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Nature Neuroscience, ISSN 1097-6256, 11/2003, Volume 6, Issue 11, pp. 1162 - 1168
The generation of neurons from stem cells involves the activity of proneural basic helix-loop-helix (bHLH) proteins, but the mechanism by which these proteins... 
VENTRAL NEURAL-TUBE | SOX2 | NERVOUS-SYSTEM | STEM-CELLS | BHLH PROTEIN | GENE-EXPRESSION | NEURONAL DIFFERENTIATION | CHICK-EMBRYO | ACHAETE-SCUTE | FATE | NEUROSCIENCES | Helix-Loop-Helix Motifs - physiology | Homeodomain Proteins - metabolism | PAX7 Transcription Factor | Phosphopyruvate Hydratase - metabolism | DNA-Binding Proteins - metabolism | Stem Cells | Tubulin - metabolism | Time Factors | Gene Expression Regulation, Developmental | Neurons - metabolism | Bromodeoxyuridine - metabolism | Membrane Glycoproteins | Spinal Cord - cytology | SOXB1 Transcription Factors | Cell Differentiation - physiology | Basic Helix-Loop-Helix Transcription Factors | DNA-Binding Proteins - physiology | HMGB Proteins | High Mobility Group Proteins - metabolism | Drosophila | Embryonic Induction | Neuropeptides - metabolism | Nuclear Proteins - metabolism | Electroporation - methods | Chick Embryo | Proto-Oncogene Proteins c-myc - metabolism | Nerve Tissue Proteins - metabolism | Transcription Factors - metabolism | Spinal Cord - embryology | Vertebrates | Animals | Eye Proteins - metabolism | Spinal Cord - physiology | Avian Proteins | LIM-Homeodomain Proteins | High Mobility Group Proteins - physiology | Mice | Nuclear Proteins - physiology | Neurofilament Proteins - metabolism | Physiological aspects | Research | DNA binding proteins | Neurons | Cell cycle | Index Medicus
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 2010, Volume 5, Issue 11, pp. e13927 - e13927
Type I interferons (IFNs) function as the first line of defense against viral infections by modulating cell growth, establishing an antiviral state and... 
H5N1 AVIAN INFLUENZA | A VIRUS | IMMUNE-RESPONSE | ANTIVIRAL RESPONSES | NEURAMINIDASE INHIBITORS | VIRAL DISEASE | MULTIDISCIPLINARY SCIENCES | CHRONIC HEPATITIS-C | BETA-INTERFERON | ALPHA-INTERFERON | CORE PROTEIN | Phosphorylation | Gene Expression - drug effects | Influenza A Virus, H5N1 Subtype - physiology | Humans | Influenza A virus - genetics | Influenza A Virus, H1N1 Subtype - physiology | Suppressor of Cytokine Signaling 1 Protein | Immunoblotting | Green Fluorescent Proteins - genetics | Lung - virology | STAT1 Transcription Factor - metabolism | Macrophages - virology | Lung - metabolism | Receptor, Interferon alpha-beta - genetics | Influenza A Virus, H5N1 Subtype - metabolism | Influenza A Virus, H1N1 Subtype - metabolism | Receptor, Interferon alpha-beta - metabolism | Green Fluorescent Proteins - metabolism | Influenza A virus - physiology | Interferons - pharmacology | Tissue Culture Techniques | Cells, Cultured | Suppressor of Cytokine Signaling Proteins - genetics | Viral Nonstructural Proteins - genetics | Macrophages - cytology | Reverse Transcriptase Polymerase Chain Reaction | Viral Nonstructural Proteins - physiology | Host-Pathogen Interactions | Microscopy, Confocal | Macrophages - metabolism | Influenza A virus - metabolism | Lung - drug effects | Interferons - metabolism | Signal Transduction - physiology | Viral Nonstructural Proteins - metabolism | STAT2 Transcription Factor - metabolism | HeLa Cells | Suppressor of Cytokine Signaling Proteins - metabolism | Infection | Avian influenza | Genes | Avian influenza viruses | Development and progression | Interferon | Biological response modifiers | Health aspects | Lung | Viruses | Genomes | Infections | Kinases | Macrophages | Drug resistance | Tissues | Influenza A | Inhibition | Stat1 protein | Deoxyribonucleic acid--DNA | Stat2 protein | Tyrosine | Translocation | Antiviral state | Stat3 protein | Gene expression | Nuclear transport | Immune systems | Signaling | Monocytes | Influenza | Replication | Index Medicus | Deoxyribonucleic acid | DNA
Journal Article
PLoS ONE, ISSN 1932-6203, 09/2016, Volume 11, Issue 9, pp. e0162356 - e0162356
The p17 protein of avian reovirus (ARV) causes cell cycle retardation in a variety of cell lines; however, the underlying mechanism(s) by which p17 regulates... 
ARREST | ACTIVATION | CHECKPOINT PATHWAY | MULTIDISCIPLINARY SCIENCES | DNA-DAMAGE | INTERPHASE REQUIRES | POLO-LIKE KINASE-1 | NONSTRUCTURAL PROTEIN | MOUTH-DISEASE VIRUS | EXPRESSION | AUTOGRAPHA-CALIFORNICA NUCLEOPOLYHEDROVIRUS | Up-Regulation | Phosphorylation | Cell Proliferation | Immunoprecipitation | Ataxia Telangiectasia Mutated Proteins - metabolism | Vimentin - metabolism | Ubiquitin - metabolism | Cercopithecus aethiops | Viral Proteins - metabolism | CDC2 Protein Kinase - metabolism | Transfection | Proteolysis | Cell Division | Cyclin-Dependent Kinase Inhibitor p21 - metabolism | G2 Phase | Protein Interaction Domains and Motifs | cdc25 Phosphatases - metabolism | Vero Cells | Protein-Serine-Threonine Kinases - metabolism | Proto-Oncogene Proteins - metabolism | Signal Transduction | Nuclear Pore Complex Proteins - metabolism | Viral Proteins - chemistry | Down-Regulation | Orthoreovirus, Avian - metabolism | Cell Cycle Proteins - metabolism | Tumor Suppressor Protein p53 - metabolism | Phosphoserine - metabolism | Chick Embryo | Checkpoint Kinase 1 - metabolism | Animals | Virus Replication | Models, Biological | Protein Binding | Proteasome Endopeptidase Complex - metabolism | Ubiquitin | Tumor proteins | Intermediate filament proteins | Goods and services tax | Cell cycle | Vimentin | Agricultural biotechnology | Polo-like kinase 1 | p53 Protein | DNA damage | Foot & mouth disease | Viruses | Genomes | Kinases | Inactivation | Phosphatase | Proteins | Pathways | p17 Protein | Inhibition | Deoxyribonucleic acid--DNA | Deactivation | CHK1 protein | Gene expression | Signaling | Cell lines | In vivo methods and tests | Molecular biology | Binding sites | Viral infections | Index Medicus | Deoxyribonucleic acid | DNA
Journal Article
PLoS ONE, ISSN 1932-6203, 10/2011, Volume 6, Issue 10, pp. e25697 - e25697
The genus Orbivirus includes both insect and tick-borne viruses. The orbivirus genome, composed of 10 segments of dsRNA, encodes 7 structural proteins... 
COMPLETE SEQUENCE | GENOME SEGMENTS | FAMILY REOVIRIDAE | OUTER-CAPSID PROTEINS | REOVIRUS-SPECIFIED POLYPEPTIDES | CRYOELECTRON MICROSCOPY | MULTIDISCIPLINARY SCIENCES | BLUETONGUE VIRUS SEROTYPE-1 | AVIAN REOVIRUS | S1 MESSENGER-RNA | MAMMALIAN-CELLS | Molecular Sequence Data | Colorimetry | Orbivirus - metabolism | Reoviridae Infections - virology | Viral Nonstructural Proteins - chemistry | Cell Nucleus - metabolism | Transfection | Cell Nucleolus - metabolism | Cloning, Molecular | Conserved Sequence | RNA, Double-Stranded - metabolism | Reoviridae Infections - metabolism | Recombinant Proteins - metabolism | Amino Acid Sequence | Cell Line | Computational Biology | Viral Nonstructural Proteins - genetics | Open Reading Frames - genetics | Subcellular Fractions - metabolism | Blotting, Western | Viral Nonstructural Proteins - isolation & purification | Protein Transport | Sequence Homology, Amino Acid | Animals | Nuclease Protection Assays | Hydrophobic and Hydrophilic Interactions | Protein Binding | Viral Nonstructural Proteins - metabolism | Microscopy, Fluorescence | Enzymes | Genomics | Antibodies | Amino acids | Genomes | Nucleic acids | Ribonuclease | Cells | Viral antibodies | Analysis | Hydrolases | Fluorescence microscopy | Protein binding | Coils | VP1 protein | Cell culture | Membranes | Fluorescence | Viruses | Infections | Confocal | Nuclei | Western blotting | Mammalian cells | Degradation | Proteins | DNA helicase | Nucleoli | Localization | Deoxyribonucleic acid--DNA | Recombinant | Arachnids | Deoxyribonuclease | Antigens | Structural proteins | Double-stranded RNA | Vectors (Biology) | Bluetongue | Insects | Ribonuclease III | Insect cells | Coiling | Cytoplasm | Viral infections | Apoptosis | Index Medicus | Deoxyribonucleic acid | DNA
Journal Article
Nature Structural & Molecular Biology, ISSN 1545-9993, 09/2005, Volume 12, Issue 9, pp. 763 - 771
The helicase-associated endonuclease for fork-structured DNA (Hef) is an archaeabacterial protein that processes blocked replication forks. Here we have... 
PROTEIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | IMMUNOGLOBULIN GENE CONVERSION | MAMMALIAN-CELLS | DAMAGE | CELL BIOLOGY | ENDONUCLEASE | BIOPHYSICS | REPLICATION FORKS | DEFICIENT | HOMOLOGOUS RECOMBINATION | DNA-REPAIR | HELICASE | Genomic Instability | Endonucleases - genetics | Fanconi Anemia - metabolism | Humans | Endonucleases - metabolism | DNA-Binding Proteins - deficiency | Avian Proteins - chemistry | Chickens - metabolism | DNA-Binding Proteins - metabolism | Nuclear Proteins - deficiency | Tumor Suppressor Proteins - genetics | Cell Cycle Proteins - genetics | Conserved Sequence | Fanconi Anemia Complementation Group C Protein | Chickens - genetics | Fanconi Anemia - genetics | Nuclear Proteins - genetics | Cell Line | Avian Proteins - metabolism | Tumor Suppressor Proteins - metabolism | Cell Cycle Proteins - metabolism | Adenosine Triphosphatases - metabolism | DNA Replication | Nuclear Proteins - metabolism | DNA - metabolism | DNA-Binding Proteins - genetics | Nuclear Proteins - chemistry | Fanconi Anemia Complementation Group Proteins | DNA Helicases - metabolism | Animals | Avian Proteins - deficiency | DNA Repair | DNA Damage | Avian Proteins - genetics | Evolution, Molecular | Physiological aspects | Tumor suppressor genes | Genetic aspects | Research | Diagnosis | DNA repair | Risk factors | Fanconi's anemia | Index Medicus
Journal Article
Nature Cell Biology, ISSN 1465-7392, 03/2007, Volume 9, Issue 3, pp. 310 - 315
Journal Article
PLoS Pathogens, ISSN 1553-7366, 09/2013, Volume 9, Issue 9, pp. e1003613 - e1003613
Covalently closed circular DNA (cccDNA) of hepadnaviruses exists as an episomal minichromosome in the nucleus of infected hepatocyte and serves as the... 
CLOSED CIRCULAR DNA | HEPATITIS-B-VIRUS | CHROMATIN | REVERSE TRANSCRIPTION | MICROBIOLOGY | LAMIVUDINE THERAPY | REPLICATIVE ACTIVITY | VIROLOGY | PEGINTERFERON ALPHA-2A | VIRAL-DNA | X PROTEIN | GENE-EXPRESSION | PARASITOLOGY | Transcription, Genetic - drug effects | Hepadnaviridae Infections - virology | Avian Proteins - antagonists & inhibitors | Avian Proteins - biosynthesis | Hepatocytes - metabolism | Protein Processing, Post-Translational - drug effects | Epigenesis, Genetic - drug effects | Protein Synthesis Inhibitors - pharmacology | Hepatitis B Virus, Duck - metabolism | Hepatocytes - drug effects | Hepadnaviridae Infections - metabolism | Cell Line | Interferon-alpha - metabolism | Avian Proteins - metabolism | DNA, Viral - metabolism | Histone Deacetylases - chemistry | Histone Deacetylases - metabolism | Down-Regulation - drug effects | DNA, Circular - metabolism | Acetylation - drug effects | Animals | Hepatitis B Virus, Duck - drug effects | Chickens | Hepatocytes - virology | Histone Deacetylase Inhibitors - pharmacology | Protein Biosynthesis - drug effects | Histones - metabolism | Lysine - chemistry | Epigenetic inheritance | Physiological aspects | Interferon | Genetic aspects | Genetic transcription | Research | Nucleotide sequencing | Health aspects | DNA viruses | DNA sequencing | Index Medicus | Proteins | Hepatitis | Cell culture | Cytokines | Deoxyribonucleic acid | DNA | DNA methylation | Epigenetics | Genomes
Journal Article