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autophagy (1792) 1792
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microtubule-associated proteins - metabolism (698) 698
microtubule-associated proteins - genetics (604) 604
proteins (600) 600
apoptosis (561) 561
autophagy - drug effects (532) 532
biochemistry & molecular biology (501) 501
autophagy - genetics (499) 499
autophagy-related proteins (496) 496
autophagy-related protein 5 (460) 460
autophagy - physiology (436) 436
autophagy-related protein 7 (423) 423
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article (365) 365
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phosphorylation (275) 275
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protein (255) 255
beclin-1 (251) 251
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degradation (240) 240
cell line (234) 234
cells, cultured (224) 224
activation (222) 222
disease (220) 220
biology (214) 214
expression (214) 214
yeast (213) 213
mice, inbred c57bl (211) 211
autophagy-related proteins - metabolism (210) 210
membrane proteins - genetics (208) 208
physiological aspects (207) 207
genetic aspects (206) 206
inhibition (203) 203
phagosomes - metabolism (201) 201
saccharomyces cerevisiae proteins - metabolism (198) 198
saccharomyces-cerevisiae (196) 196
research article (193) 193
autophagy-related proteins - genetics (188) 188
gene expression (188) 188
mutation (183) 183
cell death (181) 181
carrier proteins - genetics (180) 180
apoptosis - drug effects (178) 178
protein binding (178) 178
cell-death (174) 174
genes (173) 173
protein-serine-threonine kinases - metabolism (173) 173
apoptosis regulatory proteins - metabolism (172) 172
kinases (168) 168
oncology (167) 167
oxidative stress (165) 165
intracellular signaling peptides and proteins - metabolism (163) 163
hela cells (161) 161
tor serine-threonine kinases - metabolism (161) 161
selective autophagy (159) 159
complex (158) 158
homeostasis (157) 157
saccharomyces cerevisiae - metabolism (156) 156
autophagy-related protein-1 homolog (151) 151
pathway (150) 150
analysis (149) 149
lc3 (149) 149
mitochondria (149) 149
death (148) 148
hek293 cells (148) 148
saccharomyces cerevisiae proteins - genetics (146) 146
adaptor proteins, signal transducing - metabolism (144) 144
signal transduction - drug effects (144) 144
medicine (141) 141
ubiquitin-activating enzymes - genetics (141) 141
autophagy-related protein 5 - genetics (140) 140
binding (140) 140
lysosomes - metabolism (140) 140
health aspects (139) 139
mechanisms (138) 138
ubiquitin-activating enzymes - metabolism (138) 138
gene expression regulation (137) 137
amino acid sequence (134) 134
autophagy-related protein 8 family (133) 133
autophagy-related protein 5 - metabolism (131) 131
apoptosis regulatory proteins - genetics (130) 130
starvation (130) 130
carrier proteins - metabolism (129) 129
mitochondria - metabolism (128) 128
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Molecular Cell, ISSN 1097-2765, 05/2016, Volume 62, Issue 4, pp. 491 - 506
ULK1 and ULK2 are thought to be essential for initiating autophagy, and -deficient mice die perinatally of autophagy-related defects. Therefore, we used a... 
SEROTONIN TRANSPORTER | BIOGENESIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | EXIT SITES | EXPORT | NEURONS | AUTOPHAGOSOME FORMATION | ULK1 | COMPONENT | HOMOLOG | PROTEINS | CELL BIOLOGY | Golgi Apparatus - enzymology | Protein-Serine-Threonine Kinases - deficiency | Fibroblasts - enzymology | Phosphorylation | Vesicular Transport Proteins - metabolism | Autophagy-Related Protein 7 - metabolism | Humans | Brain - enzymology | Caenorhabditis elegans Proteins - metabolism | Homeostasis | Male | Autophagy-Related Protein-1 Homolog - metabolism | Golgi Apparatus - pathology | Mice, 129 Strain | Autophagy | Endoplasmic Reticulum - pathology | Transfection | RNA Interference | Time Factors | HEK293 Cells | Female | Nuclear Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | Endoplasmic Reticulum - enzymology | Caenorhabditis elegans - genetics | Mice, Inbred C57BL | Vesicular Transport Proteins - genetics | Protein-Serine-Threonine Kinases - genetics | Genotype | Nuclear Proteins - metabolism | Unfolded Protein Response | Autophagy-Related Protein 7 - genetics | Mice, Knockout | Protein Transport | Carrier Proteins - genetics | Phenotype | Animals | Autophagy-Related Protein-1 Homolog - deficiency | COP-Coated Vesicles - enzymology | Carrier Proteins - metabolism | Brain - pathology | Nerve Degeneration | Autophagy-Related Protein-1 Homolog - genetics | Caenorhabditis elegans - enzymology | Proteins | Neurons | Phosphoproteins | Cells
Journal Article
Aging Cell, ISSN 1474-9718, 10/2017, Volume 16, Issue 5, pp. 976 - 987
Aging is accompanied with unfavorable geometric and functional changes in the heart involving dysregulation of Akt and autophagy. This study examined the... 
cardiac geometry | contractile function | autophagy | aging | Akt | RAPAMYCIN | PROTEIN-KINASE | DIASTOLIC DYSFUNCTION | CELL BIOLOGY | GERIATRICS & GERONTOLOGY | HYPERTROPHY | LONGEVITY | OVEREXPRESSION | INSULIN-RESISTANCE | CALORIC RESTRICTION | SENESCENCE | MITOCHONDRIAL INJURY | Adaptation, Physiological | Protein Kinases - metabolism | Sirtuin 1 - metabolism | Phosphorylation | Protein Kinases - genetics | Microtubule-Associated Proteins - genetics | Calcium - metabolism | Microtubule-Associated Proteins - metabolism | Autophagy-Related Protein 7 - metabolism | Proto-Oncogene Proteins c-akt - deficiency | Atrial Remodeling - drug effects | Myocardial Contraction - drug effects | Cardiomegaly - pathology | Male | Mitochondrial Proteins - genetics | Sirtuin 1 - genetics | Autophagy - drug effects | Heterocyclic Compounds, 4 or More Rings - pharmacology | Proto-Oncogene Proteins c-akt - genetics | Mitochondrial Proteins - metabolism | Myocardium - metabolism | Membrane Proteins - metabolism | Autophagy - genetics | Forkhead Box Protein O1 - metabolism | Sarcoplasmic Reticulum Calcium-Transporting ATPases - metabolism | Signal Transduction | Membrane Proteins - genetics | Gene Expression Regulation | Myocardium - pathology | Mitochondria - metabolism | Longevity - genetics | Mitochondria - pathology | Autophagy-Related Protein 7 - genetics | Sirolimus - pharmacology | Mice, Knockout | Animals | Cardiomegaly - prevention & control | Beclin-1 - genetics | Mice | Beclin-1 - metabolism | Cardiomegaly - genetics | Sarcoplasmic Reticulum Calcium-Transporting ATPases - genetics | Forkhead Box Protein O1 - genetics | Cardiomegaly - metabolism | Heart | Laws, regulations and rules | Ablation (Surgery) | AKT protein | Autophagy | Ca2+-transporting ATPase | Mitochondria | FOXO1 protein | Aging | Oxidation | Fura-2 | Acetylation | Heart diseases | Calcium (intracellular) | Echocardiography | Contractility | AKT2 protein | Cardiomyocytes | Rapamycin | Insulin | Muscle contraction | BNIP3 protein | Life span | PTEN-induced putative kinase | Parkin protein | Intracellular | PTEN protein | Phagocytosis | Hypertrophy | Original
Journal Article
PLoS ONE, ISSN 1932-6203, 04/2017, Volume 12, Issue 4, pp. e0173676 - e0173676
Autophagy is a catabolic mechanism to degrade cellular components to maintain cellular energy levels during starvation, a condition where PPAR alpha may be... 
INSULIN SIGNALING TRANSDUCTION | GLUCOSE-HOMEOSTASIS | FIBROBLAST-GROWTH-FACTOR-21 | DEACETYLATION | METABOLISM | PATHWAY | STEATOSIS | MULTIDISCIPLINARY SCIENCES | RESISTANCE | RECEPTORS | FOXO1 | TOR Serine-Threonine Kinases - metabolism | Autophagy-Related Protein 7 - metabolism | Fibroblast Growth Factors - genetics | Autophagy-Related Protein 5 - genetics | fas Receptor - metabolism | Autophagy - drug effects | Fibroblast Growth Factors - metabolism | TOR Serine-Threonine Kinases - genetics | Liver - drug effects | fas Receptor - genetics | Autophagy - genetics | Proto-Oncogene Proteins c-akt - metabolism | Forkhead Box Protein O1 - metabolism | Signal Transduction | Liver - metabolism | PPAR alpha - genetics | Ubiquitin-Conjugating Enzymes - genetics | Stearoyl-CoA Desaturase - genetics | Mice, Knockout | Triglycerides - metabolism | Sequestosome-1 Protein - genetics | Ubiquitin-Conjugating Enzymes - metabolism | Cysteine Endopeptidases - genetics | Autophagy-Related Protein 5 - metabolism | Beclin-1 - genetics | Stearoyl-CoA Desaturase - metabolism | Mice | PPAR alpha - metabolism | Autophagy-Related Proteins - antagonists & inhibitors | Blood Glucose - metabolism | Autophagy-Related Proteins - metabolism | Forkhead Box Protein O1 - genetics | Autophagy-Related Protein 5 - antagonists & inhibitors | Microtubule-Associated Proteins - genetics | Microtubule-Associated Proteins - metabolism | Proto-Oncogene Proteins c-akt - genetics | Fenofibrate - pharmacology | Cysteine Endopeptidases - metabolism | Autophagy-Related Proteins - genetics | Sequestosome-1 Protein - metabolism | Sterol Regulatory Element Binding Protein 1 - metabolism | Autophagy-Related Protein 7 - antagonists & inhibitors | Mice, Inbred C57BL | Autophagy-Related Protein 7 - genetics | Gene Expression Regulation - drug effects | Animals | Sterol Regulatory Element Binding Protein 1 - genetics | PPAR alpha - agonists | Ubiquitin-Conjugating Enzymes - antagonists & inhibitors | Beclin-1 - metabolism | Transcription factors | Adipose tissue | Liver | Body weight | AKT protein | Biochemistry | Glucose | Assaying | Proteins | Signal transduction | Temperature effects | Fibroblasts | Physiology | Acetylation | Inhibition | Growth factors | Hepatotoxicity | Activation analysis | Methanol | Starvation | Ethanol | AMP | Metabolism | Insulin | Fatty acids | Studies | Acetaminophen | Food intake | Weight reduction | Animal welfare | Circulation | Drugs | Biotechnology | Drug abuse | Laboratories | Centrifugation | Glass | Homeostasis | Activation | Biology | Kinases | AMP-activated protein kinase | Autophagy | Nutrient status | Rodents | Nutrients | Oxidation | Heart diseases | Age | Epinephrine | AKT1 protein | Fasting | Chloroform | Diabetes mellitus | Cardiomyocytes | Acclimatization | Triglycerides | Pharmacology | Nitrogen | Calories | Medicine | Nuclear fuels | Protein kinase | Insulin resistance | Diabetes | Index Medicus
Journal Article
Journal Article
Molecular Cell, ISSN 1097-2765, 07/2017, Volume 67, Issue 1, pp. 84 - 95.e5
Journal Article
Cell Death and Disease, ISSN 2041-4889, 10/2017, Volume 8, Issue 10, pp. e3118 - e3118
Highly upregulated in liver cancer (HULC) is a long noncoding RNA (lncRNA), which has recently been identified as a key regulator in the progression of... 
BINDING-PROTEIN P62 | HEPATOCELLULAR-CARCINOMA | CANCER CELLS | SIGNALING PATHWAY | BRAIN-INJURY | POOR-PROGNOSIS | PANCREATIC-CANCER | MAMMALIAN AUTOPHAGY | NONCODING RNA HULC | CELL-DEATH | CELL BIOLOGY | RNA, Small Interfering - genetics | Microtubule-Associated Proteins - metabolism | Autophagy-Related Protein 7 - metabolism | Humans | Ovarian Neoplasms - pathology | Apoptosis - genetics | Cell Movement - genetics | Ovarian Neoplasms - genetics | Neoplasms, Glandular and Epithelial - genetics | RNA Interference | Female | Autophagy - genetics | Sequestosome-1 Protein - metabolism | Neoplasms, Glandular and Epithelial - pathology | Oncogenes - genetics | Cell Proliferation - genetics | Lysosome-Associated Membrane Glycoproteins - metabolism | Carcinogenesis - genetics | RNA, Long Noncoding - genetics | Autophagy-Related Protein 7 - genetics | Integrin beta1 - metabolism | Sequestosome-1 Protein - genetics | Animals | Mice, Nude | Carcinoma, Ovarian Epithelial | Cell Line, Tumor | Mice | Mice, Inbred BALB C | Integrin beta1 - genetics | Cell proliferation | Immunoprecipitation | Leukocyte migration | Ovarian carcinoma | Invasiveness | Hepatocellular carcinoma | siRNA | Gene expression | Autophagy | Ovarian cancer | Cell adhesion & migration | Polymerase chain reaction | Liver cancer | Cell growth | Transfection | Tumorigenesis | Protein interaction | Gastric cancer | Phagocytosis | Cell migration | Apoptosis | Tumors | Original
Journal Article
Nature, ISSN 0028-0836, 11/2018, Volume 563, Issue 7732, pp. 569 - 573
Autophagy captures intracellular components and delivers them to lysosomes, where they are degraded and recycled to sustain metabolism and to enable survival... 
ARGININOSUCCINATE SYNTHETASE EXPRESSION | HOMEOSTASIS | MELANOMA | CANCERS | DEPRIVATION | MULTIDISCIPLINARY SCIENCES | METABOLOMIC ANALYSIS | SUPPRESSION | DEFICIENCY | CYCLE | AGE | Neoplasm Transplantation | Liver - enzymology | Autophagy-Related Protein 7 - metabolism | Arginase - metabolism | Male | Autophagy-Related Protein 5 - genetics | Hepatocytes - metabolism | Arginine - administration & dosage | Allografts | Neoplasms - blood | Neoplasms - genetics | Autophagy - genetics | Arginase - blood | Cell Proliferation - genetics | Ornithine - metabolism | Carcinogenesis - genetics | Autophagy-Related Protein 7 - genetics | Carcinogenesis - drug effects | Animals | Arginine - blood | Arginine - pharmacology | Autophagy-Related Protein 5 - deficiency | Cell Proliferation - drug effects | Mice | Neoplasms - pathology | Dietary Supplements | Autophagy-Related Protein 7 - deficiency | Hepatocytes - enzymology | Autophagy (Cytology) | Arginine | Growth | Health aspects | Cancer cells | Tumors | Adipose tissues | Enzymes | Glycogen | Analysis | Liver | Dietary supplements | Physiological aspects | Cancer | Animal models | Adipose tissue | Lysosomes | Arginase | Biosynthesis | Malignancy | Gene deletion | Polyamines | Auxotrophs | Autophagy | Degradation | Proteins | Clonal deletion | Metabolites | Deletion | Tumorigenesis | Supplementation | Phenotypes | Starvation | Melanoma | Muscles | Argininosuccinate synthase | Regression analysis | Tumor cell lines | Metabolism | Survival | Intolerance | Diet | Hepatocytes | Cell lines | Stem cells | Ornithine | Phagocytosis | Apoptosis
Journal Article
Nature Communications, ISSN 2041-1723, 12/2018, Volume 9, Issue 1, pp. 1944 - 12
Cancer recurrence after initial diagnosis and treatment is a major cause of breast cancer (BC) mortality, which results from the metastatic outbreak of dormant... 
INHIBITION | ROLES | MULTIDISCIPLINARY SCIENCES | GROWTH | EXTRACELLULAR-MATRIX | MECHANISMS | MITOPHAGY | OUTGROWTH | CARCINOMA | PROGRESSION | PRINCIPLES | RNA, Small Interfering - genetics | Recurrence | Reactive Oxygen Species - metabolism | Autophagy-Related Protein 7 - metabolism | Humans | Gene Expression Regulation, Neoplastic | Autophagy - drug effects | Reactive Oxygen Species - agonists | Breast Neoplasms - metabolism | Caspases - metabolism | Female | Autophagy - genetics | Mammary Neoplasms, Animal - genetics | Autophagy-Related Protein 7 - antagonists & inhibitors | Cell Survival - drug effects | Adenine - analogs & derivatives | Signal Transduction | Caspases - genetics | Beclin-1 - antagonists & inhibitors | Adenine - pharmacology | Lymphatic Metastasis | Mitochondria - metabolism | Mitochondria - drug effects | Mitochondria - pathology | Autophagy-Related Protein 7 - genetics | Mammary Neoplasms, Animal - pathology | Animals | Breast Neoplasms - genetics | Breast Neoplasms - pathology | Mice, Nude | Mammary Neoplasms, Animal - metabolism | Beclin-1 - genetics | Cell Line, Tumor | Hydroxychloroquine - pharmacology | Cell Proliferation - drug effects | Collagen Type I - pharmacology | Mammary Neoplasms, Animal - drug therapy | Mice | Beclin-1 - metabolism | RNA, Small Interfering - metabolism | Cell proliferation | Animal models | Cell survival | Outbreaks | Breast cancer | Pharmacology | Metastasis | Autophagy | Survival | Metastases | Dormancy | Signal transduction | Mitochondria | Inhibition | Damage accumulation | Phagocytosis | Cancer | Tumors | Apoptosis
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 2017, Volume 292, Issue 33, pp. 13795 - 13808
In the adult brain, programmed death of neural stem cells is considered to be critical for tissue homeostasis and cognitive function and is dysregulated in... 
SURVIVAL | APOPTOSIS | PATHWAY | BIOCHEMISTRY & MOLECULAR BIOLOGY | P62/SQSTM1 | MITOCHONDRIA | DEGRADATION | MITOPHAGY | PROLIFERATION | MECHANISMS | INSULIN WITHDRAWAL | AMP-Activated Protein Kinases - metabolism | Autophagy-Related Protein 7 - metabolism | Humans | Protein Transport - drug effects | Hippocampus - drug effects | Neural Stem Cells - cytology | Recombinant Fusion Proteins - metabolism | Autophagy - drug effects | Protein Processing, Post-Translational - drug effects | RNA Interference | Gene Deletion | Phosphorylation - drug effects | Sequestosome-1 Protein - metabolism | Adult Stem Cells - drug effects | Autophagy-Related Protein 7 - antagonists & inhibitors | Cell Survival - drug effects | Nerve Tissue Proteins - antagonists & inhibitors | Adult Stem Cells - cytology | AMP-Activated Protein Kinases - antagonists & inhibitors | Sequestosome-1 Protein - antagonists & inhibitors | Cells, Cultured | Neural Stem Cells - drug effects | Rats | Recombinant Fusion Proteins - chemistry | Enzyme Activation - drug effects | Hippocampus - cytology | Autophagy-Related Protein 7 - genetics | Nerve Tissue Proteins - genetics | AMP-Activated Protein Kinases - chemistry | Nerve Tissue Proteins - metabolism | Hippocampus - metabolism | Point Mutation | Sequestosome-1 Protein - genetics | Adult Stem Cells - metabolism | Animals | Protein Kinase Inhibitors - pharmacology | Neural Stem Cells - metabolism | AMP-Activated Protein Kinases - genetics | Amino Acid Substitution | AMP-activated kinase (AMPK) | mitophagy | autophagy | phosphorylation | p62 (sequestosome 1 (SQSTM1)) | Protein Synthesis and Degradation
Journal Article
Nature Cell Biology, ISSN 1465-7392, 04/2018, Volume 20, Issue 4, pp. 465 - 478
The contribution of autophagy to cancer development remains controversial, largely owing to the fact that autophagy can be tumour suppressive or oncogenic in... 
HOMEOSTASIS | CELL-CULTURE METHODS | PROTEIN STABILITY | MECHANISM | UBIQUITIN LIGASE | PHOSPHORYLATION | PATHWAY | SWITCH | CANCER | EXPRESSION | CELL BIOLOGY | Nedd4 Ubiquitin Protein Ligases - metabolism | Phosphorylation | Cell Proliferation | Autophagy-Related Protein 7 - metabolism | Humans | Gene Expression Regulation, Neoplastic | Casein Kinase Ialpha - genetics | Lung Neoplasms - pathology | Autophagy | Forkhead Box Protein O3 - genetics | Ubiquitination | Time Factors | Cell Transformation, Neoplastic - genetics | HEK293 Cells | Female | Protein Interaction Domains and Motifs | Proto-Oncogene Proteins c-akt - metabolism | Carcinoma, Non-Small-Cell Lung - pathology | Lung Neoplasms - genetics | A549 Cells | PTEN Phosphohydrolase - genetics | Lung Neoplasms - enzymology | Signal Transduction | Carcinoma, Non-Small-Cell Lung - genetics | HCT116 Cells | Enzyme Stability | PTEN Phosphohydrolase - metabolism | Tumor Burden | Autophagy-Related Protein 7 - genetics | Cell Transformation, Neoplastic - metabolism | Forkhead Box Protein O3 - metabolism | Animals | Mice, Nude | Protein Binding | Mice, Inbred BALB C | Carcinoma, Non-Small-Cell Lung - enzymology | Cell Transformation, Neoplastic - pathology | Genes, ras | Casein Kinase Ialpha - metabolism | Transcription | Epithelial cells | Lung cancer | Casein kinase I | Non-small cell lung carcinoma | AKT protein | Casein | Lungs | Tumorigenesis | PTEN protein | Phagocytosis | Tumors | FOXO3 protein | Cancer
Journal Article
Journal Article