (SapM), a virulence factor of... 
rab GTP-Binding Proteins - metabolism | Tuberculosis - enzymology | Humans | Autophagosomes - enzymology | Bacterial Proteins - genetics | Lysosomes - enzymology | Tuberculosis - microbiology | rab GTP-Binding Proteins - genetics | Macrophages - enzymology | Acid Phosphatase - metabolism | Animals | Tuberculosis - genetics | Mycobacterium tuberculosis - enzymology | Protein Binding | Bacterial Proteins - metabolism | RAW 264.7 Cells | Mice | Acid Phosphatase - genetics | Macrophages - microbiology | Mycobacterium tuberculosis - genetics
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14. Full Text Gastrodin protects myocardial cells against hypoxia/reoxygenation injury in neonatal rats by inhibiting cell autophagy through the activation of mTOR signals in PI3K‐Akt pathway
by Li, Xiang and Zhu, Qinhui and Liu, Yuanyuan and Yang, Zhiyong and Li, Bin
Journal of Pharmacy and Pharmacology, ISSN 0022-3573, 02/2018, Volume 70, Issue 2, pp. 259 - 267
Objectives This study aimed to investigate the protective effect of gastrodin (GAS) on myocardial cells with hypoxia/reoxygenation (H/R) injury in neonatal... 
gastrodin | mammalian target of rapamycin | PI3K‐Akt pathway | hypoxia/reoxygenation injury | PI3K-Akt pathway | APOPTOSIS | REPERFUSION | ISCHEMIA | DEATH | MEDICINE | HEART | NEURONS | PHARMACOLOGY & PHARMACY | STRESS | Phosphorylation | TOR Serine-Threonine Kinases - metabolism | Microtubule-Associated Proteins - metabolism | Autophagosomes - enzymology | Male | Autophagy-Related Protein-1 Homolog - metabolism | Autophagy - drug effects | Myocardial Reperfusion Injury - enzymology | Dose-Response Relationship, Drug | Myocytes, Cardiac - enzymology | Autophagosomes - drug effects | Myocardial Reperfusion Injury - pathology | Benzyl Alcohols - pharmacology | Female | Proto-Oncogene Proteins c-akt - metabolism | Phosphatidylinositol 3-Kinase - metabolism | Sequestosome-1 Protein - metabolism | Cytoprotection | Animals, Newborn | Cell Survival - drug effects | Glucosides - pharmacology | Cells, Cultured | Rats, Sprague-Dawley | Autophagosomes - pathology | Myocytes, Cardiac - pathology | Animals | Myocytes, Cardiac - drug effects | Signal Transduction - drug effects | Cell Proliferation - drug effects | Myocardial Reperfusion Injury - prevention & control | TOR protein | Cell proliferation | Neonates | Rats | AKT protein | Activation | Rapamycin | Gene expression | Autophagy | 1-Phosphatidylinositol 3-kinase | Cell activation | Injury prevention | Inhibitors | Rodents | Hypoxia | Inhibition | Viability | Phagocytosis
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