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Nature (London), ISSN 1476-4687, 03/2019, Volume 567, Issue 7747, pp. 262 - 266
...). Upon binding DNA, cGAS produces cGAMP that binds to and activates the adaptor protein STING, which then activates the kinases IKK and TBK1 to induce interferons and other cytokines(2-6... 
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Nucleotides, Cyclic - metabolism | Interferons - biosynthesis | Beclin-1 - deficiency | Vesicular Transport Proteins - metabolism | Humans | Endoplasmic Reticulum - metabolism | Autophagy-Related Protein 5 - genetics | Autophagy-Related Protein-1 Homolog - metabolism | DNA Viruses - metabolism | Interferons - immunology | Autophagy | DNA Viruses - genetics | Sea Anemones | Membrane Proteins - deficiency | HEK293 Cells | Membrane Proteins - metabolism | Nucleotidyltransferases - metabolism | Protein-Serine-Threonine Kinases - metabolism | Phosphate-Binding Proteins | Signal Transduction | Membrane Proteins - genetics | DNA, Viral - metabolism | Class III Phosphatidylinositol 3-Kinases - metabolism | Autophagosomes - metabolism | Cytosol - virology | Protein Transport | Carrier Proteins - genetics | Animals | Autophagy-Related Protein-1 Homolog - deficiency | Carrier Proteins - metabolism | Monomeric GTP-Binding Proteins - metabolism | Autophagy-Related Protein 5 - deficiency | Autophagy-Related Protein 5 - metabolism | Beclin-1 - genetics | Golgi Apparatus - metabolism | Mice | Beclin-1 - metabolism | Autophagy-Related Protein-1 Homolog - genetics | Nucleotides, Cyclic - immunology | Evolution, Molecular | Biological research | Autophagy (Cytology) | Enzymes | Physiological aspects | Interferon | Research | Cytoplasm | Biology, Experimental
Journal Article
Cell host & microbe, ISSN 1931-3128, 11/2018, Volume 24, Issue 5, pp. 689 - 702.e7
... (FADD, RIPK1, RIPK3, and caspase 8) and autophagy (ATG5, ATG7, and SQSTM1) proteins. Genetic or pharmacological inhibition of autophagy induction, but not autophagy-mediated... 
caspase 8 | autophagy | HIV | CD4+ T cell | SMAC mimetics | apoptosis | XIAP | Fas | RIPK1 | BIRC2 | CD4+ T cell | Parasitology | Life Sciences & Biomedicine | Microbiology | Science & Technology | Virology | Receptor-Interacting Protein Serine-Threonine Kinases - metabolism | HIV-1 - pathogenicity | Apoptosis - drug effects | Autophagy-Related Protein 7 - metabolism | Cyclohexanes - pharmacology | Humans | Caspase 8 - metabolism | Autophagy - physiology | Intracellular Signaling Peptides and Proteins - metabolism | Autophagy - drug effects | CD4-Positive T-Lymphocytes - immunology | HIV Infections - immunology | HIV-1 - physiology | Mitochondrial Proteins - metabolism | Baculoviral IAP Repeat-Containing 3 Protein - metabolism | Cell Death | Indoles - pharmacology | Inhibitor of Apoptosis Proteins - metabolism | Sequestosome-1 Protein - metabolism | Cell Line | HIV-1 - drug effects | Dipeptides - pharmacology | Fas-Associated Death Domain Protein - metabolism | Ubiquitin-Protein Ligases - metabolism | Benzoquinones - pharmacology | Pyrroles - pharmacology | Apoptosis Regulatory Proteins | X-Linked Inhibitor of Apoptosis Protein - metabolism | Autophagy-Related Protein 5 - metabolism | Apoptosis - physiology | Beclin-1 - metabolism | Proteins | Medical colleges | Trout | Communicable diseases | T cells | HIV (Viruses) | Health aspects | HIV infection | Apoptosis
Journal Article
PloS one, ISSN 1932-6203, 04/2017, Volume 12, Issue 4, p. e0173676
.... Chronic administration of the PPARa agonist FB substantially reduced the levels of multiple autophagy proteins in the liver... 
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | TOR Serine-Threonine Kinases - metabolism | Autophagy-Related Protein 7 - metabolism | Fibroblast Growth Factors - genetics | Autophagy-Related Protein 5 - genetics | fas Receptor - metabolism | Autophagy - drug effects | Fibroblast Growth Factors - metabolism | TOR Serine-Threonine Kinases - genetics | Liver - drug effects | fas Receptor - genetics | Autophagy - genetics | Proto-Oncogene Proteins c-akt - metabolism | Forkhead Box Protein O1 - metabolism | Signal Transduction | Liver - metabolism | PPAR alpha - genetics | Ubiquitin-Conjugating Enzymes - genetics | Stearoyl-CoA Desaturase - genetics | Mice, Knockout | Triglycerides - metabolism | Sequestosome-1 Protein - genetics | Ubiquitin-Conjugating Enzymes - metabolism | Cysteine Endopeptidases - genetics | Autophagy-Related Protein 5 - metabolism | Beclin-1 - genetics | Stearoyl-CoA Desaturase - metabolism | Mice | PPAR alpha - metabolism | Autophagy-Related Proteins - antagonists & inhibitors | Blood Glucose - metabolism | Autophagy-Related Proteins - metabolism | Forkhead Box Protein O1 - genetics | Autophagy-Related Protein 5 - antagonists & inhibitors | Microtubule-Associated Proteins - genetics | Microtubule-Associated Proteins - metabolism | Proto-Oncogene Proteins c-akt - genetics | Fenofibrate - pharmacology | Cysteine Endopeptidases - metabolism | Autophagy-Related Proteins - genetics | Sequestosome-1 Protein - metabolism | Sterol Regulatory Element Binding Protein 1 - metabolism | Autophagy-Related Protein 7 - antagonists & inhibitors | Mice, Inbred C57BL | Autophagy-Related Protein 7 - genetics | Gene Expression Regulation - drug effects | Animals | Sterol Regulatory Element Binding Protein 1 - genetics | PPAR alpha - agonists | Ubiquitin-Conjugating Enzymes - antagonists & inhibitors | Beclin-1 - metabolism | Transcription factors | Adipose tissue | Liver | Body weight | AKT protein | Biochemistry | Glucose | Assaying | Proteins | Signal transduction | Temperature effects | Fibroblasts | Physiology | Acetylation | Inhibition | Growth factors | Hepatotoxicity | Activation analysis | Methanol | Starvation | Ethanol | AMP | Metabolism | Insulin | Fatty acids | Studies | Acetaminophen | Food intake | Weight reduction | Animal welfare | Circulation | Drugs | Biotechnology | Drug abuse | Laboratories | Centrifugation | Glass | Homeostasis | Activation | Biology | Kinases | AMP-activated protein kinase | Autophagy | Nutrient status | Rodents | Nutrients | Oxidation | Heart diseases | Age | Epinephrine | AKT1 protein | Fasting | Chloroform | Diabetes mellitus | Cardiomyocytes | Acclimatization | Triglycerides | Pharmacology | Nitrogen | Calories | Medicine | Nuclear fuels | Protein kinase | Insulin resistance | Diabetes
Journal Article
Biochemical journal, ISSN 1470-8728, 2011, Volume 441, Issue 2, pp. 523 - 540
...) proteins and 50 lysosomal hydrolases. Autophagosomes... 
Mitochondrion | Oxidative stress | Redox signalling | Neurodegeneration | Autophagy | Nitrative stress | Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Protein Kinases - metabolism | Transcription, Genetic - drug effects | Cardiovascular Diseases - physiopathology | Reactive Oxygen Species - metabolism | Oxidation-Reduction | Reactive Nitrogen Species - metabolism | Humans | Oxidative Stress - physiology | Hydrogen Peroxide - pharmacology | Oncogene Proteins - metabolism | Nitric Oxide - physiology | Autophagy - physiology | Intracellular Signaling Peptides and Proteins - metabolism | Mitochondria - metabolism | Mitochondria - pathology | Parkinson Disease - physiopathology | Lysosomes - physiology | Protein Deglycase DJ-1 | Animals | Signal Transduction - physiology | TOR Serine-Threonine Kinases - physiology | Neoplasms - physiopathology | neurodegeneration | AMPK, 5′-AMP-activated protein kinase | NBR1, neighbour of BRCA1 (breast cancer early-onset 1) | NGF, nerve growth factor | LC3, light chain 3 | NOX, NADPH oxidase | EM, electron microscopy | TOR, target of rapamycin | ULK, unc (unco-ordinated family member)-51-like kinase | mtDNA, mitochondrial DNA | mTOR, mammalian target of rapamycin | IKKβ, IκB kinase β | LRRK2, leucine-rich repeat kinase 2 | NAC, N-acetyl-L-cysteine | Nrf2, nuclear factor-erythroid 2-related factor 2 | PI3P, phosphatidylinositol 3-phosphate | autophagy | ECH, enoyl-CoA hydratase | BNIP3L, BNIP3-like | Drp1, dynamin-related protein 1 | tfLC3, tandem fluorescently tagged LC3 | NF-κB, nuclear factor κB | BAG, Bcl-2-associated athanogene | Keap1, Kelch-like ECH-associated protein 1 | PE, phosphatidylethanolamine | mitochondrion | 3-MA, 3-methyladenine | UCP, uncoupling protein | IκB, inhibitor of nuclear factor κB | FIP200, focal adhesion kinase family-interacting protein of 200 kDa | PI3K, phosphoinositide 3-kinase | HNE, 4-hydroxynonenal | Review | ALS, amyotrophic lateral sclerosis | redox signalling | ATG, AuTophaGy-related | adenovirus E18 19-kDa-interacting protein | Tzb, trastuzumab | mETC, mitochondrial electron-transport chain | Rubicon, RUN domain- and cysteine-rich domain-containing beclin-1-interacting protein | VDAC, voltage-dependent anion channel | IP3, inositol 1,4,5-trisphosphate | RFP, red fluorescent protein | ROS, reactive oxygen species | TNFα, tumour necrosis factor α | PINK1, PTEN (phosphatase and tensin homologue deleted on chromosome 10)-induced kinase 1 | GFP, green fluorescent protein | LAMP, lysosome-associated membrane protein | JNK1, c-Jun N-terminal kinase 1 | TAC, transverse aortic constriction | GABARAP, GABAA (γ-aminobutyric acid type A)-receptor-associated protein | HIF-1, hypoxia-inducible factor 1 | NOS, nitric oxide synthase | siRNA, small interfering RNA | SOD, superoxide dismutase | RLS, reactive lipid species | nitrative stress | RNS, reactive nitrogen species | ER, endoplasmic reticulum | TIGAR, TP53 (tumour protein 53)-induced glycolysis and apoptosis regulator | Vps34, vacuolar protein sorting 34 | oxidative stress | BNIP, Bcl-2
Journal Article
Autophagy, ISSN 1554-8635, 10/2014, Volume 7, Issue 12, pp. 1448 - 1461
.... Previously, we identified the human WIPI protein family and found that WIPI-1 specifically binds PtdIns(3... 
WIPI-1 | Atg18 | PtdInsP | LC3 | resveratrol | noncanonical autophagy | Binding | Proteins | Landes | Calcium | Bioscience | Biology | Cell | Cycle | Cancer | Organogenesis | Autophagy-Related Protein 12 | Cell Line | Autophagy-Related Proteins | Small Ubiquitin-Related Modifier Proteins/metabolism | Phosphatidylinositol Phosphates/metabolism | Protein Transport/drug effects | Humans | Autophagy/drug effects | Lipids/chemistry | Green Fluorescent Proteins/metabolism | Autophagy-Related Protein 7 | Animals | Autophagy-Related Protein 5 | Membrane Proteins/metabolism | Carrier Proteins/drug effects | Wortmannin | Resveratrol | Androstadienes/pharmacology | Stilbenes/pharmacology | Mice | Recombinant Fusion Proteins/metabolism | Phagosomes/drug effects | Ubiquitin-Activating Enzymes/metabolism | Microtubule-Associated Proteins/metabolism | Noncanonical autophagy | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Phosphatidylinositol Phosphates - metabolism | Microtubule-Associated Proteins - metabolism | Protein Transport - drug effects | Stilbenes - pharmacology | Carrier Proteins - drug effects | Recombinant Fusion Proteins - metabolism | Autophagy - drug effects | Lipids - chemistry | Phagosomes - ultrastructure | Membrane Proteins - metabolism | Phagosomes - drug effects | Green Fluorescent Proteins - metabolism | Small Ubiquitin-Related Modifier Proteins - metabolism | Phagosomes - metabolism | Ubiquitin-Activating Enzymes - metabolism | Carrier Proteins - metabolism | Androstadienes - pharmacology | Basic Research-Paper | Basic Research Paper
Journal Article
The Journal of cell biology, ISSN 1540-8140, 05/2008, Volume 181, Issue 3, pp. 497 - 510
Journal Article