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eLife, ISSN 2050-084X, 11/2016, Volume 5, Issue 2016
Selective autophagy is mediated by cargo receptors that link the cargo to the isolation membrane via interactions with Atg8 proteins... 
MOLECULAR-DYNAMICS | ATG12-ATG5 CONJUGATE | SWISS-MODEL WORKSPACE | STRUCTURAL BASIS | MEMBRANE | IN-VIVO | BIOLOGY | SCAFFOLD PROTEIN | UBIQUITIN-LIKE PROTEINS | SACCHAROMYCES-CEREVISIAE | LIPIDATION | Saccharomyces cerevisiae - genetics | Vesicular Transport Proteins - metabolism | Humans | Transcription Factor TFIIIA - genetics | Autophagy-Related Protein 5 - chemistry | Autophagy-Related Protein 5 - genetics | Autophagy-Related Protein 8 Family - metabolism | Transcription Factor TFIIIA - metabolism | Autophagy-Related Proteins - chemistry | Saccharomyces cerevisiae - metabolism | Biological Transport | Cloning, Molecular | Escherichia coli - metabolism | Protein Interaction Domains and Motifs | Autophagy - genetics | Autophagy-Related Protein 8 Family - genetics | Nuclear Proteins - genetics | Autophagy-Related Proteins - genetics | Binding Sites | Sequestosome-1 Protein - metabolism | Recombinant Proteins - metabolism | Amino Acid Sequence | Autophagy-Related Protein 12 - genetics | Protein Structure, Secondary | Signal Transduction | Vesicular Transport Proteins - genetics | Gene Expression Regulation | Receptors, Cell Surface - metabolism | Recombinant Proteins - chemistry | Nuclear Proteins - metabolism | Receptors, Cytoplasmic and Nuclear - genetics | Recombinant Proteins - genetics | Autophagy-Related Protein 8 Family - chemistry | Saccharomyces cerevisiae Proteins - genetics | Autophagy-Related Protein 12 - metabolism | Sequestosome-1 Protein - genetics | Escherichia coli - genetics | Saccharomyces cerevisiae Proteins - metabolism | Autophagy-Related Protein 5 - metabolism | Protein Binding | Molecular Docking Simulation | HeLa Cells | Autophagy-Related Proteins - metabolism | Receptors, Cell Surface - genetics | Receptors, Cytoplasmic and Nuclear - metabolism | Saccharomyces cerevisiae Proteins - chemistry | Observations | Autophagy (Cytology) | Ubiquitin | Proteins | Enzymes | Membranes | Peptides | Laboratories | Kinases | Autophagy | Phagocytosis | Binding sites | Recruitment
Journal Article
Developmental cell, ISSN 1534-5807, 2016, Volume 38, Issue 1, pp. 86 - 99
Journal Article
Structure (London), ISSN 0969-2126, 2015, Volume 23, Issue 10, pp. 1848 - 1857
The ULK1 complex, consisting of the ULK1 protein kinase itself, FIP200, Atg13, and Atg101, controls the initiation of autophagy in animals... 
protein structure | hydrogen-deuterium exchange | X-ray crystallography | Atg1 | autophagy | DOMAIN | PROTEIN | MECHANISM | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | AUTOPHAGY | IDENTIFICATION | CELL BIOLOGY | BIOPHYSICS | ROLES | ARCHITECTURE | KINASE ULK1 | BINDING | Adaptor Proteins, Signal Transducing - chemistry | Autophagy-Related Proteins | Mad2 Proteins - metabolism | Vesicular Transport Proteins - metabolism | Humans | Protein Multimerization | Molecular Sequence Data | Crystallography, X-Ray | Intracellular Signaling Peptides and Proteins - metabolism | Autophagy-Related Protein-1 Homolog | Spodoptera | Schizosaccharomyces - genetics | Sf9 Cells | Autophagy - genetics | Binding Sites | Intracellular Signaling Peptides and Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | Protein Structure, Tertiary | Recombinant Proteins - metabolism | Amino Acid Sequence | Gene Expression | Protein Structure, Secondary | Vesicular Transport Proteins - genetics | Protein-Serine-Threonine Kinases - genetics | Models, Molecular | Recombinant Proteins - chemistry | Vesicular Transport Proteins - chemistry | Mad2 Proteins - chemistry | Recombinant Proteins - genetics | Benzamidines - chemistry | Schizosaccharomyces - metabolism | Sequence Alignment | Animals | Intracellular Signaling Peptides and Proteins - chemistry | Adaptor Proteins, Signal Transducing - genetics | Mad2 Proteins - genetics | Hydrophobic and Hydrophilic Interactions | Protein Binding | Protein-Serine-Threonine Kinases - chemistry | Mutation | Adaptor Proteins, Signal Transducing - metabolism | Proteins | Cells | Hydrogen | Protein kinases
Journal Article
EMBO reports, ISSN 1469-3178, 2009, Volume 11, Issue 1, pp. 45 - 51
.... Recent evidence indicates that autophagy mediates selective removal of protein aggregates, organelles and microbes in cells... 
mitophagy | Nix | LC3 | GABARAP | selective autophagy | Selective autophagy | Mitophagy | APOPTOSIS | PROTEIN | RETICULOCYTE MATURATION | UBIQUITIN | BNIP3 | BIOCHEMISTRY & MOLECULAR BIOLOGY | E3 | CELL-DEATH | CELL BIOLOGY | STRUCTURAL BASIS | DEGRADATION | Microtubule-Associated Proteins - genetics | Microtubule-Associated Proteins - metabolism | Humans | Cercopithecus aethiops | Molecular Sequence Data | Substrate Specificity | Autophagy - physiology | Mitochondrial Proteins - genetics | Proto-Oncogene Proteins - chemistry | Mitochondrial Proteins - metabolism | Tumor Suppressor Proteins - chemistry | Tumor Suppressor Proteins - genetics | Membrane Proteins - metabolism | Binding Sites | Proto-Oncogene Proteins - metabolism | Amino Acid Sequence | Tumor Suppressor Proteins - metabolism | Membrane Proteins - genetics | Cells, Cultured | Ubiquitin-Protein Ligases - metabolism | Proto-Oncogene Proteins - genetics | Mitochondria - metabolism | Saccharomyces cerevisiae Proteins - genetics | Blotting, Western | Amino Acid Motifs | Autophagy-Related Protein 8 Family | Animals | Membrane Proteins - chemistry | Reticulocytes - cytology | Mitochondrial Proteins - chemistry | Saccharomyces cerevisiae Proteins - metabolism | Protein Binding | Mice | Receptors, GABA-A - metabolism | COS Cells | Proteins | Mitochondria | Cellular biology | Cytoplasm | Scientific Report
Journal Article
FEBS Letters, ISSN 0014-5793, 07/2015, Volume 589, Issue 16, pp. 2100 - 2109
... protein aggregates [2] . Since autophagy contributes to cell growth, adaptation, and differentiation, its malfunction is intimately associated with human diseases [3... 
Screening | G6PT | ULK1 | ATG9 | Autophagy modulator | glucose-6-phosphate transporter | N-terminus of Venus vector | chlorogenic acid | BiFC | bimolecular fluorescence complementation | CHA | C-terminus of Venus vector | NEURODEGENERATIVE DISEASE | DISEASE TYPE-IB | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL-GROWTH | MACROAUTOPHAGY | MTOR | CELL BIOLOGY | MAMMALIAN ATG PROTEINS | FORMATION SITE | BIOPHYSICS | SIGNALING PATHWAY | AMINO-ACIDS | ANTIPORTER DEFICIENT | Up-Regulation | TOR Serine-Threonine Kinases - metabolism | Vesicular Transport Proteins - metabolism | Humans | Intracellular Signaling Peptides and Proteins - metabolism | Multiprotein Complexes - metabolism | RNA Interference | Intracellular Signaling Peptides and Proteins - genetics | Monosaccharide Transport Proteins - metabolism | Peptide Fragments - genetics | Protein-Serine-Threonine Kinases - metabolism | Monosaccharide Transport Proteins - genetics | Membrane Proteins - genetics | Phagosomes - metabolism | Recombinant Proteins - chemistry | Antiporters - metabolism | Recombinant Fusion Proteins - chemistry | Huntingtin Protein | Peptide Fragments - chemistry | Models, Biological | Protein-Serine-Threonine Kinases - chemistry | Antiporters - antagonists & inhibitors | Hepatocytes - enzymology | Autophagy-Related Proteins | Phagosomes - enzymology | Cricetulus | Hepatocytes - metabolism | Autophagy | Recombinant Fusion Proteins - metabolism | Autophagy-Related Protein-1 Homolog | Mechanistic Target of Rapamycin Complex 1 | Multiprotein Complexes - antagonists & inhibitors | TOR Serine-Threonine Kinases - antagonists & inhibitors | Hepatocytes - cytology | Nerve Tissue Proteins - chemistry | Antiporters - genetics | Membrane Proteins - metabolism | Protein Interaction Domains and Motifs | Monosaccharide Transport Proteins - antagonists & inhibitors | Recombinant Proteins - metabolism | Cell Line | Peptide Fragments - metabolism | Vesicular Transport Proteins - genetics | Protein-Serine-Threonine Kinases - genetics | Mutant Proteins - metabolism | Vesicular Transport Proteins - chemistry | Recombinant Proteins - genetics | Nerve Tissue Proteins - genetics | Protein Transport | Nerve Tissue Proteins - metabolism | Animals | Membrane Proteins - chemistry | Intracellular Signaling Peptides and Proteins - chemistry | Mutant Proteins - chemistry | Amino Acid Substitution | Phosphates | Enzymes | Glucose | Analysis | Dextrose
Journal Article
Molecular cell, ISSN 1097-2765, 2015, Volume 59, Issue 2, pp. 285 - 297
.... Here, we screened degenerate peptide libraries to deduce the optimal ULK1 substrate motif and discovered 15 phosphorylation sites in core autophagy proteins that were verified as in vivo ULK1 targets... 
MAMMALIAN TARGET | COMPLEX | POTENT | PROTEIN | ATG101 | BIOCHEMISTRY & MOLECULAR BIOLOGY | AMPK | BINDING | TUMORS | MTOR | DIRECT PHOSPHORYLATION | CELL BIOLOGY | Consensus Sequence | Protein-Serine-Threonine Kinases - deficiency | RNA, Small Interfering - genetics | Phosphorylation | Humans | Molecular Sequence Data | Substrate Specificity | Autophagy - physiology | Intracellular Signaling Peptides and Proteins - metabolism | Autophagy - drug effects | Pyrimidines - chemistry | Autophagy-Related Protein-1 Homolog | Protein Kinase Inhibitors - chemistry | HEK293 Cells | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Benzamides - pharmacology | Intracellular Signaling Peptides and Proteins - genetics | Cell Survival - physiology | Protein-Serine-Threonine Kinases - metabolism | Benzamides - chemistry | Recombinant Proteins - metabolism | Amino Acid Sequence | Cell Survival - drug effects | Intracellular Signaling Peptides and Proteins - antagonists & inhibitors | Catalytic Domain - genetics | Cells, Cultured | Protein-Serine-Threonine Kinases - genetics | Recombinant Proteins - chemistry | Recombinant Proteins - genetics | Pyrimidines - pharmacology | Gene Knockout Techniques | Animals | Mice | Protein Kinase Inhibitors - pharmacology | Proteins | Medical colleges | Medical research | Cell death | Medicine, Experimental | Cellular signal transduction | Research institutes | Cells
Journal Article
Journal Article
The Journal of biological chemistry, ISSN 1083-351X, 2006, Volume 281, Issue 6, pp. 3017 - 3024
Journal Article
Autophagy, ISSN 1554-8635, 2014, Volume 7, Issue 9, pp. 993 - 1010
Journal Article
Journal Article
Nature communications, ISSN 2041-1723, 2017, Volume 8, Issue 1
Autophagy is controlled by AMPK and mTOR, both of which associate with ULK1 and control the production of phosphatidylinositol 3-phosphate (PtdIns3P), a... 
TSC1-TSC2 COMPLEX | PROTEIN CONJUGATION SYSTEM | PHOSPHATIDYLINOSITOL 3-PHOSPHATE | PHOSPHORYLATION | MEMBRANE | MULTIDISCIPLINARY SCIENCES | KINASE | LC3 LIPIDATION | BINDING-SITES | IDENTIFICATION | REPEAT PROTEIN
Journal Article