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FEBS Letters, ISSN 0014-5793, 2010, Volume 584, Issue 7, pp. 1287 - 1295
Nutrient starvation induces autophagy in eukaryotic cells through inhibition of TOR (target of rapamycin), an evolutionarily-conserved protein kinase. TOR, as... 
Autophagy-related gene 1 | UNC-51-like kinase 1 | UNC-51-like kinase 2 | Mammalian target of rapamycin | Autophagy-related gene 13 | raptor | mTOR complex 2 | mTOR complex 1 | tuberous sclerosis complex | human ortholog of yeast vacuolar protein sorting 34 | GABARAP | focal adhesion kinase (FAK) family interacting protein of 200 kDa | mammalian target of rapamycin | γ-aminobutyric acid (GABA) receptor associated protein | Rheb | mTOR | regulatory associated protein of mTOR | GAP1 | rapamycin insensitive companion of mTOR | protein kinase B | GATE-16 | TSC | PKB | general amino acid permease 1 | Autophagy-related gene | trans-Golgi network | Golgi-associated ATPase enhancer of 16 kDa | rictor | Atg | 5′-AMP-activated protein kinase | FIP200 | AMPK | ULK2 | ras homolog enriched in brain | hVps34 | ULK1 | TGN | mTORC2 | mTORC1 | BINDING PARTNER | SIGNALING PATHWAYS | RAG GTPASES | PHOSPHATIDYLINOSITOL 3-KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | SACCHAROMYCES-CEREVISIAE | P70 S6 KINASE | CELL BIOLOGY | BIOPHYSICS | PROTEIN-KINASE COMPLEX | INHIBITS CELL-GROWTH | ENDOPLASMIC-RETICULUM | C-ELEGANS | Saccharomyces cerevisiae - cytology | Animals | Models, Biological | Stress, Physiological | Saccharomyces cerevisiae - enzymology | Intracellular Signaling Peptides and Proteins - metabolism | Protein-Serine-Threonine Kinases - chemistry | TOR Serine-Threonine Kinases | Autophagy | Protein-Serine-Threonine Kinases - metabolism | Tuberous sclerosis | GABA | Protein kinases | Atg1 | Atg13
Journal Article
Annals of the Rheumatic Diseases, ISSN 0003-4967, 07/2015, Volume 74, Issue 7, pp. 1432 - 1440
ObjectivesMammalian target of rapamycin (mTOR) (a serine/threonine protein kinase) is a major repressor of autophagy, a cell survival mechanism. The specific... 
RAPAMYCIN | LIFE-SPAN | MOUSE | KINASE | GROWTH | ACTIVATED-RECEPTOR-GAMMA | AMPK | ULK1 | MODEL | RHEUMATOLOGY | AMP-Activated Protein Kinases - metabolism | TOR Serine-Threonine Kinases - metabolism | Humans | Middle Aged | Male | Autophagy - physiology | Intracellular Signaling Peptides and Proteins - metabolism | TOR Serine-Threonine Kinases - deficiency | Autophagy-Related Protein-1 Homolog | Chondrocytes - drug effects | Cartilage, Articular - metabolism | Up-Regulation - physiology | Aged, 80 and over | Osteoarthritis - pathology | Immunosuppressive Agents - pharmacology | Intracellular Signaling Peptides and Proteins - genetics | Chondrocytes - metabolism | Protein-Serine-Threonine Kinases - metabolism | Disease Models, Animal | Chondrocytes - pathology | Osteoarthritis - prevention & control | Mice, Inbred C57BL | Cells, Cultured | Gene Silencing | Protein-Serine-Threonine Kinases - genetics | Osteoarthritis - metabolism | Sirolimus - pharmacology | Matrix Metalloproteinase 13 - metabolism | Mice, Knockout | Cartilage, Articular - pathology | Animals | Dogs | Signal Transduction - physiology | Aged | Mice | Apoptosis - physiology | Cartilage, Articular - drug effects | Physiology, Pathological | Care and treatment | Analysis | Cellular signal transduction | Research | Gene expression | Osteoarthritis | Proteins | Studies | Phosphorylation | Genes | Rodents | Surgery | Homeostasis | Arthritis | Kinases | Autophagy
Journal Article
Autophagy, ISSN 1554-8627, 04/2015, Volume 11, Issue 4, pp. 670 - 684
Autophagy is a critical cellular homeostatic process that controls the turnover of damaged organelles and proteins. Impaired autophagic activity is involved in... 
CASP3, caspase 3, apoptosis-related cysteine peptidase | MAP1LC3B/LC3B, microtubule-associated protein 1 light chain 3 β | TUBB4, tubulin, β 4, class IV | DRAM2, DNA-damage regulated autophagy modulator 2 | IL13, interleukin 13 | CAV1, caveolin 1, caveolae protein, 22kDa | CCL3, chemokine (C-C motif) ligand 3 | ATG9B, autophagy-related 9B | RELA, v-rel reticuloendotheliosis viral oncogene homolog A | TGFB1, transforming growth factor, β 1 | ATG4B, autophagy-related 4B | epithelial cell | ATG3, autophagy-related 3 | CXCR2, chemokine (C-X-C motif) receptor 2 | lung fibrosis | IFNG, interferon, gamma | ATG7, autophagy-related 7 | ATG5, autophagy-related 5 | CXCL1, chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity α) | autophagin-1 | GFP-LC3B, green fluorescent protein-LC3B | TGFBR2, transforming growth factor, β receptor II (70/80kDa) | autophagy | TNF, tumor necrosis factor | IL12B, interleukin 12B | WT, wild type | idiopathic pulmonary fibrosis | IPF, idiopathic pulmonary fibrosis | SQSTM1, sequestosome 1 | ACTA2, actin, α 2, smooth muscle, aorta | BAX, BCL2-associated X protein | ATG4B | cysteine peptidase | Epithelial cell | Autophagin-1 | Autophagy | Idiopathic pulmonary fibrosis | Lung fibrosis | APOPTOSIS | LUNG INJURY | RECEPTOR | CELL BIOLOGY | DISEASES | EPITHELIAL-CELLS | IL-17A PROMOTES | INFLAMMATION | MICE | EXPRESSION | CAVEOLIN-1 | Autophagy-Related Proteins | Cytokines - metabolism | Gene Expression - drug effects | Epithelial Cells - drug effects | Apoptosis - genetics | Autophagy - physiology | Idiopathic Pulmonary Fibrosis - chemically induced | Autophagy - drug effects | Idiopathic Pulmonary Fibrosis - metabolism | Mice, Knockout | Animals | Cysteine Endopeptidases - metabolism | Cysteine Endopeptidases - genetics | Bleomycin - pharmacology | Homeostasis - drug effects | Epithelial Cells - cytology | Cytokines - genetics
Journal Article
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, ISSN 1422-0067, 08/2019, Volume 20, Issue 15, p. 3768
Journal Article
Journal Article
Autophagy, ISSN 1554-8627, 12/2014, Volume 10, Issue 12, pp. 2251 - 2268
How autophagic degradation is linked to endosomal trafficking routes is little known. Here we screened a collection of uncharacterized Drosophila mutants... 
Socs36E, suppressor of cytokine signaling at 36E | Vps25, vacuolar protein sorting 25 | dome | ESCRT, endosomal sorting complex required for transport | Syb, Synaptobrevin | hop-Stat92E, hopscotch-signal transducer and activator of transcription protein at 92E | SNARE | EM, electron microscopy | FE, follicular epithelium | usnp | CEDNIK, cerebral dysgenesis, neuropathy, ichthyosis, and palmoplantar keratoderma | V-ATPase, vacuolar H | dome, domeless | NECD, N extracellular domain | Vamp, vesicle-associated membrane protein | trafficking | N, Notch | CFP, cyan fluorescent protein | Atg, autophagy-related | GFP, green fluorescent protein | autophagy | MENE, mutant eye no eclosion | ATPase | Notch | WT, wild type | refP, refractory to sigma P | MVB, multivesicular body | + | Snap29 | NPF, asparagine-proline-phenylalanine | SNARE, soluble NSF attachment protein receptor | os, outstretched | E(spl)mβ-HLH, enhancer of split mβ, helix-loop-helix | Syx, syntaxin | histone H3, His3 | Snap29, synaptosomal-associated protein 29 kDa | Dome | Trafficking | Usnp | Autophagy | ACTIVATION | FUSION | ATPASE | COMPLEX GENES | CELL BIOLOGY | GENETIC SCREEN | SNAP-29 | PATHWAY | NOTCH RECEPTOR | UNCONVENTIONAL SECRETION | MELANOGASTER | Exosomes - metabolism | Vesicular Transport Proteins - metabolism | Humans | Phagosomes - metabolism | Qb-SNARE Proteins - metabolism | Protein Transport - physiology | Autophagy - physiology | Drosophila Proteins - metabolism | Cell Movement - physiology | Endosomes - metabolism | Drosophila melanogaster - metabolism | Animals | Qc-SNARE Proteins - metabolism | SNARE Proteins - metabolism | Protein Binding - physiology
Journal Article
PLoS ONE, ISSN 1932-6203, 04/2012, Volume 7, Issue 4, p. e33454
Rationale and Objective: Autophagy is a cellular process directed at eliminating or recycling cellular proteins. Recently, the autophagy pathway has been... 
NASAL | SNP | MULTIDISCIPLINARY SCIENCES | RISK | LOCI | IMMUNOLOGY | ALLERGIC DISEASES | EXPRESSION | Haplotypes | Asthma - metabolism | Luciferases, Renilla - genetics | Microtubule-Associated Proteins - genetics | Microtubule-Associated Proteins - metabolism | Humans | Child, Preschool | Male | Case-Control Studies | Luciferases, Renilla - biosynthesis | HEK293 Cells | Female | Transcription, Genetic | Nasal Mucosa - metabolism | Child | Genes, Reporter | Promoter Regions, Genetic | Ubiquitin-Activating Enzymes - genetics | Genetic Association Studies | Gene Frequency | Ubiquitin-Activating Enzymes - metabolism | Sequence Analysis, DNA | Asthma - genetics | Linkage Disequilibrium | Autophagy-Related Protein 7 | Luciferases, Firefly - biosynthesis | Autophagy-Related Protein 5 | Adolescent | Luciferases, Firefly - genetics | Polymorphism, Single Nucleotide | Asthma - pathology | Infection | Cellular proteins | Asthma in children | Analysis | Genes | Genetic aspects | Single nucleotide polymorphisms | Pediatrics | Pathogenesis | Families & family life | Nervous system | Infections | Single-nucleotide polymorphism | Family medical history | Autophagy | Proteins | Hepatitis | Children | Genealogy | RNA polymerase | Epithelium | Allergies | Asthma | Medicine | Genetic variance | Hospitals | Influenza | Tagging | Adults | Phagocytosis | Apoptosis
Journal Article
Journal Article
PLOS ONE, ISSN 1932-6203, 04/2019, Volume 14, Issue 4, p. e0215818
This study aimed to analyze changes in the expression of autophagy- and phagocytosis-related genes in patients with dilated cardiomyopathy (DCM), especially in... 
PHAGOSOMES | SYSTEM | CELLS | GOLGI | MULTIDISCIPLINARY SCIENCES | GUIDELINES | Humans | Middle Aged | Male | Gene Expression Profiling | RNA, Messenger - metabolism | Case-Control Studies | Angiotensin-Converting Enzyme Inhibitors - therapeutic use | Cardiomyopathy, Dilated - drug therapy | Ventricular Dysfunction, Left - genetics | Myocardium - metabolism | Adult | Female | Autophagy - genetics | Nuclear Proteins - genetics | Autophagy-Related Proteins - genetics | Heart Ventricles - pathology | Adrenergic beta-Antagonists - therapeutic use | Cardiomyopathy, Dilated - genetics | RNA, Messenger - genetics | Gene Expression Regulation | Myocardium - pathology | Nuclear Proteins - metabolism | Receptors, Cytoplasmic and Nuclear - genetics | Cardiomyopathy, Dilated - metabolism | Ventricular Dysfunction, Left - physiopathology | Mineralocorticoid Receptor Antagonists - therapeutic use | Ventricular Dysfunction, Left - metabolism | Sequence Analysis, RNA | Ventricular Dysfunction, Left - drug therapy | Cardiomyopathy, Dilated - physiopathology | Adaptor Proteins, Signal Transducing - genetics | Diuretics - therapeutic use | Heart Ventricles - metabolism | Adaptor Proteins, Signal Transducing - metabolism | Autophagy-Related Proteins - metabolism | Receptors, Cytoplasmic and Nuclear - metabolism | Heart | Ethylenediaminetetraacetic acid | Medical research | RNA | Analysis | Genes | Medicine, Experimental | Aprotinin | Gene expression | Cardiomyopathy, Dilated | Usage | Cardiomyopathy | Genetic aspects | Research | Electron microscopy | Heart diseases | Left ventricular function | Heart failure | Biomedical research | Disease | Remodeling | Kinases | Tissues | Ribonucleic acid--RNA | Autophagy | Gene sequencing | Proteins | Hospitals | Transmission electron microscopy | Molecular modelling | Disease transmission | Dilated cardiomyopathy | Ventricle | Cardiology | Phagocytosis | Ribonucleic acid
Journal Article