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Autophagy, ISSN 1554-8627, 09/2011, Volume 7, Issue 9, pp. 1045 - 1051
Multiple stress pathways result in the induction of autophagy and apoptosis. Current methods (e.g., protein gel blot, microscopy) do not offer quantitative... 
Binding | Proteins | Landes | Calcium | Bioscience | Biology | Cell | Cycle | Cancer | Organogenesis | Autophagy | Multispectral imaging cytometry | Influenza | New methodology | Apoptosis | influenza | CROSS-TALK | new methodology | autophagy | BECLIN 1 | multispectral imaging cytometry | apoptosis | CELL-DEATH | CELL BIOLOGY | Leukocytes, Mononuclear - metabolism | Image Cytometry - methods | Apoptosis - drug effects | Apoptosis - radiation effects | Autophagy - radiation effects | Microtubule-Associated Proteins - metabolism | Humans | Autophagy - drug effects | Lysosomes - radiation effects | Chloroquine - pharmacology | Lysosomes - metabolism | Ultraviolet Rays | Time Factors | Leukocytes, Mononuclear - radiation effects | Signal Transduction - radiation effects | Fibroblasts - metabolism | Lysosomes - drug effects | Leukocytes, Mononuclear - drug effects | Animals | Fibroblasts - radiation effects | Signal Transduction - drug effects | Embryo, Mammalian - cytology | Fibroblasts - drug effects | Leukocytes, Mononuclear - cytology | Fibroblasts - cytology | Mice | Autophagy/radiation effects | Signal Transduction/radiation effects | Image Cytometry/methods | Autophagy/drug effects | Life Sciences | Lysosomes/drug effects | Immunology | Fibroblasts/metabolism | Leukocytes, Mononuclear/radiation effects | Fibroblasts/drug effects | Leukocytes, Mononuclear/metabolism | Apoptosis/radiation effects | Leukocytes, Mononuclear/drug effects | Fibroblasts/cytology | Apoptosis/drug effects | Fibroblasts/radiation effects | Lysosomes/metabolism | Leukocytes, Mononuclear/cytology | Signal Transduction/drug effects | Chloroquine/pharmacology | Embryo, Mammalian/cytology | Lysosomes/radiation effects | Microtubule-Associated Proteins/metabolism
Journal Article
Nature medicine, ISSN 1546-170X, 2016, Volume 22, Issue 12, pp. 1428 - 1438
... extends the lifespan of mice and exerts cardioprotective effects, reducing cardiac hypertrophy and preserving diastolic function in old mice... 
MEDICINE, RESEARCH & EXPERIMENTAL | PRESSURE-OVERLOAD | BIOCHEMISTRY & MOLECULAR BIOLOGY | MITOCHONDRIAL AUTOPHAGY | PRESERVED EJECTION FRACTION | TANDEM MASS-SPECTROMETRY | DIASTOLIC HEART-FAILURE | ROBUST QUANTIFICATION | ARGININE BIOAVAILABILITY | CELL BIOLOGY | SALT-SENSITIVE RATS | AMINO-ACIDS | MYOCARDIAL HYPERTROPHY | Mitochondria, Heart - metabolism | Prospective Studies | Diastole | Gene Expression - drug effects | Longevity - drug effects | Humans | Middle Aged | Aging - drug effects | Immunoblotting | Male | Autophagy-Related Protein 5 - genetics | Chromatography, High Pressure Liquid | Mitochondria, Heart - drug effects | Autophagy - drug effects | Aging - immunology | Mass Spectrometry | Cardiovascular Diseases - epidemiology | Heart Failure | Adult | Female | Surveys and Questionnaires | Blood Pressure - drug effects | Rats, Inbred Dahl | Phosphorylation - drug effects | Cytokines - immunology | Glucose Tolerance Test | Echocardiography | Diet - statistics & numerical data | Connectin - drug effects | Cardiomegaly - diagnostic imaging | Rats | Inflammation | Cardiotonic Agents - pharmacology | Heart - diagnostic imaging | Animals | Myocytes, Cardiac - drug effects | Connectin - metabolism | Cytokines - drug effects | Mitochondrial Degradation - drug effects | Spermidine - pharmacology | Heart - drug effects | Aged | Mice | Aging - metabolism | Cardiovascular diseases | Polyamines | Research | Aging | Cardiomyocytes | Mitochondria
Journal Article
Autophagy, ISSN 1554-8627, 05/2012, Volume 8, Issue 5, pp. 812 - 825
.... Furthermore, our results revealed that curcumin causes some novel cellular mechanisms that promote autophagy as a protective effect... 
autophagy | endothelial cell | FOXO1 | oxidative stress | curcumin | Binding | Proteins | Landes | Calcium | Bioscience | Biology | Cell | Cycle | Cancer | Organogenesis | Oxidative stress | Endothelial cell | Curcumin | Autophagy | TOR Serine-Threonine Kinases - metabolism | Apoptosis - drug effects | Humans | Phosphatidylinositol 3-Kinases - metabolism | Protein Transport - drug effects | Autophagy - drug effects | Gene Knockdown Techniques | Proto-Oncogene Proteins c-bcl-2 - metabolism | Cell Nucleus - metabolism | Forkhead Transcription Factors - metabolism | Protective Agents - pharmacology | Protein Binding - drug effects | Cytoprotection - drug effects | Membrane Proteins - metabolism | Proto-Oncogene Proteins c-akt - metabolism | Beclin-1 | Hydrogen Peroxide - toxicity | rab GTP-Binding Proteins - metabolism | Cell Survival - drug effects | Human Umbilical Vein Endothelial Cells - drug effects | Curcumin - pharmacology | Down-Regulation - drug effects | Ubiquitin-Activating Enzymes - metabolism | Apoptosis Regulatory Proteins - metabolism | Up-Regulation - drug effects | Acetylation - drug effects | Autophagy-Related Protein 7 | Human Umbilical Vein Endothelial Cells - enzymology | Signal Transduction - drug effects | Models, Biological | Human Umbilical Vein Endothelial Cells - pathology | Forkhead Box Protein O1 | Oxidative Stress - drug effects | Cell Nucleus - drug effects | CELL BIOLOGY
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 2016, Volume 113, Issue 6, pp. E782 - E790
Epstein–Barr virus (EBV) is an oncogenic herpesvirus that has been causally linked to the development of B-cell and epithelial malignancies. Early after... 
B cell | Epstein-Barr virus | Metabolism | Oncogene-induced senescence | Autophagy | TRANSFORMATION | SURVIVAL | autophagy | DNA-DAMAGE RESPONSE | MULTIDISCIPLINARY SCIENCES | CANCER | REPLICATION | SIGNALING PATHWAY | metabolism | TUMORIGENESIS | oncogene-induced senescence | LYMPHOCYTES | Metabolomics | Cell Transformation, Viral - drug effects | TOR Serine-Threonine Kinases - metabolism | DNA Replication - drug effects | Humans | Herpesvirus 4, Human - drug effects | Cellular Senescence - drug effects | Dimethylformamide - pharmacology | Autophagy - drug effects | Mechanistic Target of Rapamycin Complex 1 | Multiprotein Complexes - metabolism | Deoxyglucose - pharmacology | Cell Respiration - drug effects | B-Lymphocytes - virology | Stress, Physiological - drug effects | B-Lymphocytes - pathology | B-Lymphocytes - ultrastructure | Oncogenes | DNA Damage - drug effects | Herpesvirus 4, Human - physiology | Tumor Suppressor Protein p53 - metabolism | Mitochondria - metabolism | Transcriptome - genetics | Mitochondria - drug effects | Transcription Factors - metabolism | B-Lymphocytes - drug effects | Signal Transduction - drug effects | Cell Cycle Checkpoints - drug effects | Cell Proliferation - drug effects | Cell interaction | B cells | Host-virus relationships | Observations | Health aspects | Biological Sciences | PNAS Plus | Epstein–Barr virus
Journal Article
Autophagy, ISSN 1554-8627, 09/2012, Volume 8, Issue 9, pp. 1333 - 1341
Photodynamic therapy (PDT) involves photosensitizing agents that, in the presence of oxygen and light, initiate formation of cytotoxic reactive oxygen species... 
apoptosis | lysosomes | autophagy | subcellular localization | photodynamic therapy | Binding | Proteins | Landes | Calcium | Bioscience | Biology | Cell | Cycle | Cancer | Organogenesis | Lysosomes | Photodynamic therapy | Autophagy | Subcellular localization | Apoptosis | CANCER-CELLS | ACTIVATION | AUTOPHAGIC RESPONSES | WST11 | CELL BIOLOGY | CYTOCHROME-C | BCL-2 | PHOTOSENSITIZER NPE6 | REACTIVE OXYGEN | MEMBRANE PERMEABILIZATION | Apoptosis - drug effects | Apoptosis - radiation effects | Microtubule-Associated Proteins - metabolism | Fluorescence | Phagosomes - radiation effects | Protein Transport - drug effects | Recombinant Fusion Proteins - metabolism | Vacuoles - drug effects | Cell Shape - radiation effects | Lysosomes - radiation effects | Photosensitizing Agents - pharmacology | Cell Nucleus - metabolism | Lysosomes - metabolism | Cell Nucleus - radiation effects | Light | Phagosomes - ultrastructure | Microtubule-Associated Proteins - deficiency | Phagosomes - drug effects | Lysosomes - drug effects | Cell Survival - drug effects | Green Fluorescent Proteins - metabolism | Permeability - drug effects | Subcellular Fractions - drug effects | Bacteriochlorophylls - pharmacology | Porphyrins - pharmacology | Cell Nucleus - ultrastructure | Amines - metabolism | Cell Survival - radiation effects | Subcellular Fractions - metabolism | Cell Shape - drug effects | Vacuoles - radiation effects | Autophagy-Related Protein 7 | Animals | Permeability - radiation effects | Protein Transport - radiation effects | Subcellular Fractions - radiation effects | Bacteriochlorophylls - chemistry | Cell Line, Tumor | Vacuoles - metabolism | Mice | Cell Nucleus - drug effects | Basic Research Paper
Journal Article
Nature communications, ISSN 2041-1723, 2019, Volume 10, Issue 1, pp. 651 - 17
.... Concomitantly, DMC induces autophagy, which is essential for its cytoprotective effects from yeast to mice... 
NITROGEN CATABOLITE REPRESSION | GATA FACTORS | YEAST | LIFE-SPAN | REGULATOR | AMINO-ACID CONTROL | TOR PROTEINS | MECHANISM | MULTIDISCIPLINARY SCIENCES | NUCLEAR GLN3 IMPORT | HEALTH | GATA Transcription Factors - drug effects | Longevity - drug effects | Plant Extracts - pharmacology | Angelica - chemistry | Humans | Aging - drug effects | Male | Saccharomyces cerevisiae - drug effects | Autophagy - drug effects | Transcription Factors - drug effects | Saccharomyces cerevisiae - metabolism | Cell Line - drug effects | Medicine, East Asian Traditional | Flavonoids - administration & dosage | Cation Transport Proteins - genetics | Flavonoids - pharmacology | Cell Death - drug effects | Signal Transduction | Mice, Inbred C57BL | Saccharomyces cerevisiae Proteins - genetics | Transcription Factors - genetics | Myocardial Ischemia - drug therapy | Sirolimus - pharmacology | Drosophila melanogaster - drug effects | Mechanistic Target of Rapamycin Complex 1 - metabolism | Gene Expression Regulation - drug effects | Animals | Caenorhabditis elegans - drug effects | Aging - physiology | Mice | Longevity - physiology | Senescence | Transcription factors | Yeast | Neurodegenerative diseases | Health promotion | Deceleration | Pharmacology | Longevity | Metabolism | Risk analysis | Autophagy | Risk factors | Neurological diseases | Flavonoids | Life span | Ischemia | Aging | Aging (natural) | Phagocytosis
Journal Article
The Journal of biological chemistry, ISSN 0021-9258, 08/2013, Volume 288, Issue 33, pp. 24247 - 24263
Journal Article
Nanomedicine, ISSN 1549-9634, 2010, Volume 6, Issue 3, pp. 427 - 441
Abstract Identification of pharmacological and toxicological profiles is of critical importance for the use of nanoparticles as drug carriers in nanomedicine and for the biosafety evaluation... 
Internal Medicine | Lysosomes | Mitochondria | Target treatment | Alzheimer disease | Single-walled carbon nanotubes | Organelles | MEDICINE, RESEARCH & EXPERIMENTAL | BIOCOMPATIBILITY | RATS | NANOSCIENCE & NANOTECHNOLOGY | MAMMALIAN-CELLS | DELIVERY | NANOPARTICLES | REACTIVE OXYGEN | IN-VIVO | HUMAN EPIDERMAL-KERATINOCYTES | CYTOTOXICITY | Memory - drug effects | Organ Specificity - drug effects | Drug Carriers - adverse effects | Intestinal Absorption - drug effects | Drug Carriers - toxicity | Mitochondria - ultrastructure | Autophagy - drug effects | Alzheimer Disease - pathology | Lysosomes - metabolism | Nanotubes, Carbon - toxicity | Brain - ultrastructure | Spectrum Analysis, Raman | Lysosomes - drug effects | Cell Survival - drug effects | Alzheimer Disease - physiopathology | Reproducibility of Results | Subcellular Fractions - drug effects | Acetylcholine - pharmacology | Alzheimer Disease - drug therapy | Nanotubes, Carbon - ultrastructure | Mitochondria - metabolism | Mitochondria - drug effects | Subcellular Fractions - metabolism | Brain - drug effects | Lysosomes - ultrastructure | Acetylcholine - administration & dosage | Animals | Nanomedicine - methods | Brain - pathology | Nanotubes, Carbon - adverse effects | Drug Carriers - pharmacokinetics | Mice | Health Status | Index Medicus
Journal Article
Radiotherapy and Oncology, ISSN 0167-8140, 2011, Volume 99, Issue 3, pp. 287 - 292
Journal Article
Drug resistance updates, ISSN 1368-7646, 2011, Volume 14, Issue 3, pp. 191 - 201
.... Three basic categories underlie most cases of chemotherapy failure: Inadequate pharmacokinetic properties of the drug, tumor cell intrinsic factors such as the... 
Infectious Disease | Hematology, Oncology and Palliative Medicine | HIF-2α | Hypoxia | HIF-1α | Microenvironment | Drug resistance | Autophagy | Cancer | p53 | CANCER-CELLS | TRANSCRIPTIONAL ACTIVITY | HIF-1 alpha | HIF-2 alpha | INDUCIBLE FACTOR 1-ALPHA | ENDOTHELIAL-GROWTH-FACTOR | DNA-DAMAGE | BREAST-CANCER | FACTOR-I-ALPHA | PHARMACOLOGY & PHARMACY | FACTORS HIF-1-ALPHA | MULTIDRUG-RESISTANCE | FACTOR-1 HIF-1 | Neoplasms - metabolism | Apoptosis - drug effects | Humans | Gene Expression Regulation, Neoplastic | Hypoxia-Inducible Factor 1, alpha Subunit - antagonists & inhibitors | Autophagy - drug effects | Tumor Suppressor Protein p53 - genetics | Hypoxia - metabolism | Basic Helix-Loop-Helix Transcription Factors - metabolism | Neoplasms - genetics | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Antineoplastic Agents - pharmacology | Tumor Microenvironment - drug effects | Cell Hypoxia - drug effects | Basic Helix-Loop-Helix Transcription Factors - genetics | Hypoxia-Inducible Factor 1, alpha Subunit - genetics | Tumor Suppressor Protein p53 - metabolism | Basic Helix-Loop-Helix Transcription Factors - antagonists & inhibitors | Mitochondria - metabolism | Mitochondria - drug effects | Neoplasms - drug therapy | Cell Cycle | Signal Transduction - drug effects | Cell Line, Tumor | Cell Proliferation - drug effects | Cell Hypoxia - genetics | Neoplasms - pathology | Drug Resistance, Neoplasm - drug effects | Chemotherapy | Cell death | Drug interactions | Biochemistry | DNA binding proteins | Tumor proteins | Tumors
Journal Article